公开(公告)号：US20080103167A1

公开(公告)日：2008-05-01

申请号：US11547046

申请日：2005-04-01

Applicant: Gregory Raymond Bebernitz ,  Ramesh Chandra Gupta ,  Vikrant Vijaykumar Jagtap ,  Appaji Baburao Mandhare ,  Davinder Tuli

Inventor： Gregory Raymond Bebernitz ,  Ramesh Chandra Gupta ,  Vikrant Vijaykumar Jagtap ,  Appaji Baburao Mandhare ,  Davinder Tuli

IPC: A61K31/437 ,  A61K31/429 ,  C07D513/04 ,  A61K31/4365

CPC classification number: C07D513/04

Abstract: The present invention provides compounds of the formula (I), which are activators of glucokinase activity and, thus, may be employed as therapeutic agents for the treatment of glucokinase mediated conditions. Accordingly, the compounds of formula (I) may be employed for the prevention and the treatment of impaired glucose tolerance, Type 2 diabetes and obesity.

Abstract translation: 本发明提供了作为葡萄糖激酶活性的激活剂的式（I）化合物，因此可用作治疗葡糖激酶介导的病症的治疗剂。 因此，式（I）化合物可用于预防和治疗葡萄糖耐量异常，2型糖尿病和肥胖症。

公开(公告)号：US20070178179A1

公开(公告)日：2007-08-02

申请号：US11519327

申请日：2006-09-11

Applicant: Vijai Lakshmi ,  Ajet Saxena ,  Rajesh Kumar ,  Raghwendra Pal ,  Satyawan Singh ,  Arvind Srivastava ,  Preeti Tiwari ,  Deepak Raina ,  Anil Rastogi ,  Mahendra Srivastava ,  Ramesh Chandra ,  Anju Puri ,  Ram Raghubir ,  Poonam Gupta ,  Narender Tadigoppula ,  Brijendra Tripathi ,  Sudhir Srivastava

Inventor： Vijai Lakshmi ,  Ajet Saxena ,  Rajesh Kumar ,  Raghwendra Pal ,  Satyawan Singh ,  Arvind Srivastava ,  Preeti Tiwari ,  Deepak Raina ,  Anil Rastogi ,  Mahendra Srivastava ,  Ramesh Chandra ,  Anju Puri ,  Ram Raghubir ,  Poonam Gupta ,  Narender Tadigoppula ,  Brijendra Tripathi ,  Sudhir Srivastava

IPC: A61K36/185

CPC classification number: A61K36/58 ,  C07D493/18

Abstract: A bioactive fraction obtained from Xylocarpus that is useful for the treatment of diabetes and dyslipidemia. This fraction can be provided in a pharmaceutical composition that is useful as antidiabetic and antidyslipidemic agent, or can be used in a method of treating diabetes and dyslipidemia in a subject. Also, a process for the preparation of bioactive fraction from Xylocarpus. Novel isomeric xyloccensins and the preparation of such compounds. Also, pharmaceutical compositions comprising a therapeutically effective amount of such novel isomeric xyloccensins optionally along with one or more pharmaceutically acceptable carriers, additives, lubricant and diluents and the use of such pharmaceutical compositions in a method for treating dyslipidemia.

Abstract translation: 从Xylocarpus得到的可用于治疗糖尿病和血脂异常的生物活性成分。 该级分可以提供在可用作抗糖尿病和抗脂肪代谢剂的药物组合物中，或可用于治疗受试者的糖尿病和血脂异常的方法。 另外，从Xylocarpus制备生物活性成分的方法。 新型异构体的木糖蛋白和这些化合物的制备。 此外，药物组合物包含治疗有效量的这种新型异构的木糖蛋白，任选地与一种或多种药学上可接受的载体，添加剂，润滑剂和稀释剂一起使用，以及这些药物组合物在治疗血脂异常的方法中的用途。

公开(公告)号：US06160139A

公开(公告)日：2000-12-12

申请号：US048279

申请日：1998-03-26

Applicant: Amrit Goswami ,  Rumi Kataky ,  Ramesh Chandra Rastogi ,  Anil C. Ghosh

Inventor： Amrit Goswami ,  Rumi Kataky ,  Ramesh Chandra Rastogi ,  Anil C. Ghosh

IPC: C07J7/00

CPC classification number: C07J7/00

Abstract: The invention relates to a process for the production of 16-dehydropregnenolone acetate of the formula ##STR1## comprising the oxidation of pseudodiosgenin diacetate in the presence of a phase transfer catalyst at a temperature between 0-15.degree. C. to produce diosone followed by the hydrolysis and degradation of diosone to produce 16-dehydropregnenolone acetate.

Abstract translation: 本发明涉及一种制备下式的16-脱氢孕烯醇酮醋酸酯的方法，该方法包括在相转移催化剂存在下在0-15℃的温度下氧化假二十二烷基二乙酸酯以产生二酮，接着水解和降解 的二酮以产生16-脱氢孕烯醇酮乙酸酯。

公开(公告)号：US5752072A

公开(公告)日：1998-05-12

申请号：US644753

申请日：1996-05-09

Applicant: Ramesh Chandra Agarwal

Inventor： Ramesh Chandra Agarwal

IPC: G06F7/24 ,  G06F7/08 ,  G06F7/42

CPC classification number: G06F7/24

Abstract: A sorting scheme which does not require any compare or branch instructions is particularly useful for computers with multiple parallel functional units. Sorting two numbers or binary strings is performed using arithmetic instructions instead of conventional compare and branch instructions, thereby improving the performance of superscalar and very large instruction word (VLIW) computers. When applied to reduced instruction set computers (RISC), the sorting scheme provides better utilization of floating-point units. The sorting scheme allows floating point representation of data and floating-point instructions to sort binary strings.

Abstract translation: 不需要任何比较或分支指令的排序方案对于具有多个并行功能单元的计算机特别有用。 使用算术指令而不是传统的比较和分支指令对两个数字或二进制串进行排序，从而提高超标量和非常大的指令字（VLIW）计算机的性能。 当应用于精简指令集计算机（RISC）时，排序方案可以更好地利用浮点数据。 排序方案允许数据的浮点表示和浮点指令对二进制字符串进行排序。

公开(公告)号：US20240096509A1

公开(公告)日：2024-03-21

申请号：US18093517

申请日：2023-01-05

Applicant: Ramesh Chandra ,  Monica Chandra

Inventor： Ramesh Chandra ,  Monica Chandra

IPC: G21B1/05

CPC classification number: G21B1/057

Abstract: We describe, herein, a new class of controlled fusion machines that are expected to successfully implement confinement of the hot plasma using a set of electric and magnetic fields. It includes usage of electrostatic charges along with a large ratio of the concentration of positively charged nuclei to the concentration of negatively charged electrons. It would lead to a stable steady state with a very high Q value that is expected to be orders of magnitude higher than achieved so far by any of the controlled fusion machines. Even though usage of superconductors or near superconductors is not necessary to achieve this performance, it is desirable to use superconductors for optimal performance. So, in some of the preferred embodiments of the invention, superconductor or near superconductor structures are built into the design of the machine itself, even though, it is possible to just use superconductors or near superconductors as stand-alone components in the machine.

公开(公告)号：US11486110B2

公开(公告)日：2022-11-01

申请号：US17556364

申请日：2021-12-20

Applicant: Ramesh Chandra Gupta

Inventor： Ramesh Chandra Gupta

IPC: E02D5/24 ,  E02D3/12 ,  E02D3/08 ,  E02D7/02

Abstract: The porous displacement piles comprising (a) closed-ended pipe piles with small holes and or narrow slots, filled with compacted sandy soil, (b) closed-ended porous pipe piles such as closed-ended pipe pile with very small holes and or very narrow slots, and (c) a precast prestressed porous concrete piles are driven through inside the already driven non-displacement hollow pipe piles in a grid pattern to create excess pore-water pressures generally ranging between 50 and 1500 kPa in cohesive soils, which begin dissipating through inside the porous displacement piles to rapidly consolidate and densify the said cohesive soil. The porous displacement piles are designed for permitting free flow of the pressurized pore-water and to prevent migration of particles of cohesive soil into the porous displacement pile using filter design criteria or verified by laboratory tests. These piles when driven in sandy soils densify sandy soils instantaneously.

公开(公告)号：US20220235531A1

公开(公告)日：2022-07-28

申请号：US17637751

申请日：2020-11-20

Applicant: Ramesh Chandra Gupta

Inventor： Ramesh Chandra Gupta

IPC: E02D5/66 ,  E02D7/06 ,  E02D27/16 ,  E02D27/34

Abstract: The rapid consolidation and compaction method comprises (i) first driving a hollow pipe, (ii) driving a pipe with a removable end plate after filling and compacting the sandy material in it, through the hollow pipe, to required depth, creating high excess pore-water pressures in the range of 50 to 300 KPa in clayey soils, (iv) pulling out the pipe section leaving behind the removable end plate and thereby installing porous displacement piles which allows dissipation of the excess pore-water pressures horizontally to the porous displacement pile, in which the excess water flows out vertically to the ground surface, and (v) the length of the drainage path is reduced to half the spacing between adjoining porous displacement piles, allowing rapid consolidation resulting in increase in density. Installing the porous displacement piles in the layer of loose to medium dense sand layer results in the instantaneous increase in its density.

公开(公告)号：US11261576B1

公开(公告)日：2022-03-01

申请号：US17090858

申请日：2020-11-05

Applicant: Ramesh Chandra Gupta

Inventor： Ramesh Chandra Gupta

IPC: E02D5/24 ,  E02D27/16 ,  E02D7/02

Abstract: The rapid consolidation and compaction method comprises (i) first driving a hollow pipe, (ii) driving a pipe with a removable end plate after filling and compacting the sandy material in it, through the hollow pipe, to required depth, creating high excess pore-water pressures in the range of 50 to 300 KPa in clayey soils, (iv) pulling out the pipe section leaving behind the removable end plate and thereby installing porous displacement piles which allows dissipation of the excess pore-water pressures horizontally to the porous displacement pile, in which the excess water flows out vertically to the ground surface, and (v) the length of the drainage path is reduced to half the spacing between adjoining porous displacement piles, allowing rapid consolidation resulting in increase in density. Installing the porous displacement piles in the layer of loose to medium dense sand layer results in the instantaneous increase in its density.

公开(公告)号：US20180120283A1

公开(公告)日：2018-05-03

申请号：US15838660

申请日：2017-12-12

Applicant: Ramesh Chandra Gupta

Inventor： Ramesh Chandra Gupta

IPC: G01N33/24 ,  G01N3/08 ,  E02D1/02

CPC classification number: G01N33/24 ,  E02D1/025 ,  E02D1/027 ,  G01N3/08 ,  G01N3/12 ,  G01N2203/0254 ,  G01N2203/0266

Abstract: The expandable jacket and flexible ring comprises of the segmented circular arch shaped plates and bands or rings around the segmented plates. The test preparation consists of a membrane surrounding a specimen with or without a filter, segmented plates surrounding the membrane, and bands or rings around the segmented plates to permit uniform radial expansion of the specimen through its height when increments of vertical load are applied during the test, thereby providing accurate values of area of cross-section, deviator stress, volume change, modulus of elasticity, Poisson's ratio and shear strength. Using the flexible ring, three-dimensional consolidation tests are performed to determine three-dimensional coefficient of consolidation and coefficients of consolidation in horizontal and vertical directions. Removable attachments are used for assembling the expandable jacket and flexible ring during the test. A calibration device is used to determine the modulus of elasticity of the membrane and expandable jacket and flexible ring.

公开(公告)号：US20140057925A1

公开(公告)日：2014-02-27

申请号：US14006016

申请日：2012-03-16

Applicant: Shriprakash Dhar Dwived ,  Ramesh Chandra Singh ,  Jigar Mukundbhai Raval

Inventor： Shriprakash Dhar Dwived ,  Ramesh Chandra Singh ,  Jigar Mukundbhai Raval

IPC: C07D405/12

CPC classification number: C07D405/12 ,  A61K31/404

Abstract: The present invention relates to an amorphous form of vilazodone hydrochloride and process for the preparation of amorphous form of vilazodone hydrochloride. The invention also relates to pharmaceutical compositions that include a therapeutically effective amount of the amorphous form of vilazodone hydrochloride and use of said compositions for the treatment of major depressive disorder (MDD).

Abstract translation: 本发明涉及无定形形式的盐酸维拉佐酮及其制备无定形形式的盐酸维拉唑酮。 本发明还涉及药物组合物，其包括治疗有效量的无定形形式的盐酸维拉唑酮和所述组合物用于治疗重度抑郁障碍（MDD）的用途。