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    APPARATUS AND METHODS FOR FILLING A DRUG ELUTING MEDICAL DEVICE VIA CAPILLARY ACTION
    12.
    发明申请
    APPARATUS AND METHODS FOR FILLING A DRUG ELUTING MEDICAL DEVICE VIA CAPILLARY ACTION 有权
    用于通过毛细管动作填充药物治疗医疗装置的装置和方法

    公开(公告)号：US20130284310A1

    公开(公告)日：2013-10-31

    申请号：US13457398

    申请日：2012-04-26

    Applicant: Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

    Inventor： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

    IPC: B65B1/04

    CPC classification number: A61F2/91 ,  A61F2/82 ,  A61F2240/00 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2420/02

    Abstract: Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

    Abstract translation: 公开了用于在形成支架的中空丝内填充治疗物质或药物的方法和装置。 将支架放置在容纳流体药物制剂的腔室内。 在填充期间，室被保持在或接近流体药物制剂的溶剂的气液平衡。 为了填充支架，将支架的一部分放置成与流体药物制剂接触，直到由空心线限定的腔空间通过毛细作用填充流体药物制剂。 填充完成后，支架缩回，使得支架不再与流体药物制剂接触。 室内的溶剂蒸气压降低以蒸发流体药物制剂的溶剂。 芯吸装置可以控制流体药物制剂转移到支架中。

    HOLLOW DRUG-FILLED STENT AND METHOD OF FORMING HOLLOW DRUG-FILLED STENT
    13.
    发明申请
    HOLLOW DRUG-FILLED STENT AND METHOD OF FORMING HOLLOW DRUG-FILLED STENT 有权
    中空药液填充瓶和形成中药液灌注液的方法

    公开(公告)号：US20130274864A1

    公开(公告)日：2013-10-17

    申请号：US13446910

    申请日：2012-04-13

    Applicant: Ryan BIENVENU ,  James Mitchell ,  Dustin Thompson

    Inventor： Ryan BIENVENU ,  James Mitchell ,  Dustin Thompson

    IPC: A61F2/86 ,  B21F1/00

    CPC classification number: A61F2/915 ,  A61F2/86 ,  A61F2002/91575 ,  A61F2230/0091 ,  A61F2240/001 ,  A61F2250/0068 ,  A61F2250/0098 ,  A61L31/022 ,  A61L31/16 ,  A61L31/18

    Abstract: A stent is formed from a wire having an outer member, a radiopaque core member disposed within a portion of the outer member, and an annular lumen between the radiopaque core member and the outer member. A substance is disposed in the annular lumen to be eluted through at least one opening disposed through the outer member. A plurality of radiopaque core members are disposed within portions of the outer member and are separated by lumens defined by the inner surface of the outer member. The lumens and annular lumens are in fluid communication with each other. In a method for making the stent, a composite wire including an outer member, an intermediate member, and a core member is shaped into a stent pattern and processed to remove the intermediate member and portions of the radiopaque core member, without damaging the outer member.

    Abstract translation: 支架由具有外部构件，设置在外部构件的一部分内的不透射线芯构件和不透射线芯构件和外部构件之间的环形腔构成的线形成。 物质被布置在环形腔中以通过穿过外部构件设置的至少一个开口被洗脱。 多个不透射线的芯构件设置在外部构件的部分内并且由外部构件的内表面限定的腔分开。 管腔和环形腔相互流体连通。 在制造支架的方法中，将包括外部构件，中间构件和芯部构件的复合线材成形为支架图案并进行处理以去除不透射线的芯构件的中间构件和部分，而不损坏外部构件 。

    SECURITY POLICY FLOW DOWN SYSTEM
    14.
    发明申请
    SECURITY POLICY FLOW DOWN SYSTEM 有权
    安全政策流失系统

    公开(公告)号：US20130167191A1

    公开(公告)日：2013-06-27

    申请号：US13336737

    申请日：2011-12-23

    Applicant: Bruce Barnett ,  Scott Evans ,  Robert James Mitchell, JR. ,  Thomas Markham ,  Stephen Dill ,  Vincent Hannon ,  John Patrick Elliott ,  Andrew Crapo

    Inventor： Bruce Barnett ,  Scott Evans ,  Robert James Mitchell, JR. ,  Thomas Markham ,  Stephen Dill ,  Vincent Hannon ,  John Patrick Elliott ,  Andrew Crapo

    IPC: G06F21/00

    CPC classification number: G06F21/6218 ,  G06F21/604

    Abstract: A system and method are provided that distill an organization's information security plan into a detailed and unambiguous security object model. The developed security object model provides a visualization of complex relationships between individual elements and levels that is usable to carry into effect the organization's information security plan. Configuration control and a verifiable level of security compliance are provided through implementation of the organization's information security plan by the developed security object model. The developed security object model is hosted on a computing platform in communication with at least the organization's network to provide information security plan compliance, configuration control and gap analysis in a usable form to the organization.

    Abstract translation: 提供了一种系统和方法，将组织的信息安全计划分解成一个详细而明确的安全对象模型。 开发的安全对象模型提供了可用于实现组织信息安全计划的各个元素和级别之间的复杂关系的可视化。 通过开发的安全对象模型，通过实施组织的信息安全计划来提供配置控制和可验证的安全合规级别。 开发的安全对象模型托管在至少与组织网络通信的计算平台上，以可用形式向组织提供信息安全计划合规性，配置控制和差距分析。

    Apparatus and methods for loading a drug eluting medical device
    15.
    发明授权
    Apparatus and methods for loading a drug eluting medical device 有权
    用于装载药物洗脱医疗装置的装置和方法

    公开(公告)号：US08460745B2

    公开(公告)日：2013-06-11

    申请号：US12884503

    申请日：2010-09-17

    Applicant: James Mitchell ,  Justin Peterson ,  Dishuan Chu ,  Joseph Traina ,  Salvador Avelar ,  Michele Silver

    Inventor： James Mitchell ,  Justin Peterson ,  Dishuan Chu ,  Joseph Traina ,  Salvador Avelar ,  Michele Silver

    IPC: B05D7/22 ,  B05D1/18 ,  A61F2/06 ,  B65B31/02 ,  A61L33/00

    CPC classification number: A61L31/16 ,  A61F2240/001 ,  A61F2250/0068

    Abstract: Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

    Abstract translation: 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。

    Stability and Speech Audibility Improvements in Hearing Devices
    16.
    发明申请
    Stability and Speech Audibility Improvements in Hearing Devices 有权
    听力设备的稳定性和语音听觉改善

    公开(公告)号：US20130089227A1

    公开(公告)日：2013-04-11

    申请号：US13286089

    申请日：2011-10-31

    Applicant: James Mitchell KATES

    Inventor： James Mitchell KATES

    IPC: H04R25/00

    CPC classification number: H04R25/453

    Abstract: A hearing device includes a first filter configured for providing a first frequency part of an input signal of the hearing device, the first frequency part comprising a low pass filtered part, a second filter configured for providing a second frequency part of the input signal, the second frequency part comprising a high pass filtered part, a first synthesizing unit configured for generating a first synthetic signal from the first frequency part using a first model based on a first periodic function, and a combiner configured for combining the second frequency part with the first synthetic signal for provision of a combined signal.

    Abstract translation: 听力装置包括：第一滤波器，被配置为提供听力装置的输入信号的第一频率部分，第一频率部分包括低通滤波部分，第二滤波器，被配置为提供输入信号的第二频率部分， 第二频率部分包括高通滤波部分，第一合成单元，被配置为使用基于第一周期性函数的第一模型从第一频率部分生成第一合成信号;以及组合器，被配置为将第二频率部分与第一频率部分 用于提供组合信号的合成信号。

    System and method for advanced condition monitoring of an asset system
    17.
    发明授权
    System and method for advanced condition monitoring of an asset system 有权
    资产系统高级状态监测系统和方法

    公开(公告)号：US08352216B2

    公开(公告)日：2013-01-08

    申请号：US12129622

    申请日：2008-05-29

    Applicant: Rajesh Venkat Subbu ,  John Erik Hershey ,  Xiao Hu ,  Robert James Mitchell, Jr. ,  Avinash Vinayak Taware ,  Piero Patrone Bonissone

    Inventor： Rajesh Venkat Subbu ,  John Erik Hershey ,  Xiao Hu ,  Robert James Mitchell, Jr. ,  Avinash Vinayak Taware ,  Piero Patrone Bonissone

    IPC: G06F11/28

    CPC classification number: G06F11/30 ,  G05B23/024

    Abstract: A method for advanced condition monitoring of an asset system includes sensing actual values of an operating condition for an operating regime of the asset system using at least one sensor; estimating sensed values of the operating condition by using an auto-associative neural network; determining a residual vector between the estimated sensed values and the actual values; and performing a fault diagnostic on the residual vector. In another method, an operating space of the asset system is segmented into operating regimes; the auto-associative neural network determines estimates of actual measured values; a residual vector is determined from the auto-associative neural network; a fault diagnostic is performed on the residual vector; and a change of the operation of the asset system is determined by analysis of the residual vector. An alert is provided if necessary. A smart sensor system includes an on-board processing unit for performing the method of the invention.

    Abstract translation: 一种用于资产系统的高级状态监测的方法包括使用至少一个传感器来感测资产系统的操作状态的操作条件的实际值; 通过使用自动关联神经网络来估计操作条件的感测值; 确定估计的感测值和实际值之间的残差矢量; 并对残差向量进行故障诊断。 在另一种方法中，资产系统的运营空间被划分为运行状态; 自相关神经网络确定实际测量值的估计值; 从自相关神经网络确定残差向量; 对残差矢量执行故障诊断; 通过分析残差向量来确定资产系统的运作变化。 必要时提供警报。 智能传感器系统包括用于执行本发明的方法的车载处理单元。

    METHODS OF PREPARING POLYMER-ORGANOCLAY COMPOSITES AND ARTICLES DERIVED THEREFROM
    19.
    发明申请
    METHODS OF PREPARING POLYMER-ORGANOCLAY COMPOSITES AND ARTICLES DERIVED THEREFROM 有权
    制备聚合物 - 组织复合材料的方法及其衍生物

    公开(公告)号：US20120190791A1

    公开(公告)日：2012-07-26

    申请号：US13430801

    申请日：2012-03-27

    Applicant: Kwok Pong Chan ,  Sarah Elizabeth Genovese ,  Erik C. Hagberg ,  David Bruce Hall ,  John Lester Maxam ,  Tara J. Mullen ,  Roy Ray Odle ,  Albert Santo Stella ,  James Mitchell White

    Inventor： Kwok Pong Chan ,  Sarah Elizabeth Genovese ,  Erik C. Hagberg ,  David Bruce Hall ,  John Lester Maxam ,  Tara J. Mullen ,  Roy Ray Odle ,  Albert Santo Stella ,  James Mitchell White

    IPC: C08K9/04 ,  C08L79/08

    CPC classification number: C08F2/44

    Abstract: A method for preparing a polymer-organoclay composite composition comprises combining a solvent and an unexfoliated organoclay to provide a first mixture, wherein the unexfoliated organoclay comprises alternating inorganic silicate layers and organic layers, and has an initial spacing between the silicate layers; exposing the first mixture to an energized condition of a sufficient intensity and duration to increase the initial spacing of the inorganic silicate layers, to provide a second mixture; contacting the second mixture with a polymer composition so that the polymer composition fills at least one region located between at least one pair of silicate layers, wherein the polymer composition is at least partially soluble in the solvent; and removing at least a portion of the solvent from the second mixture, wherein the inorganic silicate layers remain separated by the polymer after removal of the solvent.

    Abstract translation: 一种制备聚合物 - 有机粘土复合材料组合物的方法，包括将溶剂和未剥离的有机粘土组合以提供第一混合物，其中未剥离的有机粘土包含交替的无机硅酸盐层和有机层，并且在硅酸盐层之间具有初始间隔; 将第一混合物暴露于足够强度和持续时间的通电状态以增加无机硅酸盐层的初始间隔，以提供第二混合物; 使所述第二混合物与聚合物组合物接触，使得所述聚合物组合物填充位于至少一对硅酸盐层之间的至少一个区域，其中所述聚合物组合物至少部分地可溶于所述溶剂中; 以及从所述第二混合物中除去至少一部分所述溶剂，其中在去除所述溶剂之后，所述无机硅酸盐层保持被所述聚合物分离。

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