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    KIT FOR THE IMPLANTATION OF A DENTAL IMPLANT
    11.
    发明申请
    KIT FOR THE IMPLANTATION OF A DENTAL IMPLANT 审中-公开

    公开(公告)号：US20170252131A1

    公开(公告)日：2017-09-07

    申请号：US15512841

    申请日：2014-09-19

    Applicant: Stichting VU-VUMC

    Inventor： Daniel KOOPS

    IPC: A61C8/00 ,  A61C1/08

    Abstract: The present invention provides a kit for use for the implantation of a dental implant, comprising an implant guide comprising a proximal end and a distal end, wherein the distal end is configured to be detachably attached to a dental implant, said implant guide comprising a cylindrical body, wherein the cylindrical body comprises a cylindrical outer surface and a circumferential groove in the outer surface, and a template configured to be arranged at a predetermined location with respect to a jaw, wherein the template comprises at least one implantation channel to guide the cylindrical body of the implant guide in a desired implantation direction during implantation of a dental implant in the jaw, and a stop surface at an end of the implantation channel.The kit comprises a stop element comprising a first part and a second part, wherein the first part and the second part are configured to be movable between a first state, in which the first part and the second part are spaced at a first distance, and a second state, in which the first part and the second part are spaced at a second distance, wherein the first distance is smaller than the second distance, and wherein the first and second parts are biased to the first state, wherein the second distance is the same or larger than a distance between diametrically opposite sides of the outer surface of the implant guide, such that, before implantation, the first part and the second part can be arranged, in the second state, on diametrically opposite sides of the outer surface, and that during movement in the implantation direction of the dental implant into the jaw, the stop surface of the implantation channel will push the stop element towards the groove until the groove will allow the first and second part to move towards the first state and the stop element will be caught by the groove, therewith blocking further movement of the implant guide in the implantation direction.

    MOLECULAR MANIPULATION SYSTEM AND METHOD
    12.
    发明申请
    MOLECULAR MANIPULATION SYSTEM AND METHOD 审中-公开
    分子操作系统和方法

    公开(公告)号：US20160138095A1

    公开(公告)日：2016-05-19

    申请号：US14898112

    申请日：2014-06-11

    Applicant: Stichting VU-VUMC

    Inventor： Erwin Johannes Gerard Peterman ,  Gijs Jan Lodewijk Wuite ,  Gerrit Sitters ,  Douwe Kamsma

    IPC: C12Q1/68 ,  G01N29/06

    CPC classification number: C12Q1/6837 ,  G01N29/0681 ,  G02B21/32

    Abstract: A molecular manipulation system for investigating molecules, having a sample holder constructed to hold a sample comprising a plurality of molecules attached on one side to a surface in the sample holder and on another side attached to a microbead of a plurality of microbeads. The system having; an acoustic wave generator to generate an acoustic wave exerting a force on the microbeads in the sample; and a detector device to detect a response of the plurality of microbeads in the sample on the force exerted by the acoustic wave to investigate the molecules attached to the microbeads.

    Abstract translation: 一种用于调查分子的分子操纵系统，具有样品架，其被构造成将包含附着在一侧的多个分子的样品保持在样品保持器中的表面上，另一侧附着在多个微珠的微珠上。 系统有 声波发生器，用于产生在样品中的微珠上施加力的声波; 以及检测器装置，用于检测样品中的多个微珠对由声波施加的力的响应，以研究附着于微珠的分子。

    Suture device
    13.
    发明授权
    Suture device 有权

    公开(公告)号：US10058324B2

    公开(公告)日：2018-08-28

    申请号：US14358136

    申请日：2012-11-16

    Applicant: Stichting VU-VUMC

    Inventor： Rianne Irene Van Loenen ,  Micha Ilan Paalman ,  Alexander Arnold Frederik Adriaan Veenhof

    IPC: A61B17/04 ,  A61B17/12

    CPC classification number: A61B17/0469 ,  A61B2017/047 ,  A61B2017/0472 ,  F04C2270/0421

    Abstract: A suture device includes a needle operating device movable longitudinally with respect to a housing between at least an insertion position and a needle transfer position. The needle operating device includes an elongate operating element arranged extending from a distal end of the housing to or near a housing proximal end. A needle holder connected at a distal end of the operating element holds two or more needles, with free ends directed in proximal direction. The holder is movable with respect to a protection device between at least a protecting position shielding the free ends, and a non-protecting position for the same. A needle receive device at a distal end of the housing receives the free ends when the operating device is moved to the transfer position. In at least the insertion position the holder and the protection device are spaced longitudinally from the housing to receive a tissue therebetween.

    RADIOLABELED QUINAZOLINE DERIVATIVES
    15.
    发明申请
    RADIOLABELED QUINAZOLINE DERIVATIVES 审中-公开
    放射性喹唑啉衍生物

    公开(公告)号：US20150368230A1

    公开(公告)日：2015-12-24

    申请号：US14765042

    申请日：2014-01-28

    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  STICHTING VU-VUMC

    Inventor： Paul SLOBBE ,  Alex Johannes POOT ,  Augustinus Antonius Maria Silvester VAN DONGEN ,  Heiko NIESSEN ,  Albert Dirk WINDHORST

    IPC: C07D405/12 ,  A61K51/04

    CPC classification number: C07D405/12 ,  A61K51/0459 ,  C07B2200/05

    Abstract: Novel radiotracer for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging are described. Specifically, the invention relates to 18F-labeled afatinib suitable as a PET or SPECT tracer for imaging epidermal growth factor receptor (EGFR, erbB1) and human epidermal growth factor receptor 2 (Her2, erbB2), to a precursor compound for use in its synthesis, to methods for the preparation 18F-labeled afatinib, as well as to the use thereof in in vivo diagnosis, tumor imaging or patient stratification on the basis of mutational status of EGFR (erbB1) and Her2 (erbB2).

    Abstract translation: 描述了用于正电子发射断层扫描（PET）或单光子发射计算机断层摄影（SPECT）成像的新型放射性示踪剂。 具体地说，本发明涉及适用于成像表皮生长因子受体（EGFR，erbB1）和人表皮生长因子受体2（Her2，erbB2）的PET或SPECT示踪剂的18F-标记的阿片碱，用于其合成中的前体化合物 ，用于制备18F标记的阿伐替尼的方法，以及其在体内诊断，肿瘤成像或患者分层中的用途，其基于EGFR（erbB1）和Her2（erbB2）的突变状态。

    BIOMARKERS
    18.
    发明申请
    BIOMARKERS 审中-公开
    生物标志

    公开(公告)号：US20150141273A1

    公开(公告)日：2015-05-21

    申请号：US14396522

    申请日：2013-04-26

    Applicant: STICHTING VU-VUMC

    Inventor： Linda Janna Willemien Bosch ,  Meike De Wit ,  Beatriz Pinto Morais de Carvalho ,  Remond Johnnes Adriaan Fijneman ,  Gerrit Albert Meijer ,  Comelia Ramona Jimenez ,  Sander Rogier Piersma ,  Viet Thang Pham ,  Gideon Oudgenoeg

    IPC: G01N33/68 ,  G01N33/574

    CPC classification number: G01N33/57419 ,  G01N33/6848 ,  G01N2500/10 ,  G01N2570/00 ,  G01N2800/7028

    Abstract: The invention provides a method for screening for colorectal cancer, the method comprising: screening a biological sample from an individual for one or more biomarkers selected from the group defined in Table 1 and/or Table 6, wherein the presence of or increased expression of the one or more biomarkers relative to a control sample is indicative that the individual is at risk of suffering from or is suffering from colorectal cancer. The invention also provides an array and kit suitable for use in the methods of the invention, methods of treating colorectal cancer and therapeutic agents for use in methods of treating cancer.

    Abstract translation: 本发明提供了筛选结肠直肠癌的方法，该方法包括：从个体中筛选一种或多种选自表1和/或表6中定义的组的生物标志物的生物样品，其中存在或增加表达 一个或多个相对于对照样品的生物标志物表明个体处于患有或正在患有结肠直肠癌的风险中。 本发明还提供适用于本发明方法的阵列和试剂盒，治疗结肠直肠癌的方法和用于治疗癌症的方法中的治疗剂。

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