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142 条记录 (耗时 0.041 秒)

    DERIVATISATION OF BIOLOGICAL MOLECULES
    12.
    发明申请
    DERIVATISATION OF BIOLOGICAL MOLECULES 有权
    生物分子的衍生物

    公开(公告)号：US20140030210A1

    公开(公告)日：2014-01-30

    申请号：US14037777

    申请日：2013-09-26

    申请人： BIOCOMPATIBLES UK LIMITED

    发明人： Stephen James BROCCHINI ,  Antony Robert GODWIN ,  Yiqing TANG ,  Andrew Lennard LEWIS

    IPC分类号： C07K17/08 ,  C08F30/02

    CPC分类号： A61K47/48176 ,  A61K38/00 ,  A61K38/21 ,  A61K47/58 ,  A61K47/60 ,  C07C323/22 ,  C07K17/08 ,  C08F4/00 ,  C08F4/06 ,  C08F30/02 ,  C08F130/02

    摘要： The present disclosure relates to a new polymerisation process in which ethylenically unsaturated monomers are polymerised by a living radical polymerisation process in the presence of an initiator and a catalyst. Polymers produced by this new process are also thought to be novel and may be used to derivatise biological molecules to improve their efficacy as therapeutic treatments. A preferred polymer is of formula The polymers are particularly suitable for derivatising proteins, such as interferon-α.

    摘要翻译： 本公开涉及一种新的聚合方法，其中烯属不饱和单体通过活性自由基聚合方法在引发剂和催化剂存在下聚合。 通过这种新方法生产的聚合物也被认为是新的，可用于衍生生物分子以提高其作为治疗疗法的功效。 优选的聚合物具有下式聚合物特别适用于衍生化蛋白质，例如干扰素-α。

    Implants for use in brachytherapy and other radiation therapy that resist migration and rotation
    15.
    发明授权
    Implants for use in brachytherapy and other radiation therapy that resist migration and rotation 有权
    用于近距离放射治疗和其他放射治疗的植入物，可抵抗迁移和旋转

    公开(公告)号：US08114007B2

    公开(公告)日：2012-02-14

    申请号：US12335435

    申请日：2008-12-15

    申请人： Gary A. Lamoureux ,  James Matons ,  Warren W. Johnston ,  Matthew Bouffard ,  Warren Rice

    发明人： Gary A. Lamoureux ,  James Matons ,  Warren W. Johnston ,  Matthew Bouffard ,  Warren Rice

    IPC分类号： A61M36/00

    CPC分类号： A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024

    摘要： In an embodiment a therapeutic member includes a solitary radioactive seed. The seed includes a metallic housing with radioactive material contained within the metallic housing. The metallic housing has a first longitudinal end and a second longitudinal end and a longitudinal length between the first and second longitudinal ends. A polymeric material is molded to completely and monolithically encapsulate the metallic housing of the solitary radioactive seed. The implantable therapeutic member is adapted to be implanted into patient tissue using a hollow needle. A portion of the molded polymeric material extends from one of the first and second longitudinal ends of the metallic housing to reduce a tendency of the seed to migrate and rotate within a patient's body after implantation of the member. The portion of the molded polymeric material, that extends from one of the first and second longitudinal ends of the metallic housing, causes the implantable therapeutic member to have a longitudinal length that is greater than the longitudinal length of the metallic housing.

    摘要翻译： 在一个实施方案中，治疗构件包括孤立的放射性种子。 种子包括金属外壳，放射性材料包含在金属外壳内。 金属壳体具有第一纵向端部和第二纵向端部以及在第一和第二纵向端部之间的纵向长度。 将聚合物材料模制成完全和整体地包封孤立的放射性种子的金属壳体。 可植入治疗构件适于使用中空针植入患者组织。 模制的聚合物材料的一部分从金属外壳的第一和第二纵向端之一延伸，以减少种植物在植入构件之后在患者体内迁移和旋转的倾向。 模制聚合物材料的从金属外壳的第一和第二纵向端之一延伸的部分使可植入治疗构件的纵向长度大于金属外壳的纵向长度。

    Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings
    16.
    发明授权
    Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings 失效
    使用由挤出线股架构成的股线进行间质放射治疗的输送系统和方法

    公开(公告)号：US08066627B2

    公开(公告)日：2011-11-29

    申请号：US11455305

    申请日：2006-06-16

    申请人： Richard A. Terwilliger ,  Gary A. Lamoureux

    发明人： Richard A. Terwilliger ,  Gary A. Lamoureux

    IPC分类号： A61M36/00 ,  A61M36/04

    CPC分类号： B29C47/028 ,  A61N5/1027 ,  A61N2005/1023 ,  B29C47/0023 ,  B29C47/021 ,  G21G4/08

    摘要： A delivery system and method for interstitial radiation therapy comprising substantially axially stiff and longitudinally flexible elongated members made of material which is bioabsorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the elongate member. The radioactive seeds can be dispersed within assembled half-shells made of the same material. The housing for the radiation seeds can also be manufactured from extruded material. A system for manufacturing the interstitial radiation therapy seed strands that automatically makes the seed strands at the patient's bedside. The delivery system and method further customize the member based on a prescription.

    摘要翻译： 一种用于间质放射治疗的输送系统和方法，包括由活体组织中生物可吸收的材料制成的基本上轴向刚性和纵向柔性的细长构件，以及以预定阵列分散在细长构件内的多个放射性种子。 放射性种子可以分散在由相同材料制成的组装的半壳内。 用于辐射种子的外壳也可以由挤压材料制成。 用于制造间质放射治疗种子股的系统，其自动使种子股在病人的床边。 递送系统和方法基于处方进一步定制成员。

    DRUG DELIVERY FROM EMBOLIC AGENTS
    17.
    发明申请
    DRUG DELIVERY FROM EMBOLIC AGENTS 审中-公开
    药物从药剂代用药

    公开(公告)号：US20110182952A1

    公开(公告)日：2011-07-28

    申请号：US13084228

    申请日：2011-04-11

    申请人： Andrew Lennard LEWIS ,  Peter W. STRATFORD ,  Simon William LEPPARD

    发明人： Andrew Lennard LEWIS ,  Peter W. STRATFORD ,  Simon William LEPPARD

    IPC分类号： A61K9/14 ,  A61P23/02 ,  A61K31/167 ,  A61K31/245

    CPC分类号： A61L24/0015 ,  A61L24/0031 ,  A61L2300/402 ,  A61L2430/36

    摘要： A pharmaceutical composition for embolization of blood vessels, especially for benign tumours, comprises a polymeric embolic agent and, associated with the polymer in a releasable form, a local anaesthetic agent. The polymer is preferably in particulate form, such as in the form of microspheres. A suitable polymer Is a crosslinked polyvinyl alcohol polymer formed by the copolymerization of PVA macromer with other ethylenically unsaturated monomers. The composition provides a synergistic treatment for the symptoms of tumours such as uterine fibrioids, leading to size regression as well as pain relief.

    摘要翻译： 用于栓塞血管，特别是良性肿瘤的药物组合物包含聚合物栓塞剂，并且以可释放形式的聚合物与局部麻醉剂相关联。 聚合物优选为颗粒形式，例如以微球的形式。 合适的聚合物是通过PVA大分子单体与其它烯属不饱和单体的共聚形成的交联聚乙烯醇聚合物。 该组合物对诸如子宫纤维样肿瘤的症状提供协同治疗，导致大小消退以及疼痛缓解。

    EPITHELIAL DELIVERY
    19.
    发明申请
    EPITHELIAL DELIVERY 审中-公开
    上传

    公开(公告)号：US20110150941A1

    公开(公告)日：2011-06-23

    申请号：US12991349

    申请日：2009-05-14

    申请人： Giuseppe Battaglia

    发明人： Giuseppe Battaglia

    IPC分类号： A61K9/00 ,  C12N5/00 ,  A61K31/4164 ,  A61P31/04

    CPC分类号： A61K9/0014 ,  A61K9/1273 ,  A61K47/32 ,  A61K47/34 ,  C08F293/005 ,  C08F2438/01

    摘要： The present invention relates to composition comprising vesicles and associated with the vesicles, a chemical agent, for use in a method of treatment by therapy wherein the chemical agent is delivered trans- and/or intra-epithelially to a human or animal body, wherein the constructs comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block.Methods for forming the composition are also provided.

    摘要翻译： 本发明涉及包含囊泡并与泡囊相关的组合物，化学试剂，用于通过治疗方法治疗，其中化学试剂被递送和/或上皮外递送至人或动物体，其中 构建体包含具有亲水和疏水嵌段的两亲性嵌段共聚物。 还提供了用于形成组合物的方法。