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公开(公告)号：US20090122302A1
公开(公告)日：2009-05-14
申请号：US12261967
申请日：2008-10-30
申请人： Johannes F. De Boer
发明人： Johannes F. De Boer
IPC分类号： G01J1/10
摘要： According to an exemplary embodiment, systems and methods can be provided for compensating for, reducing and/or eliminating data associated with at least one aberration provided within a sample. For example, using such exemplary systems and methods, it may be possible to transmit at least one first electromagnetic radiation to the sample via an optical fiber. At least one second electromagnetic radiation can be received from the sample, and the first and second radiations may be associated with one another At least one first intensity of at least one portion of the second radiation within a core of the optical fiber and at least one portion of at least one second intensity of the second radiation within a cladding of the optical fiber at least partially surrounding to the core can be detected. Further, the first radiation and/or the second radiation can be modified as a function of the first and second intensities so as to compensate for, reduce and/or eliminate the data associated with the aberration.
摘要翻译： 根据示例性实施例，可以提供系统和方法来补偿，减少和/或消除与提供在样本内的至少一个像差有关的数据。 例如，使用这样的示例性系统和方法，可以经由光纤将至少一个第一电磁辐射发射到样品。 可以从样品接收至少一个第二电磁辐射，并且第一和第二辐射可以彼此相关联。光纤内核中的第二辐射的至少一部分的至少一个第一强度和至少一个 可以检测至少部分围绕芯的光纤的包层内的第二辐射的至少一个第二强度的部分。 此外，第一辐射和/或第二辐射可以被修改为第一和第二强度的函数，以便补偿，减少和/或消除与像差有关的数据。
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12.发明授权Apparatus, method and system for performing phase-resolved optical frequency domain imaging 有权用于执行相位分辨光学频域成像的装置，方法和系统公开(公告)号：US09060689B2
公开(公告)日：2015-06-23
申请号：US11445990
申请日：2006-06-01
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Johannes F. De Boer , Benjamin J. Vakoc , Seok-Hyun Yun
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Johannes F. De Boer , Benjamin J. Vakoc , Seok-Hyun Yun
CPC分类号： A61B5/0073 , A61B5/0066 , A61B2560/0223 , G01B9/02091 , G01N21/45 , G01N21/4795 , G01N21/49
摘要： Apparatus, system and method are provided which utilize signals received from a reference and a sample. In particular, a radiation is provided which includes at least one first electro-magnetic radiation directed to the sample and at least one second electro-magnetic radiation directed to the reference. A frequency of the radiation varies over time. An interference can be detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. It is possible to obtain a particular signal associated with at least one phase of at least one frequency component of the interference, and compare the particular signal to at least one particular information. Further, it is possible to receive at least one portion of the radiation and provide a further radiation, such that the particular signal can be calibrated based on the further signal.
摘要翻译： 提供了使用从参考和样本接收的信号的装置，系统和方法。 特别地，提供了一种辐射，其包括指向样品的至少一个第一电磁辐射和指向该参考的至少一个第二电磁辐射。 辐射的频率随时间而变化。 可以在与第一辐射相关联的至少一个第三辐射与与第二辐射相关联的至少一个第四辐射之间检测干扰。 可以获得与干扰的至少一个频率分量的至少一个相位相关联的特定信号，并将特定信号与至少一个特定信息进行比较。 此外，可以接收辐射的至少一部分并提供另外的辐射，使得可以基于另外的信号来校准特定信号。
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公开(公告)号：US08416818B2
公开(公告)日：2013-04-09
申请号：US13160335
申请日：2011-06-14
申请人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
发明人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
IPC分类号： H01S3/10
CPC分类号： G01J3/10 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02091 , G01J3/12 , G01J9/0215 , G01N21/4795 , G02B27/48 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S5/141 , H01S5/146 , H01S5/4087
摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.
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公开(公告)号：US07933021B2
公开(公告)日：2011-04-26
申请号：US12261967
申请日：2008-10-30
申请人： Johannes F. De Boer
发明人： Johannes F. De Boer
IPC分类号： G01N9/02
摘要： According to an exemplary embodiment, systems and methods can be provided for compensating for, reducing and/or eliminating data associated with at least one aberration provided within a sample. For example, using such exemplary systems and methods, it may be possible to transmit at least one first electromagnetic radiation to the sample via an optical fiber. At least one second electromagnetic radiation can be received from the sample, and the first and second radiations may be associated with one another At least one first intensity of at least one portion of the second radiation within a core of the optical fiber and at least one portion of at least one second intensity of the second radiation within a cladding of the optical fiber at least partially surrounding to the core can be detected. Further, the first radiation and/or the second radiation can be modified as a function of the first and second intensities so as to compensate for, reduce and/or eliminate the data associated with the aberration.
摘要翻译： 根据示例性实施例，可以提供系统和方法来补偿，减少和/或消除与提供在样本内的至少一个像差有关的数据。 例如，使用这样的示例性系统和方法，可以经由光纤将至少一个第一电磁辐射发射到样品。 可以从样品接收至少一个第二电磁辐射，并且第一和第二辐射可以彼此相关联。光纤内核中的第二辐射的至少一部分的至少一个第一强度和至少一个 可以检测至少部分围绕芯的光纤的包层内的第二辐射的至少一个第二强度的部分。 此外，第一辐射和/或第二辐射可以被修改为第一和第二强度的函数，以便补偿，减少和/或消除与像差有关的数据。
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15.发明授权公开(公告)号：US07742173B2
公开(公告)日：2010-06-22
申请号：US11697012
申请日：2007-04-05
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , G01B9/02002 , G01B9/02004 , G01B9/02011 , G01B9/02091 , G01B2290/70
摘要： Arrangements and methods are provided for obtaining data associated with a sample. For example, at least one first electro-magnetic radiation can be provided to a sample and at least one second electro-magnetic radiation can be provided to a reference (e.g., a non-reflective reference). A frequency of such radiation(s) can repetitively vary over time with a first characteristic period. In addition, a polarization state of the first electro-magnetic radiation, the second electro-magnetic radiation, a third electro-magnetic radiation (associated with the first radiation) or a fourth electro-magnetic radiation (associated with the second radiation) can repetitively vary over time with a second characteristic period which is shorter than the first period. The data for imaging at least one portion of the sample can be provided as a function of the polarization state. In addition or alternatively, the third and fourth electro-magnetic radiations can be combined so as to determine an axial reflectance profile of at least one portion of the sample.
摘要翻译： 提供了用于获取与样本相关的数据的安排和方法。 例如，可以向样品提供至少一个第一电磁辐射，并且可以向参考（例如，非反射参考）提供至少一个第二电磁辐射。 这种辐射的频率可以在第一特征周期内随时间重复地变化。 此外，第一电磁辐射，第二电磁辐射，第三电磁辐射（与第一辐射相关联）或第四电磁辐射（与第二辐射相关联）的极化状态可以重复地 随着时间而变化，其具有比第一周期短的第二特征周期。 用于成像至少一部分样品的数据可以作为偏振态的函数提供。 另外或替代地，可以组合第三和第四电磁辐射，以便确定样品的至少一部分的轴向反射率分布。
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16.发明申请APPARATUS AND METHOD FOR RANGING AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS 有权通过平行检测光谱仪的低相干干涉LCI和光学相干TOMOGRAPHY OCT信号的范围和噪声降低的装置和方法公开(公告)号：US20100094576A1
公开(公告)日：2010-04-15
申请号：US12570443
申请日：2009-09-30
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译： 通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。 对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。 结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。 信号保持不变。 喷射噪声的降低增加了系统的动态范围和灵敏度。
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17.发明申请Process, System And Software Arrangement For A Chromatic Dispersion Compensation Using Reflective Layers In Optical Coherence Tomography (OCT) Imaging 有权在光学相干断层扫描（OCT）成像中使用反射层进行色散补偿的过程，系统和软件布置公开(公告)号：US20090196477A1
公开(公告)日：2009-08-06
申请号：US11569790
申请日：2004-07-23
IPC分类号： G06K9/00
CPC分类号： A61B3/102 , G01B9/02004 , G01B9/02044 , G01B9/02069 , G01B9/02083 , G01B9/02091 , G01N21/4795
摘要： A system, process and software arrangement are provided to compensate for a dispersion in at least one portion of an image. In particular, information associated with the portion of the image is obtained. The portion of the image can be associated with an interference signal that includes a first electromagnetic radiation received from a sample and a second electromagnetic radiation received from a reference. The dispersion in the at least one portion of the image can be compensated by controlling a phase of at least one spectral component of the interference signal.
摘要翻译： 提供了系统，过程和软件布置以补偿图像的至少一部分中的色散。 特别地，获得与图像部分相关联的信息。 图像的部分可以与包括从样本接收的第一电磁辐射和从参考接收的第二电磁辐射的干扰信号相关联。 可以通过控制干扰信号的至少一个光谱分量的相位来补偿图像的至少一部分中的色散。
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18.发明申请公开(公告)号：US20070236700A1
公开(公告)日：2007-10-11
申请号：US11697012
申请日：2007-04-05
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , G01B9/02002 , G01B9/02004 , G01B9/02011 , G01B9/02091 , G01B2290/70
摘要： Arrangements and methods are provided for obtaining data associated with a sample. For example, at least one first electro-magnetic radiation can be provided to a sample and at least one second electro-magnetic radiation can be provided to a reference (e.g., a non-reflective reference). A frequency of such radiation(s) can repetitively vary over time with a first characteristic period. In addition, a polarization state of the first electro-magnetic radiation, the second electro-magnetic radiation, a third electro-magnetic radiation (associated with the first radiation) or a fourth electro-magnetic radiation (associated with the second radiation) can repetitively vary over time with a second characteristic period which is shorter than the first period. The data for imaging at least one portion of the sample can be provided as a function of the polarization state. In addition or alternatively, the third and fourth electro-magnetic radiations can be combined so as to determine an axial reflectance profile of at least one portion of the sample.
摘要翻译： 提供了用于获取与样本相关的数据的安排和方法。 例如，可以向样品提供至少一个第一电磁辐射，并且可以向参考（例如，非反射参考）提供至少一个第二电磁辐射。 这种辐射的频率可以在第一特征周期内随时间重复地变化。 此外，第一电磁辐射，第二电磁辐射，第三电磁辐射（与第一辐射相关联）或第四电磁辐射（与第二辐射相关联）的偏振状态可以重复地 随着时间而变化，其具有比第一周期短的第二特征周期。 用于成像至少一部分样品的数据可以作为偏振态的函数提供。 另外或替代地，可以组合第三和第四电磁辐射，以便确定样品的至少一部分的轴向反射率分布。
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19.发明申请SYSTEMS, METHOD AND COMPUTER-ACCESSIBLE MEDIUM WHICH UTILIZE SYNTHETIC APERTURE(S) FOR EXTENDING DEPTH-OF-FOCUS OF OPTICAL COHERENCE TOMOGRAPHY IMAGING 审中-公开使用合成孔径的光学相干图像成像深度的系统，方法和计算机可访问介质公开(公告)号：US20140218744A1
公开(公告)日：2014-08-07
申请号：US14170805
申请日：2014-02-03
IPC分类号： G01B9/02
CPC分类号： G01B9/02091
摘要： An exemplary apparatus can be provided for generating at least one image of a structure. The apparatus can include at least one first arrangement that has a structural configuration with a first aperture and a second aperture. At least one detector second arrangement can b provided which is configured to detect (i) a first electro-magnetic signal provided to or from the structure via the first aperture, and (ii) a second electromagnetic signal provided to or from the structure via the second aperture. The first and second signals can be associated with data regarding at least one portion of the structure. The exemplary apparatus can further include at least one processing third arrangement which is configured to combine an amplitude and a phase of each of the first and second signals with one another to form a combined amplitude and a combined phase of a combined signal, and then generate the image(s) based on the combined signal.
摘要翻译： 可以提供用于产生结构的至少一个图像的示例性装置。 该装置可以包括具有第一孔和第二孔的结构构造的至少一个第一装置。 至少一个检测器第二布置可以被提供，其被配置为检测（i）经由第一孔提供给结构或从结构提供的第一电磁信号，以及（ii）经由该结构提供给第二电磁信号 第二个光圈。 第一和第二信号可以与关于结构的至少一部分的数据相关联。 该示例性装置还可以包括至少一个处理第三布置，其被配置为将第一和第二信号中的每一个的幅度和相位彼此组合以形成组合信号的组合幅度和组合相位，然后生成 基于组合信号的图像。
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20.发明授权Apparatus and method for ranging and noise reduction of low coherence interferometry (LCI) and optical coherence tomography (OCT) signals by parallel detection of spectral bands 有权用于通过光谱带的并行检测的低相干干涉测量（LCI）和光学相干断层扫描（OCT）信号的测距和降噪的装置和方法公开(公告)号：US07903257B2
公开(公告)日：2011-03-08
申请号：US11954794
申请日：2007-12-12
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译： 通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。 对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。 结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。 信号保持不变。 喷射噪声的降低增加了系统的动态范围和灵敏度。
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