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    RADIATION STERILIZATION OF IMPLANTABLE MEDICAL DEVICES
    181.
    发明申请
    RADIATION STERILIZATION OF IMPLANTABLE MEDICAL DEVICES 审中-公开
    可植入医疗器械的辐射灭菌

    公开(公告)号：US20150217009A1

    公开(公告)日：2015-08-06

    申请号：US14620090

    申请日：2015-02-11

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Greg Simmons ,  Brian Riggs

    IPC: A61L2/08

    CPC classification number: A61L2/087 ,  A61L2/08 ,  A61L2/24

    Abstract: A system and method for sterilization of medical devices includes methods for reducing the variance in dose levels over the medical device by either varying the dose levels for each pass before a radiation source, such as an electron beam, or by increasing the number of passes before a radiation source.

    Abstract translation: 用于医疗装置的灭菌的系统和方法包括通过改变辐射源（例如电子束）之前的每次通过来改变剂量水平，或通过增加先前的通过次数来减少医疗装置上的剂量水平的变化的方法 辐射源。

    Non-compliant multilayered balloon for a catheter
    182.
    发明授权
    Non-compliant multilayered balloon for a catheter 有权
    用于导管的不符合标准的多层气囊

    公开(公告)号：US09095689B2

    公开(公告)日：2015-08-04

    申请号：US13775724

    申请日：2013-02-25

    Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

    Inventor： Jonathan P. Durcan

    IPC: A61M31/00 ,  A61M37/00 ,  A61M25/10 ,  A61F2/958 ,  A61L29/06

    CPC classification number: A61M25/1029 ,  A61F2/958 ,  A61F2250/0018 ,  A61F2250/0063 ,  A61L29/06 ,  A61M25/10 ,  A61M25/104 ,  A61M2025/1075 ,  A61M2025/1084 ,  B29C67/0014 ,  C08L77/00

    Abstract: Balloon catheter comprises an elongate catheter shaft having a proximal section, a distal section, and an inflation lumen, and a multilayer balloon on the distal section of the shaft. The multilayer balloon comprises a first layer made of a first polymer material having a first Shore durometer hardness, a second layer made of a second polymer material having a second Shore durometer hardness lower than the first shore durometer hardness, wherein the second layer is an inner layer relative to the first layer, and an outer-most layer made of a third polymer material having a third Shore durometer hardness lower than the second Shore durometer hardness.

    Abstract translation: 气囊导管包括具有近端部分，远侧部分和充气腔的细长导管轴，以及在轴的远侧部分上的多层气囊。 多层气囊包括由具有第一肖氏硬度硬度的第一聚合物材料制成的第一层，由第二聚合物材料制成的第二层，其具有低于第一肖氏硬度计硬度的第二肖氏硬度计硬度，其中第二层是内部 层和由第三聚合物材料制成的最外层，其具有低于第二肖氏硬度计硬度的第三肖氏硬度计硬度。

    METHOD FOR RADIATION STERILIZATION OF MEDICAL DEVICES
    187.
    发明申请
    METHOD FOR RADIATION STERILIZATION OF MEDICAL DEVICES 审中-公开
    医疗器械辐射灭菌方法

    公开(公告)号：US20150157751A1

    公开(公告)日：2015-06-11

    申请号：US14625335

    申请日：2015-02-18

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Stan Lam ,  James Wise

    IPC: A61L2/08

    CPC classification number: A61L2/087 ,  A61L2/081 ,  A61L2/082 ,  A61L2202/21

    Abstract: Sterilization of medical devices can be performed by stacking packages containing the medical devices. The packages are arranged in a partially-overlapping orientation which is at an oblique angle to the direction of irradiation. The partially-overlapping orientation and oblique angle are predetermined for high sterilization throughput and tight control of irradiation. Instead arranging the packages directly on a sterilization platform at a sterilization facility, the packages can be stacked in the partially-overlapping orientation into a transport container at a location remote from the sterilization facility. The transport container maintains the orientation of the packages. Thereafter, the transport container is placed on the sterilization platform, which results in greater uniformity in radiation exposure while maintaining a high level of sterilization throughput.

    Abstract translation: 可以通过堆叠包含医疗装置的包装来进行医疗装置的灭菌。 包装以与照射方向成倾斜角度的部分重叠取向布置。 部分重叠的取向和倾斜角度是预定的，用于高灭菌吞吐量和严格控制照射。 相反地​​，将包装直接放置在消毒设备的消毒平台上，可以将包装以部分重叠的方式堆叠在远离灭菌设备的位置处的运输容器中。 运输容器保持包装的方向。 此后，将运输容器放置在灭菌平台上，这样可以在保持高水平的灭菌生产能力的同时使辐射暴露更均匀。

    Plasticizers For Coating Compositions
    188.
    发明申请
    Plasticizers For Coating Compositions 审中-公开
    涂料组合物增塑剂

    公开(公告)号：US20150150989A1

    公开(公告)日：2015-06-04

    申请号：US14621301

    申请日：2015-02-12

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Stephen Dirk Pacetti ,  Yiwen Tang ,  Syed Faiyaz Ahmed Hossainy

    IPC: A61K47/34 ,  C09D167/00 ,  C08K5/1575 ,  A61K31/436

    CPC classification number: A61K47/34 ,  A61K31/436 ,  A61L27/34 ,  A61L27/502 ,  A61L31/10 ,  A61L31/141 ,  C08K5/1575 ,  C08L67/04 ,  C09D167/00

    Abstract: A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof

    Abstract translation: 提供了可用于形成具有生物相容性聚合物的涂料组合物的生物相容性增塑剂。 涂料组合物还可以包括生物有益的聚合物和/或生物活性剂。 涂料组合物可以在可植入装置上形成涂层。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管阻塞 ，输尿管阻塞，肿瘤阻塞或其组合

    DIOXANONE-BASED COPOLYMERS FOR IMPLANTABLE DEVICES
    190.
    发明申请
    DIOXANONE-BASED COPOLYMERS FOR IMPLANTABLE DEVICES 审中-公开
    用于可植入器件的基于二氧化硅的共聚物

    公开(公告)号：US20150134048A1

    公开(公告)日：2015-05-14

    申请号：US14602617

    申请日：2015-01-22

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Ni Ding

    IPC: A61L31/06 ,  A61K31/436 ,  A61F2/82 ,  C08G63/66

    CPC classification number: A61L31/06 ,  A61F2/82 ,  A61F2250/0067 ,  A61K31/436 ,  C08G63/64 ,  C08G63/66 ,  C08G63/664 ,  C08G63/78

    Abstract: The present invention is directed to polymeric materials comprising biodegradable, dioxanone-based copolymers and implantable devices (e.g., drug-delivery stents) formed of such materials. The polymeric materials can also contain at least one additional biocompatible moiety, at least one non-fouling moiety, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric materials are designed to improve the mechanical, physical and biological properties of implantable devices formed thereof.

    Abstract translation: 本发明涉及包含由这些材料形成的可生物降解的二恶烷酮基共聚物和可植入装置（例如药物递送支架）的聚合物材料。 聚合物材料还可含有至少一种另外的生物相容性部分，至少一种非结垢部分，至少一种生物有益材料，至少一种生物活性剂或其组合。 聚合材料被设计成改善由其形成的可植入装置的机械，物理和生物学特性。

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