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11.发明申请ALPHA-(TRIFLUOROMETHYL-SUBSTITUTED ARYLOXY, ARYLAMINO, ARYLTHIO OR ARYLMETHYL)-TRIFLUOROMETHYL-SUBSTITUTED PHENYLACETIC ACIDS AND DERIVATIVES AS ANTIDIABETIC AGENTS 审中-公开ALPHA-（三氟甲磺酸取代的芳基，亚氨基，芳基或芳基甲基） - 三氟甲基取代的苯甲酸和衍生物作为抗菌剂公开(公告)号：US20080287441A1
公开(公告)日：2008-11-20
申请号：US12107691
申请日：2008-04-22
Applicant: Zuchun Zhao , Xin Chen , Jianchao Wang , Hongbin Sun , Jack Shih-Chieh Liang
Inventor： Zuchun Zhao , Xin Chen , Jianchao Wang , Hongbin Sun , Jack Shih-Chieh Liang
IPC: A61K31/5377 , C07C63/72 , A61K31/192 , C07D211/94 , A61K31/44 , C07C69/76 , C07D257/04 , A61K31/24 , C07C47/00 , A61K31/11 , C07D413/12
CPC classification number: C07C47/277 , C07B2200/07 , C07C43/23 , C07C45/41 , C07C45/44 , C07C47/55 , C07C51/09 , C07C59/68 , C07C69/007 , C07C69/736 , C07C205/26 , C07C205/37 , C07C205/38 , C07C229/36 , C07C233/18 , C07C323/62 , C07D213/64 , C07D257/04
Abstract: Compounds having a formula: or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.
Abstract translation: 提供具有式：或其药学上可接受的盐或前药的化合物，并且可用于治疗代谢性疾病。
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公开(公告)号：US07049432B2
公开(公告)日：2006-05-23
申请号：US10163439
申请日：2002-06-04
Applicant: Muthiah Manoharan , George Just , Andrei Guzaev , Arlène Roland , Jianchao Wang , Michael E. Jung
Inventor： Muthiah Manoharan , George Just , Andrei Guzaev , Arlène Roland , Jianchao Wang , Michael E. Jung
Abstract: The present invention provides alkylphosphonate dimers and oligonucleotides prepared therefrom. The invention further provides novel methods for the preparation of these alkylphosphonate dimers. Methods for the preparation of substantially diastereomerically pure alkylphosphonate dimers are also provided.
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13.发明授权Method and apparatus for constructing a latin square matrix for network communication 有权用于构建用于网络通信的拉丁方阵的方法和装置公开(公告)号：US06456620B1
公开(公告)日：2002-09-24
申请号：US09251562
申请日：1999-02-17
Applicant: Jianchao Wang , Yuanyuan Yang
Inventor： Jianchao Wang , Yuanyuan Yang
IPC: H04L1228
CPC classification number: H04L49/1507
Abstract: Disclosed is a method for all-to-all personalized exchange for a class of multistage interconnecting networks (MINs). The method is based on a Latin square matrix corresponding to a set of admissible permutations of a multistage interconnecting network. Disclosed are first and second methods for constructing a Latin square matrix used in the personalized exchange technique. Also disclosed is a generic method for decomposing all-to-all personalized exchange patterns into admissible permutations to form the Latin square matrix for self-routing networks which are a subclass of the MINs.
Abstract translation: 公开了一种用于一类多级互连网络（MIN）的全面个性化交换的方法。 该方法基于与多级互连网络的一组可接受排列相对应的拉丁方阵。 公开了用于构建在个性化交换技术中使用的拉丁方阵的第一和第二种方法。 还公开了一种用于将所有对所有个性化交换模式分解为可接受置换的通用方法，以形成作为MIN的子类的自路由网络的拉丁方阵。
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公开(公告)号：US07642358B2
公开(公告)日：2010-01-05
申请号：US11326616
申请日：2006-01-04
Applicant: Zuchun Zhao , Xin Chen , Jianchao Wang , Hongbin Sun , Jack Shih-Chieh Liang
Inventor： Zuchun Zhao , Xin Chen , Jianchao Wang , Hongbin Sun , Jack Shih-Chieh Liang
IPC: A61K31/423 , C07D263/57
CPC classification number: C07D207/325 , C07D231/12 , C07D235/18 , C07D239/26 , C07D249/08 , C07D249/20 , C07D261/08 , C07D263/57 , C07D271/06 , C07D277/66 , C07D413/04 , C07D413/12
Abstract: Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid metabolism and insulin secretion.
Abstract translation: 提供取代的苯乙酸，苯乙醇和相关化合物，其可用于治疗或控制与葡萄糖代谢，脂质代谢和胰岛素分泌相关的许多疾病。
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公开(公告)号：US07582668B2
公开(公告)日：2009-09-01
申请号：US11598250
申请日：2006-11-08
Applicant: Xiangping Qian , Luke W. Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley P. Morgan , David J. Morgans, Jr. , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin J. Duffy , Duke Fitch , Rosanna Tedesco
Inventor： Xiangping Qian , Luke W. Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley P. Morgan , David J. Morgans, Jr. , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin J. Duffy , Duke Fitch , Rosanna Tedesco
IPC: A61K31/4178 , C07D403/10
CPC classification number: C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
Abstract: Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
Abstract translation: 提供了可用于治疗癌症或其它增殖性疾病的式I化合物及其药学上可接受的盐。
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Patent Agency Ranking
公开(公告)号：US20080255182A1
公开(公告)日：2008-10-16
申请号：US12007143
申请日：2008-01-07
Applicant: Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
Inventor： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC: A61K31/437 , A61P35/00
CPC classification number: C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
Abstract translation: 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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17.发明授权α-(Trifluoromethyl-substituted aryloxy, arylamino, arylthio or arylmethyl)-trifluoromethyl-substituted phenylacetic acids and derivatives as antidiabetic agents 失效α-（三氟甲基取代的芳氧基，芳基氨基，芳硫基或芳基甲基） - 三氟甲基取代的苯乙酸及其衍生物作为抗糖尿病药公开(公告)号：US07371888B2
公开(公告)日：2008-05-13
申请号：US11061302
申请日：2005-02-17
Applicant: Zuchun Zhao , Xin Chen , Jianchao Wang , Hongbin Sun , Jack Shih-Chieh Liang
Inventor： Zuchun Zhao , Xin Chen , Jianchao Wang , Hongbin Sun , Jack Shih-Chieh Liang
IPC: C07C69/73 , C07C315/00 , A01N29/02
CPC classification number: C07C47/277 , C07B2200/07 , C07C43/23 , C07C45/41 , C07C45/44 , C07C47/55 , C07C51/09 , C07C59/68 , C07C69/007 , C07C69/736 , C07C205/26 , C07C205/37 , C07C205/38 , C07C229/36 , C07C233/18 , C07C323/62 , C07D213/64 , C07D257/04
Abstract: Compounds having a formula: or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.
Abstract translation: 提供具有式：或其药学上可接受的盐或前药的化合物，并且可用于治疗代谢性疾病。
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公开(公告)号：US20070149516A1
公开(公告)日：2007-06-28
申请号：US11598250
申请日：2006-11-08
Applicant: Xiangping Qian , Luke Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley Morgan , David Morgans , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
Inventor： Xiangping Qian , Luke Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley Morgan , David Morgans , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC: A61K31/5383 , A61K31/4745 , A61K31/424 , A61K31/4196 , A61K31/4172
CPC classification number: C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
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公开(公告)号：US20060094708A1
公开(公告)日：2006-05-04
申请号：US11121709
申请日：2005-05-03
Applicant: Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish
Inventor： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish
IPC: A61K31/55 , A61K31/4745 , A61K31/424 , A61K31/421 , A61K31/4196 , A61K31/4184 , C07D491/02 , C07D487/02
CPC classification number: C07D403/12 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/28 , C07C275/40 , C07C281/06 , C07C311/37 , C07C2601/14 , C07D207/273 , C07D211/76 , C07D213/30 , C07D231/12 , C07D233/62 , C07D235/18 , C07D235/26 , C07D261/08 , C07D263/10 , C07D271/06 , C07D277/56 , C07D285/02 , C07D295/155 , C07D333/38 , C07D403/10 , C07D471/04 , C07F9/6506 , C07F9/6561
Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
Abstract translation: 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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20.发明授权Oligonucleotides having alkylphosphonate linkages and methods for their preparation 失效具有烷基膦酸酯键的寡核苷酸及其制备方法公开(公告)号：US06486313B1
公开(公告)日：2002-11-26
申请号：US09252521
申请日：1999-02-18
Applicant: Muthiah Manoharan , George Just , Andrei Guzaev , Arlène Roland , Jianchao Wang , Michael E. Jung
Inventor： Muthiah Manoharan , George Just , Andrei Guzaev , Arlène Roland , Jianchao Wang , Michael E. Jung
IPC: C07H2102
Abstract: The present invention provides alkylphosphonate dimers and oligonucleotides prepared therefrom. The invention further provides novel methods for the preparation of these alkylphosphonate dimers. Methods for the preparation of substantially diastereomerically pure alkylphosphonate dimers are also provided.
Abstract translation: 本发明提供烷基膦酸二聚体和由其制备的寡核苷酸。 本发明还提供了制备这些烷基膦酸二聚体的新方法。 还提供了制备基本上非对映体纯的烷基膦酸二聚体的方法。
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