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公开(公告)号：US20110048939A1
公开(公告)日：2011-03-03
申请号：US12940564
申请日：2010-11-05
IPC分类号： G01N27/403
CPC分类号： G01N33/502 , B01L3/5025 , B01L2300/0829 , B01L2300/0851 , B01L2300/0893 , B01L2300/16 , G01N27/28 , G01N33/48728 , G01N33/5438 , G01N33/6872 , G01N2500/04 , G01N2500/10 , Y10T29/49826
摘要： The present invention relates to a structure comprising a biological membrane and a porous or perforated substrate, a biological membrane, a substrate, a high throughput screen, methods for production of the structure membrane and substrate, and a method for screening a large number of test compounds in a short period. More particularly it relates to a structure comprising a biological membrane adhered to a porous or perforated substrate, a biological membrane capable of adhering with high resistance seals to a substrate such as perforated glass and the ability to form sheets having predominantly an ion channel or transporter of interest, a high throughput screen for determining the effect of test compounds on ion channel or transporter activity, methods for manufacture of the structure, membrane and substrate, and a method for monitoring ion channel or transporter activity in a membrane.
摘要翻译： 本发明涉及一种包括生物膜和多孔或穿孔基底，生物膜，基底，高通量筛选，结构膜和基底的制备方法以及筛选大量试验的方法的结构 化合物在短时间内。 更具体地说，涉及一种结构，该结构包括附着于多孔或多孔基底的生物膜，能够将高电阻密封粘附到诸如多孔玻璃的基底上的生物膜，以及形成主要具有离子通道或转运体 兴趣，用于确定测试化合物对离子通道或转运蛋白活性的影响的高通量筛选，用于制造结构，膜和底物的方法，以及用于监测膜中的离子通道或转运蛋白活性的方法。
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公开(公告)号：US07846389B2
公开(公告)日：2010-12-07
申请号：US11133808
申请日：2005-05-20
CPC分类号： G01N33/502 , B01L3/5025 , B01L2300/0829 , B01L2300/0851 , B01L2300/0893 , B01L2300/16 , G01N27/28 , G01N33/48728 , G01N33/5438 , G01N33/6872 , G01N2500/04 , G01N2500/10 , Y10T29/49826
摘要： The present invention relates to a structure comprising a biological membrane and a porous or perforated substrate, a biological membrane, a substrate, a high throughput screen, methods for production of the structure membrane and substrate, and a method for screening a large number of test compounds in a short period. More particularly it relates to a structure comprising a biological membrane adhered to a porous or perforated substrate, a biological membrane capable of adhering with high resistance seals to a substrate such as perforated glass and the ability to form sheets having predominantly an ion channel or transporter of interest, a high throughput screen for determining the effect of test compounds on inn channel or transporter activity, methods for manufacture of the structure, membrane and substrate, and a method for monitoring ion channel or transporter activity in a membrane.
摘要翻译： 本发明涉及一种包括生物膜和多孔或穿孔基底，生物膜，基底，高通量筛选，结构膜和基底的制备方法以及筛选大量试验的方法的结构 化合物在短时间内。 更具体地说，涉及一种结构，该结构包括附着于多孔或多孔基底的生物膜，能够将高电阻密封粘附到诸如多孔玻璃的基底上的生物膜，以及形成主要具有离子通道或转运体 感兴趣的，用于确定测试化合物对宿主通道或转运蛋白活性的影响的高通量筛选，用于制造结构，膜和底物的方法以及用于监测膜中的离子通道或转运蛋白活性的方法。
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公开(公告)号：US07532375B2
公开(公告)日：2009-05-12
申请号：US11575261
申请日：2005-09-23
IPC分类号： G02B26/08
CPC分类号： G02B23/2469 , A61B1/00183 , G02B21/06 , G02B23/2423 , G02B23/2476 , G02B26/10
摘要： A scanning method and apparatus, the apparatus comprising a fork with first and second forwardly extending tines and a rearwardly extending counterweight member, a mount for supporting the fork at a point between the tines and the counterweight member, and a drive for effecting relative vibration between the tines to provide a fast scan and for driving the fork to provide a slow scan transverse to the fast scan.
摘要翻译： 一种扫描方法和装置，该装置包括具有第一和第二向前延伸的叉的叉和向后延伸的配重构件，用于在叉与配重构件之间的点处支撑叉的安装件，以及用于在叉和配重构件之间实现相对振动的驱动器 叉子提供快速扫描和驱动叉子以提供横向于快速扫描的缓慢扫描。
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公开(公告)号：US07384733B1
公开(公告)日：2008-06-10
申请号：US09857456
申请日：1999-12-06
CPC分类号： G01N33/48728 , C12M41/46
摘要： The invention provides a novel development of the conventional patch clamp technique for measurement of whole cell electrical activity. The invention provides for one or more cell or cells to be suspended in a liquid medium at a liquid/air interface (by virtue of the effect of surface tension at the interface) whereby the cell or cells are accessible at the interface to a microstructure electrode (such as a pipette tip) to which a cell can attach to form an electrical seal, for the purpose of whole cell voltage clamp recording. According to the invention the electrode can be caused to form a high resistance electrical seal with a cell suspended in the liquid at the liquid/air interface without the need to press the cell against a solid support surface. The invention also provides apparatus for carrying out the interface patch clamp technique and control logic for operating a computer to carry out the interface patch clamp technique.
摘要翻译： 本发明提供了用于测量全细胞电活动的常规膜片钳技术的新发展。 本发明提供一种或多种在液体/空气界面处悬浮在液体介质中的细胞或细胞（借助于界面处的表面张力的作用），由此在与微结构电极的界面处可接触细胞或细胞 （例如移液管尖端），电池可以附接到其上以形成电气密封，用于全电池电压钳记录的目的。 根据本发明，可以使电极与在液体/空气界面处悬浮在液体中的电池形成高电阻电气密封，而不需要将电池压在固体支撑表面上。 本发明还提供了用于执行界面膜片钳技术的装置和用于操作计算机以执行界面膜片钳技术的控制逻辑。
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公开(公告)号：US07294102B2
公开(公告)日：2007-11-13
申请号：US10822718
申请日：2004-04-13
IPC分类号： A61B1/00
CPC分类号： A61B1/31 , A61B1/00096 , A61B1/00188 , A61B5/0068 , G02B7/005 , G02B21/241 , G02B23/2476
摘要： A position control apparatus for controlling position along an axis, comprising: an extensible member that can be extended and contracted along said axis, comprising shape memory alloy locatable to expand and contract along said axis, heating means for controlling said temperature of said shape memory alloy, and a feedback mechanism for controlling said heating means and responsive to variations in said position, wherein said position is controllable by means of said heating means and can be stabilized by means of said feedback mechanism.
摘要翻译： 一种用于沿着轴线控制位置的位置控制装置，包括：可沿着所述轴线延伸和收缩的可延伸构件，包括可沿着所述轴线膨胀和收缩的形状记忆合金，用于控制所述形状记忆合金的所述温度的加热装置 以及用于控制所述加热装置并响应于所述位置的变化的反馈机构，其中所述位置可通过所述加热装置控制，并且可以通过所述反馈机构稳定。
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公开(公告)号：US5514949A
公开(公告)日：1996-05-07
申请号：US190012
申请日：1994-01-21
申请人： Guenter Bross , Gerard Byrne
发明人： Guenter Bross , Gerard Byrne
IPC分类号： G05F3/26 , H01L21/331 , H01L21/8222 , H01L27/02 , H01L27/082 , H01L29/73 , H01L29/732 , H03F1/52 , H03F3/343 , H03F3/347 , G05F3/16
CPC分类号： G05F3/265 , H01L27/0248 , H01L27/0825
摘要： A current mirror having at least one pnp-transistor and providing overvoltage protection has three collectors designed as partial collectors. Two of the partial collectors and the base are linked to a reference-current source and the other partial collector is linked to a terminal connection of the current source to be protected from overvoltage. In the event of an overvoltage across the terminal connection, an emitter is formed by the partial collector linked to this terminal connection which limits the received current in proportion, conditional upon the topology, with the mirror-reference current.
摘要翻译： PCT No.PCT / DE93 / 00401 Sec。 371日期1994年1月21日 102（e）日期1994年1月21日PCT提交1993年5月7日PCT公布。 第WO93 / 23876号公报 日期为1993年11月25日。具有至少一个pnp晶体管并提供过电压保护的电流镜具有三个收集器，设计为部分收集器。 部分收集器和基座中的两个链接到参考电流源，而另一个部分收集器链接到当前源的终端连接以防过电压。 在终端连接过电压的情况下，通过连接到该终端连接的部分收集器形成发射器，其以拓扑结构与镜像参考电流成比例地限制接收电流。
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公开(公告)号：US06936462B1
公开(公告)日：2005-08-30
申请号：US09719236
申请日：1999-06-14
CPC分类号： G01N33/502 , B01L3/5025 , B01L2300/0829 , B01L2300/0851 , B01L2300/0893 , B01L2300/16 , G01N27/28 , G01N33/48728 , G01N33/5438 , G01N33/6872 , G01N2500/04 , G01N2500/10 , Y10T29/49826
摘要： The present invention relates to a structure comprising a biological membrane and a porous or perforated substrate, a biological membrane, a substrate, a high throughput screen, methods for production of the structure membrane and substrate, and a method for screening a large number of test compounds in a short period. More particularly it relates to a structure comprising a biological membrane adhered to a porous or perforated substrate, a biological membrane capable of adhering with high resistance seals to a substrate such as perforated glass and the ability to form sheets having predominantly an ion channel or transporter of interest, a high throughput screen for determining the effect of test compounds on ion channel or transporter activity, methods for manufacture of the structure, membrane and substrate, and a method for monitoring ion channel or transporter activity in a membrane.
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