公开(公告)号：US12180197B2

公开(公告)日：2024-12-31

申请号：US17690851

申请日：2022-03-09

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas J. Brizgys ,  Chienhung Chou ,  Jeromy J. Cottell ,  Chao-I Hung ,  Michael L. Mitchell ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Suzanne M. Szewczyk ,  James G. Taylor ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D405/14 ,  A61K31/4545 ,  A61K31/4725 ,  A61K45/06 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

公开(公告)号：US20240400568A1

公开(公告)日：2024-12-05

申请号：US18645837

申请日：2024-04-25

Applicant: GILEAD SCIENCES, INC. ,  CARNA BIOSCIENCES, INC.

Inventor： Masaaki Sawa ,  Mai Arai ,  Ryoko Nakai ,  Hirokazu Matsumoto ,  Catherine Pugh ,  Eric Hu ,  Juan Guerrero ,  Jesse Jacobsen ,  Jonathan William Medley ,  Jie Xu ,  Latesh Lad ,  Leena Patel ,  Michael Graupe ,  Qingming Zhu ,  Stephen Holmbo ,  Tetsuya Kobayashi ,  Will Watkins ,  Yasamin Moazami ,  Suet C. Yeung ,  Julian A. Codelli ,  Heath A. Weaver

IPC: C07D487/04 ,  A61K31/395 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  A61K31/553 ,  A61K31/695 ,  A61K31/704 ,  A61K31/7068 ,  A61K35/15 ,  A61K35/17 ,  A61K39/395 ,  A61K45/06 ,  C07D519/00 ,  C07F7/18

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

公开(公告)号：US20240390349A1

公开(公告)日：2024-11-28

申请号：US18639097

申请日：2024-04-18

Applicant: Gilead Sciences, Inc.

Inventor： Rebecca R. Begley ,  Polina German ,  Justin Lutz ,  Rameshraja Palaparthy ,  Abdul Naveed Shaik ,  Martin S. Rhee ,  Renu Singh

IPC: A61K31/4439 ,  A61K45/06 ,  A61P31/18

Abstract: The present disclosure relates to dosing regimens of an HIV capsid inhibitor and methods for the treatment or prevention of a human immunodeficiency virus (HIV) infection in a patient.

公开(公告)号：US20240383922A1

公开(公告)日：2024-11-21

申请号：US18631866

申请日：2024-04-10

Applicant: Gilead Sciences, Inc.

Inventor： Wilian Augusto Cortopassi Coelho ,  Chaodi Dai ,  Katherine De La Fuente ,  Julie Farand ,  Juan A. Guerrero ,  Tezcan Guney ,  Hongyan Guo ,  Safaa S. Jamshed ,  Darryl Kato ,  Irene N. Kiburu ,  Scott E. Lazerwith ,  James B.C. Mack ,  Joshua L. Martin ,  Jessica L. McKinley ,  Jonathan William Medley ,  Hyung-Jung Pyun ,  Thomas P. Stratton ,  Rhiannon Thomas-Tran ,  Maoqun Tian ,  Vickie H. Tsui ,  William J. Watkins ,  Jie Xu ,  Adam D. Zajdlik ,  Jennifer R. Zhang

IPC: C07D519/00 ,  A61K31/553 ,  A61K45/06

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

公开(公告)号：US20240376077A1

公开(公告)日：2024-11-14

申请号：US18632593

申请日：2024-04-11

Applicant: Gilead Sciences, Inc.

Inventor： Michael Graupe ,  Steven J. Henry ,  John O. Link ,  Charles William Rowe ,  Roland D. Saito ,  Scott D. Schroeder ,  Dimitrios Stefanidis ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61K31/4439 ,  A61K31/537 ,  A61K31/675 ,  A61K31/7076 ,  A61K45/06 ,  C07C317/08 ,  C07D231/54 ,  C07F5/02

Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US12110294B2

公开(公告)日：2024-10-08

申请号：US17243911

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  C07K16/28

CPC classification number: C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  C07K16/2818 ,  C07K16/2827

Abstract: The present disclosure provides pyrimidine dione compounds of Formula I






and pharmaceutical compositions thereof, for treating cancer, including solid tumors either-used alone or in combination with other anti-cancer agents.

公开(公告)号：US20240307502A1

公开(公告)日：2024-09-19

申请号：US18673424

申请日：2024-05-24

Applicant: Gilead Sciences, Inc. ,  Novo Nordisk A/S

Inventor： Constantine Stephen Djedjos ,  Bryan John McColgan ,  Robert Paul Myers ,  Gangadharan Mani Subramanian ,  Lene Melchiorsen ,  Morten Hansen

IPC: A61K38/26 ,  A61K9/00 ,  A61K31/4439 ,  A61K31/519 ,  A61P1/16 ,  A61P3/04 ,  A61P3/10

CPC classification number: A61K38/26 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/4439 ,  A61K31/519 ,  A61P1/16 ,  A61P3/04 ,  A61P3/10

Abstract: The present disclosure relates to a method of treating non-alcoholic steatohepatitis (NASH) comprising administering to a subject with NASH a combination therapy comprising semaglutide, firsocostat, and/or cilofexor.

公开(公告)号：US12084510B2

公开(公告)日：2024-09-10

申请号：US16797364

申请日：2020-02-21

Applicant: GILEAD SCIENCES, INC. ,  NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： Ilia Alexandre Tikhomirov ,  Maria L. Jaramillo ,  Maureen D. O'Connor-McCourt ,  Traian Sulea ,  Renald Gilbert ,  Bruno Gaillet ,  Jason Baardsnes ,  Myriam Banville ,  Suzanne Grothe

IPC: C07K16/30 ,  C07K16/28

CPC classification number: C07K16/30 ,  C07K16/2863 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567

Abstract: Herein described are antibodies to epidermal growth factor receptor (EGER) having an EGER binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.

公开(公告)号：US12077537B2

公开(公告)日：2024-09-03

申请号：US18110126

申请日：2023-02-15

Applicant: Gilead Sciences, Inc.

Inventor： Chienhung Chou ,  Scott E. Lazerwith ,  John O. Link ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D513/06 ,  A61K31/4365 ,  A61K31/437 ,  A61K45/06 ,  C07D403/12 ,  C07D471/04 ,  C07D471/06 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K45/06 ,  C07D403/12 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.

公开(公告)号：US20240263190A1

公开(公告)日：2024-08-08

申请号：US18414151

申请日：2024-01-16

Applicant: Gilead Sciences, Inc.

Inventor： Daniel Rohrer ,  Peter Brams

IPC: C12N15/85 ,  C07K16/18

CPC classification number: C12N15/8509 ,  C07K16/18 ,  A01K2207/15 ,  A01K2227/105

Abstract: Human immunoglobulin light chain transgene constructs are provided that encode two different rearranged light chain V-J regions arranged in such a manner that one of the two alternate light chains is expressed from the construct upon recombination in B cells. Transgenic animals comprising the transgene are also provided. The binary light chain transgene thus allows for expression of two alternate fixed light chains in the animals. Methods of using the transgenic animals are also provided.