公开(公告)号：US08900474B2

公开(公告)日：2014-12-02

申请号：US13530401

申请日：2012-06-22

申请人： Kyoungja Woo ,  Seokheon Lee ,  Wooyoung Park ,  Youngbeom Yu

发明人： Kyoungja Woo ,  Seokheon Lee ,  Wooyoung Park ,  Youngbeom Yu

IPC分类号： C01G49/02 ,  H01F1/00 ,  C07F15/00 ,  C30B29/22 ,  C01G49/08 ,  C30B7/00 ,  C30B29/60 ,  C30B29/16 ,  B82Y40/00 ,  B82Y30/00

CPC分类号： C01G49/08 ,  B82Y30/00 ,  B82Y40/00 ,  C01P2002/72 ,  C01P2004/52 ,  C01P2004/64 ,  C01P2006/42 ,  C30B7/00 ,  C30B29/16 ,  C30B29/22 ,  C30B29/60 ,  H01F1/0054 ,  Y10S977/788 ,  Y10S977/896

摘要： A superparamagnetic nanoparticle is comprised of superparamagnetic nanocrystals less than 20 nm in size, and molecules having containing 3 to 5 carboxyl groups, wherein the molecules bond to surfaces of the superparamagnetic nanocrystals. A method for producing superparamagnetic nanoparticles includes preparing an alkaline solution with pH 10 to 14, producing a mixture in which molecules containing 3 to 5 carboxyl groups, a divalent transition metal and ferric precursors are dissolved, and adding the mixture into the alkaline solution.

摘要翻译： 超顺磁性纳米粒子由尺寸小于20nm的超顺磁性纳米晶体和含有3至5个羧基的分子组成，其中分子键合到超顺磁性纳米晶体的表面。 制备超顺磁性纳米颗粒的方法包括制备pH10至14的碱性溶液，产生其中溶解含有3至5个羧基的分子，二价过渡金属和铁前体的混合物，并将该混合物加入到碱性溶液中。

公开(公告)号：US20130029320A1

公开(公告)日：2013-01-31

申请号：US13560285

申请日：2012-07-27

申请人： Sang Kyung KIM ,  Kyoungja Woo ,  Yu Ri Choi

发明人： Sang Kyung KIM ,  Kyoungja Woo ,  Yu Ri Choi

IPC分类号： G01N21/64 ,  C12M1/34

CPC分类号： G01N21/6428 ,  G01N2021/6432

摘要： Disclosed are a method for detecting a biomolecule including: immobilizing a nucleic acid aptamer capable of specifically binding to a biomolecule to be detected on the surface of a bead on which fluorophores are arranged; hybridizing the nucleic acid aptamer with a guard nucleic acid (g-nucleic acid) labeled with a quencher to quench fluorescence; and reacting a sample including the biomolecule to be detected with the nucleic acid aptamer and detecting a fluorescence signal emitted as the biomolecule binds with the nucleic acid aptamer and the g-nucleic acid labeled with the quencher is separated, and a device for detecting a biomolecule for conducting the detection method. The present disclosure allows for effective, convenient and fast detection of the biomolecule to be detected, enables quantitative analysis, and enables detection of even a trace amount of sample.

摘要翻译： 本发明公开了一种检测生物分子的方法，包括：将能够特异性结合待检测的生物分子的核酸适配体固定在配置有荧光体的珠粒的表面上; 将核酸适体与用猝灭剂标记的保护核酸（g-核酸）杂交以淬灭荧光; 并且使包含待检测的生物分子的样品与核酸适配体反应并检测作为生物分子发射的荧光信号与核酸适配体结合，并用猝灭剂标记的g-核酸被分离，并且用于检测生物分子的装置 用于进行检测方法。 本公开允许有效，方便和快速地检测待检测的生物分子，使得能够进行定量分析，并且甚至能够检测痕量的样品。

公开(公告)号：US20090110642A1

公开(公告)日：2009-04-30

申请号：US11967385

申请日：2007-12-31

申请人： Kyoungja Woo ,  Jihyung Moon

发明人： Kyoungja Woo ,  Jihyung Moon

IPC分类号： A61K49/18 ,  B82B1/00

CPC分类号： A61K49/186 ,  A61K49/0052 ,  A61K49/0067 ,  A61K49/1836 ,  A61K49/1839 ,  B82Y5/00

摘要： Methods of preparing bio-imaging nanoparticles having high dispersibility in an aqueous solution, biocompatibility, and targetability with high yield, by early introduction of an irregular structure are disclosed.

摘要翻译： 公开了通过早期引入不规则结构制备在水溶液中具有高分散性的生物成像纳米颗粒的方法，生物相容性和高产率的可目标性。

公开(公告)号：US07122168B2

公开(公告)日：2006-10-17

申请号：US10678047

申请日：2003-10-01

申请人： Kyoungja Woo ,  Jae-Pyoung Ahn ,  Hae-Weon Lee

发明人： Kyoungja Woo ,  Jae-Pyoung Ahn ,  Hae-Weon Lee

IPC分类号： C01G1/00 ,  C01G49/00

CPC分类号： B82Y30/00 ,  C01G49/06 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/64 ,  C01P2006/42 ,  Y10S977/773 ,  Y10S977/775 ,  Y10S977/777 ,  Y10S977/811

摘要： In a metal oxide nanoparticle and a synthetic method thereof, and in particular to maghemite (γ-Fe2O3) nanoparticles usable as a superhigh density magnetic recording substance by having good shape anisotropy and magnetic characteristics, hematite (α-Fe2O3) nanoparticles usable as a precursor to the maghemite or a catalyst, maghemite and hematite-mixed nanoparticles and a synthetic method thereof, the method for synthesizing metal oxide nanoparticles includes forming a reverse micelle solution by adding distilled water, a surfactant and a solvent to metallic salt not less than trivalent, precipitating and separating gel type amorphous metal oxide particles by adding proton scavenger to the reverse micelle solution; adjusting a molar ratio of metal oxide to the surfactant by washing the gel type amorphous metal oxide particles with a polar solvent; and crystallizing metal oxide nanoparticles through heating or reflux after dispersing the gel type amorphous metal oxide particles in a non-polar solvent having a high boiling point.

摘要翻译： 在金属氧化物纳米颗粒及其合成方法中，特别涉及可用作超高密度磁记录物质的磁赤铁矿（γ-Fe 2 O 3 O 3）纳米颗粒，其具有良好的 形状各向异性和磁特性，可用作磁赤铁矿或催化剂的前体的赤铁矿（α-Fe 2 O 3 O 3）纳米颗粒和合成的赤铁矿 方法，合成金属氧化物纳米粒子的方法包括：通过向不同于三价的金属盐中加入蒸馏水，表面活性剂和溶剂形成反胶束溶液，通过向反相中加入质子清除剂沉淀和分离凝胶型无定形金属氧化物颗粒 胶束溶液; 通过用极性溶剂洗涤凝胶型无定形金属氧化物颗粒来调节金属氧化物与表面活性剂的摩尔比; 以及在将凝胶型无定形金属氧化物颗粒分散在具有高沸点的非极性溶剂中之后通过加热或回流结晶金属氧化物纳米颗粒。

公开(公告)号：US20120263777A1

公开(公告)日：2012-10-18

申请号：US13197946

申请日：2011-08-04

申请人： Kyoungja WOO ,  Hye Hun PARK ,  Wooyoung PARK

发明人： Kyoungja WOO ,  Hye Hun PARK ,  Wooyoung PARK

IPC分类号： A01N25/26 ,  B32B9/04 ,  B01D43/00 ,  B01J23/745 ,  B01J23/755 ,  B01J23/889 ,  B01J23/75 ,  B01J23/89 ,  B01J21/08 ,  B01J31/02 ,  B01J35/10 ,  B01J23/50 ,  B01J23/52 ,  B01J37/34 ,  A61K8/00 ,  A61K8/02 ,  B05D7/00 ,  B05D1/18 ,  B03C1/02 ,  B82Y30/00 ,  B82Y40/00

CPC分类号： B01J35/0033 ,  A01N25/26 ,  B01J23/40 ,  B01J23/50 ,  B01J23/52 ,  B01J23/74 ,  B01J31/0274 ,  B01J35/0013 ,  B01J37/0211 ,  B01J37/0221 ,  B01J37/024 ,  B01J37/0244 ,  B82Y30/00 ,  C07C213/02 ,  C07C215/76 ,  A01N59/16

摘要： An environment-friendly porous bead-satellite nanoparticles composite which has excellent recovery and repeated usage performance and can be used as a catalyst, an antiviral agent, or an antimicrobial, and a fabrication method thereof are provided. The porous bead-satellite nanoparticles composite includes a porous bead, a molecule having a first end coupled to the surface of the porous bead and including a functional group at a second end, and satellite nanoparticles coupled to the functional group, wherein the porous bead may have a core-shell structure including a cluster core of nanoparticles and a porous bead shell covering the cluster core.

摘要翻译： 提供了具有优异的回收率和重复使用性能并可用作催化剂，抗病毒剂或抗微生物剂的环境友好的多孔珠 - 卫星纳米复合材料及其制造方法。 多孔珠卫星纳米复合材料包括多孔珠，分子具有耦合到多孔珠的表面的第一末端并且在第二末端包含官能团，以及耦合到官能团的卫星纳米颗粒，其中多孔珠可以 具有核 - 壳结构，其包括纳米颗粒的簇核和覆盖簇核的多孔珠壳。

公开(公告)号：US20080044657A1

公开(公告)日：2008-02-21

申请号：US11642772

申请日：2006-12-19

申请人： Kyoungja Woo ,  Dong Hyun Koo

发明人： Kyoungja Woo ,  Dong Hyun Koo

IPC分类号： B32B1/00 ,  B05D7/00 ,  B32B15/02

CPC分类号： B82Y30/00 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0067 ,  B82Y5/00 ,  Y10S977/827 ,  Y10S977/83 ,  Y10T428/2998

摘要： There is provided an organic-inorganic composite material containing a single nanoparticle therein, which is prepared by individually dispersing hydrophilic inorganic nanoparticles having a uniform particle size and conjugating biodegradable polymers to the surface of the nanoparticle, and a method of preparing the same. More particularly, the preparation method of the present invention comprises the following steps: 1) preparing hydrophilic nanoparticles by conjugating organic substances having a thiol group and a hydrophilic amine group to the surface of a core or a core/shell inorganic nanoparticle protected with a surfactant through a metal-thiolate (M-S) bond between them; 2) adjusting the concentration of the hydrophilic nanoparticles prepared in step 1) to 2×10−6 M or less and treating them in a sonication bath to prepare individually dispersed nanoparticles in the form of a single particle; and 3) conjugating biopolymers to the nanoparticle individually dispersed in step 2) through the formation of an amide bond between them under treatment in a sonication bath. The organic-inorganic composite material of the present invention exhibits high efficient photoluminescence and photostability as well as excellent chemical stability, dispersibility in water, biocompatibility and targetibility. Thus, it can be effectively used as a raw material for bioimaging or film coating.

摘要翻译： 提供一种其中含有单一纳米颗粒的有机 - 无机复合材料，其通过将具有均匀粒度的亲水性无机纳米颗粒和将可生物降解的聚合物共轭分散在纳米颗粒的表面上而制备，及其制备方法。 更具体地说，本发明的制备方法包括以下步骤：1）通过将具有硫醇基和亲水性胺基的有机物质缀合到核表面或用表面活性剂保护的核/壳无机纳米颗粒的表面制备亲水性纳米颗粒 通过它们之间的金属硫醇盐（MS）键; 2）将步骤1）中制备的亲水性纳米颗粒的浓度调节至2×10 -6 M或更小，并在超声处理浴中处理它们以制备单一颗粒形式的单独分散的纳米颗粒; 和3）将生物聚合物与步骤2）中分散分散的纳米颗粒共轭，通过在超声处理浴中处理之间通过它们之间形成酰胺键。 本发明的有机 - 无机复合材料显示出高效的光致发光和光稳定性以及优异的化学稳定性，在水中的分散性，生物相容性和可目标性。 因此，其可以有效地用作生物成像或薄膜包衣的原料。