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49 条记录 (耗时 0.036 秒)

    Vacuum dilution extraction gas sampling system
    11.
    发明授权
    Vacuum dilution extraction gas sampling system 失效
    真空稀释萃取气采样系统

    公开(公告)号：US5458010A

    公开(公告)日：1995-10-17

    申请号：US218563

    申请日：1994-03-28

    申请人： John E. Traina ,  Richard Myers

    发明人： John E. Traina ,  Richard Myers

    IPC分类号： G01N1/22 ,  G01N1/24 ,  G01N1/28 ,  G01N33/00 ,  G05D11/03 ,  B01L7/00

    CPC分类号： G01N1/2258 ,  G01N33/0011 ,  G01N33/0016 ,  G05D11/03 ,  G01N1/2252 ,  G01N1/24 ,  G01N2001/2261 ,  G01N2001/2264 ,  G01N2001/244

    摘要： A gas sampling system utilizing a pair of parallel sonic orifices. One of the orifices is connected to a source of filtered, heated samples. The second, larger orifice is connected to a source of dilution gas. A vacuum pump maintains a substantial vacuum behind the orifices, thus assuring critical flow therethrough. The sample and diffusion gas are mixed behind the orifices and transported under partial vacuum for analysis. The dew point of the sample is affected by both the ratio of the diameter of orifices and the degree of vacuum transporting the gas mixture. As such, the dew point can be varied indefinitely by any reasonable combination of orifice ratio and vacuum pump strength.

    摘要翻译： 采用一对平行声波孔的气体采样系统。 其中一个孔连接到过滤的加热样品源。 第二个更大的孔连接到稀释气体源。 真空泵在孔之后保持相当的真空，从而确保通过其中的临界流。 将样品和扩散气体混合在孔的后面并在部分真空下运输用于分析。 样品的露点受到孔直径与输送气体混合物的真空度的影响。 因此，露点可以通过孔径比和真空泵强度的任何合理的组合而无限地变化。

    Functional arrays for high throughput characterization of gene expression regulatory elements
    15.
    发明申请
    Functional arrays for high throughput characterization of gene expression regulatory elements 审中-公开
    用于基因表达调节元件高通量表征的功能阵列

    公开(公告)号：US20070161031A1

    公开(公告)日：2007-07-12

    申请号：US11636385

    申请日：2006-12-07

    申请人： Nathan Trinklein ,  Shelley Aldred ,  Sara Cooper ,  Richard Myers

    发明人： Nathan Trinklein ,  Shelley Aldred ,  Sara Cooper ,  Richard Myers

    IPC分类号： C40B30/06 ,  C40B40/02 ,  C40B50/06

    CPC分类号： C12N15/1086 ,  C12Q1/6897

    摘要： The present invention provides compositions, kits, assemblies, libraries, arrays, and high throughput methods for large scale structural and functional characterization of gene expression regulatory elements in a genome of an organism, especially in a human genome. In one aspect of the invention, an array of expression constructs is provided, each of the expression constructs comprising: a nucleic acid segment operably linked with a reporter sequence in an expression vector such that expression of the reporter sequence is under the transcriptional control of the nucleic acid segment, the nucleic acid segment varying in the library and having a diversity of at least 50. The nucleic acid segments can be a large library of gene expression regulatory elements such as transcriptional promoters. The present invention can have a wide variety of applications such as in personalized medicine, pharmacogenomics, and correlation of polymorphisms with phenotypic traits.

    摘要翻译： 本发明提供组合物，试剂盒，组装，文库，阵列和高通量方法，用于在生物体，特别是人类基因组的基因组中的基因表达调控元件的大规模结构和功能表征。 在本发明的一个方面，提供了表达构建体的阵列，每个表达构建体包含：与表达载体中的报道序列可操作地连接的核酸片段，使得报告序列的表达在 核酸片段，核酸片段在文库中变化并具有至少50的多样性。核酸片段可以是基因表达调节元件如转录启动子的大型文库。 本发明可以具有广泛的应用，例如个性化医学，药物基因组学和多态性与表型性状的相关性。

    Measuring particulate matter in a fluid
    16.
    发明授权
    Measuring particulate matter in a fluid 有权

    公开(公告)号：US07224455B2

    公开(公告)日：2007-05-29

    申请号：US10857548

    申请日：2004-05-28

    申请人： Richard Myers ,  Edward L. McCall ,  Gerald F. McGowan ,  Edward A. Smierciak

    发明人： Richard Myers ,  Edward L. McCall ,  Gerald F. McGowan ,  Edward A. Smierciak

    IPC分类号： G01N21/00

    CPC分类号： G01N21/53 ,  G01N2021/4707

    摘要： A device for measuring near forward scatter caused by particulate matter in a fluid is disclosed. The device comprises, according to various embodiments, a transceiver and a reflector. The transceiver includes a light source and a detector. The reflector is positioned opposite the transceiver so that at least a portion of the fluid is present between the transceiver and the reflector. The reflector includes a front portion facing the transceiver. Optical energy from the light source incident upon the reflector is reflected towards the transceiver as a return beam of optical energy, wherein the detector senses primarily optical energy of the return beam that is scattered over a range of near forward angles by particulate matter in the fluid.

    Electron-beam melt refining of ferroniobium
    19.
    发明授权
    Electron-beam melt refining of ferroniobium 失效
    电子束熔炼精炼铌

    公开(公告)号：US06007597A

    公开(公告)日：1999-12-28

    申请号：US31608

    申请日：1998-02-27

    申请人： Richard S. Puopolo ,  John Roger Peterson ,  Richard Myers

    发明人： Richard S. Puopolo ,  John Roger Peterson ,  Richard Myers

    IPC分类号： C21C5/52 ,  C22B9/22 ,  C21B11/10 ,  C01G31/00 ,  C22B1/00

    CPC分类号： C22B9/228 ,  C21C5/5264 ,  Y02P10/216

    摘要： Niobium, Nb, is refined from FeNb by electron beam melt refining. The amount of the impurities in the FeNb which form suboxides with oxygen is optionally determined. Sufficient oxygen is added to form oxides with these impurities. The electron beam melt refining process is carried out at a sufficiently high temperature and under a sufficiently low vacuum so that the impurities are removed as oxides from the liquid Nb and the purified Nb is recovered. Preferably the oxygen is added as an oxygen-containing compound such as Nb.sub.2 O.sub.5. The recovered Nb can be subjected to additional electron beam melt refining cycles to obtain the desired purity.

    摘要翻译： 铌Nb通过电子束熔融精炼从FeNb中精制而成。 任选地测定与氧形成低氧化物的FeNb中杂质的量。 加入足够的氧以形成具有这些杂质的氧化物。 电子束熔融精炼工艺在足够高的温度和足够低的真空下进行，使得杂质作为氧化物从液体Nb中除去并且纯化的Nb被回收。 优选地，氧作为含氧化合物例如Nb 2 O 5加入。 回收的Nb可以进行额外的电子束熔炼精炼循环以获得所需的纯度。

    Enhanced Type S pitot tube with reduced and symmetric response to pitch
    20.
    发明授权
    Enhanced Type S pitot tube with reduced and symmetric response to pitch 失效
    增强型S皮托管，对音调具有减小和对称的响应

    公开(公告)号：US5535634A

    公开(公告)日：1996-07-16

    申请号：US395421

    申请日：1995-02-28

    申请人： John E. Traina ,  Richard Myers

    发明人： John E. Traina ,  Richard Myers

    IPC分类号： G01F1/46

    CPC分类号： G01F1/46

    摘要： A improved Type S or reverse type pitot tube has two conduit legs which are mirror images of one another. Each conduit leg has an input portion having a pressure port therein, a support portion and a connecting portion connected between the input portion and the support portion. The support portion and the connecting portion lie in one plane which plane is substantially perpendicular to a centerline through the input portions. The conduit legs are shaped and oriented relative to one another so that the pressure ports of the input portions of the first and second conduits are collinear and when placed in a conduit, the pitot tube will be symmetrical in a yaw plane and both symmetrical and non-interfering in a pitch plane. The first and second conduits are spaced apart over at least a portion of their length to define an opening adjacent the input portions which opening is at least 3 times wider and deeper than the input portions. With this pitot tube the errors in flow measurement which result from the pitch angle flow are negligible in most cases and never result in a low biased reading.

    摘要翻译： 改进的S型或反型皮托管具有彼此成镜像的两个导管腿。 每个导管腿具有其中具有压力端口的输入部分，支撑部分和连接在输入部分和支撑部分之间的连接部分。 支撑部分和连接部分位于一个平面中，该平面基本上垂直于通过输入部分的中心线。 导管腿相对于彼此成形和定向，使得第一和第二导管的输入部分的压力端口共线，并且当放置在导管中时，皮托管将在偏航平面中对称，并且对称和非对称 在间距平面上干扰。 第一和第二导管在它们的长度的至少一部分上间隔开以限定邻近输入部分的开口，该开口比输入部分宽至少3倍。 对于这个皮托管来说，由于桨距角流动引起的流量测量误差在大多数情况下是可以忽略的，从不导致读数偏低。