公开(公告)号：US20120323279A1

公开(公告)日：2012-12-20

申请号：US13161705

申请日：2011-06-16

Applicant: Yang-Hwei Tsuang ,  Chun-Jen Liao ,  Huang-Chien Liang ,  Shih-Jui Han ,  Fon-Yih Tsuang ,  Chang-Jung Chiang

Inventor： Yang-Hwei Tsuang ,  Chun-Jen Liao ,  Huang-Chien Liang ,  Shih-Jui Han ,  Fon-Yih Tsuang ,  Chang-Jung Chiang

IPC: A61B17/88

CPC classification number: A61B17/8863 ,  A61B17/0625 ,  A61B17/7002 ,  A61B17/7083 ,  A61B17/7085 ,  A61B17/7089 ,  A61B17/7091 ,  A61B2090/037

Abstract: A spinal fixation assembly includes a pedicle rod and pedicle screws which secure the pedicle rod to the spine. Each pedicle screw includes a head configured to receive a portion of the pedicle rod, and a threaded portion extending from a first end of the head and configured to engage a vertebra. The pedicle rod is secured to the head by a fastener. The head includes a breakaway region that defines a location in which at least a first portion of the head can be easily separated from the remainder of the head upon application of sufficient force to the first portion. A minimally invasive method of implanting the spinal fixation assembly is disclosed.

Abstract translation: 脊柱固定组件包括将椎弓根杆固定到脊柱的椎弓根杆和椎弓根螺钉。 每个椎弓根螺钉包括构造成接收椎弓根杆的一部分的头部，以及从头部的第一端延伸并被配置为接合椎骨的螺纹部分。 椎弓根杆通过紧固件固定到头部。 头部包括一个分离区域，该区域限定了一个位置，其中当对第一部分施加足够的力时，头部的至少第一部分可以容易地与头部的其余部分分离。 公开了一种植入脊柱固定组件的微创方法。

公开(公告)号：US20110160732A1

公开(公告)日：2011-06-30

申请号：US12830536

申请日：2010-07-06

Applicant: Chun-Jen Liao ,  Ching-Chuan Jiang ,  Sung-Ching Chen ,  Pei-Chi Hsu ,  Shih-Jui Han

Inventor： Chun-Jen Liao ,  Ching-Chuan Jiang ,  Sung-Ching Chen ,  Pei-Chi Hsu ,  Shih-Jui Han

IPC: A61B17/16 ,  A61B17/56

CPC classification number: A61F2/3859 ,  A61B17/1637 ,  A61B17/1668 ,  A61B17/742 ,  A61B2017/00969 ,  A61F2/28 ,  A61F2/30721 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/4644 ,  A61F2002/2828 ,  A61F2002/2832 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/30766

Abstract: A bone repairing kit including a drilling device, a pushing device, a clamping member and a hole saw is provided. An end of a tube body of the drilling device is a knife portion. When the tube body rotates with respect to a femur, a bone column is cut by the knife portion and located in the tube body. The pushing device includes a hollow tube and a push bar. The hollow tube is for receiving the tube body. The push bar is for touching and pushing the bone column in the tube body. The clamping member is for clamping the bone column. The hole saw includes a receiving body and cutting knives. The receiving body has a recess for receiving an end of the bone column. The cutting knives surrounding on an inner wall of the recess are for cutting an edge of the end of the bone column.

Abstract translation: 提供了包括钻孔装置，推动装置，夹紧构件和孔锯的骨修复工具。 钻孔装置的管体的端部是刀部。 当管体相对于股骨旋转时，骨柱由刀部分切割并位于管体中。 推动装置包括中空管和推杆。 中空管用于容纳管体。 推杆用于接触并推动管体中的骨柱。 夹紧构件用于夹紧骨柱。 孔锯包括接收体和切割刀。 接收体具有用于接收骨柱端部的凹部。 围绕凹槽内壁的切割刀片用于切割骨柱端部的边缘。

公开(公告)号：US20060153814A1

公开(公告)日：2006-07-13

申请号：US11030150

申请日：2005-01-07

Applicant: Chun-Jen Liao ,  Jui-Hsiang Chen ,  Chen-Chi Tsai ,  Yung-Chih Wu ,  Shu-Fang Chiang ,  Yi-Jung Hsiang

Inventor： Chun-Jen Liao ,  Jui-Hsiang Chen ,  Chen-Chi Tsai ,  Yung-Chih Wu ,  Shu-Fang Chiang ,  Yi-Jung Hsiang

IPC: A61K35/12 ,  A61F2/00

CPC classification number: C12N5/0068 ,  A61L27/46 ,  A61L27/56 ,  C12N2533/18 ,  C08L5/04

Abstract: A porous matrix, preparation thereof, and methods of using the same. The porous matrix of calcium alginate is prepared using a plurality of particles containing a multivalent cation, admixing the particles with ionic cross-linked polysaccharides and water to form a mixture, introducing a cross linker to solidify the mixture, dissolving the particles of the mixture in an acid to form a porous structure, and neutralizing and cross-linking the porous structure.

Abstract translation: 多孔基体，其制备方法及其使用方法。 藻酸钙的多孔基质是使用多个含有多价阳离子的颗粒制备的，将颗粒与离子交联的多糖和水混合以形成混合物，引入交联剂固化混合物，将混合物的颗粒溶解在 酸形成多孔结构，中和并交联多孔结构。

公开(公告)号：US20060148072A1

公开(公告)日：2006-07-06

申请号：US11202020

申请日：2005-08-12

Applicant: Chun-Jen Liao ,  Yung-Chin Wu ,  Ko-Chun Hsu ,  Hua-Chun Hsu ,  Chen-Chi Tsai ,  Da-Pan Chen

Inventor： Chun-Jen Liao ,  Yung-Chin Wu ,  Ko-Chun Hsu ,  Hua-Chun Hsu ,  Chen-Chi Tsai ,  Da-Pan Chen

IPC: C12M1/00

CPC classification number: C12M27/08 ,  C12M25/16

Abstract: A bioreactor system. A supply container receives a cultivation solution. A bioreactor container is connected to the supply container and includes a porous carrier. The porous carrier carries a plurality of cells. The cultivation solution circulates between the supply container and the bioreactor container, providing needed nutrients to the cells.

Abstract translation: 生物反应器系统。 供应容器接收培养液。 生物反应器容器连接到供应容器并且包括多孔载体。 多孔载体携带多个单元。 培养液在供应容器和生物反应器容器之间循环，向细胞提供所需的营养。

公开(公告)号：US20050249695A1

公开(公告)日：2005-11-10

申请号：US11107412

申请日：2005-04-14

Applicant: Joerg Tiller ,  Chun-Jen Liao ,  Kim Lewis ,  Alexander Klibanov

Inventor： Joerg Tiller ,  Chun-Jen Liao ,  Kim Lewis ,  Alexander Klibanov

IPC: A01N43/40 ,  A61L27/34 ,  A61L27/50 ,  A61K31/785

CPC classification number: A61L27/50 ,  A01N43/40 ,  A61L27/34 ,  A01N25/34 ,  A01N25/10 ,  A01N2300/00 ,  C08L33/14

Abstract: Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are disclosed for covalently derivatizing the surfaces of common materials with an antibacterial polycation, e.g., poly(vinyl-N-pyridinium bromide); the first step of the methods involves coating the surface with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner are bactericidal, i.e., they kill on contact up to 99% of deposited Gram-positive and Gram-negative bacteria, whether deposited through air or water.

Abstract translation: 公开了包含固定在材料上的聚合物的杀菌组合物。 还公开了包含这种杀菌组合物的医疗装置。 公开了用抗菌聚阳离子共价衍生普通材料的表面的方法，例如聚（乙烯基-N-吡啶鎓溴化物）; 该方法的第一步包括用纳米二氧化硅涂覆表面。 以这种方式衍生的各种商业合成聚合物是杀菌剂的，即它们在接触高达99％的沉积的革兰氏阳性和革兰氏阴性细菌时杀死，无论是通过空气还是水沉积。

公开(公告)号：US08673636B2

公开(公告)日：2014-03-18

申请号：US13614766

申请日：2012-09-13

Applicant: Ching-Chuan Jiang ,  Chun-Jen Liao ,  Wen-Hsiang Chang ,  Huang-Chi Chen ,  Wei-Ju Liao ,  Wen-Hsi Wang

Inventor： Ching-Chuan Jiang ,  Chun-Jen Liao ,  Wen-Hsiang Chang ,  Huang-Chi Chen ,  Wei-Ju Liao ,  Wen-Hsi Wang

IPC: A01N1/00 ,  C12M1/00 ,  A61K38/43

CPC classification number: A61M37/00 ,  C12M1/40 ,  C12M21/08 ,  C12M23/20 ,  C12M35/08 ,  C12N5/06

Abstract: One embodiment provides a method for enzymatic treatment, including the steps of forming a closed space on a local tissue area with a device and infusing an enzyme solution into the closed space for enzymatic treatment. The method according to the embodiment is capable of treating the local tissue area with enzymes for enhancing cell proliferation in the treated tissue area and preventing damage of the adjacent normal tissues. A device and kit used for the method are also provided.

Abstract translation: 一个实施方案提供了一种用于酶处理的方法，包括以下步骤：用装置在局部组织区域上形成封闭空间，并将酶溶液注入封闭空间进行酶处理。 根据实施方案的方法能够用酶处理局部组织区域，以增强处理组织区域中的细胞增殖并防止相邻正常组织的损伤。 还提供了用于该方法的装置和试剂盒。

公开(公告)号：US20120323278A1

公开(公告)日：2012-12-20

申请号：US13161686

申请日：2011-06-16

Applicant: Yang-Hwei Tsuang ,  Chun-Jen Liao ,  Huang-Chien Liang ,  Shih-Jui Han ,  Fon-Yih Tsuang ,  Chang-Jung Chiang

Inventor： Yang-Hwei Tsuang ,  Chun-Jen Liao ,  Huang-Chien Liang ,  Shih-Jui Han ,  Fon-Yih Tsuang ,  Chang-Jung Chiang

IPC: A61B17/70 ,  A61B17/04 ,  A61B17/86

CPC classification number: A61B17/7002 ,  A61B17/1671 ,  A61B17/1757 ,  A61B17/7032 ,  A61B17/7085 ,  A61B17/7089 ,  A61B17/7091 ,  A61B17/8863 ,  A61B2090/037

Abstract: A spinal fixation assembly includes a pedicle rod and pedicle screws which secure the pedicle rod to the spine. Each pedicle screw includes a head configured to receive a portion of the pedicle rod, and a threaded portion extending from a first end of the head and configured to engage a vertebra. The pedicle rod is secured to the head by a fastener. The head includes a breakaway region that defines a location in which at least a first portion of the head can be easily separated from the remainder of the head upon application of sufficient force to the first portion. A minimally invasive method of implanting the spinal fixation assembly is disclosed.

Abstract translation: 脊柱固定组件包括将椎弓根杆固定到脊柱的椎弓根杆和椎弓根螺钉。 每个椎弓根螺钉包括构造成接收椎弓根杆的一部分的头部，以及从头部的第一端延伸并被配置为接合椎骨的螺纹部分。 椎弓根杆通过紧固件固定到头部。 头部包括一个分离区域，该区域限定了一个位置，其中当对第一部分施加足够的力时，头部的至少第一部分可以容易地与头部的其余部分分离。 公开了一种植入脊柱固定组件的微创方法。

公开(公告)号：US20120215322A1

公开(公告)日：2012-08-23

申请号：US13458903

申请日：2012-04-27

Applicant: Chun-Jen LIAO ,  Sheng-Hong TSENG ,  Huang-Chien LIANG ,  Chun-Hung CHEN ,  Yi-Chun SU

Inventor： Chun-Jen LIAO ,  Sheng-Hong TSENG ,  Huang-Chien LIANG ,  Chun-Hung CHEN ,  Yi-Chun SU

IPC: A61F2/02

CPC classification number: A61F2/2875 ,  A61B17/688 ,  A61F2/2846 ,  A61F2/30907 ,  A61F2002/285 ,  A61F2002/30433 ,  A61F2002/30448 ,  A61F2002/30462 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0075 ,  A61L27/3675

Abstract: An artificial dura biomedical device and a brain surgery method utilizing the same are disclosed. The steps includes: fixing an artificial dura to a partial skull; and fixing the partial skull with the artificial dura to a cut hole of a whole skull. The artificial dura biomedical device includes an artificial dura and a connecting element. The connecting element fixes the partial skull with the artificial dura.

Abstract translation: 公开了一种人造硬脑膜生物医学装置和利用其的脑手术方法。 步骤包括：将人造硬膜固定在部分头骨上; 并将具有人造硬脑膜的部分头骨固定到整个头骨的切割孔。 人造硬脑膜生物医学装置包括人造硬膜和连接元件。 连接元件用人造硬脑膜固定部分头骨。

公开(公告)号：US08062372B2

公开(公告)日：2011-11-22

申请号：US11611821

申请日：2006-12-15

Applicant: Yang-Hwei Tsuang ,  Jui-Sheng Sun ,  Chun-Jen Liao ,  Chen-Chi Tsai ,  Shan-Chang Chueh ,  Yi-Hung Lin ,  Shian-Yih Wang ,  I-Fan Chiu

Inventor： Yang-Hwei Tsuang ,  Jui-Sheng Sun ,  Chun-Jen Liao ,  Chen-Chi Tsai ,  Shan-Chang Chueh ,  Yi-Hung Lin ,  Shian-Yih Wang ,  I-Fan Chiu

IPC: A61F2/44

CPC classification number: A61F2/4455 ,  A61F2/30771 ,  A61F2002/2835 ,  A61F2002/3008 ,  A61F2002/30153 ,  A61F2002/30163 ,  A61F2002/30171 ,  A61F2002/30772 ,  A61F2002/4629 ,  A61F2230/0019 ,  A61F2230/0028 ,  A61F2230/005 ,  A61F2250/0098 ,  A61F2310/00179 ,  A61F2310/00365

Abstract: A spinal fusion device abutting and fixed between adjacent vertebrae. The spinal fusion device includes a support frame. The support frame has a plurality of extending bodies, each radially extending from a center of the support frame. A predetermined gap exists between every two adjacent extending bodies, receiving a bone graft.

Abstract translation: 脊椎融合装置邻接并固定在相邻的椎骨之间。 脊柱融合装置包括支撑框架。 支撑框架具有多个延伸体，每个延伸体从支撑框架的中心径向延伸。 在每两个相邻的延伸体之间存在预定的间隙，接收骨移植物。

公开(公告)号：US20110137318A1

公开(公告)日：2011-06-09

申请号：US12630078

申请日：2009-12-03

Applicant: Chun-Jen Liao ,  Yang-Hwei Tsuang ,  Huang-Chien Liang ,  Chun-Hung Chen ,  Fon-Yih Tsuang ,  Yi-Jie Kuo

Inventor： Chun-Jen Liao ,  Yang-Hwei Tsuang ,  Huang-Chien Liang ,  Chun-Hung Chen ,  Fon-Yih Tsuang ,  Yi-Jie Kuo

IPC: A61B17/58

CPC classification number: A61B17/8822 ,  A61B17/8836 ,  A61L24/001 ,  A61L24/02 ,  A61L24/06 ,  A61L2430/02 ,  C08L67/04

Abstract: A method for filling a bone defect in a subject in need thereof is disclosed. The method includes heating a bone cement composition at a first temperature where the bone cement composition is fluidic, and delivering an effective amount of the fluidic bone cement composition at a second temperature to the bone defect thereby filling the bone defect and allowing the fluidic bone cement composition to solidify, the second temperature being sufficiently high for maintaining the bone cement composition fluidic without causing thermal necrosis. Also disclosed are systems for carrying out the method.

Abstract translation: 公开了一种在有需要的受试者中填充骨缺损的方法。 该方法包括在骨水泥组合物为流体的第一温度下加热骨水泥组合物，并将第二温度下的有效量的流体骨粘固剂组合物递送至骨缺损，由此填充骨缺损并允许流体骨粘固剂 组合物固化，第二温度足够高以保持骨水泥组合物流体化而不引起热坏死。 还公开了用于执行该方法的系统。