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    Apparatus, method and system for performing phase-resolved optical frequency domain imaging
    1.
    发明授权
    Apparatus, method and system for performing phase-resolved optical frequency domain imaging 有权
    用于执行相位分辨光学频域成像的装置，方法和系统

    公开(公告)号：US09060689B2

    公开(公告)日：2015-06-23

    申请号：US11445990

    申请日：2006-06-01

    申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Johannes F. De Boer ,  Benjamin J. Vakoc ,  Seok-Hyun Yun

    发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Johannes F. De Boer ,  Benjamin J. Vakoc ,  Seok-Hyun Yun

    IPC分类号： G01N21/55 ,  A61B5/00 ,  G01N21/45 ,  G01N21/47 ,  G01N21/49 ,  G01B9/02

    CPC分类号： A61B5/0073 ,  A61B5/0066 ,  A61B2560/0223 ,  G01B9/02091 ,  G01N21/45 ,  G01N21/4795 ,  G01N21/49

    摘要： Apparatus, system and method are provided which utilize signals received from a reference and a sample. In particular, a radiation is provided which includes at least one first electro-magnetic radiation directed to the sample and at least one second electro-magnetic radiation directed to the reference. A frequency of the radiation varies over time. An interference can be detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. It is possible to obtain a particular signal associated with at least one phase of at least one frequency component of the interference, and compare the particular signal to at least one particular information. Further, it is possible to receive at least one portion of the radiation and provide a further radiation, such that the particular signal can be calibrated based on the further signal.

    摘要翻译： 提供了使用从参考和样本接收的信号的装置，系统和方法。 特别地，提供了一种辐射，其包括指向样品的至少一个第一电磁辐射和指向该参考的至少一个第二电磁辐射。 辐射的频率随时间而变化。 可以在与第一辐射相关联的至少一个第三辐射与与第二辐射相关联的至少一个第四辐射之间检测干扰。 可以获得与干扰的至少一个频率分量的至少一个相位相关联的特定信号，并将特定信号与至少一个特定信息进行比较。 此外，可以接收辐射的至少一部分并提供另外的辐射，使得可以基于另外的信号来校准特定信号。

    Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
    3.
    发明授权
    Methods and systems for performing angle-resolved fourier-domain optical coherence tomography 有权
    用于进行角度分辨的傅里叶变换光学相干断层扫描的方法和系统

    公开(公告)号：US07982879B2

    公开(公告)日：2011-07-19

    申请号：US11677278

    申请日：2007-02-21

    申请人： Adrien E. Desjardins ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett Eugene Bouma

    发明人： Adrien E. Desjardins ,  Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett Eugene Bouma

    IPC分类号： G01B9/02

    CPC分类号： G01N21/4795 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02043 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/70 ,  G01N2021/4714

    摘要： Arrangements, apparatus and methods are provided according to exemplary embodiments of the present invention. In particular, at least one first electro-magnetic radiation may be received and at least one second electro-magnetic radiation within a solid angle may be forwarded to a sample. The second electro-magnetic radiation may be associated with the first electro-magnetic radiation. A plurality of third electro-magnetic radiations can be received from the sample which is associated with the second electro-magnetic radiation, and at least one portion of the third electro-magnetic radiation is provided outside a periphery of the solid angle. Signals associated with each of the third electro-magnetic radiations can be simultaneously detected, with the signals being associated with information for the sample at a plurality of depths thereof. The depths can be determined using at least one of the third electro-magnetic radiations without a need to utilize another one of the third electro-magnetic radiations.

    摘要翻译： 根据本发明的示例性实施例提供了安排，装置和方法。 特别地，可以接收至少一个第一电磁辐射，并且将立体角内的至少一个第二电磁辐射转发到样品。 第二电磁辐射可以与第一电磁辐射相关联。 可以从与第二电磁辐射相关联的样品接收多个第三电磁辐射，并且第三电磁辐射的至少一部分设置在立体角的外围。 可以同时检测与每个第三电磁辐射相关联的信号，其中信号与样品在其多个深度处的信息相关联。 可以使用第三电磁辐射中的至少一个来确定深度，而不需要利用第三电磁辐射中的另一个。

    Methods and systems for monitoring and obtaining information of at least one portion of a sample using conformal laser therapy procedures, and providing electromagnetic radiation thereto
    4.
    发明授权
    Methods and systems for monitoring and obtaining information of at least one portion of a sample using conformal laser therapy procedures, and providing electromagnetic radiation thereto 有权
    用于使用保形激光治疗程序监测和获得样品的至少一部分的信息并向其提供电磁辐射的方法和系统

    公开(公告)号：US07538859B2

    公开(公告)日：2009-05-26

    申请号：US11670058

    申请日：2007-02-01

    申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

    发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

    IPC分类号： G01L1/24

    CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B5/6852 ,  A61B18/24 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/207 ,  A61B2090/306 ,  A61B2090/3614

    摘要： In one exemplary embodiment of the present invention, method and system can be provided for obtaining information associated with at least one portion of a sample. For example, a temperature change can be caused in the portion of the sample. At least one first electro-magnetic radiation can be forwarded to a section near or in the portion of the sample. A deformation of the section can be identified at a plurality of depths as a function of (i) a phase of at least one second electro-magnetic radiation provided from the section, and/or (ii) a rate of change of the phase and/or an amplitude of the second electro-magnetic radiation. In another exemplary embodiment of the present invention, method and system can be provided for controlling a temperature distribution in a sample. For example, an electro-magnetic radiation can be provided to the section in the sample at a particular wavelength. The temperature distribution can be controlled by modifying the particular wavelength of the electro-magnetic radiation when the electro-magnetic radiation is provided to the section.

    摘要翻译： 在本发明的一个示例性实施例中，可以提供方法和系统来获得与样本的至少一部分相关联的信息。 例如，可以在样品的部分中引起温度变化。 至少一个第一电磁辐射可以转发到样品附近或部分的部分。 可以在多个深度处识别该部分的变形作为（i）从该部分提供的至少一个第二电磁辐射的相位和/或（ii）相的变化率和 /或第二电磁辐射的振幅。 在本发明的另一示例性实施例中，可以提供方法和系统来控制样品中的温度分布。 例如，可以以特定波长向样品中的部分提供电磁辐射。 当电磁辐射提供给该部分时，可以通过修改电磁辐射的特定波长来控制温度分布。

    Apparatus for applying a plurality of electro-magnetic radiations to a sample
    7.
    发明授权
    Apparatus for applying a plurality of electro-magnetic radiations to a sample 有权
    用于将多个电磁辐射施加到样品的装置

    公开(公告)号：US09186066B2

    公开(公告)日：2015-11-17

    申请号：US11670027

    申请日：2007-02-01

    申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

    发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

    IPC分类号： A61B18/18 ,  A61B5/00 ,  A61B18/24 ,  A61B17/00 ,  A61B17/22 ,  A61B18/20 ,  A61B19/00

    CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B5/6852 ,  A61B18/24 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/207 ,  A61B2090/306 ,  A61B2090/3614

    摘要： An apparatus for applying a plurality of electro-magnetic radiations to a sample is provided. In one exemplary embodiment, the apparatus can include an arrangement which has a specific portion with a plurality of channels. One of channels can facilitate a first radiation of the radiations to be forwarded to the sample that is within an anatomical structure, and another one of the channels can facilitate a second radiation of the radiations to be forwarded to the sample. The first radiation may have a first wavelength band, and the second radiation may have a second wavelength band. The first wavelength band may be substantially different from the second wavelength band. According to another exemplary embodiment, the first radiation can be adapted to be delivered to a first area of the sample, and the second radiation may be capable of being delivered to a second area of the sample. The first area may be substantially enclosed by the second area. According to yet another exemplary embodiment of the present invention, each of the channels can facilitate at least one particular radiation of the radiations to be forwarded to the sample that is within an anatomical structure of the sample, the radiations being delivered to different areas of the sample. Centers of every one of the areas may be provided substantially along a line.

    摘要翻译： 提供了一种向样品施加多个电磁辐射的装置。 在一个示例性实施例中，装置可以包括具有多个通道的特定部分的装置。 通道中的一个可以促进要转发到解剖结构内的样品的辐射的第一辐射，并且另一个通道可以促进辐射的第二次辐射以被转发到样品。 第一辐射可以具有第一波长带，并且第二辐射可以具有第二波长带。 第一波长带可能与第二波长带显着不同。 根据另一示例性实施例，第一辐射可以适于被传送到样品的第一区域，并且第二辐射可以能够被传送到样品的第二区域。 第一区域可以基本上被第二区域包围。 根据本发明的另一个示例性实施例，每个通道可以促进辐射的至少一个特定辐射被转发到样品的解剖结构内的样品，辐射被递送到样品的解剖结构中 样品。 可以基本沿着一条线提供每个区域的中心。

    METHODS AND SYSTEMS FOR OPTICAL IMAGING OR EPITHELIAL LUMINAL ORGANS BY BEAM SCANNING THEREOF
    8.
    发明申请
    METHODS AND SYSTEMS FOR OPTICAL IMAGING OR EPITHELIAL LUMINAL ORGANS BY BEAM SCANNING THEREOF 有权
    通过光束扫描对光学成像或上传光学仪器的方法和系统

    公开(公告)号：US20140301620A1

    公开(公告)日：2014-10-09

    申请号：US14243508

    申请日：2014-04-02

    申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc ,  Norman S. Nishioka

    发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc ,  Norman S. Nishioka

    IPC分类号： G06T7/00

    CPC分类号： A61B5/0084 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/6852 ,  A61B5/7271 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/10101

    摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

    摘要翻译： 提供了布置，装置，系统和系统以获得至少一个管腔或中空样品中的至少一个部分的数据。 该装置，系统或装置可以（可通过患者的嘴部或鼻子中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可见） 第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是 被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置 其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

    Apparatus for controlling at least one of at least two sections of at least one fiber
    9.
    发明授权
    Apparatus for controlling at least one of at least two sections of at least one fiber 有权
    用于控制至少一个光纤的至少两个部分中的至少一个的装置

    公开(公告)号：US07418169B2

    公开(公告)日：2008-08-26

    申请号：US11670069

    申请日：2007-02-01

    申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

    发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

    IPC分类号： G02B6/26 ,  G02B6/06

    CPC分类号： A61B18/24 ,  A61B1/00082 ,  A61B1/00096 ,  A61B1/00172 ,  A61B1/00183 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/2211 ,  A61B2018/2272 ,  G02B23/2423

    摘要： An apparatus for controlling at least one of at least two sections of at least one fiber can be provided. The apparatus can include an arrangement which may be provided between the first and second sections of a particular continuous fiber of the fibers. A particular one of the first and second sections may be provided in a particular orientation that is perpendicular to an extension of the particular fiber. The arrangement is capable of controlling the particular fiber such that the particular one of the sections is capable of being rotated for at least 360° with respect to the particular orientation. The arrangement can include a further arrangement that is capable of at least partially wrapping the particular fiber around the second arrangement, and controlling the particular fiber such that the particular one of the sections is capable of being rotated with respect to the particular orientation during a transmission of the electro-magnetic radiation.

    摘要翻译： 可以提供一种用于控制至少一个光纤的至少两个部分中的至少一个的装置。 该装置可以包括可以设置在纤维的特定连续纤维的第一和第二部分之间的装置。 第一和第二部分中的特定一个可以以垂直于特定纤维的延伸部的特定方向设置。 该装置能够控制特定光纤，使得特定的一个部分能够相对于特定取向旋转至少360°。 该布置可以包括能够至少部分地围绕第二布置包围特定纤维并且控制特定光纤的另外的布置，使得特定的一个部分能够在传输期间相对于特定取向旋转 的电磁辐射。

    APPARATUS AND METHODS FOR ENHANCING OPTICAL COHERENCE TOMOGRAPHY IMAGING USING VOLUMETRIC FILTERING TECHNIQUES
    10.
    发明申请
    APPARATUS AND METHODS FOR ENHANCING OPTICAL COHERENCE TOMOGRAPHY IMAGING USING VOLUMETRIC FILTERING TECHNIQUES 有权
    使用体积滤波技术增强光学相干成像的装置和方法

    公开(公告)号：US20080049232A1

    公开(公告)日：2008-02-28

    申请号：US11844454

    申请日：2007-08-24

    申请人： Benjamin J. Vakoc ,  Adrien Desjardins ,  Guillermo J. Tearney ,  Brett Eugene Bouma

    发明人： Benjamin J. Vakoc ,  Adrien Desjardins ,  Guillermo J. Tearney ,  Brett Eugene Bouma

    IPC分类号： G01B9/02

    CPC分类号： A61B3/1225 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/6852

    摘要： Apparatus and method can be provided, whereas a particular radiation which includes at least one first electro-magnetic radiation can be directed to at least one sample and at least one second electro-magnetic radiation can be directed to a reference. The first electro-magnetic radiation having a particular cross-sectional width may be applied to at least one portion of the sample to generate at least one third electro-magnetic radiation. The first electro-magnetic radiation can be provided in the portion along a particular axis for a distance between a multiplier of 0.5 and 100 of the particular cross-sectional width. An interference can be detected between the third electro-magnetic radiation associated with the first electro-magnetic radiation and at least one fourth electro-magnetic radiation associated with the second electro-magnetic radiation. Further, an asymmetrical cross-sectional area of the first electro-magnetic radiation can be provided.

    摘要翻译： 可以提供装置和方法，而包括至少一个第一电磁辐射的特定辐射可以被引导到至少一个样品，并且至少一个第二电磁辐射可以被引导到参考。 具有特定横截面宽度的第一电磁辐射可以被施加到样品的至少一部分以产生至少一个第三电磁辐射。 第一电磁辐射可以沿着特定轴线的部分设置在特定横截面宽度的0.5和100之间的距离上。 可以在与第一电磁辐射相关联的第三电磁辐射与与第二电磁辐射相关联的至少一个第四电磁辐射之间检测到干扰。 此外，可以提供第一电磁辐射的不对称横截面面积。