摘要:
The present invention discloses a linear-edged 3D solid or hollow microneedle or microknife. A tip edge of the microneedle or microknife is a linear edge parallel to a group of (111) oriented facets of monocrystalline silicon. The linear edge extends along a straight or curved line and has a narrow width. An opening is formed on one or each side adjoining the linear tip edge, or is formed at the middle of the linear tip edge. The opening is communicated with a channel formed from the bottom surface of the microneedle or microknife, so as to form a through hole from the tip to the bottom of the microneedle or microknife. The triangular channel has six side walls of (111) oriented facets. The microneedle or microknife is used for transdermal drug delivery, body fluid withdrawing or the like. Methods for producing a microneedle or microknife are also disclosed.
摘要:
A re-configurable correlation unit for correlating a sequence of chip samples comprising: 1) a memory for storing the chip samples; 2) a plurality of add-subtract cells, each add-subtract cell receiving a plurality of real bits, a, and a plurality of imaginary bits, b, from a first chip sample; and 3) a plurality of sign select units. Each sign select units receives from one add-subtract cells a first input equal to a sum (a+b) of the real bits, a, and the imaginary bits, b, and a second input equal to a difference (a−b) of the real bits, a, and the imaginary bits, b. Each sign select unit generates a real output and an imaginary output, wherein each of the real and imaginary outputs is equal to one of: 1) the sum (a+b) multiplied by one of +1 and −1 and 2) the difference (a−b) multiplied by one of +1 and −1.
摘要:
Pharmaceutical polypeptide compositions promote the survival of cardiac cells, recruit cardiac cells to the cardiac area, stimulate the differentiation of cardiac cells, stimulate the proliferation of cardiac cells, and promote the activity of cardiac cells, thereby treating cardiac conditions. Methods of providing these compositions to the cardiac area include catheterization and direct injection. In preferred embodiments, the compositions comprise one of more of the following growth factors: EGF, hFGF, cardiotrophin-1, thrombin, PDGF-BB, amphiregulin, epiregulin, HB-EGF, TGFalpha, betacellulin, heregulin alpha, NRG-1-beta1-HRG-beta1, FGF 9.
摘要:
Disclosed are newly identified Interleukin 24 and APO2L splice variant molecules, their polypeptide sequences, and the polynucleotides encoding the polypeptide sequences. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells, and, for example, heterologous secretory leader sequences. Also disclosed are methods for using such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.
摘要:
A method of operating an engine having at least one cylinder, said cylinder including at least one electric valve actuator, said actuator including at least a coil and an armature moveable thereto, the method comprising during a non-firing state of the cylinder: holding the armature of the actuator at a first position away from an equilibrium position by supplying a first amount of current to a first coil of the actuator; and reducing current supplied to the first coil from said first amount to a lower second amount to cause the armature to begin moving toward the equilibrium position; and during a subsequent firing state of the cylinder, varying an amount of holding current supplied to the first coil for holding the armature away from the equilibrium position based on at least said second amount of current.
摘要:
The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.
摘要:
A system for precisely measuring layer-to-layer mis-registration is provided. The system includes a new type of mark and a comparison system, which compare the right and left signals from the mark to eliminate non-alignment noise, to enlarge the alignment information hundreds times then the actual shiftiness between two layers and to measure the mis-registration.
摘要:
A method for increasing decoder throughput is provided that includes dividing a data block into a plurality of segments. For each of the segments, the segment is decoded by performing a plurality of processes for the segment. At least one process for a current segment is performed while at least one process for a preceding segment is performed. Also, at least one process for the current segment is performed while at least one process for a subsequent segment is performed.
摘要:
The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.