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11.发明授权Amino acid sequences for therapeutic and prophylactic use against diseases due to Clostridium difficile toxins 失效用于针对艰难梭菌毒素引起的疾病的治疗和预防用途的氨基酸序列公开(公告)号：US06667035B1
公开(公告)日：2003-12-23
申请号：US09508413
申请日：2000-03-27
IPC分类号： A61K39395
CPC分类号： C07K14/33 , A61K39/00 , C07K16/1282 , C07K2317/13 , C07K2317/24
摘要： The invention relates to monoclonal antibodies capable of recognizing and neutralizing epitopes from the ligand domain, the translocation domain or the catalytic domain of the enterotoxin (toxin A) and cytotoxin (toxin B) from Clostridium difficile, as well as their production and therapeutical and prophylactic applications to diseases due to the toxins.
摘要翻译： 本发明涉及能够识别和中和来自难辨梭状芽胞杆菌的肠毒素（毒素A）和细胞毒素（毒素B）的配体结构域，易位结构域或催化结构域的表位的单克隆抗体，以及它们的生产和治疗和预防 应用于因毒素引起的疾病。
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公开(公告)号：US20130280286A1
公开(公告)日：2013-10-24
申请号：US13483701
申请日：2012-05-30
申请人： Christoph VON EICHEL-STREIBER , Jessica REINEKE , Stefan TENZER , Hansjörg SCHILD , Maja RUPNIK
发明人： Christoph VON EICHEL-STREIBER , Jessica REINEKE , Stefan TENZER , Hansjörg SCHILD , Maja RUPNIK
IPC分类号： A61K31/6615 , C12N9/99 , C07K14/33 , A61K31/336 , C07K16/40
CPC分类号： C07K14/33 , A61K31/04 , A61K31/336 , A61K31/661 , A61K31/6615 , A61K39/08 , A61K2039/505 , C07K16/1282 , C07K16/40 , C07K2317/76 , C12N9/99
摘要： The medicament for the prevention or the relief of poisoning by large clostridial cytotoxins (LCTs), in particular Clostridium difficile toxins A and B (TcdA and TcdB), is characterized by containing as active ingredient at least one effector, namely an inhibitor or activator of the autocatalytic protease activity of LCTs (large clostridial cytotoxins).
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公开(公告)号：US07700091B2
公开(公告)日：2010-04-20
申请号：US10894438
申请日：2004-07-19
CPC分类号： C12R1/01 , A01K2217/05 , A61K48/00 , C07K14/195 , C12N15/85 , C12N15/87 , C12N2800/108
摘要： The present invention concerns a TGC method for inducting targeted somatic transgenesis in an animal host, whereby bacteria with a foreign DNA integrated into an episomal vector release, under the control of eukaryotic regulatory elements forulterior transcription and expression, said foreign DNA in the case of infection of a foreign organism, organ, tissue, cell line or individual cells, causing transcription and expression of foreign DNA and/or foreign protein in said location.
摘要翻译： 本发明涉及用于在动物宿主中诱导靶向体细胞转位的TGC方法，由此将外源DNA整合到附加型载体释放中的细菌在真核调节元件前体转录和表达的控制下，在感染情况下表示外源DNA 的外来生物，器官，组织，细胞系或个体细胞，导致外源DNA和/或外源蛋白在所述位置的转录和表达。
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14.发明申请公开(公告)号：US20090220517A1
公开(公告)日：2009-09-03
申请号：US12162804
申请日：2006-11-29
CPC分类号： C07K14/37 , A61K39/00 , A61K2039/523 , C07K14/4748 , C12N15/74
摘要： The present invention relates to a method for producing carrier microorganisms, in particular bacteria, which, through targeted genetic manipulation, carry epitopes or epitomers, respectively, on their surfaces. Epitomers are antigenically effective epitopes that can be found in the polypeptide chain in multiple identical copies, and which, when expressed on the surface of the bacteria, can be used for immunization with particular success. A further aspect relates to correspondingly produced bacteria and their uses as vaccines, in particular in cancer therapy.
摘要翻译： 本发明涉及一种用于生产载体微生物，特别是细菌的方法，其通过目标遗传操作分别在其表面上携带表位或表位。 表面活性剂是抗原有效的表位，其可以在多个相同的拷贝中在多肽链中发现，并且当在细菌表面上表达时，可以特别成功地用于免疫。 另一方面涉及相应产生的细菌及其作为疫苗的用途，特别是在癌症治疗中。
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公开(公告)号：US20070031906A1
公开(公告)日：2007-02-08
申请号：US11462925
申请日：2006-08-07
IPC分类号： G01N33/554 , G01N33/569
CPC分类号： G01N33/56916 , G01N2333/255 , G01N2469/10
摘要： Disclosed is a diagnostic test system for detecting Salmonella infections in a sample using monoclonal antibodies specific for SipC-protein.
摘要翻译： 公开了一种用于使用针对SipC蛋白特异性的单克隆抗体检测样品中的沙门氏菌感染的诊断测试系统。
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