公开(公告)号：US06511962B1

公开(公告)日：2003-01-28

申请号：US09760328

申请日：2001-01-12

Applicant: Donald B Borders ,  William V Curran ,  Amedeo A Fantini ,  Noreen D Francis ,  Howard Jarolmen ,  Richard A Leese

Inventor： Donald B Borders ,  William V Curran ,  Amedeo A Fantini ,  Noreen D Francis ,  Howard Jarolmen ,  Richard A Leese

IPC: A61K3812

CPC classification number: C09K3/10 ,  A61K38/00 ,  C07K1/14 ,  C07K7/08 ,  C07K7/56 ,  C07K9/00 ,  C07K11/02 ,  C08L23/08 ,  C08L23/0869 ,  C08L51/06 ,  C08L2203/14 ,  C09K2003/1037 ,  C09K2200/06 ,  C09K2200/062 ,  C09K2200/0622 ,  C08L2666/04 ,  C08L2666/02

Abstract: The present invention provides a laspartomycin core peptide, a laspartomycin core peptide derivative, a antimicrobial laspartomycin derivative, a method for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial laspartomycin derivatives, pharmaceutical compositions of antimicrobial laspartomycin derivatives, methods of inhibiting microbial growth and methods for treating and/or preventing microbial infections in a subject.

Abstract translation: 本发明提供了一种天蓝假单胞菌核心肽，一拉曲霉素核心肽衍生物，一种抗微生物蓝鲸霉素衍生物，一种制备蓝鲸霉素核心肽的方法，制备蓝鲸霉素核心肽衍生物的方法，制备抗菌蓝鲸霉素衍生物的方法，抗菌蓝鲸霉素衍生物的药物组合物， 抑制微生物生长的方法以及治疗和/或预防受试者微生物感染的方法。

公开(公告)号：US4968493A

公开(公告)日：1990-11-06

申请号：US371666

申请日：1989-06-19

Applicant: Guy T. Carter ,  Michael Greenstein ,  Joseph J. Goodman ,  Donald B. Borders ,  William M. Maiese ,  Raymond T. Testa

Inventor： Guy T. Carter ,  Michael Greenstein ,  Joseph J. Goodman ,  Donald B. Borders ,  William M. Maiese ,  Raymond T. Testa

IPC: A23K20/195 ,  C12P1/06

CPC classification number: C12P1/06 ,  A23K20/195

Abstract: This invention provides a method for treating chronic respiratory disease, fowl cholera and necrotic enteritis in infected birds, by orally administering thereto a pharmaceutically effective amount of antibiotic LL-E19020.alpha., antibiotic LL-E19020.beta. or a physiologically acceptable salt thereof.

Abstract translation: 本发明提供一种通过口服给药药用有效量的抗生素LL-E19020α，抗生素LL-E19020β或其生理上可接受的盐来治疗感染禽类的慢性呼吸道疾病，家禽霍乱和坏死性肠炎的方法。

公开(公告)号：US4870019A

公开(公告)日：1989-09-26

申请号：US933651

申请日：1986-11-21

Applicant: Jane P. Kirby ,  Donald B. Borders ,  May D. Lee ,  William M. Maiese ,  Raymond T. Testa ,  David P. Labeda

Inventor： Jane P. Kirby ,  Donald B. Borders ,  May D. Lee ,  William M. Maiese ,  Raymond T. Testa ,  David P. Labeda

IPC: C12P1/06

CPC classification number: C12P1/06 ,  Y10S435/822

Abstract: A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).

Abstract translation: 描述了一种名为LL-C19004的新型抗菌剂，该抗菌剂通过微生物发酵，在控制条件下使用新品种的Saccharothrix，Saccharothrix espanaensis（NRRL 15764）产生。

公开(公告)号：US4859598A

公开(公告)日：1989-08-22

申请号：US820048

申请日：1986-01-21

Applicant: Guy T. Carter ,  Donald B. Borders ,  Joseph J. Goodman ,  David P. Labeda

Inventor： Guy T. Carter ,  Donald B. Borders ,  Joseph J. Goodman ,  David P. Labeda

IPC: A23K20/195 ,  C07D491/16 ,  C12P17/18

CPC classification number: C07D491/16 ,  A23K20/195 ,  C12P17/188 ,  C12R1/03 ,  Y10S435/825

Abstract: Antibiotic LL-D42067.beta. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.

Abstract translation: 抗生素LL-D42067通过有氧发酵得到的微生物Actinomadura madurae亚种simaoensis NRRL 15734，可用作抗菌和抗寄生虫剂。

公开(公告)号：US4650765A

公开(公告)日：1987-03-17

申请号：US760870

申请日：1985-07-30

Applicant: Jane P. Kirby ,  Amedeo A. Fantini ,  Donald B. Borders ,  Raymond T. Testa ,  John H. E. J. Martin, deceased

Inventor： Jane P. Kirby ,  Amedeo A. Fantini ,  Donald B. Borders ,  Raymond T. Testa ,  John H. E. J. Martin, deceased

IPC: C07K9/00 ,  C12P1/06 ,  C12P19/58 ,  C12P19/12 ,  C12P21/02

CPC classification number: C12R1/625 ,  C07K9/003 ,  C12P1/06 ,  C12P19/58

Abstract: This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.

Abstract translation: 本发明涉及在微生物发酵期间，在受控条件下，使用新型微生物Streptoverticillium stramineum及其突变体的两种新的抗菌和抗肿瘤药物，称为LL-BO1208α和LL-BO1208β。

公开(公告)号：US4568646A

公开(公告)日：1986-02-04

申请号：US694567

申请日：1985-01-24

Applicant: May D. Lee ,  Donald B. Borders ,  David P. Labeda ,  Amedeo A. Fantini ,  Raymond T. Testa

Inventor： May D. Lee ,  Donald B. Borders ,  David P. Labeda ,  Amedeo A. Fantini ,  Raymond T. Testa

IPC: A61K38/00 ,  C07K5/06 ,  C12N1/20 ,  A61K37/00 ,  C12R1/01 ,  C12R1/04 ,  C12R1/365

CPC classification number: C07K5/06026 ,  C12R1/01 ,  A61K38/00 ,  Y10S435/822 ,  Y10S435/826 ,  Y10S435/872

Abstract: This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139.beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.

Abstract translation: 本公开描述了一种名为LL-D05139β的新型抗细菌剂和抗肿瘤剂，其在微生物发酵下，在控制条件下使用新的Glycomyces harbinensis gen。 诺夫山脉 nov。及其突变体。

公开(公告)号：US4552867A

公开(公告)日：1985-11-12

申请号：US510694

申请日：1983-07-05

Applicant: John H. E. J. Martin ,  Jane P. Kirby ,  Donald B. Borders ,  Amedeo A. Fantini ,  Raymond T. Testa

Inventor： John H. E. J. Martin ,  Jane P. Kirby ,  Donald B. Borders ,  Amedeo A. Fantini ,  Raymond T. Testa

IPC: C12N1/20 ,  A61K35/74 ,  A61P31/04 ,  A61P35/00 ,  C07G11/00 ,  C07K9/00 ,  C12P1/06 ,  C12P19/58 ,  C12R1/625 ,  A61K37/02 ,  A61K31/71 ,  C12P19/12 ,  C12P21/02

CPC classification number: C12R1/625 ,  C07K9/003 ,  C12P1/06 ,  C12P19/58 ,  Y10S930/19

Abstract: This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.

Abstract translation: 本发明涉及在微生物发酵期间，在受控条件下，使用新型微生物Streptoverticillium stramineum及其突变体的两种新的抗菌和抗肿瘤药物，称为LL-BO1208α和LL-BO1208β。

公开(公告)号：US4384043A

公开(公告)日：1983-05-17

申请号：US298674

申请日：1981-09-02

Applicant: John H. E. J. Martin ,  David P. Labeda ,  Joseph D. Korshalla ,  Donald B. Borders ,  Raymond T. Testa

Inventor： John H. E. J. Martin ,  David P. Labeda ,  Joseph D. Korshalla ,  Donald B. Borders ,  Raymond T. Testa

IPC: C07K5/078 ,  C12P21/04 ,  C12N1/20 ,  C12P17/18 ,  C12R1/465

CPC classification number: C07K5/06139 ,  C12R1/465 ,  Y10S435/886

Abstract: This disclosure describes a novel process for the production of the known antibiotic nosiheptide using a new strain of Streptomyces glaucogriseus and mutants thereof.

Abstract translation: 本公开描述了使用新的葡萄球菌链霉菌（Streptomyces glaucogriseus）及其突变体生产已知抗生素诺西肽的新方法。

公开(公告)号：US4234717A

公开(公告)日：1980-11-18

申请号：US17000

申请日：1979-03-02

Applicant: Homer D. Tresner ,  Amedeo A. Fantini ,  Donald B. Borders ,  William J. McGahren

Inventor： Homer D. Tresner ,  Amedeo A. Fantini ,  Donald B. Borders ,  William J. McGahren

IPC: C07H15/207 ,  C12P19/46 ,  A61K31/71 ,  C07H15/22

CPC classification number: C12R1/365 ,  C07H15/207 ,  C12P19/46

Abstract: This disclosure describes three new antibiotics designated BM782.alpha.1, BM782.alpha.2, and BM782.alpha.1a which are produced in a microbiological fermentation under controlled conditions using a new strain of an undetermined species of the genus Nocardia or mutants thereof. These new antibacterial agents are active against Mycobacterium tuberculosis as well as both gram-positive and gram-negative microorganisms and thus are useful for inhibiting the growth of such bacteria and bacilli wherever they may be found.

Abstract translation: 本公开描述了在受控条件下使用诺卡氏菌属的未确定物种的新菌株或其突变体在微生物发酵中产生的三种称为BM782α1，BM782α2和BM782α1a的新抗生素。 这些新的抗菌剂对结核分枝杆菌以及革兰氏阳性和革兰氏阴性微生物均有活性，因此可用于抑制这些细菌和杆菌的生长。

公开(公告)号：US4699790A

公开(公告)日：1987-10-13

申请号：US775901

申请日：1985-09-13

Applicant: Jane P. Kirby ,  Donald B. Borders ,  May D. Lee ,  William M. Maiese ,  Raymond T. Testa ,  David P. Labeda

Inventor： Jane P. Kirby ,  Donald B. Borders ,  May D. Lee ,  William M. Maiese ,  Raymond T. Testa ,  David P. Labeda

IPC: C12P1/06 ,  A61K35/72 ,  C12P1/02

CPC classification number: C12P1/06

Abstract: A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).

Abstract translation: 描述了一种名为LL-C19004的新型抗菌剂，该抗菌剂通过微生物发酵，在控制条件下使用新品种的Saccharothrix，Saccharothrix espanaensis（NRRL 15764）产生。