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    Novel thienobenzazepines as anti-depressants
    12.
    发明授权
    Novel thienobenzazepines as anti-depressants 失效
    新的三苯并噻吩作为抗病毒剂

    公开(公告)号：US3856910A

    公开(公告)日：1974-12-24

    申请号：US40914473

    申请日：1973-10-24

    Applicant: ROUSSEL UCLAF

    Inventor： NEDELEC L ,  GUILLAUME J ,  ALLAIS A

    IPC: C07D495/04 ,  C07D495/20 ,  A61K27/00

    CPC classification number: C07D495/04

    Abstract: Novel 4-(alkylaminoalkyl)-(4H)-thieno-(3,2-b)(f)-benzazepines of the formula
    WHEREIN R1 and R2 are selected from the group consisting of hydrogen, halogen, -CF3, lower alkoxy optionally substituted, lower alkylthio, lower alkyl, optionally substituted sulfonamido, diloweralkylamino and acylamino wherein the acyl is derived from an organic carboxylic acid of one to 18 carbon atoms, R is selected from the group consisting of hydrogen and lower alkyl, A is alkylene of two to five carbon atoms, optionally substituted by lower alkyl, B is selected from the group consisting of hydrogen, lower alkyl and arloweralkyl, C is selected from the group consisting of lower alkyl and arloweralkyl and B and C taken together are alkylene of two to six carbon atoms optionally interrupted with one or two heteroatoms, Y is selected from the group consisting of hydrogen, hydroxy, lower alkoxy and lower alkanoyloxy, X is hydrogen and taken together with Y forms a carbon-carbon double bond, Z'' is selected from the group consisting of hydrogen and lower alkyl and Z is selected from the group consisting of hydrogen, lower alkyl and lower alkoxy and taken with Y forms a member of the group consisting of 0, lower alkylenedioxy, loweralkylenedithio and thioloweralkyleneoxy and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressant activity with a large therapeutic index and their preparation and novel intermediates.

    Abstract translation: 式WHEREIN R1和R2的新型4-（烷基氨基烷基） - [4H] - 噻吩并 - [3,2-b] [f] - 苯并氮杂选自氢，卤素，-CF 3，任选取代的低级烷氧基 ，低级烷硫基，低级烷基，任选取代的磺酰氨基，二低级烷基氨基和酰基氨基，其中酰基衍生自1至18个碳原子的有机羧酸，R选自氢和低级烷基，A是两个至 五个碳原子，任选被低级烷基取代，B选自氢，低级烷基和芳基烷基，C选自低级烷基和低级烷基，B和C一起为二至六碳的亚烷基 任选地被一个或两个杂原子中断的原子，Y选自氢，羟基，低级烷氧基和低级烷酰氧基，X是氢并与Y一起形成碳 - 碳双键，Z'选自 由氢和低级烷基组成的组，Z选自氢，低级烷基和低级烷氧基，Y取代为= 0，低级亚烷基二氧基，低级亚烷基二硫和硫代低级亚烷基氧基团的成员， 具有大的治疗指数的抗抑郁活性的有毒的药学上可接受的酸加成盐及其制备方法和新的中间体。

    11 alpha-alkoxylated steroids, process and therapeutic method
    16.
    发明授权
    11 alpha-alkoxylated steroids, process and therapeutic method 失效
    11 ALPHA-ALKOXYLATED STEROIDS，PROCESS AND THERAPEUTIC METHOD

    公开(公告)号：US3818056A

    公开(公告)日：1974-06-18

    申请号：US25921872

    申请日：1972-06-02

    Applicant: ROUSSEL UCLAF

    Inventor： PIERDET A ,  BONNE C

    IPC: A61K31/565 ,  C07C20060101 ,  C07J1/00 ,  C07C169/08

    CPC classification number: C07J1/007 ,  C07J1/0096

    Abstract: WHEREIN R is alkyl having one to three carbon atoms, X represents a member selected from the group consisting of hydrogen, aliphatic hydrocarbon having one to six carbon atoms, halogenated aliphatic hydrocarbon having one to six carbon atoms, and cycloalkyl having three to six carbon atoms, Y is alkyl having one to six carbon atoms, Z represents a member selected from the group consisting of hydrogen, alkyl having one to six carbon atoms and phenyl alkyl having seven to nine carbon atoms, and R'' represents a member selected from the group consisting of hydrogen and the acyl of an organic carboxylic acid having from one to 18 carbon atoms; as well as a process for preparing the compounds, therapeutic compositions and methods. The 11 Alpha alkoxylated steroids possess anti-estrogenic, anti-gonadotrophic and exogenic anti-androgenic activity.

    11 Alpha -ALKOXYLATED STEROIDS HAVING THE FORMULA

    Abstract translation: 11具有式的α-羟基化甾族化合物R是具有1至3个碳原子的烷基，X表示选自氢，具有1-6个碳原子的脂族烃，具有1-6个碳原子的卤代脂族烃， 和具有3至6个碳原子的环烷基，Y是具有1至6个碳原子的烷基，Z表示选自氢，具有1至6个碳原子的烷基和具有7至9个碳原子的苯基烷基的成员，R “表示选自氢和具有1至18个碳原子的有机羧酸的酰基的成员; 以及制备化合物的方法，治疗组合物和方法。 11种α-烷氧基化甾族化合物具有抗雌激素，抗促性腺激素和外源性抗雄激素活性。

    Novel 11beta-alkoxy steroids
    17.
    发明授权
    Novel 11beta-alkoxy steroids 失效
    新型11BETA-ALKOXY STEROIDS

    公开(公告)号：US3810887A

    公开(公告)日：1974-05-14

    申请号：US20156471

    申请日：1971-11-23

    Applicant: ROUSSEL UCLAF

    Inventor： SALMON J ,  BUCOURT R ,  PIERDET A

    IPC: A61K31/565 ,  C07C20060101 ,  C07J1/00 ,  C07C169/08 ,  C07C173/00

    CPC classification number: C07J1/0092 ,  C07J1/0096

    Abstract: 11B-ALKOXY-$4-GONENES OF THE FORMULA

    6-Y,7-Y'',11-(X-O-),13-R,17-(R2-O-),17-R1-GON-4-EN-3-ONE

    WHEREIN R AND X ARE ALKYL OF 1 TO 4 CARBON ATOMS, R1 IS A SATURATED OR UNSATURATED HYDROCARBON OF 1 TO 6 CARBON ATOMS, R2 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND ACYL OF AN ORGANIC CARBOXYLIC ACID OF 1 TO 18 CARBON ATOMS AND Y AND Y'' ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND METHYL AND THE ENOLIC ESTERS THEREOF WITH AN ORGANIC CARBOXYLIC ACID OF 1 TO 18 CARBON ATOMS WHICH POSESS ANTI-ANDROGENIC AND ANTIESTROGENIC ACTIVITY, THEIR PREPARATION AND NOVEL INTERMEDIATES.

    Herbicidal method
    18.
    发明授权
    Herbicidal method 失效
    除草方法

    公开(公告)号：US3801302A

    公开(公告)日：1974-04-02

    申请号：US3801302D

    申请日：1971-09-15

    Applicant: ROUSSEL UCLAF

    Inventor： PERRONNET J ,  GIRAULT P

    IPC: A01N20060101 ,  A01N37/52 ,  A01N9/20

    CPC classification number: C07C251/72

    Abstract: Herbicidal compositions comprising an effective amount of at least one compound of the formula

    WHEREIN X is selected from the group consisting of hydrogen and lower alkyl of one to six carbon atoms when Y is selected from the group consisting of bromine and chlorine and when Y is hydrogen, X is selected from the group consisting of chlorine, bromine and lower alkyl of one to six carbon atoms and n is 1, 2 or 3 and to a method of killing plants.

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