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11.发明申请公开(公告)号：US20090043389A1
公开(公告)日：2009-02-12
申请号：US12191490
申请日：2008-08-14
申请人： GORDANA VUNJAK-NOVAKOVIC , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Katherine G. Truncale
发明人： GORDANA VUNJAK-NOVAKOVIC , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Katherine G. Truncale
IPC分类号： A61F2/08
CPC分类号： A61F2/28 , A61B17/00491 , A61F2/30756 , A61F2/3094 , A61F2/3859 , A61F2/4644 , A61F2002/2817 , A61F2002/2839 , A61F2002/2867 , A61F2002/30004 , A61F2002/30062 , A61F2002/30112 , A61F2002/30113 , A61F2002/30121 , A61F2002/30125 , A61F2002/30136 , A61F2002/30153 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30228 , A61F2002/3028 , A61F2002/30759 , A61F2002/30764 , A61F2002/4635 , A61F2210/0004 , A61F2230/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0019 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2250/0014 , A61F2310/00365 , A61F2310/00383 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/48 , A61L27/52 , A61L2430/06
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore in an interference fit and is surrounded by milled cartilage and carrier. A method for inserting the assembly into a cartilage defect area is disclosed.
摘要翻译： 本发明涉及一种软骨修复组件，其包括具有整体上覆软骨帽的软骨下骨的成形结构，其被处理以除去生物可吸收载体中的细胞碎片和蛋白聚糖和研磨的软骨。 成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得当在孔中心定位时所述成形的骨和软骨帽不会以过盈配合接合孔的侧壁并被碾磨的软骨和载体包围 。 公开了一种将组件插入软骨缺损区域的方法。
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12.发明申请Method for the treatment of diseased, degenerated, or damaged tissue using three dimensional tissue produced in vitro in combination with tissue cells and/or exogenic factors 审中-公开使用体外结合组织细胞和/或外源因子产生的三维组织治疗患病，退化或损伤的组织的方法公开(公告)号：US20050074477A1
公开(公告)日：2005-04-07
申请号：US10501520
申请日：2003-11-07
申请人： Olivera Josimovic-Alasevic , Jeannette Libera , Hans-Peter Wiesmann , Ulrich Joos , Gordana Vunjak-Novakovic
发明人： Olivera Josimovic-Alasevic , Jeannette Libera , Hans-Peter Wiesmann , Ulrich Joos , Gordana Vunjak-Novakovic
CPC分类号： C12N5/0655 , A61K35/12 , C12N13/00
摘要： The invention relates to a tissue replacement structure comprising (a) a preformed three-dimensional tissue which can be produced by obtaining cells from a human or animal organism and culturing them in a stationary fashion as a suspension culture in cell culture vessels with hydrophobic surface and tapering bottom until a cell aggregate is formed which has differentiated cells embedded therein and has an outer region wherein cells capable of proliferation and migration are present; (b) (i) an autologous cell suspension which can be produced from endogenous cells, with endogenous serum being added, with no addition of growth-promoting compounds, (ii) implants or support materials and/or (iii) growth factors; and/or (c) can be obtained by exposure of the tissue according to (a) to electromagnetic fields, mechanical stimulation and/or ultrasound.
摘要翻译： 本发明涉及一种组织置换结构，其包括（a）预先形成的三维组织，其可以通过从人或动物生物获得细胞并以静止方式将其作为悬浮培养物在具有疏水性表面的细胞培养容器中培养而制备， 逐渐变细的底部，直到形成细胞聚集体，其具有嵌入其中的分化细胞，并且具有其中存在能够增殖和迁移的细胞的外部区域; （b）（i）可以从内源细胞产生的自体细胞悬浮液，加入内源血清，不加生长促进化合物，（ii）植入物或支持材料和/或（iii）生长因子; 和/或（c）可以通过根据（a）将组织暴露于电磁场，机械刺激和/或超声波来获得。
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公开(公告)号：US09206383B2
公开(公告)日：2015-12-08
申请号：US12961309
申请日：2010-12-06
申请人： Gordana Vunjak-Novakovic , Warren Grayson , Qun Wan , Donald O. Freytes , Amandine Godier-Furnémont , Nina Tandon , Keith Yeager , George Eng , Sarindr Bhumiratana , Robert Maidhof
发明人： Gordana Vunjak-Novakovic , Warren Grayson , Qun Wan , Donald O. Freytes , Amandine Godier-Furnémont , Nina Tandon , Keith Yeager , George Eng , Sarindr Bhumiratana , Robert Maidhof
CPC分类号： C12M23/44 , C12M21/08 , C12M23/42 , C12M23/46 , C12M23/58 , C12M25/14 , C12M29/10 , C12M29/20 , C12M35/02 , C12M41/46 , C12M41/48
摘要： Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a mechanical transmission module, a gas exchange module, a temperature module, a humidity module and/or a CO2 module, among others. The bioreactor and functional modules can include standard or universal connectors to facilitate connection and movement of modules. The bioreactor system can be controlled and/or monitored by a controller that can individually identify and control each connected module and that can be adapted to collect signal data from sensors embedded in any of the modules.
摘要翻译： 公开了生物反应器装置，系统和方法。 生物反应器系统可以包括可以单独控制和可识别的一个或多个生物反应器模块。 生物反应器模块可以连接到一个或多个功能模块，例如泵模块，刺激信号发生模块，马达模块，机械传动模块，气体交换模块，温度模块，湿度模块和/或二氧化碳 模块等。 生物反应器和功能模块可以包括标准或通用连接器，以便于模块的连接和移动。 生物反应器系统可以被控制器控制和/或监控，所述控制器可以单独地识别和控制每个连接的模块，并且可以适于从嵌入在任何模块中的传感器收集信号数据。
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公开(公告)号：US09068282B2
公开(公告)日：2015-06-30
申请号：US12934666
申请日：2009-04-08
摘要： A system and method for making a biomaterial device includes a support structure providing a shape for a biomaterial device. At least one applicator has a supply of biomaterial solution and is positioned along the support structure. The at least one applicator forms a biomaterial fiber by applying shear force to the biomaterial solution and delivering the biomaterial fiber to the support structure. A controller causes relative movement between the support structure and the at least one applicator, and the biomaterial fiber is arranged on the support structure according to the relative movement to form the biomaterial device. The biomaterial may be silk fibroin which may be wound onto a reciprocating and rotating mandrel. Control over the properties of the biomaterial device is achieved through appropriate selection of material processing, winding strategy, and post-winding processing.
摘要翻译： 用于制造生物材料装置的系统和方法包括为生物材料装置提供形状的支撑结构。 至少一个施用器具有生物材料溶液的供应并且沿着支撑结构定位。 所述至少一个施用器通过向所述生物材料溶液施加剪切力并将所述生物材料纤维递送到所述支撑结构来形成生物材料纤维。 控制器引起支撑结构和至少一个施加器之间的相对运动，并且根据相对运动将生物材料纤维布置在支撑结构上以形成生物材料装置。 生物材料可以是可以卷绕到往复和旋转的心轴上的丝素蛋白。 通过适当选择材料加工，卷绕策略和后卷绕处理，可以控制生物材料装置的性能。
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公开(公告)号：US20150004643A1
公开(公告)日：2015-01-01
申请号：US14126902
申请日：2012-06-15
IPC分类号： G01N33/50
CPC分类号： G01N33/5091 , C12N5/0068 , C12N2503/00 , C12N2535/10
摘要： Methods for determining cell chirality using micropatterned substrates are disclosed. Also provided are methods for diagnosing diseases such as genetic diseases or cancer by comparing the chirality of sample cells from a subject with normal cells, and determining a difference in chirality between the sample cells and normal cells.
摘要翻译： 公开了使用微图案化底物测定细胞手性的方法。 还提供了通过将来自受试者的样品细胞的手性与正常细胞进行比较来诊断诸如遗传疾病或癌症的疾病的方法，并且确定样品细胞与正常细胞之间手性的差异。
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公开(公告)号：US20140094410A1
公开(公告)日：2014-04-03
申请号：US13680570
申请日：2012-11-19
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
摘要翻译： 本发明提供生产多孔丝素蛋白支架材料的方法。 多孔丝素蛋白支架可用于组织工程。 可以调节本文所述的丝素蛋白支架的孔隙率以模拟在天然组织中发现的密度梯度。 因此，用于三维组织工程的方法，例如， 还提供使用丝素蛋白骨架材料的骨和软骨。
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公开(公告)号：US08361617B2
公开(公告)日：2013-01-29
申请号：US12836692
申请日：2010-07-15
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present application provides a composition comprising porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffold described herein can be adjusted to mimic the gradient of densities found in natural tissue.
摘要翻译： 本申请提供了包含多孔丝素蛋白支架材料的组合物。 多孔丝素蛋白支架可用于组织工程。 可以调节本文所述的丝素蛋白支架的孔隙率，以模拟在天然组织中发现的密度梯度。
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18.发明申请Methods, Devices and Systems for Bone Tissue Engineering Using a Bioreactor 有权使用生物反应器进行骨组织工程的方法，装置和系统公开(公告)号：US20120035742A1
公开(公告)日：2012-02-09
申请号：US13148735
申请日：2010-03-03
CPC分类号： A61F2/28 , A61F2/30942 , A61F2/3099 , A61F2002/30957 , C12M21/08 , C12M25/14 , C12M29/10
摘要： An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold.
摘要翻译： 可以使用能够灌注大复合多孔支架的生物反应器离体培养解剖学形状的人骨移植物。 衍生自靶基因图像建模的支架植入人间充质干细胞并培养。 配置成容纳复杂的三维支架几何形状的生物反应器提供用于灌注细胞的受控流。 作为介质灌注的结果，可以在整个支架上实现均匀的细胞生长。 在一个实施方案中，生物反应器具有模具，灌注介质在压力下被泵送并且多个端口通过介质离开模具。
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公开(公告)号：US20110136225A1
公开(公告)日：2011-06-09
申请号：US12961309
申请日：2010-12-06
申请人： Gordana Vunjak-Novakovic , Warren Grayson , Qun Wan , Donald Freytes , Amandine Godier-Furnémont , Nina Tandon , Keith Yeager , George Eng , Sarindr Bhumiratana , Robert Maidhof
发明人： Gordana Vunjak-Novakovic , Warren Grayson , Qun Wan , Donald Freytes , Amandine Godier-Furnémont , Nina Tandon , Keith Yeager , George Eng , Sarindr Bhumiratana , Robert Maidhof
CPC分类号： C12M23/44 , C12M21/08 , C12M23/42 , C12M23/46 , C12M23/58 , C12M25/14 , C12M29/10 , C12M29/20 , C12M35/02 , C12M41/46 , C12M41/48
摘要： Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a mechanical transmission module, a gas exchange module, a temperature module, a humidity module and/or a CO2 module, among others. The bioreactor and functional modules can include standard or universal connectors to facilitate connection and movement of modules. The bioreactor system can be controlled and/or monitored by a controller that can individually identify and control each connected module and that can be adapted to collect signal data from sensors embedded in any of the modules.
摘要翻译： 公开了生物反应器装置，系统和方法。 生物反应器系统可以包括可以单独控制和可识别的一个或多个生物反应器模块。 生物反应器模块可以连接到一个或多个功能模块，例如泵模块，刺激信号发生模块，马达模块，机械传动模块，气体交换模块，温度模块，湿度模块和/或二氧化碳 模块等。 生物反应器和功能模块可以包括标准或通用连接器，以便于模块的连接和移动。 生物反应器系统可以被控制器控制和/或监控，所述控制器可以单独地识别和控制每个连接的模块，并且可以适于从嵌入在任何模块中的传感器收集信号数据。
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公开(公告)号：US20100279112A1
公开(公告)日：2010-11-04
申请号：US12836692
申请日：2010-07-15
IPC分类号： B32B9/02
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
摘要翻译： 本发明提供生产多孔丝素蛋白支架材料的方法。 多孔丝素蛋白支架可用于组织工程。 可以调节本文所述的丝素蛋白支架的孔隙率以模拟在天然组织中发现的密度梯度。 因此，用于三维组织工程的方法，例如， 还提供使用丝素蛋白骨架材料的骨和软骨。
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