-
公开(公告)号：US08999969B2
公开(公告)日：2015-04-07
申请号：US13383180
申请日：2010-07-07
申请人： Richard L. Mackman , David Sperandio , Hai Yang
发明人： Richard L. Mackman , David Sperandio , Hai Yang
IPC分类号： A61K31/55 , C07D495/04
CPC分类号： C07D495/04
摘要： The present invention relates to anti-RSV compounds of Formula (I) and methods for use of the compounds in the treatment and prevention of RSV infection.
摘要翻译： 本发明涉及式（I）的抗RSV化合物及其用于治疗和预防RSV感染的方法。
-
公开(公告)号：US20090202470A1
公开(公告)日：2009-08-13
申请号：US11658419
申请日：2005-07-26
申请人： Constantine G. Boojamra , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Oleg V. Petrakosvsky , Adrian S. Ray , Lijun Zhang
发明人： Constantine G. Boojamra , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Oleg V. Petrakosvsky , Adrian S. Ray , Lijun Zhang
CPC分类号： C07H19/16 , A61K31/341 , A61K31/513 , A61K31/662 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65616 , C07H19/00 , C07H19/20 , A61K2300/00
摘要： The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
-
公开(公告)号：US07452901B2
公开(公告)日：2008-11-18
申请号：US10833293
申请日：2004-04-26
申请人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
发明人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
IPC分类号： A61K31/44 , C07D239/00
CPC分类号： A61K31/7076 , A61K31/675 , A61K31/7072 , A61K47/548 , C07H19/04
摘要： The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的抗癌化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
-
公开(公告)号：US07432261B2
公开(公告)日：2008-10-07
申请号：US10833294
申请日：2004-04-26
申请人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralph F. Hirschmann , Thorsten Kirschberg , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , Peter H. Nelson , David A. Oare , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
发明人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Maria Fardis , Craig Gibbs , Ralph F. Hirschmann , Thorsten Kirschberg , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , Peter H. Nelson , David A. Oare , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang
IPC分类号： A61K31/60 , C07D237/00
CPC分类号： C07F9/65583 , A61K31/60 , A61K47/548 , C07F9/4006 , C07F9/4021 , C07F9/46 , C07F9/572 , C07F9/5728 , C07F9/65031 , C07F9/65038 , C07F9/650905 , C07F9/6524 , C07F9/653 , C07F9/65515 , C07F9/65517 , C07F9/65586 , C07F9/6561 , C07F9/65616
摘要： The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的抗炎化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
-
公开(公告)号：US07417055B2
公开(公告)日：2008-08-26
申请号：US10832811
申请日：2004-04-26
申请人： Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Thorsten Kirschberg , Richard L. Mackman , Sundaramoorthi Swaminathan , William J. Watkins
发明人： Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Thorsten Kirschberg , Richard L. Mackman , Sundaramoorthi Swaminathan , William J. Watkins
IPC分类号： A61K31/44 , C07D239/72
CPC分类号： A61K31/662 , A61K47/54 , A61K47/548 , C07F9/58 , C07F9/6561
摘要： The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的激酶抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法，以及可用于制备这些化合物的方法和中间体。
-
公开(公告)号：US08513184B2
公开(公告)日：2013-08-20
申请号：US13315069
申请日：2011-12-08
申请人： Todd Appleby , Hans G. Fliri , Andrew J. Keats , Linos Lazarides , Richard L. Mackman , Simon N. Pettit , Karine G. Poullennec , Jonathan Sanvoisin , Victoria A. Steadman , Gregory M. Watt
发明人： Todd Appleby , Hans G. Fliri , Andrew J. Keats , Linos Lazarides , Richard L. Mackman , Simon N. Pettit , Karine G. Poullennec , Jonathan Sanvoisin , Victoria A. Steadman , Gregory M. Watt
CPC分类号： A61K38/06 , A61K45/06 , C07D487/04 , C07D487/08 , C07D498/08 , C07D498/18 , C07K5/02 , C07K5/06052
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
-
![Pyrazolo[1,5-a]pyrimidines for antiviral treatment](/abs-image/US/2013/07/16/US08486938B2/abs.jpg.150x150.jpg)
公开(公告)号：US08486938B2
公开(公告)日：2013-07-16
申请号：US13167618
申请日：2011-06-23
申请人： Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
发明人： Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D495/04 , C07D513/04 , C07D519/00 , C07F9/65616
摘要： The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
摘要翻译： 本发明提供了本文所述的式I或式II化合物或其药学上可接受的盐或酯。 其化合物及其组合物可用于治疗肺炎链球菌病毒感染。 提供的化合物，组合物和方法特别可用于治疗人呼吸道合胞病毒感染。
-
公开(公告)号：US20130022573A1
公开(公告)日：2013-01-24
申请号：US13315069
申请日：2011-12-08
申请人： Todd Appleby , Hans G. Fliri , Andrew J. Keats , Linos Lazarides , Richard L. Mackman , Simon N. Pettit , Karine G. Poullennec , Jonathan Sanvoisin , Victoria A. Steadman , Gregory M. Watt
发明人： Todd Appleby , Hans G. Fliri , Andrew J. Keats , Linos Lazarides , Richard L. Mackman , Simon N. Pettit , Karine G. Poullennec , Jonathan Sanvoisin , Victoria A. Steadman , Gregory M. Watt
CPC分类号： A61K38/06 , A61K45/06 , C07D487/04 , C07D487/08 , C07D498/08 , C07D498/18 , C07K5/02 , C07K5/06052
摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
-
公开(公告)号：US20120196846A1
公开(公告)日：2012-08-02
申请号：US13383180
申请日：2010-07-07
申请人： Richard L. Mackman , David Sperandio , Hai Yang
发明人： Richard L. Mackman , David Sperandio , Hai Yang
IPC分类号： A61K31/55 , A61P29/00 , A61P31/12 , C07D223/14 , A61P31/14
CPC分类号： C07D495/04
摘要： The present invention relates to anti-RSV compounds of Formula (I) and methods for use of the compounds in the treatment and prevention of RSV infection.
摘要翻译： 本发明涉及式（I）的抗RSV化合物及其用于治疗和预防RSV感染的方法。
-
公开(公告)号：US20120157404A1
公开(公告)日：2012-06-21
申请号：US13291977
申请日：2011-11-08
申请人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
发明人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
IPC分类号： A61K31/4184 , A61K31/501 , A61K31/439 , A61K31/7056 , A61K31/7068 , A61K31/496 , A61P31/14
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
-
-
-
-
-
-
-
-
-
搜索结果
35 条记录 (耗时 0.074 秒)
