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17 条记录 (耗时 0.017 秒)

    Human methionine synthase reductase: cloning, and methods for evaluating risk of, preventing, or treating neural tube defects, cardiovascular disease, cancer, and down's syndrome
    11.
    发明授权
    Human methionine synthase reductase: cloning, and methods for evaluating risk of, preventing, or treating neural tube defects, cardiovascular disease, cancer, and down's syndrome 失效
    人甲硫氨酸合成酶还原酶：克隆和评估神经管缺陷，心血管疾病，癌症和衰老综合征的风险，预防或治疗的方法

    公开(公告)号：US07063944B1

    公开(公告)日：2006-06-20

    申请号：US09487841

    申请日：2000-01-19

    申请人： Roy A. Gravel ,  Rima Rozen ,  Daniel Leclerc ,  Aaron Wilson ,  David Rosenblatt

    发明人： Roy A. Gravel ,  Rima Rozen ,  Daniel Leclerc ,  Aaron Wilson ,  David Rosenblatt

    IPC分类号： C12Q1/68 ,  C12Q1/00 ,  C12P19/34 ,  C07H21/04

    CPC分类号： C12N9/1007

    摘要： The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular disease, Down's Syndrome or cancer. The invention also features therapeutic methods for treating and/or reducing the risk of cardiovascular disease, Down's Syndrome, cancer, or neural tube defects. Also provided are the sequences of the human methionine synthase reductase gene and protein and compounds and kits for performing the methods of the invention.

    摘要翻译： 本发明的特征在于一种编码甲硫氨酸合成酶还原酶的新基因。 本发明还特征在于一种用于检测高半胱氨酸血症的可能性增加的方法，反过来，增加或减少了神经管缺陷，心血管疾病，唐氏综合征或癌症的可能性。 本发明还具有用于治疗和/或降低心血管疾病唐氏综合征，癌症或神经管缺陷风险的治疗方法。 还提供了人甲硫氨酸合酶还原酶基因和蛋白质的序列，以及用于实施本发明方法的化合物和试剂盒。

    Solid state electrochemical sensors
    14.
    发明授权
    Solid state electrochemical sensors 失效
    固态电化学传感器

    公开(公告)号：US5944970A

    公开(公告)日：1999-08-31

    申请号：US841031

    申请日：1997-04-29

    申请人： David Rosenblatt

    发明人： David Rosenblatt

    IPC分类号： G01N27/333 ,  G01N27/414

    CPC分类号： G01N27/4148

    摘要： A solid state electrochemical sensor includes a conductive base layer which supports a chemically sensitive membrane, a guard ring layer located below the base layer and insulated therefrom by a dielectric insulator ring layer. The two ring layers define a central hole through which access to the underside of the base layer is provided. The side wall of the hole is coated with a dielectric oxide layer and a metal conductor is laid on the oxide layer and is ohmically bonded to the base layer. A second dielectric oxide layer covers the metal conductor and a metallic inner guard layer covers the second dielectric oxide layer and is in ohmic contact with the guard ring layer. A CMOS buffer amplifier (voltage follower amplifier) is formed on the lower surface of the guard ring layer. The input to the buffer amplifier is coupled to the conductor in ohmic contact with the base layer and the output of the buffer amplifier is coupled to the guard ring. The guard ring and the metallic inner guard layer form an active shield (guard) around the conductor which transmits the potential of the membrane to the amplifier. The amplifier powers the guard to the same potential as the membrane which insures that the membrane potential is read properly without corruption due to capacitive loading by parasitics, shorting caused by leakage currents, or capacitively coupled noise.

    摘要翻译： 固体电化学传感器包括支撑化学敏感膜的导电基底层，位于基底层下方并通过介电绝缘体环层绝缘的保护环层。 两个环形层限定了一个中心孔，通过该中心孔提供对底层的下侧的接近。 孔的侧壁涂覆有电介质氧化物层，并且金属导体铺设在氧化物层上并与欧姆式结合到基底层上。 第二电介质氧化物层覆盖金属导体，金属内部保护层覆盖第二电介质氧化物层并且与保护环层欧姆接触。 在保护环层的下表面上形成有CMOS缓冲放大器（电压跟随放大器）。 缓冲放大器的输入端与基极欧姆接触地耦合到导体，缓冲放大器的输出耦合到保护环。 护环和金属内保护层在导体周围形成有源屏蔽（保护），其将膜的电位传递到放大器。 放大器为防护层提供与膜相同的电位，确保膜电位被正确读取，而不会由于寄生效应的容性负载而损坏，由漏电流引起的短路或电容耦合噪声。

    Distributed resonant cavity light beam modulator
    16.
    发明授权
    Distributed resonant cavity light beam modulator 失效
    分布式谐振腔光束调制器

    公开(公告)号：US5337183A

    公开(公告)日：1994-08-09

    申请号：US963494

    申请日：1992-10-20

    申请人： David Rosenblatt

    发明人： David Rosenblatt

    IPC分类号： G02F1/01 ,  G02F1/015 ,  G02F1/03 ,  G02F3/02 ,  G02F1/07 ,  G02B1/10 ,  G02B27/44 ,  G02F1/035

    CPC分类号： G02F1/01 ,  G02F1/015 ,  G02F1/0338 ,  G02F2201/302 ,  G02F2202/101 ,  G02F2202/105 ,  G02F2203/01 ,  G02F2203/10 ,  G02F2203/12 ,  G02F2203/22 ,  G02F3/024

    摘要： An optical apparatus consisting of a laser for producing a coherent polarized beam of electromagnetic radiation of a preselected wavelength. A substrate of silicon has a first transparent cover layer for receiving the polarized beam substantially normally incident thereto, and a second transparent guide layer for receiving the polarized beam from the first layer and for supporting at least one resonant mode. The first and second layers have a preselected index of refraction and a grating is interposed between them, having a grating period less than half the preselected wavelength. The layers and grating interact to produce a standing wave resonance by Bragg reflection. A control obtains a resonance wavelength in the guide layer equal to the predetermined radiation wavelength and thereby high reflectance to modulate the polarized beam. The grating can be optimized for angular bandwidth by controlling the grating's Fourier components either in a single layer or in two grating layers which can also include a termination.

    摘要翻译： 一种由用于产生预选波长的电磁辐射的相干偏振光束的激光器组成的光学装置。 硅衬底具有用于接收基本上正常入射到其上的偏振光束的第一透明覆盖层和用于从第一层接收偏振光束并用于支持至少一个谐振模式的第二透明引导层。 第一层和第二层具有预选的折射率，并且在它们之间插入光栅，其光栅周期小于预选波长的一半。 层和光栅通过布拉格反射相互作用产生驻波共振。 控制器获得等于预定辐射波长的引导层中的共振波长，从而获得高反射率以调制偏振光束。 可以通过在单层或两个光栅层中控制光栅的傅立叶分量来对角度带宽进行优化，也可以包括终端。