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1.发明授权Amino acid sequences for therapeutic and prophylactic use against diseases due to clostridium difficile toxins 有权用于针对艰难梭菌毒素引起的疾病的治疗和预防用途的氨基酸序列公开(公告)号：US07151159B2
公开(公告)日：2006-12-19
申请号：US10745102
申请日：2003-12-23
IPC分类号： C07K1/00 , C07K14/00 , C07K16/00 , A61K39/395
CPC分类号： C07K14/33 , A61K39/00 , C07K16/1282 , C07K2317/13 , C07K2317/24
摘要： The invention relates to monoclonal antibodies capable of recognizing and neutralizing epitopes from the ligand domain, the translocation domain or the catalytic domain of the enterotoxin (toxin A) and cytotoxin (toxin B) from Clostridium difficile, as well as their production and therapeutic and prophylactic applications to diseases caused by said toxins.
摘要翻译： 本发明涉及能够识别和中和来自艰难梭菌的肠毒素（毒素A）和细胞毒素（毒素B）的配体结构域，易位结构域或催化结构域的表位的单克隆抗体，以及它们的生产和治疗和预防 对所述毒素引起的疾病的应用。
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2.发明授权Amino acid sequences for therapeutic and prophylactic use against diseases due to Clostridium difficile toxins 失效用于针对艰难梭菌毒素引起的疾病的治疗和预防用途的氨基酸序列公开(公告)号：US06667035B1
公开(公告)日：2003-12-23
申请号：US09508413
申请日：2000-03-27
IPC分类号： A61K39395
CPC分类号： C07K14/33 , A61K39/00 , C07K16/1282 , C07K2317/13 , C07K2317/24
摘要： The invention relates to monoclonal antibodies capable of recognizing and neutralizing epitopes from the ligand domain, the translocation domain or the catalytic domain of the enterotoxin (toxin A) and cytotoxin (toxin B) from Clostridium difficile, as well as their production and therapeutical and prophylactic applications to diseases due to the toxins.
摘要翻译： 本发明涉及能够识别和中和来自难辨梭状芽胞杆菌的肠毒素（毒素A）和细胞毒素（毒素B）的配体结构域，易位结构域或催化结构域的表位的单克隆抗体，以及它们的生产和治疗和预防 应用于因毒素引起的疾病。
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公开(公告)号：US06825028B1
公开(公告)日：2004-11-30
申请号：US09581005
申请日：2000-06-06
IPC分类号： C12N120
CPC分类号： C12N15/85 , A61K48/00 , A61K48/0008 , A61K2039/522 , A61K2039/523 , C12N15/87
摘要： Disclosed is a TGC method for inducting targeted somatic transgenesis in an animal host, whereby bacteria with a foreign DNA integrated into an episomal vector release, under the control of eukaryotic regulatory elements for ulterior transcription and expression, said foreign DNA in the case of infection of a foreign organism, organ, tissue, cell line or individual cells, causing transcription and expression of foreign DNA and/or foreign protein in said location.
摘要翻译： 公开了用于在动物宿主中诱导靶向体细胞转位的TGC方法，其中外源DNA整合到附加型载体释放中的细菌在真核调节元件的控制下用于不规则转录和表达，在外源DNA在感染的情况下 外来生物，器官，组织，细胞系或个体细胞，在所述位置引起外源DNA和/或外源蛋白质的转录和表达。
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公开(公告)号：US20050042755A1
公开(公告)日：2005-02-24
申请号：US10894438
申请日：2004-07-19
IPC分类号： A01K67/027 , A61K48/00 , C07K14/195 , C12N1/21 , C12N15/09 , C12N15/85 , C12N15/87 , C12N15/74
CPC分类号： C12R1/01 , A01K2217/05 , A61K48/00 , C07K14/195 , C12N15/85 , C12N15/87 , C12N2800/108
摘要： The present invention concerns a TGC method for inducting targeted somatic transgenesis in an animal host, whereby bacteria with a foreign DNA integrated into an episomal vector release, under the control of eukaryotic regulatory elements forulterior transcription and expression, said foreign DNA in the case of infection of a foreign organism, organ, tissue, cell line or individual cells, causing transcription and expression of foreign DNA and/or foreign protein in said location.
摘要翻译： 本发明涉及用于在动物宿主中诱导靶向体细胞转位的TGC方法，由此将外源DNA整合到附加型载体释放中的细菌在真核调节元件前体转录和表达的控制下，在感染情况下表示外源DNA 的外来生物，器官，组织，细胞系或个体细胞，导致外源DNA和/或外源蛋白在所述位置的转录和表达。
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5.发明授权公开(公告)号：US08282943B2
公开(公告)日：2012-10-09
申请号：US11921421
申请日：2006-05-31
IPC分类号： A61K39/385 , A01N63/02
CPC分类号： C07K14/51 , A61K39/0011 , A61K2039/523 , C07K16/24 , C07K16/30 , C07K2317/23 , Y02A50/478
摘要： The invention is relates to drugs on the basis of antibodies against non-cellular bone matrix proteins, especially BSP, for use in the prevention and treatment of bone metastases. According to the invention, the antibodies are induced in the patient by recombinantly expressing antigenic determinants of bone matrix proteins in Listeria and anchoring them on the surfaces thereof. The antigenic determinants are selected according to whether they are characteristic of antigens that are expressed by the tumor cells themselves.
摘要翻译： 本发明涉及基于针对用于预防和治疗骨转移的非细胞骨基质蛋白，特别是BSP的抗体的药物。 根据本发明，通过在利斯特氏菌中重组表达骨基质蛋白的抗原决定簇并将其锚定在其表面上，在患者体内诱导抗体。 根据它们是否由肿瘤细胞本身表达的抗原的特征来选择抗原决定簇。
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公开(公告)号：US06849715B2
公开(公告)日：2005-02-01
申请号：US09126816
申请日：1998-07-31
CPC分类号： C12N9/1051 , A61K38/45 , A61K47/6829 , Y10S530/825
摘要： A method of treating a disorder characterized by an activating mutation in a Ras proto-oncogene, comprising contacting cells of a patient suffering from the disorder with a protein having the toxic activity of Clostridium sordellii toxin LT under conditions favoring inactivation of Ras by glucosylation of Ras' threonine 35 in said cell. The protein preferably is an immunotoxin that contains as a toxic domain the catalytic domain of toxin LT.
摘要翻译： 一种治疗特征在于Ras原癌基因中的活化突变的病症的方法，其包括使患有该病症的患者的细胞与具有毒梭菌毒素LT毒性的蛋白质在有助于通过Ras的葡糖基化失活Ras的条件下接触 '苏氨酸35在细胞中。 蛋白质优选是含有毒素LT的催化结构域作为毒性结构域的免疫毒素。
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公开(公告)号：US07700091B2
公开(公告)日：2010-04-20
申请号：US10894438
申请日：2004-07-19
CPC分类号： C12R1/01 , A01K2217/05 , A61K48/00 , C07K14/195 , C12N15/85 , C12N15/87 , C12N2800/108
摘要： The present invention concerns a TGC method for inducting targeted somatic transgenesis in an animal host, whereby bacteria with a foreign DNA integrated into an episomal vector release, under the control of eukaryotic regulatory elements forulterior transcription and expression, said foreign DNA in the case of infection of a foreign organism, organ, tissue, cell line or individual cells, causing transcription and expression of foreign DNA and/or foreign protein in said location.
摘要翻译： 本发明涉及用于在动物宿主中诱导靶向体细胞转位的TGC方法，由此将外源DNA整合到附加型载体释放中的细菌在真核调节元件前体转录和表达的控制下，在感染情况下表示外源DNA 的外来生物，器官，组织，细胞系或个体细胞，导致外源DNA和/或外源蛋白在所述位置的转录和表达。
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8.发明申请公开(公告)号：US20090220517A1
公开(公告)日：2009-09-03
申请号：US12162804
申请日：2006-11-29
CPC分类号： C07K14/37 , A61K39/00 , A61K2039/523 , C07K14/4748 , C12N15/74
摘要： The present invention relates to a method for producing carrier microorganisms, in particular bacteria, which, through targeted genetic manipulation, carry epitopes or epitomers, respectively, on their surfaces. Epitomers are antigenically effective epitopes that can be found in the polypeptide chain in multiple identical copies, and which, when expressed on the surface of the bacteria, can be used for immunization with particular success. A further aspect relates to correspondingly produced bacteria and their uses as vaccines, in particular in cancer therapy.
摘要翻译： 本发明涉及一种用于生产载体微生物，特别是细菌的方法，其通过目标遗传操作分别在其表面上携带表位或表位。 表面活性剂是抗原有效的表位，其可以在多个相同的拷贝中在多肽链中发现，并且当在细菌表面上表达时，可以特别成功地用于免疫。 另一方面涉及相应产生的细菌及其作为疫苗的用途，特别是在癌症治疗中。
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9.发明申请公开(公告)号：US20090142372A1
公开(公告)日：2009-06-04
申请号：US11921421
申请日：2006-05-31
CPC分类号： C07K14/51 , A61K39/0011 , A61K2039/523 , C07K16/24 , C07K16/30 , C07K2317/23 , Y02A50/478
摘要： The invention is relates to drugs on the basis of antibodies against non-cellular bone matrix proteins, especially BSP, for use in the prevention and treatment of bone metastases. According to the invention, the antibodies are induced in the patient by recombinantly expressing antigenic determinants of bone matrix proteins in Listeria and anchoring them on the surfaces thereof. The antigenic determinants are selected according to whether they are characteristic of antigens that are expressed by the tumor cells themselves.
摘要翻译： 本发明涉及基于针对用于预防和治疗骨转移的非细胞骨基质蛋白，特别是BSP的抗体的药物。 根据本发明，通过在利斯特氏菌中重组表达骨基质蛋白的抗原决定簇并将其锚定在其表面上，在患者体内诱导抗体。 根据它们是否由肿瘤细胞本身表达的抗原的特征来选择抗原决定簇。
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