公开(公告)号：US20140166000A1

公开(公告)日：2014-06-19

申请号：US14104481

申请日：2013-12-12

Applicant: Wake Forest University Health Sciences

Inventor： Michael A. Olympio

IPC: A61M16/04

CPC classification number: A61M16/0493 ,  A61M16/0488 ,  A61M2025/0183

Abstract: Tracheal assembly devices include: (a) a mouthpiece sized and configured to allow an endotracheal tube to extend outwardly therefrom; and (b) a cutting blade in communication with an outwardly facing portion of the mouthpiece. The mouthpiece can include at least one outwardly projecting substantially rigid short tube defining an open channel. The short tube can be configured to allow the endotracheal tube to slidably move therethrough. The cutting blade may be held in a handle releasably attached to the short tube.

Abstract translation: 气管组装装置包括：（a）口部的尺寸和构造允许气管内管从其向外延伸; 和（b）与所述接口管的向外部分连通的切割刀片。 接口管可以包括限定开放通道的至少一个向外突出的基本上刚性的短管。 短管可以被配置为允许气管内管可滑动地移动通过。 切割刀片可以保持在可释放地附接到短管的手柄中。

公开(公告)号：US08673002B2

公开(公告)日：2014-03-18

申请号：US13901115

申请日：2013-05-23

Applicant: Wake Forest University Health Sciences

Inventor： Keith Andrew Walter ,  Kurt Weber

IPC: A61F2/16

CPC classification number: A61F2/148 ,  A61F2/0095 ,  A61F2/142 ,  A61F9/007

Abstract: Systems, devices and methods for performing small incision DLEK include providing a corneal transplantation donor tissue graft; then forming the tissue graft into an implantable configuration using the flexible substrate. Related medical kits and tools for forming a compact or rolled donor tissue graft are also described.

Abstract translation: 用于进行小切口DLEK的系统，装置和方法包括提供角膜移植供体组织移植物; 然后使用柔性基底将组织移植物形成可植入构型。 还描述了用于形成紧密或轧制的供体组织移植物的相关医疗试剂盒和工具。

公开(公告)号：US20130344056A1

公开(公告)日：2013-12-26

申请号：US14010902

申请日：2013-08-27

Applicant: Wake Forest University Health Sciences

Inventor： Mark E. Van Dyke ,  Thomas L. Smith ,  Michael Callahan ,  Luke Burnett

IPC: A61K38/17 ,  A61K38/48 ,  A61K31/727

CPC classification number: A61K38/1748 ,  A61K9/0019 ,  A61K31/727 ,  A61K38/015 ,  A61K38/166 ,  A61K38/482 ,  A61K38/49 ,  A61K45/06 ,  A61L15/44 ,  A61L2300/252 ,  A61K2300/00

Abstract: Provided herein are keratin compositions useful for treating ischemia and/or reperfusion injury, such as that associated with myocardial infarct, ischemic stroke, brain trauma such as traumatic brain injury, hypothermia, chronic wounds, and burns.

Abstract translation: 本文提供了可用于治疗缺血和/或再灌注损伤的角蛋白组合物，例如与心肌梗塞，缺血性卒中，脑外伤如创伤性脑损伤，低体温，慢性伤口和烧伤相关的损伤。

公开(公告)号：US20130253529A1

公开(公告)日：2013-09-26

申请号：US13901115

申请日：2013-05-23

Applicant: Wake Forest University Health Sciences

Inventor： Keith Andrew Walter ,  Kurt Weber

IPC: A61F2/14

CPC classification number: A61F2/148 ,  A61F2/0095 ,  A61F2/142 ,  A61F9/007

Abstract: Systems, devices and methods for performing small incision DLEK include providing a corneal transplantation donor tissue graft; then forming the tissue graft into an implantable configuration using the flexible substrate. Related medical kits and tools for forming a compact or rolled donor tissue graft are also described.

Abstract translation: 用于进行小切口DLEK的系统，装置和方法包括提供角膜移植供体组织移植物; 然后使用柔性基底将组织移植物形成可植入构型。 还描述了用于形成紧密或轧制的供体组织移植物的相关医疗试剂盒和工具。

公开(公告)号：US20130231554A1

公开(公告)日：2013-09-05

申请号：US13780323

申请日：2013-02-28

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Youngkyoo Jung

IPC: A61B5/055 ,  A61B5/00

CPC classification number: A61B5/055 ,  A61B5/0263 ,  A61B5/7257 ,  A61B5/7425 ,  A61B2576/026 ,  G01R33/5608 ,  G01R33/56366 ,  G06T7/0012 ,  G06T2207/10088 ,  G06T2207/30016 ,  G06T2207/30104

Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional color blood flow map that combines X and Y encoded primary and secondary peak data of 1-dimensional Inverse Fourier Transform images to visually indicate (i) anterior/posterior and right/left directional components of respective feeding arteries using defined colors and (ii) brightness to indicate an amount of blood flow associated with each voxel, with increased brightness associated with increased blood flow.

Abstract translation: 方法，系统，计算机程序，电路和工作站被配置为生成至少一个二维彩色血流图，其组合了X维和Y编码的一维傅里叶逆变换图像的主峰数据和次峰值数据，以在视觉上指示（i） （ii）明亮度以指示与每个体素相关联的血流量，具有与增加的血液流量相关联的增加的亮度。

公开(公告)号：US20130197640A1

公开(公告)日：2013-08-01

申请号：US13765104

申请日：2013-02-12

Applicant: Wake Forest University Health Sciences

Inventor： George J. Christ ,  Benjamin T. Corona

IPC: C12N5/071 ,  A61F2/08

CPC classification number: A61L27/3895 ,  A61F2/08 ,  A61F2002/0894 ,  A61K35/12 ,  A61K35/34 ,  A61L27/3826 ,  A61L27/3873 ,  C12M35/02 ,  C12N5/0658 ,  C12N5/0697 ,  C12N2527/00 ,  C12N2533/54 ,  C12N2533/90

Abstract: Provided herein are methods of culturing organized skeletal muscle tissue from precursor muscle cells by cyclically stretching and relaxing said muscle cells on a support in vitro for a time sufficient to produce said organized skeletal muscle tissue, including reseeding said organized skeletal muscle tissue by contacting additional precursor muscle cells to said organized skeletal muscle tissue on said solid support, and then repeating said step of cyclically stretching and relaxing said muscle cells in said support in vitro for time sufficient to enhance the density (i.e., increased number of nuclei and/or number of multinucleated cells) of said organized skeletal muscle tissue on said support.

Abstract translation: 本文提供的方法是通过在体外在载体上循环拉伸和松弛所述肌肉细胞足以产生所述有组织的骨骼肌组织的时间，包括通过使另外的前体接触来重新接合所述组织的骨骼肌组织，从前体肌细胞培养有组织的骨骼肌组织 将肌细胞移动到所述固体支持物上的所述有组织的骨骼肌组织，然后重复所述在体外循环拉伸和松弛所述支持体中所述肌肉细胞的时间足以提高密度（即增加的细胞核数量和/或数量） 所述组织的骨骼肌组织在所述支持体上的多核细胞）。

公开(公告)号：US20130136692A1

公开(公告)日：2013-05-30

申请号：US13692324

申请日：2012-12-03

Applicant: Wake Forest University Health Sciences

Inventor： Waldemar Debinski ,  Jill Wykosky ,  Denise Gibo

IPC: C07K14/705 ,  A61K31/7088 ,  A61K38/20 ,  A61K39/395 ,  A61K38/17 ,  A61K45/06

CPC classification number: A61K38/177 ,  A61K38/00 ,  A61K38/2086 ,  A61K38/45 ,  A61K45/06 ,  A61K47/64 ,  A61K47/642 ,  A61K47/6801 ,  A61K49/0002 ,  C07K14/52 ,  C07K14/705 ,  C12Y204/02036

Abstract: The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.

公开(公告)号：US20250154471A1

公开(公告)日：2025-05-15

申请号：US18741884

申请日：2024-06-13

Applicant: Wake Forest University Health Sciences

Inventor： Anthony Atala ,  James J. Yoo

IPC: C12N5/071 ,  A61K9/00 ,  A61K35/12 ,  A61K35/22 ,  G01N15/01 ,  G01N15/10 ,  G01N15/1031 ,  G01N33/569

Abstract: Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein cells have been expanded in vitro. The kidney cells may include peritubular interstitial cells of the kidney, and preferably produce erythropoietin (EPO). The kidney cells may also be selected based upon EPO production. Methods of producing an isolated population of EPO producing cells are also provided, and methods of treating a kidney disease resulting in decreased EPO production in a patient in need thereof are provided, including administering the population to the patient, whereby the cells produce EPO in vivo.

公开(公告)号：US12268467B2

公开(公告)日：2025-04-08

申请号：US16694017

申请日：2019-11-25

Applicant: Wake Forest University Health Sciences

Inventor： James J. Yoo ,  Anthony Atala ,  Kyle W. Binder ,  Weixin Zhao ,  Dennis Dice ,  Tao Xu

IPC: A61B5/00 ,  A61M35/00 ,  B41J3/407 ,  A61B17/00 ,  A61B17/322 ,  A61B34/10

Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data useful to create a map of a bodily surface; and (b) a printer operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the bodily surface based upon the data or map. Methods of forming a tissue on a bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing bodily surface data.

公开(公告)号：US20250101517A1

公开(公告)日：2025-03-27

申请号：US18655068

申请日：2024-05-03

Applicant: Arthur KRIGSMAN ,  WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Arthur KRIGSMAN ,  Stephen WALKER

IPC: C12Q1/6883 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/68

Abstract: The invention provides compositions and methods for identifying autism and autism spectrum disorders in humans. The invention also includes compositions and methods for identifying unique blood-based gene expression profiles in children with regressive autism spectrum disorder (ASD) and ilcocolitis.