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公开(公告)号：US20190261943A1
公开(公告)日：2019-08-29
申请号：US16174395
申请日：2018-10-30
Applicant: Muffin Incorporated
Inventor： Neal E. Fearnot , Peter S. McKinnis , Kasper Klausen
Abstract: Described are methods and systems and system components useful for percutaneously delivering or retrieving vascular implant devices, such as filters, utilizing intravenous ultrasound (IVUS) imaging alone or in combination with external (e.g. transabdominal) ultrasound or other imaging technology. Implants deliverable by such systems, such as vena cava or other vascular filters, can have two or more echogenic markers spaced at such a distance that they are separately discernible by IVUS and/or external ultrasound imaging.
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公开(公告)号：US10111645B2
公开(公告)日：2018-10-30
申请号：US13731313
申请日：2012-12-31
Applicant: Muffin Incorporated
Inventor： Neal E. Fearnot , Peter S. McKinnis , Kasper Klausen
Abstract: Described are methods and systems and system components useful for percutaneously delivering or retrieving vascular implant devices, such as filters, utilizing intravenous ultrasound (IVUS) imaging alone or in combination with external (e.g. transabdominal) ultrasound or other imaging technology. Implants deliverable by such systems, such as vena cava or other vascular filters, can have two or more echogenic markers spaced at such a distance that they are separately discernible by IVUS and/or external ultrasound imaging.
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公开(公告)号：US09931439B2
公开(公告)日：2018-04-03
申请号：US14088606
申请日：2013-11-25
Inventor： Neal E. Fearnot , Michael C. Hiles , Jeremy Metz , F. Joseph Obermiller , Andrew J. Kaucher , Steven Charlebois
CPC classification number: A61L27/60 , A61F2/0063 , A61F2/02 , A61F2002/0072 , A61F2210/0076 , A61F2250/0003 , A61F2250/0068 , A61L27/3633 , A61L27/38
Abstract: Described are medical graft materials and devices which can be usefully modified with liquid additives such as cell suspensions, bioactive agents, or combinations of these. The medical graft materials and devices can have a first outer surface and a second outer surface and can define an internal chamber between the first outer surface and the second outer surface. The medical graft materials and devices can also have at least one region of the graft material interrupting the chamber and surrounded by the chamber. Also described are methods for making and using these medical graft materials and devices.
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公开(公告)号：US20170173309A1
公开(公告)日：2017-06-22
申请号：US15453194
申请日：2017-03-08
Applicant: Muffin Incorporated
Inventor： Frank J. Fischer, JR. , James R. Randolph , Neal E. Fearnot , Jimmy L. Taylor, JR. , Gary B. Shirley
Abstract: Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.
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公开(公告)号：US09675323B2
公开(公告)日：2017-06-13
申请号：US14211780
申请日：2014-03-14
Applicant: Muffin Incorporated
Inventor： Peter S. McKinnis , Yun Zhou , Sarah Robbins , Neal E. Fearnot
CPC classification number: A61B8/4281 , A61B1/00064 , A61B8/0891 , A61B8/12 , A61B8/4272 , A61B8/445 , A61B8/4461 , A61N7/022 , A61N2007/0043 , A61N2007/0082
Abstract: There are disclosed embodiments of devices and methods for imaging the inside of a body part, particularly a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a linear motor, a shaft or filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.
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Patent Agency Ranking
公开(公告)号：US20170144782A1
公开(公告)日：2017-05-25
申请号：US15282001
申请日：2016-09-30
Applicant: Muffin Incorporated
Inventor： Richard B. Sisken , James Thomas Jones , Charles Leland Baxter , Marc C. Buhrmester , William J. Havel , James D. Purdy , Neal E. Fearnot , Kyle D. Amick
Abstract: A filling and sealing system is provided for efficiently filling a series of individual vials with therapeutic liquids. In particular embodiments, the system includes a filling zone or station, a sealing zone or station, an unloading zone or station, and electronic controls.
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公开(公告)号：US09456802B2
公开(公告)日：2016-10-04
申请号：US14051812
申请日：2013-10-11
Applicant: Muffin Incorporated
Inventor： Yun Zhou , Peter S. McKinnis , Neal E. Fearnot
CPC classification number: A61B8/4461 , A61B8/12 , A61B8/445 , A61B8/4483 , A61B8/4494 , A61B8/483 , F04C2270/041 , G01S15/8943 , G10K11/357
Abstract: A system for use with ultrasound procedures including an ultrasound control and/or imaging system which has a microminiature motor, a rotatable reflector and a stationary ultrasound transducer. The transducer may be placed between the motor and the reflector, so as to eliminate the need for placement of wires or other artifact-creating items in the path of ultrasound signals. In particular embodiments, such systems can be incorporated in or retrofitted to commercially standard diagnostic and therapeutic catheters or other housings. Examples can be used in variety of ultrasound procedures, e.g. to perform intravascular ultrasound (IVUS) imaging.
Abstract translation: 一种用于超声波程序的系统，包括具有微型马达，可旋转反射器和固定超声换能器的超声控制和/或成像系统。 传感器可以放置在电动机和反射器之间，以便消除在超声波信号的路径中布置导线或其它造假物品的需要。 在特定实施例中，这样的系统可以并入或改装到商业标准的诊断和治疗导管或其它外壳中。 例子可用于各种超声程序，例如 进行血管内超声（IVUS）成像。
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公开(公告)号：US20160082157A1
公开(公告)日：2016-03-24
申请号：US14835005
申请日：2015-08-25
Applicant: Muffin Incorporated , Cook Biotech Incorporated
Inventor： Michael C. Hiles , Chad E. Johnson , Neal E. Fearnot , Thomas Payne , Ronald Jankowski
CPC classification number: A61L27/50 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3808 , A61L27/3826 , A61L2430/02 , A61L2430/06 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/34 , C12M21/08 , C12M23/06 , C12M23/34 , C12M25/14 , C12N5/0062 , C12N2533/54
Abstract: Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
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19.发明申请PRODUCTS COMPRISING AN EXTRACELLULAR MATRIX MATERIAL AND OSTEOGENIC PROTEIN 审中-公开包含细胞外基质材料和蛋白质蛋白质的产品公开(公告)号：US20150065425A1
公开(公告)日：2015-03-05
申请号：US14474722
申请日：2014-09-02
Applicant: Muffin Incorporated
Inventor： Shelley L. Wallace , Amanda F. Taylor , Steven Charlebois , Christine M. Steinhart , Neal E. Fearnot
CPC classification number: A61L27/3633 , A61L27/12 , A61L27/54 , A61L2300/414 , A61L2400/06 , A61L2430/02
Abstract: Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.
Abstract translation: 成骨组合物包括脱细胞的细胞外基质组织和骨形态发生蛋白，优选BMP-2。 所述组合物有利地使用BMP，其可以以相对低的剂量使用并且可以结合残留在脱细胞的细胞外基质组织中的天然组分（例如天然硫酸化糖胺聚糖如肝素和/或硫酸乙酰肝素）。 还描述了制备和使用这些组合物的方法。 组合物和相关方法可用于治疗患病或受损的骨组织。
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公开(公告)号：US20140221820A1
公开(公告)日：2014-08-07
申请号：US14170705
申请日：2014-02-03
Applicant: Muffin Incorporated
Inventor： Peter S. McKinnis , Yun Zhou , Neal E. Fearnot
CPC classification number: A61B8/481 , A61B5/065 , A61B8/0841 , A61B8/488 , A61B90/39 , A61B2090/3925
Abstract: Devices and methods for enhancing observability under ultrasound imaging of medical devices include temporal markers which are dynamic, producing a variable ultrasound image over time. Included are rotating markers which produce a Doppler shift visible through ultrasound imaging in a Doppler mode and which enhance visibility of the marker. Other devices and methods include alternating streams of fluid contrast agents and saline as well as destroying a fluid contrast agent stream with a high intensity ultrasound pulse.
Abstract translation: 用于增强医疗装置的超声成像的可观察性的装置和方法包括动态的时间标记，随着时间产生可变超声图像。 包括旋转标记，其产生通过多普勒模式的超声成像可见的多普勒频移，并增强标记的可见性。 其他装置和方法包括流体造影剂和盐水的交替流以及破坏具有高强度超声脉冲的流体造影剂流。
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