公开(公告)号：US12096986B2

公开(公告)日：2024-09-24

申请号：US17314338

申请日：2021-05-07

Applicant: The Board of Regents of the University of Nebraska

Inventor： Ioannis S. Chatzizisis

IPC: A61B34/10 ,  A61B90/00 ,  G06T17/20

CPC classification number: A61B34/10 ,  A61B90/37 ,  G06T17/20 ,  A61B2034/102 ,  A61B2034/105 ,  A61B2090/3762 ,  A61B2090/378 ,  G06T2210/41

Abstract: In accordance with embodiments of this disclosure, a computational simulation platform comprises a computer-implemented method that includes: generating a mesh or meshless three-dimensional (3D) reconstruction of a vessel lumen and a surface of the vessel lumen based on invasive or non-invasive imaging; assigning material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging; performing balloon pre-dilation, stenting and balloon post-dilation computational simulations with the 3D reconstructed vessel lumen and surface of the vessel lumen; and assessing stent and vessel morphometric and biomechanical measures based on the computational simulations.

公开(公告)号：US20240287329A1

公开(公告)日：2024-08-29

申请号：US18573837

申请日：2022-06-23

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. ,  VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERITY ,  BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Eric MARKVICKA ,  Aaron HAAKE ,  Michael D. BARTLETT ,  Ravi Tej Anand TUTIKA ,  Gwyneth SCHLOER

IPC: C09D11/023 ,  B29C64/118 ,  B29C64/209 ,  B29K21/00 ,  B29K75/00 ,  B29K83/00 ,  B29K105/16 ,  B29K505/00 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/10 ,  C09D11/102 ,  C09D11/322

CPC classification number: C09D11/023 ,  B29C64/118 ,  B29C64/209 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/10 ,  C09D11/102 ,  C09D11/322 ,  B29K2021/003 ,  B29K2075/00 ,  B29K2083/00 ,  B29K2105/16 ,  B29K2505/00 ,  B29K2869/00

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to methods of additive manufacture of emulsion compositions. In various aspects, the present disclosure relates to composite materials incorporating microstructures formed by inclusion compositions, and methods of their manufacture. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20240252264A1

公开(公告)日：2024-08-01

申请号：US18607863

申请日：2024-03-18

Applicant: Board of Regents of the University of Nebraska

Inventor： Joseph Palmowski ,  Shane Farritor

IPC: A61B34/30 ,  B25J9/10 ,  B25J9/12 ,  B25J17/02

CPC classification number: A61B34/30 ,  B25J9/102 ,  B25J9/126 ,  B25J17/0258 ,  A61B2034/305

Abstract: Disclosed herein are various robotic surgical devices and systems that include first and second elongate bodies, first and second driveshafts disposed through the second elongate body, and an in-line shoulder joint with a robotic arm coupled thereto. In certain implementations, the in-line shoulder joint has a differential yoke and a dual shaft disposed within the yoke lumen.

公开(公告)号：US20240230683A1

公开(公告)日：2024-07-11

申请号：US18560365

申请日：2022-05-13

Applicant: Board of Regents of the University Of Nebraska

Inventor： Howard GENDELMAN ,  R. Lee MOSLEY ,  Mai MOSTAFA ,  Katherine OLSON

IPC: G01N33/68 ,  A61K31/198 ,  A61K38/17 ,  A61K38/19 ,  A61K38/22 ,  A61P25/16

CPC classification number: G01N33/6896 ,  A61K31/198 ,  A61K38/1709 ,  A61K38/193 ,  A61K38/2278 ,  A61P25/16 ,  G01N2333/4703 ,  G01N2333/916 ,  G01N2800/2835 ,  G01N2800/52

Abstract: Provided are methods for monitoring the progression of Parkinson's Disease, and methods for monitoring or determining the effectiveness of therapeutics for the treatment of Parkinson's Disease, as well as methods for treatment thereof, by assessing one or more biomarkers, such as NF-κB and/or calcineurin.

公开(公告)号：US20240180627A1

公开(公告)日：2024-06-06

申请号：US18417779

申请日：2024-01-19

Applicant: Board of Regents of the University of Nebraska

Inventor： Hani HAIDER ,  Ibrahim AL-SHAWI ,  Osvaldo Andres BARRERA

IPC: A61B34/20 ,  A61B1/313 ,  A61B5/00 ,  A61B5/06 ,  A61B5/107 ,  A61B17/14 ,  A61B17/17 ,  A61B34/00 ,  A61B34/10 ,  A61B34/37 ,  A61B90/00

CPC classification number: A61B34/20 ,  A61B1/3132 ,  A61B5/061 ,  A61B5/1076 ,  A61B17/142 ,  A61B17/1703 ,  A61B34/37 ,  A61B34/76 ,  A61B5/00 ,  A61B2034/102 ,  A61B2034/2057 ,  A61B2034/2065 ,  A61B2090/061 ,  A61B2090/064 ,  A61B2090/3983 ,  G06T2207/30004 ,  G06V2201/034

Abstract: A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.

公开(公告)号：US20240156442A1

公开(公告)日：2024-05-16

申请号：US18550838

申请日：2022-03-23

Applicant: Board of Regents of the University of Nebraska

Inventor： Thang Nguyen ,  Michael Wadman ,  Wesley Zeger

IPC: A61B10/00 ,  A61M3/02

CPC classification number: A61B10/0051 ,  A61M3/0262 ,  A61M3/0283 ,  A61M2210/0618

Abstract: An apparatus for collecting a nasal specimen includes a device body with a nozzle at a distal end of the device body. The nozzle is configured to interface with a nasal cavity. The apparatus further includes an irrigation path and a collection path within the device body. The collection path may be separate from the irrigation path. The irrigation path is configured to direct a fluid from an irrigation chamber into the nasal cavity in order to dislodge a sample from the nasal cavity. When the fluid flows back out of the nasal cavity, the collection path is configured to direct at least a portion of the fluid and the sample dislodged from the nasal cavity into a collection chamber.

公开(公告)号：US20240096493A1

公开(公告)日：2024-03-21

申请号：US18469022

申请日：2023-09-18

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Matteo Ligorio ,  Rebecca Napier ,  William Gasper ,  Dario Ghersi

IPC: G16H50/20 ,  G06T7/00 ,  G06T7/50 ,  G16H50/50 ,  G16H70/60

CPC classification number: G16H50/20 ,  G06T7/0012 ,  G06T7/50 ,  G16H50/50 ,  G16H70/60 ,  G06T2207/20021 ,  G06T2207/20036 ,  G06T2207/20081 ,  G06T2207/30096 ,  G06T2207/30242

Abstract: Aspects of the present disclosure relate to systems and methods for analyzing a tumor, and more specifically, analyzing a tumor to identify a biological aggressiveness of the tumor. One example method for tumor analysis includes: receiving one or more input features associated with a geometric shape of a tumor, the one or more input features including at least a value indicating a circularity of the tumor; determining, via a machine learning component, a characteristic of the tumor based on the one or more input features, the characteristic being indicative of patient survivability; and outputting an indication of the characteristic.

公开(公告)号：US20240000800A1

公开(公告)日：2024-01-04

申请号：US18172024

申请日：2023-02-21

Applicant: Board of Regents of the University of Nebraska

Inventor： Dong Wang ,  Fang Yuan ,  Zhenshan Jia ,  Xiaobei Wang

IPC: A61K31/57 ,  C07J41/00 ,  A61K9/107 ,  A61K47/10 ,  A61K47/34

CPC classification number: A61K31/57 ,  C07J41/0016 ,  C07J41/0005 ,  A61K9/1075 ,  A61K47/10 ,  A61K47/34 ,  C07J51/00

Abstract: Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.

公开(公告)号：US11840540B2

公开(公告)日：2023-12-12

申请号：US17382083

申请日：2021-07-21

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Amarnath Natarajan ,  Sandeep Rana

IPC: C07D487/10 ,  C07D491/107 ,  A61P35/00 ,  C07D519/00

CPC classification number: C07D491/107 ,  A61P35/00 ,  C07D487/10 ,  C07D519/00

Abstract: Provided herein are compounds and methods for modulating the NFκB pathway. More particularly, provided are inhibitors of the NFκB pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, autoimmune diseases, inflammatory diseases, diabetes, cardiovascular diseases, or neurological diseases.

公开(公告)号：US20230390456A1

公开(公告)日：2023-12-07

申请号：US18026502

申请日：2021-10-25

Applicant: Board of Regents of the University of Nebraska

Inventor： Jingwei XIE

IPC: A61L27/34 ,  A61L27/56 ,  A61L27/18 ,  A61L27/54

CPC classification number: A61L27/34 ,  A61L27/56 ,  A61L27/18 ,  A61L27/54 ,  A61L2400/12 ,  A61L2400/18

Abstract: Surface modified scaffolds are provided as well as methods of use thereof and methods of making.