公开(公告)号：US20210361583A1

公开(公告)日：2021-11-25

申请号：US17327732

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer TOLEDANO ,  Karine NEIMANN ,  Danil FINKEL-MOISEEV ,  Maya ERLICH ,  Dorit MARCO

IPC: A61K9/48 ,  A61K31/202 ,  A61K9/50 ,  A61K31/235 ,  A61K31/336 ,  A61K9/00

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20210346279A1

公开(公告)日：2021-11-11

申请号：US17313136

申请日：2021-05-06

Applicant: Sol-Gel Technologies Ltd.

Inventor： Marcel ZIGHELBOIM ,  Moshe ARKIN ,  Karine NEIMANN ,  Hila HAKAK DJERBI

IPC: A61K9/00 ,  A61K31/05 ,  A61K31/517 ,  A61P17/04 ,  A61K9/06

Abstract: The present invention, in some embodiments thereof, relates to a topical composition for use in treating, preventing, alleviating and/or ameliorating pruritus, wherein the composition comprises tapinarof and the pruritus is not associated with atopic dermatitis, psoriasis or any combination thereof.

公开(公告)号：US20210315834A1

公开(公告)日：2021-10-14

申请号：US17227459

申请日：2021-04-12

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ori Nov ,  Marcel Zighelboim ,  Karine Neimann

IPC: A61K31/05 ,  A61K45/06 ,  A61K9/00 ,  A61K31/517 ,  A61K31/4174 ,  A61K9/06

Abstract: The present invention is directed to a composition comprising aryl hydrocarbon receptor (AhR) agonists and combinations for the prevention and treatment of alopecia and hair loss, e.g. when such conditions are caused by chemotherapy, radiation therapy or hormone replacement therapy.

公开(公告)号：US11071878B2

公开(公告)日：2021-07-27

申请号：US15924331

申请日：2018-03-19

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K9/00 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K8/11 ,  A61K9/06 ,  A61K9/50 ,  B01J13/18 ,  F28D20/02 ,  A61K9/10 ,  A61K47/38 ,  A61K47/32

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US20210113511A1

公开(公告)日：2021-04-22

申请号：US17137883

申请日：2020-12-30

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Ofra Levy-Hacham ,  Rinat Mizrahi

IPC: A61K31/203 ,  A61K9/00 ,  A61P17/10 ,  A61K9/50 ,  A61K31/327

Abstract: The present application is directed to regimens, methods of treatment, and compositions for the treatment of acne in a subject suffering therefrom.

公开(公告)号：US10945987B2

公开(公告)日：2021-03-16

申请号：US16794734

申请日：2020-02-19

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Ofra Levy-Hacham ,  Ori Nov ,  Vered Ram

IPC: A61K31/327 ,  A61P17/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61P17/00 ,  A61K9/50 ,  A61K9/10

Abstract: A regimen is described for providing early onset of action in the therapeutic treatment of rosacea including topically applying a pharmaceutical composition to the skin of a subject in need of said treatment. The pharmaceutical composition includes about 1% to about 10% benzoyl peroxide as the only active ingredient, and a pharmaceutically acceptable carrier or excipient. The pharmaceutical composition is applied once daily for a period of at least about 2, 4, 8 or 12 weeks. Based on early onset of action, a primary measure of success is at least about 9%, primary measure of success being defined as a 2-grade improvement in IGA of clear or almost clear; and a secondary measure of success is at least about 40%, secondary measure of success being defined as mean inflammatory lesion count percent reduction from baseline, after at least about 2 weeks of treatment.

公开(公告)号：US20200377455A1

公开(公告)日：2020-12-03

申请号：US16493391

申请日：2018-03-12

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Stephen CHERKEZ ,  Veera Reddy ARAVA ,  Madhusudhanarao RAYAPUREDDI ,  Venkateswarlu JASTI

IPC: C07D207/12

Abstract: The present application provides novel process for the preparation of glycopyrrolate tosylate.

公开(公告)号：US20140147396A1

公开(公告)日：2014-05-29

申请号：US13686533

申请日：2012-11-27

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Hanan SERTCHOOK ,  Ofer TOLEDANO ,  Haim BAR-SIMANTOV

IPC: A61K31/327

CPC classification number: A61K31/165 ,  A61K9/00 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/1075 ,  A61K9/501 ,  A61K31/192 ,  A61K31/327 ,  A61K31/704 ,  A61K31/7052 ,  A61K31/7056 ,  A61K47/10 ,  A61K47/14 ,  A61K2300/00

Abstract: The present invention relates to pharmaceutical compositions for topical use (including also dermatological compositions), for treating skin conditions and afflictions, such as rosacea and symptoms and conditions associated there from.

Abstract translation: 本发明涉及用于局部使用的药物组合物（包括皮肤病学组合物），用于治疗皮肤病症和疾病，例如红斑痤疮和与之相关的症状和病症。

公开(公告)号：US20110177951A1

公开(公告)日：2011-07-21

申请号：US13056952

申请日：2009-08-02

Applicant: Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Raed Abu-Reziq

Inventor： Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Raed Abu-Reziq

IPC: A01N37/22 ,  A61K9/50 ,  A61K8/11 ,  A61K31/327 ,  A61K31/07 ,  A01N25/08 ,  A01P3/00 ,  A01P7/04 ,  A61P17/06 ,  A61P17/04 ,  A61P17/10 ,  A61P17/08 ,  A61P17/00 ,  A61P31/10 ,  A61P31/04 ,  A61P29/00 ,  A61Q19/00 ,  A01P13/00 ,  B82Y5/00

Abstract: The present invention provides a process for preparing microcapsules comprising a core material encapsulated by a metal oxide shell, microcapsules obtained therewith and uses thereof.

Abstract translation: 本发明提供一种制备微胶囊的方法，其包含由金属氧化物壳包封的芯材料，由其获得的微胶囊及其用途。

公开(公告)号：US07758888B2

公开(公告)日：2010-07-20

申请号：US09983229

申请日：2001-10-23

Applicant: Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

Inventor： Noa Lapidot ,  Shlomo Magdassi ,  David Avnir ,  Claudio Rottman ,  Orit Gans ,  Alon Seri-Levy

IPC: A61K9/14 ,  A61K9/00 ,  A61K9/50 ,  A61K8/00 ,  A61K8/02 ,  A61K8/04 ,  A61K8/11 ,  A61K8/64 ,  A61K8/66 ,  A61K8/19 ,  A61K8/25 ,  A61K8/26 ,  A61K8/27 ,  A61K8/28 ,  A61K8/29 ,  A61K8/38 ,  A61K6/00 ,  A61K38/00 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/355 ,  A61K31/375 ,  A61K31/51 ,  A61K31/65 ,  A61K31/59 ,  A61K31/525 ,  A61K31/34 ,  A61K31/19 ,  A61K31/07

CPC classification number: A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/37 ,  A61K8/38 ,  A61K8/602 ,  A61K8/671 ,  A61K9/501 ,  A61K9/5031 ,  A61K9/5115 ,  A61K9/5138 ,  A61K2800/412 ,  A61K2800/75 ,  A61Q1/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/937 ,  Y10S514/944 ,  Y10S514/945

Abstract: A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.

Abstract translation: 一种用于局部施用的治疗性，化妆品或药妆组合物，其能够稳定活性成分并递送活性成分，其包含多个具有核 - 壳结构的微胶囊。 微胶囊的直径约为0.1至100微米。 每个微胶囊的核心包括至少一种活性成分并且被包封在微胶囊壳内。 壳由至少一种通过溶胶 - 凝胶法获得的无机聚合物组成，并且外壳在局部施用之前保护活性成分，并被设计成在施用后从微胶囊中释放活性成分。 该组合物可用于包封在其它制剂中不稳定或对皮肤有刺激性的活性成分，例如过氧化苯甲酰。