-
公开(公告)号：US08815857B2
公开(公告)日：2014-08-26
申请号：US13570432
申请日：2012-08-09
申请人： Todd Bosanac , Angela Berry , John David Ginn , Tamara Denise Hopkins , Sabine Schlyer , Fariba Soleymanzadeh , John Westbrook , Maolin Yu , Zhonghua Zhang
发明人： Todd Bosanac , Angela Berry , John David Ginn , Tamara Denise Hopkins , Sabine Schlyer , Fariba Soleymanzadeh , John Westbrook , Maolin Yu , Zhonghua Zhang
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D401/04 , C07D401/12 , C07D413/14 , C07D413/12 , C07D417/12 , C07D417/04 , C07D417/14
CPC分类号： C07D417/14 , C07D417/04 , C07D417/12
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 5和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
-
公开(公告)号：US20120142677A1
公开(公告)日：2012-06-07
申请号：US13141105
申请日：2009-12-15
申请人： Angela Berry , Rajashekhar Betageri , Eugene Richard Hickey , Someina Khok , Doris Riether , Lifen Wu , Renee M. Zindell
发明人： Angela Berry , Rajashekhar Betageri , Eugene Richard Hickey , Someina Khok , Doris Riether , Lifen Wu , Renee M. Zindell
IPC分类号： A61K31/4439 , C07D413/12 , A61K31/422 , C07D401/12 , C07D417/14 , A61K31/427 , A61K31/541 , A61K31/5377 , A61P11/00 , A61P29/00 , A61P37/00 , A61P19/00 , A61P37/08 , A61P7/00 , A61P17/00 , A61P13/12 , A61P1/16 , A61P1/00 , A61P25/28 , A61P27/16 , A61P11/02 , A61P11/04 , A61P27/02 , A61P25/00 , A61P35/00 , A61P5/00 , A61P37/06 , A61P1/06 , A61P9/10 , A61P9/04 , A61P43/00 , C07D413/14
CPC分类号： C07D417/12 , C07D207/16 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. (I)
摘要翻译： 公开了调节CB2受体的化合物。 根据本发明的化合物与CB2受体结合并且是激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。 （一世）
-
公开(公告)号：US08048899B2
公开(公告)日：2011-11-01
申请号：US12564132
申请日：2009-09-22
申请人： Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Markus Ostermeier , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi
发明人： Alessandra Bartolozzi , Angela Berry , Eugene Richard Hickey , Markus Ostermeier , Doris Riether , Achim Sauer , David Smith Thomson , Lifen Wu , Renee M. Zindell , Patricia Amouzegh , Nigel James Blumire , Stephen Peter East , Monika Ermann , Someina Khor , Innocent Mushi
IPC分类号： A61K31/433 , A61K31/42 , A61K31/422 , A61K31/4196 , C07D285/135 , C07D413/12 , C07D261/14 , C07D249/16
CPC分类号： C07D413/12 , C07D249/14 , C07D261/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要： are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 被披露。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
-
公开(公告)号：US20110130431A1
公开(公告)日：2011-06-02
申请号：US13022866
申请日：2011-02-08
申请人： Angela BERRY , Pier Francesco CIRILLO , Eugene Richard HICKEY , Doris RIETHER , David THOMSON , Renee M. ZINDELL , Nigel BLUMIRE , Chandana CHOWDHURY , Monika ERMANN , James Edward JENKINS , Innocent MUSHI , Christopher Francis PALMER , Malcolm TAYLOR
发明人： Angela BERRY , Pier Francesco CIRILLO , Eugene Richard HICKEY , Doris RIETHER , David THOMSON , Renee M. ZINDELL , Nigel BLUMIRE , Chandana CHOWDHURY , Monika ERMANN , James Edward JENKINS , Innocent MUSHI , Christopher Francis PALMER , Malcolm TAYLOR
IPC分类号： A61K31/42 , C07D261/14 , C07D277/46 , C07D231/40 , C07D213/75 , C07C233/07 , C07D277/82 , C07D409/04 , C07D217/22 , A61K31/426 , A61K31/415 , A61K31/44 , A61K31/167 , A61K31/428 , A61K31/472 , A61P29/00
CPC分类号： C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
-
公开(公告)号：US20080039464A1
公开(公告)日：2008-02-14
申请号：US11781336
申请日：2007-07-23
申请人： Angela BERRY , Pier CIRILLO , Eugene HICKEY , Doris RIETHER , David Thomson , Monika ERMANN , James JENKINS , Innocent MUSHI , Malcolm TAYLOR , Chandana CHOWDHURY , Christopher PALMER , Nigel BLUMIRE
发明人： Angela BERRY , Pier CIRILLO , Eugene HICKEY , Doris RIETHER , David Thomson , Monika ERMANN , James JENKINS , Innocent MUSHI , Malcolm TAYLOR , Chandana CHOWDHURY , Christopher PALMER , Nigel BLUMIRE
IPC分类号： A61K31/5377 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/426 , A61P29/00 , C07D215/38 , C07D249/14 , C07D277/38 , C07D417/12 , C07D413/14 , C07D413/12 , C07D285/135 , C07D261/14 , C07D231/38 , A61P37/00 , A61P25/04 , A61K31/433 , A61K31/4439 , A61K31/47
CPC分类号： C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compound of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
-
公开(公告)号：US09315454B2
公开(公告)日：2016-04-19
申请号：US13521246
申请日：2011-01-11
申请人： Alessandra Bartolozzi , Angela Berry , Doris Riether , Monika Ermann , James Edward Jenkins , Innocent Mushi
发明人： Alessandra Bartolozzi , Angela Berry , Doris Riether , Monika Ermann , James Edward Jenkins , Innocent Mushi
IPC分类号： C07C317/06 , A61K31/165 , C07C323/41 , C07C317/44 , C07D211/54 , C07D213/40 , C07D261/08 , C07D265/30 , C07D295/185 , C07D295/205 , C07D309/04 , C07D333/20 , C07D333/38 , C07D413/12
CPC分类号： C07C323/41 , C07C317/44 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D211/54 , C07D213/40 , C07D261/08 , C07D265/30 , C07D295/185 , C07D295/205 , C07D309/04 , C07D333/20 , C07D333/38 , C07D413/12
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
-
公开(公告)号：US08829034B2
公开(公告)日：2014-09-09
申请号：US13022866
申请日：2011-02-08
申请人： Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David Thomson , Renee M. Zindell , Nigel Blumire , Chandana Parke , Monika Ermann , James Edward Jenkins , Innocent Mushi , Christopher Francis Palmer , Malcolm Taylor
发明人： Angela Berry , Pier Francesco Cirillo , Eugene Richard Hickey , Doris Riether , David Thomson , Renee M. Zindell , Nigel Blumire , Chandana Parke , Monika Ermann , James Edward Jenkins , Innocent Mushi , Christopher Francis Palmer , Malcolm Taylor
IPC分类号： C07D409/04 , C07D309/02 , A61K31/351 , A61K31/42 , C07D261/12 , C07D217/22 , C07D277/82 , C07D309/04 , C07D277/46 , C07C317/44 , C07D213/75 , C07D417/12 , C07D407/12 , C07D405/12 , C07D413/12 , C07D215/38 , C07D403/12 , C07D231/40
CPC分类号： C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
-
公开(公告)号：US08629157B2
公开(公告)日：2014-01-14
申请号：US13141105
申请日：2009-12-15
申请人： Angela Berry , Rajashekhar Betageri , Eugene Richard Hickey , Someina Khor , Doris Riether , Lifen Wu , Renee M. Zindell
发明人： Angela Berry , Rajashekhar Betageri , Eugene Richard Hickey , Someina Khor , Doris Riether , Lifen Wu , Renee M. Zindell
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/426 , A61K31/427 , A61K31/421 , A61K31/422 , A61K31/433 , A61K31/4245 , C07D417/12 , C07D417/14 , C07D413/12 , C07D413/14 , C07D401/04
CPC分类号： C07D417/12 , C07D207/16 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain (I).
摘要翻译： 公开了调节CB2受体的化合物。 根据本发明的化合物与CB2受体结合并且是激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛（I）。
-
公开(公告)号：US20130203729A1
公开(公告)日：2013-08-08
申请号：US13570432
申请日：2012-08-09
申请人： Todd BOSANAC , Angela BERRY , John David GINN , Tamara Denise HOPKINS , Sabine SCHLYER , Fariba SOLEYMANZADEH , John WESTBROOK , Maolin YU , Zhonghua ZHANG
发明人： Todd BOSANAC , Angela BERRY , John David GINN , Tamara Denise HOPKINS , Sabine SCHLYER , Fariba SOLEYMANZADEH , John WESTBROOK , Maolin YU , Zhonghua ZHANG
IPC分类号： C07D417/14 , C07D417/04 , C07D417/12
CPC分类号： C07D417/14 , C07D417/04 , C07D417/12
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 5和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
-
公开(公告)号：US20120316173A1
公开(公告)日：2012-12-13
申请号：US13521246
申请日：2011-01-11
申请人： Alessandra Bartolozzi , Angela Berry , Doris Riether , Monika Ermann , James Edward Jenkins , Innocent Mushi
发明人： Alessandra Bartolozzi , Angela Berry , Doris Riether , Monika Ermann , James Edward Jenkins , Innocent Mushi
IPC分类号： A61K31/164 , A61K31/165 , C07D333/20 , A61K31/381 , C07D295/192 , A61K31/495 , C07D295/205 , C07D265/30 , A61K31/5375 , C07D211/54 , A61K31/445 , C07D409/06 , A61K31/496 , C07D309/06 , A61K31/351 , C07D261/08 , A61K31/422 , A61K31/42 , C07D413/12 , A61P37/06 , A61P9/10 , A61P37/08 , A61P17/00 , A61P13/12 , A61P11/04 , A61P29/00 , A61P25/06 , C07C317/44
CPC分类号： C07C323/41 , C07C317/44 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D211/54 , C07D213/40 , C07D261/08 , C07D265/30 , C07D295/185 , C07D295/205 , C07D309/04 , C07D333/20 , C07D333/38 , C07D413/12
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译： 公开了式（I）的化合物。 根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。 作为激动剂的那些化合物另外可用于治疗疼痛。
-
-
-
-
-
-
-
-
-
搜索结果
28 条记录 (耗时 0.037 秒)
