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公开(公告)号：US4705688A
公开(公告)日：1987-11-10
申请号：US880230
申请日：1986-06-30
申请人： Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
发明人： Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
CPC分类号： C12P1/06
摘要： This invention relates to antibiotic LL-E19020.alpha. and LL-E19020.beta. derived from the microorganism Streptomyces lydicus subspecies tanzanius NRRL 18036, which are useful as an antibacterial agent.
摘要翻译： 本发明涉及衍生自微生物链霉菌属（Streptomyces lydicus subspecies tanzanius）NRRL 18036的抗生素LL-E19020α和LL-E19020ββ，其可用作抗菌剂。
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2.发明授权Method for controlling chronic respiratory disease, fowl cholera and necrotic enteritis in avian species 失效控制禽类物种慢性呼吸道疾病，禽霍乱和坏死性肠炎的方法
公开(公告)号：US4968493A
公开(公告)日：1990-11-06
申请号：US371666
申请日：1989-06-19
申请人： Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
发明人： Guy T. Carter , Michael Greenstein , Joseph J. Goodman , Donald B. Borders , William M. Maiese , Raymond T. Testa
IPC分类号： A23K20/195 , C12P1/06
CPC分类号： C12P1/06 , A23K20/195
摘要： This invention provides a method for treating chronic respiratory disease, fowl cholera and necrotic enteritis in infected birds, by orally administering thereto a pharmaceutically effective amount of antibiotic LL-E19020.alpha., antibiotic LL-E19020.beta. or a physiologically acceptable salt thereof.
摘要翻译： 本发明提供一种通过口服给药药用有效量的抗生素LL-E19020α，抗生素LL-E19020β或其生理上可接受的盐来治疗感染禽类的慢性呼吸道疾病，家禽霍乱和坏死性肠炎的方法。
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公开(公告)号：US4845037A
公开(公告)日：1989-07-04
申请号：US891082
申请日：1986-07-31
IPC分类号： C12N1/20 , A61K20060101 , A61K31/535 , A61K35/74 , A61P31/04 , A61P33/10 , C07G11/00 , C12N20060101 , C12N1/00 , C12N1/06 , C12N5/00 , C12N15/00 , C12P1/00 , C12P1/06 , C12P17/16 , C12P17/18 , C12R1/29
CPC分类号： C12R1/29 , Y10S435/867
摘要： A biologically pure culture of Micromonospora purpureochromogenes ssp. Wuxiensis and its use in an aerobic fermentation process to produce the antibacterial and antiparasitic agent LL-D42067.alpha..
摘要翻译： 一种生物学纯培养的小单孢菌紫色荧光发生物 无锡植物及其在好氧发酵过程中的应用，产生抗菌和抗寄生虫剂LL-D42067α。
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公开(公告)号：US5169956A
公开(公告)日：1992-12-08
申请号：US543290
申请日：1990-06-25
CPC分类号： C07H19/01 , A01N63/02 , C12P1/06 , Y10S435/88 , Y10S435/886
摘要： This invention relates to new agents designated LL-F28249.alpha., LL-F28249.beta., LL-F28249.gamma., LL-F28249.delta., LL-F28249.epsilon., LL-F28249.zeta., LL-F28249.eta., LL-F28249.theta., LL-F28249.iota., LL-F28249.kappa., LL-F28249.lambda., LL-F28249.mu., LL-F28249.nu., and LL-F2924.omega., to their production by fermentation, to methods for their recovery and concentration from crude solutions, to processes for their purification and to pharmaceutically and pharmacologically-acceptable salts thereof. The present invention includes within its scope the biologically pure culture which produces there agents, derived from a newly-discovered and previously uncultured microorganism, Streptomyces cyaneogriseus subsp. noncyanogenus, NRRL 15773.
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5.发明授权Biologically pure culture of the microorganism, streptomyces cyaneogriseus subspecies noncyanogenus, or a mutant thereof 失效微生物的生物学纯培养物，非花青素链霉菌亚种，或其突变体
公开(公告)号：US5418168A
公开(公告)日：1995-05-23
申请号：US927581
申请日：1992-08-10
CPC分类号： C07H19/01 , A01N63/02 , C12P1/06 , Y10S435/88 , Y10S435/886
摘要： This invention relates to new agents designated LL-F28249.alpha., LL-F28249.beta., LL-F28249.gamma., LL-F28249.delta., LL-F28249.epsilon., LL-F28249.zeta., LL-F28249.eta., LL-F28249.theta., LL-F28249.iota., LL-F28249.kappa., LL-F28249.lambda., LL-F28249.mu., LL-F28249.nu., and LL-F28249.omega., to their production by fermentation, to methods for their recovery and concentration from crude solutions, to processes for their purification and to pharmaceutically and pharmacologically-acceptable salts thereof. The present invention includes within its scope the biologically pure culture which produces there agents, derived from a newly-discovered and previously uncultured microorganism, Streptomyces cyaneogriseus subsp. noncyanogenus, NRRL 15773.
摘要翻译： 本发明涉及称为LL-F28249α，LL-F28249β，LL-F28249γ，LL-F28249Δ，LL-F28249ε，LL-F28249zeta，LL-F28249 eta，LL-F28249θ，LL-F28249 iota，LL-F28249 kappa，LL-F28249λ，LL-F28249 mu，LL-F28249nu和LL-F28249 omega，通过发酵生产，其从粗溶液中回收和浓缩的方法，以及其纯化方法 以及其药学上和药理上可接受的盐。 本发明在其范围内包括衍生自新发现和先前未培养的微生物Streptomyces cyaneogriseus subsp。的生物纯培养物。 非花青素，NRRL 15773。
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公开(公告)号：US5510251A
公开(公告)日：1996-04-23
申请号：US318001
申请日：1994-10-04
CPC分类号： C07H19/01 , A01N63/02 , C12P1/06 , Y10S435/88 , Y10S435/886
摘要： This invention relates to new agents designated LL-F28249.alpha., LL-F28249.beta., LL-F28249.gamma., LL-F28249.delta., LLF28249.epsilon., LL-F28249.zeta., LL-F28249.eta., LL-F28249.theta., LL-F28249.iota., LL-F28249.kappa., LL-F28249.lambda., LL-F28249.mu., LL-F28249.nu., and LL-F28249.omega., to their production by fermentation, to methods for their recovery and concentration from crude solutions, to processes for their purification and to pharmaceutically and pharmacologically-acceptable salts thereof. The present invention includes within its scope the biologically pure culture which produces there agents, derived from a newly-discovered and previously uncultured microorganism, Streptomyces cyaneogriseus subsp. noncyanogenus, NRRL 15773.
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公开(公告)号：US5106994A
公开(公告)日：1992-04-21
申请号：US732252
申请日：1985-05-10
CPC分类号： C07H19/01 , A01N63/02 , C12P1/06 , Y10S435/886
摘要： This invention relates to new agents designated LL-F28249.alpha., LL-F28249.beta., LL-F28249.gamma., LL-F28249.delta., LLF28249.epsilon., LL-F28249.zeta., LL-F28249.eta., LL-F28249.theta., LL-F28249.iota., LL-F28249.kappa., LL-F28249.lambda., LL-F28249.mu., LL-F28249.nu., and LL-F28249.omega., to their production by fermentation, to methods for their recovery and concentration from crude solutions, to processes for their purification and to pharmaceutically and pharmacologically-acceptable salts thereof. The present invention includes within its scope the biologically pure culture which produces there agents, derived from a newly-discovered and previously uncultured microorganism, Streptomyces cyaneogriseus subsp. noncyanogenus, NRRL 15773.
摘要翻译： 本发明涉及称为LL-F28249α，LL-F28249β，LL-F28249γ，LL-F28249Δ，LLF28249ε，LL-F28249zeta，LL-F28249 eta，LL-F28249θ，LL-F28249Iota， LL-F28249 kappa，LL-F28249 lambda，LL-F28249 mu，LL-F28249 nu和LL-F28249 omega，通过发酵生产，从其回收和从粗溶液中浓缩的方法，其纯化方法和 其药学上可接受的盐。 本发明在其范围内包括衍生自新发现和先前未培养的微生物Streptomyces cyaneogriseus subsp。的生物纯培养物。 非花青素，NRRL 15773。
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8.发明申请Portable Preparation, Analysis, and Detection Apparatus for Nucleic Acid Processing 审中-公开用于核酸加工的便携式制备，分析和检测装置公开(公告)号：US20090321259A1
公开(公告)日：2009-12-31
申请号：US12433201
申请日：2009-04-30
IPC分类号： C12Q1/68 , G01N27/447
CPC分类号： G01N27/447 , C12M47/06 , C12Q1/6806 , C12Q1/686
摘要： The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.
摘要翻译： 本教导包括用于裂解和/或纯化生物样品的装置和方法。 该装置可以包括具有包含生物样品接收区域，多个电极和一个或多个筛分基质的腔室的药筒。 电极可以被配置成通过产生脉冲电场来裂解生物样品。 电极也可以被配置为热裂解生物样品。 电极还可以被配置成通过一个或多个筛分基质电泳移动生物样品。 样品的一部分可以在膜上分离。 可以扩增和检测在膜上分离的样品的部分。 样品的一部分可以在存在于盒中的收集区域中分离。 分离在收集区域中的样品的部分可以从盒中取出。
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公开(公告)号：US07514046B2
公开(公告)日：2009-04-07
申请号：US10861784
申请日：2004-06-04
申请人： Persefoni Kechagia , Michael Greenstein , Bruce Brogden , Ed Donlon , Masayoshi Hayashi , Aaron J. Rulison
发明人： Persefoni Kechagia , Michael Greenstein , Bruce Brogden , Ed Donlon , Masayoshi Hayashi , Aaron J. Rulison
IPC分类号： B01L1/00
CPC分类号： B01L9/527 , B01L3/5027 , B01L3/502715 , B01L99/00 , B01L2300/022 , B01L2300/024 , B01L2400/0415 , B01L2400/0487 , G01N1/40 , G01N27/44704 , G01N27/44773 , G01N27/44791
摘要： This invention provides methods and systems for flushing, washing, and priming microscale devices for reuse. Washing and priming methods include flowing solutions from a manifold to flush wells and microchannels of a microfluidic chip. Systems include manifolds adapted to seal and flow solutions or gasses into chip wells. Devices include microfluidic devices with data storage modules to track the reprocessing status of the microscale devices.
摘要翻译： 本发明提供用于冲洗，洗涤和引发微型装置以重新使用的方法和系统。 洗涤和引发方法包括从歧管流动的溶液冲洗微流体芯片的阱和微通道。 系统包括适于密封并将溶液或气体流入芯片井的歧管。 设备包括具有数据存储模块的微流体设备，以跟踪微型设备的再处理状态。
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公开(公告)号：US07344894B2
公开(公告)日：2008-03-18
申请号：US09981440
申请日：2001-10-16
申请人： Michael Greenstein , Frederick Stawitcke , Vladimir Drbal , Ganapati R. Mauze , Rick Pittaro , Richard Pering , Ed Verdonk , Don Alden , Frank Ingle , Klaus Stefan Drese , Hans-Joachim Hartmann , Olaf Soerensen
发明人： Michael Greenstein , Frederick Stawitcke , Vladimir Drbal , Ganapati R. Mauze , Rick Pittaro , Richard Pering , Ed Verdonk , Don Alden , Frank Ingle , Klaus Stefan Drese , Hans-Joachim Hartmann , Olaf Soerensen
IPC分类号： G01N33/543
CPC分类号： B01L7/00 , B01L3/5027 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2300/1872
摘要： A method and miniature analytical device with thermal regulation of reactant using a localized heat source capable of emitting electromagnetic radiation, such as light emitting diodes (“LED”s) and vertical cavity surface emitting lasers (“VCSEL”s), generating internal heat, such as resistive, inductive and Peltier heaters, or external heating. The miniature analytical device comprises of array of temperature-controlled zones to restrict the volume heated and localize the heating by having the localized heat source comprise an array of emitters or heaters.
摘要翻译： 使用能够发射电磁辐射的局部热源的反应物的热调节方法和微型分析装置，例如发光二极管（“LED”）和垂直腔表面发射激光器（“VCSEL”），产生内部热量， 例如电阻式，感应型和珀耳帖式加热器，或外部加热。 微型分析装置包括温度控制区的阵列，以通过使局部热源包括发射器或加热器的阵列来限制加热的体积并定位加热。
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