公开(公告)号：US20120004173A1

公开(公告)日：2012-01-05

申请号：US13233315

申请日：2011-09-15

申请人： Ichiro Ono

发明人： Ichiro Ono

IPC分类号： A61K38/18 ,  A61P17/02 ,  A61Q19/08

CPC分类号： A61K9/0019 ,  A61K8/66 ,  A61K9/0021 ,  A61K38/1825 ,  A61K2800/91 ,  A61Q19/08

摘要： It is to provide a method for treating skin aging, or a method for treating skin scar that can exert a sufficient effect. A composition for treating skin aging comprising bFGF for treating aging of the skin that is administered intradermally or subcutaneously, or a composition for treating skin scar comprising bFGF for treating scar of skin that is administered intradermally or subcutaneously is utilized. Preferred examples of aging of skin include skin wrinkle, pigmented spot, sagging skin, rough skin, skin thinning, decrease of skin viscoelasticity, etc., and preferred examples of scar include keloid, hypertrophic scar, scar contracture, etc.

摘要翻译： 本发明提供一种治疗皮肤老化的方法，或者可以发挥充分效果的治疗皮肤瘢痕的方法。 利用皮肤衰老治疗用组合物，其包含用于治疗皮内或皮下施用的皮肤老化的bFGF或用于治疗皮肤瘢痕的组合物，其包含用于治疗皮内或皮下给药的皮肤瘢痕的bFGF。 皮肤老化的优选实例包括皮肤皱纹，着色点，下垂皮肤，粗糙皮肤，皮肤变薄，皮肤粘弹性降低等，并且瘢痕疙瘩，肥大性瘢痕，瘢痕挛缩等的优选实例。

公开(公告)号：US20090142403A1

公开(公告)日：2009-06-04

申请号：US12325015

申请日：2008-11-28

申请人： Ichiro ONO ,  Yoshikiyo AKASAKA ,  Takehiko NAKAJIMA

发明人： Ichiro ONO ,  Yoshikiyo AKASAKA ,  Takehiko NAKAJIMA

IPC分类号： A61K9/14 ,  A61K47/42 ,  A61K31/7088 ,  A61K35/12 ,  A61K38/18 ,  A61K47/02

CPC分类号： A61K31/7088 ,  A61K38/18 ,  A61K38/1825 ,  A61K38/1875 ,  A61K48/0075 ,  A61K48/0091 ,  A61K2300/00

摘要： An organ regeneration device adapted to be used by placing it into a defective portion of an organ to regenerate the organ is provided. The organ regeneration device has a base body having a shape corresponding to a shape of the defective portion of the organ. The organ regeneration device also has particles carried on the base body, wherein the particles are composed of a different material from that of the base body. The organ regeneration device also has a growth-related substance contained in the organ regeneration device for growth and differentiation of cells around the defective portion. The growth-related substance contains an angiogenesis factor. Further, the growth-related substance contains nucleic acid containing a base sequence coding for amino-acid sequence of a growth factor different from the angiogenesis factor. Furthermore, the nucleic acid is introduced into a host cell.

摘要翻译： 提供了一种适于通过将其置于器官的缺陷部分以再生器官而使用的器官再生装置。 器官再生装置具有与器官的有缺陷部的形状对应的形状的基体。 器官再生装置还具有承载在基体上的颗粒，其中颗粒由与基体不同的材料构成。 器官再生装置还具有包含在器官再生装置中的生长相关物质，用于在缺陷部分周围的细胞的生长和分化。 生长相关物质含有血管生成因子。 此外，生长相关物质含有含有编码不同于血管生成因子的生长因子的氨基酸序列的碱基序列的核酸。 此外，将核酸引入宿主细胞。

公开(公告)号：US06733528B2

公开(公告)日：2004-05-11

申请号：US10212151

申请日：2002-08-06

申请人： Keita Abe ,  Masanori Nakasu ,  Ichiro Ono

发明人： Keita Abe ,  Masanori Nakasu ,  Ichiro Ono

IPC分类号： A61F202

CPC分类号： A61L27/12 ,  B29C64/165

摘要： A method for forming an implant having a desired shape includes the steps of (a) forming a layer of ingredient powder having a predetermined thickness composed of an ingredient powder, and (b) applying an reactant liquid to the layer in accordance with the desired shape of the implant, portions of the ingredient powder reacting with the reactant liquid being hardened. The above steps are repeated to stack a plurality of the layers having hardened portions, respectively, to form a three-dimensional implant formed by a stack of the hardened portions of the layers of the ingredient powder. The ingredient powder is a powder including at least one of a-tricalcium phosphate and tetracalcium phosphate, and a Ca/P ratio of the powder is within a range of 1.40 through 2.0.

摘要翻译： 用于形成具有所需形状的植入物的方法包括以下步骤：（a）形成具有由成分粉末组成的预定厚度的成分粉末层，和（b）根据期望的形状将反应物液体施加到该层 的植入物，与反应物液体反应的成分粉末的部分被硬化。 重复上述步骤以分别堆叠具有硬化部分的多个层，以形成由成分粉末的层的硬化部分的堆叠形成的三维植入物。 成分粉末是包含磷酸三钙和磷酸四钙中的至少一种的粉末，粉末的Ca / P比在1.40〜2.0的范围内。

公开(公告)号：US06660281B1

公开(公告)日：2003-12-09

申请号：US09606017

申请日：2000-06-29

申请人： Tetsuo Nakanishi ,  Koji Sakuta ,  Ichiro Ono

发明人： Tetsuo Nakanishi ,  Koji Sakuta ,  Ichiro Ono

IPC分类号： A61K600

CPC分类号： A61K8/895 ,  A61K8/27 ,  A61K8/29 ,  A61K8/894 ,  A61K8/897 ,  A61Q1/02 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q5/00 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  C01P2004/10 ,  C01P2004/32 ,  C01P2006/22 ,  C01P2006/60 ,  C01P2006/80 ,  C08G77/50 ,  C08L83/06 ,  C08L83/14 ,  C09C3/12

摘要： Powders treated with silicones represented by the following formula (1): R1aR2bR3cSiO(4−a−b−c)/2  (1) wherein R1, R2, R3 a, b and c are as defined herein, are suitable for use in cosmetic materials.

摘要翻译： 用下式（1）表示的硅氧烷处理的粉末：其中R 1，R 2，R 3 a，b和c如本文所定义，适用于化妆品材料。

公开(公告)号：US6027816A

公开(公告)日：2000-02-22

申请号：US184506

申请日：1998-11-02

申请人： Ichiro Ono ,  Yuko Kawamura

发明人： Ichiro Ono ,  Yuko Kawamura

IPC分类号： G02B1/04 ,  G02B1/10 ,  G02C7/02 ,  G02C7/10 ,  B32B27/00 ,  B05D5/00

CPC分类号： G02B1/105 ,  G02C7/021 ,  G02C7/108 ,  Y10T428/25 ,  Y10T428/31507 ,  Y10T428/31511 ,  Y10T428/31551 ,  Y10T428/31598 ,  Y10T428/31663

摘要： A colored plastic lens includes a plastic substrate having first and second surfaces, a resin film with a pigment dispersed therein formed on one of the first and second surfaces of the plastic substrate, and a coating film, preferably a hard coat film, formed on the resin film and the surface of the lens on which the resin film is not formed. A method of forming the colored plastic lens includes providing a plastic substrate having first and second sides, dispersing a pigment in a resin vehicle, coating the pigment dispersed in the resin vehicle on one of the first and second sides of the plastic substrate to thereby form a resin film, and forming a coating film, preferably a hard coat film, on the resin film and the surface of the lens on which the resin film is not formed.

摘要翻译： 彩色塑料透镜包括具有第一表面和第二表面的塑料基板，在塑料基板的第一和第二表面之一上形成有分散在其中的颜料的树脂膜，以及形成在塑料基板上的涂膜，优选为硬涂膜 树脂膜和未形成树脂膜的透镜的表面。 形成着色塑料透镜的方法包括提供具有第一和第二侧面的塑料基材，将颜料分散在树脂载体中，将分散在树脂载体中的颜料涂覆在塑料基材的第一和第二侧中的一个上，从而形成 树脂膜，在树脂膜和未形成树脂膜的透镜的表面上形成涂膜，优选硬涂膜。

公开(公告)号：US5489328A

公开(公告)日：1996-02-06

申请号：US380693

申请日：1995-01-30

申请人： Ichiro Ono ,  Hitoshi Uehara ,  Shoji Ichinohe

发明人： Ichiro Ono ,  Hitoshi Uehara ,  Shoji Ichinohe

IPC分类号： C08G77/24 ,  C08G77/50 ,  C09D183/08 ,  C09D183/14 ,  C09K3/18

CPC分类号： C08G77/24 ,  C08G77/50 ,  C09D183/08 ,  C09D183/14

摘要： A hydrolyzate resulting from co-hydrolysis of a perfluoroalkyl group-containing organic silicon compound and a hydrolyzable group-containing methylpolysiloxane compound in a hydrophilic solvent and water constitutes a water repellent agent which is effective for imparting water repellency and facilitating falling of water droplets and thus imparting excellent water repellency and stain-proofness to a surface of an article treated therewith.

摘要翻译： 在亲水性溶剂和水中含有全氟烷基的有机硅化合物和含水解性基团的甲基聚硅氧烷化合物的水解产生的水解产物构成防水剂，其有效地赋予防水性并有利于水滴的下落，因此 赋予其处理用品的表面优异的防水性和防污性。

公开(公告)号：US5032636A

公开(公告)日：1991-07-16

申请号：US480329

申请日：1990-02-13

申请人： Ichiro Ono ,  Hiroshi Yoshioka

发明人： Ichiro Ono ,  Hiroshi Yoshioka

IPC分类号： C07F7/18 ,  C08K5/5419

CPC分类号： C08K5/5419 ,  C07F7/182

摘要： Organosilicon compounds of a novel class are disclosed including .alpha.,.omega.-bis(alkoxy silyl)-substituted alkane compounds represented by the general formula(RO).sub.m (CH.sub.3).sub.3-m Si--CH.sub.2).sub.n Si(CH.sub.3).sub.3-m (OR).sub.m,in which R is a monovalent hydrocarbon group having 1 to 4 carbon atoms, e.g., methyl and ethyl, the subscript n is a positive integer in the range from 10 to 18 and the subscript m is 1, 2 or 3. The compound is useful as an additive in various kinds of synthetic resin-based compositions for the purpose of improving the properties such as flexibility, weatherability, cold resistance and mechanical strengths.

摘要翻译： 公开了一类新的有机硅化合物，其包括由通式（RO）m（CH 3）3-mSi-CH 2）n Si（CH 3）3-m（OR）表示的α，ω-双（烷氧基甲硅烷基）取代的烷烃化合物， m，其中R为具有1至4个碳原子的一价烃基，例如甲基和乙基，下标n为10至18的正整数，下标m为1,2或3.化合物 可用作各种合成树脂基组合物中的添加剂，用于改善柔软性，耐候性，耐寒性和机械强度等性能。

公开(公告)号：US20140363832A1

公开(公告)日：2014-12-11

申请号：US14344873

申请日：2012-09-14

申请人： Kiyoshi Yanagisawa ,  Takashi Takahashi ,  Kohei Yokoi ,  Yoshinori Hasegawa ,  Ken-ichiro Ono ,  Kasumi Yagi ,  Hitomi Masuda ,  Toshiyuki Takeuchi

发明人： Kiyoshi Yanagisawa ,  Takashi Takahashi ,  Kohei Yokoi ,  Yoshinori Hasegawa ,  Ken-ichiro Ono ,  Kasumi Yagi ,  Hitomi Masuda ,  Toshiyuki Takeuchi

IPC分类号： G01N33/574 ,  C07K16/18

CPC分类号： G01N33/57423 ,  C07K14/47 ,  C07K16/18 ,  G01N33/57407

摘要： The present invention provides a method for testing mesothelioma comprising a step of determining a concentration of a human periostin protein in at least one type of sample of blood or pleural fluid of a subject. In the step of determining the concentration of human periostin protein, an antibody directed against human periostin protein may be used. The present invention further provides a kit for diagnosing mesothelioma, said kit comprising an antibody directed against human periostin protein. In the kit for diagnosing mesothelioma, the antibody directed against a human periostin protein may be an antibody that binds to a polypeptide consisting of an amino acid sequence set out in SE ID NO: 2.

摘要翻译： 本发明提供了一种用于测试间皮瘤的方法，包括测定受试者的至少一种类型的血液或胸膜液样品中人骨膜素蛋白浓度的步骤。 在确定人骨膜素蛋白浓度的步骤中，可以使用针对人骨膜素蛋白的抗体。 本发明还提供了用于诊断间皮瘤的试剂盒，所述试剂盒包含针对人骨膜素蛋白的抗体。 在用于诊断间皮瘤的试剂盒中，针对人骨膜素蛋白的抗体可以是与由SE ID NO：2中列出的氨基酸序列组成的多肽结合的抗体。

公开(公告)号：US20110293618A1

公开(公告)日：2011-12-01

申请号：US13054554

申请日：2009-07-16

申请人： Ken-ichiro Ono ,  Takashi Takahashi

发明人： Ken-ichiro Ono ,  Takashi Takahashi

IPC分类号： A61K39/395 ,  C12P21/02 ,  C12N5/10 ,  C12N1/21 ,  A61P35/04 ,  G01N33/574 ,  C07K16/18 ,  C07H21/00 ,  A61P35/00 ,  C12N15/63 ,  C12N1/19

CPC分类号： G01N33/574 ,  A61K2039/505 ,  C07K16/3023 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/5011

摘要： The present invention provides novel antibodies that recognize the extracellular domain of a human CLCP1 antigen; nucleic acids encoding the antibodies; vectors carrying the nucleic acids in an expressible manner; transformed cells containing the vectors; methods for producing the antibodies; diagnostic methods for cancer or prognosis of cancer, immunohistological or immunocytological assay methods, and kits for determining the expression level of CLCP1 in cells or tissues, all of which use the antibodies; pharmaceutical compositions comprising the antibodies; agents for treating or preventing CLCP1-expressing cancer; agents for inhibiting growth, migration, invasion, or metastasis of CLCP1-expressing cancer cells; immunostaining agents for staining CLCP1-expressing cancer cells; and agents for treating or preventing CLCP1-expressing tumor. The present invention also provides methods of screening for candidate substances that inhibit cancer cell growth, invasion, migration, or metastasis, or candidate substances having cytotoxicity against cancer cells.

摘要翻译： 本发明提供识别人CLCP1抗原的细胞外结构域的新型抗体; 编码抗体的核酸; 以可表达的方式携带核​​酸的载体; 含有载体的转化细胞; 生产抗体的方法; 用于癌症或癌症预后的诊断方法，免疫组织化学或免疫细胞学测定方法以及用于测定细胞或组织中所有这些抗体的CLCP1表达水平的试剂盒; 包含抗体的药物组合物; 治疗或预防CLCP1表达癌症的药剂; 用于抑制表达CLCP1的癌细胞的生长，迁移，侵袭或转移的药剂; 用于染色表达CLCP1的癌细胞的免疫染色剂; 和用于治疗或预防表达CLCP1的肿瘤的药剂。 本发明还提供筛选抑制癌细胞生长，侵袭，迁移或转移的候选物质或对癌细胞具有细胞毒性的候选物质的方法。

公开(公告)号：US20110028699A1

公开(公告)日：2011-02-03

申请号：US12934299

申请日：2009-03-24

申请人： Ichiro Ono

发明人： Ichiro Ono

IPC分类号： C07K14/50

CPC分类号： A61K9/0019 ,  A61K8/66 ,  A61K9/0021 ,  A61K38/1825 ,  A61K2800/91 ,  A61Q19/08

摘要： It is to provide an agent for preventing and treating skin aging, or an agent for treating skin scar that can exert a sufficient effect. An agent for preventing and treating skin aging comprising bFGF for treating aging of the skin that is administered intradermally or subcutaneously, or an agent for treating skin scar comprising bFGF for treating scar of skin that is administered intradermally or subcutaneously is utilized. Preferred examples of aging of skin include skin wrinkle, pigmented spot, sagging skin, rough skin, skin thinning, decrease of skin viscoelasticity, etc., and preferred examples of scar include keloid, hypertrophic scar, scar contracture, etc.

摘要翻译： 本发明提供用于预防和治疗皮肤老化的药剂，或者可以发挥足够效果的治疗皮肤疤痕的药剂。 利用包含用于治疗皮内或皮下给药的皮肤老化的bFGF或用于治疗皮肤瘢痕的皮肤瘢痕的药剂，用于预防和治疗皮肤老化的药剂，其包含用于治疗皮内或皮下给药的皮肤瘢痕的bFGF。 皮肤老化的优选实例包括皮肤皱纹，着色点，下垂皮肤，粗糙皮肤，皮肤变薄，皮肤粘弹性降低等，并且瘢痕疙瘩，肥大性瘢痕，瘢痕挛缩等的优选实例。