公开(公告)号：US20150174153A1

公开(公告)日：2015-06-25

申请号：US14414994

申请日：2013-07-16

Applicant: UNIVERSITE CLAUDE BERNARD LYON I ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON ,  UNIVERSITE JEAN MONNET. SAINT ETIENNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

Inventor： Fatiha Nothias ,  Sylvia Soares ,  Laurent David ,  Alexandra Montembault

IPC: A61K31/722 ,  A61K45/06 ,  A61K9/16

CPC classification number: A61K31/722 ,  A61K9/16 ,  A61K45/06 ,  A61L27/20 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/32 ,  C08L5/08

Abstract: The present invention relates to chitosan hydrogel microparticles of a median size d50 comprised between 1 and 500 μm (obtained from a number distribution), the chitosan having a degree of acetylation of less than equal to 20% and its concentration in the hydrogel being comprised between 0.25 and 5% by weight based on a total weight of the hydrogel, for use in neuron regeneration and/or in the repair of the nervous system, advantageously of the central nervous system, and/or in the grafting of neurons and/or in the treatment of neurodegenerative diseases and/or in the treatment of paralyses.It also relates to an implant comprising an aqueous suspension of microparticles mixed with Schwann cells and/or stem cells and/or trophic factors.

Abstract translation: 本发明涉及中等尺寸d50的壳聚糖水凝胶微粒，其含量在1〜500μm之间（从数量分布得到），乙酰化程度小于等于20％的壳聚糖，其水凝胶中的浓度在 0.25和5重量％，基于水凝胶的总重量，用于神经元再生和/或神经系统的修复，有利的是中枢神经系统和/或在神经元的嫁接和/或在 治疗神经变性疾病和/或治疗麻痹症。 它还涉及包含与雪旺细胞和/或干细胞和/或营养因子混合的微粒的水性悬浮液的植入物。

公开(公告)号：US20250136715A1

公开(公告)日：2025-05-01

申请号：US18835795

申请日：2023-02-03

Applicant: GCS INSTITUT DE CANCEROLOGIE STRASBOURG EUROPE ,  MEXBRAIN ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON

Inventor： Alexandre DETAPPE ,  Xavier PIVOT ,  Pierre COLIAT ,  Olivier TILLEMENT ,  Thomas GREA ,  François LUX ,  Laurent DAVID

IPC: C07K16/32 ,  A61K47/36 ,  C07K16/28

Abstract: A pharmaceutical formulation of a pharmaceutically active protein including an effective amount of a protein or a combination of proteins, a chitosan A and at least one statistic polysaccharide B. Also, a kit including the at least one first container containing the chitosan A and the statistic polysaccharide B and at least one second container containing the protein or combination of proteins. Further, the pharmaceutical formulation or the kit for use in the treatment of cancer, typically breast or gastric cancer.

公开(公告)号：US20240094205A1

公开(公告)日：2024-03-21

申请号：US18264965

申请日：2022-02-11

Applicant: UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT ETIENNE ,  BIOSPEEDIA

Inventor： Evelyne BEGAUD ,  Yves GERMANI ,  Bruno POZZETTO ,  Thomas BOURLET ,  Cyrille Hedi HADDAR ,  Sylvie PILLET ,  Sandra MOUNIER

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  G01N2333/165 ,  G01N2469/10

Abstract: The invention relates to a method for in vitro diagnosis of a viral infection due to the presence of a vims in a subject,



comprising a step of detecting at least one antigen specific for said vims by means of an immunological test carried out on a biological
sample from said subject, characterized in that said biological sample consists of a combination of saliva and secretions from the anterior
nasal vestibule of the subject.

公开(公告)号：US20230288430A1

公开(公告)日：2023-09-14

申请号：US17923161

申请日：2021-05-04

Applicant: Etablissement Français du Sang ,  UNIVERSITE JEAN MONNET SAINT ETIENNE MAISON DE L'UNIVERSITE 10 RUE TREFILERIE 42100 SAINT-ETIENNE

Inventor： Fabrice COGNASSE ,  Thi Kim Anh NGUYEN-PEYRE ,  Olivier GARRAUD ,  Hind HAMZEH-COGNASSE

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2333/70596 ,  G01N2333/912 ,  G01N2333/523 ,  G01N2333/70578 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/7095

Abstract: The present invention relates to a method for detecting inflammation-related platelet activation, comprising measuring the quantity, concentration and/or the proportion of seven specific biomarkers representative of 47 intra-platelet, soluble and membrane molecules, in a biological sample. Said panel of seven biomarkers is particularly useful for implementing a method of diagnosing inflammation-related platelet activation in an individual, a method for monitoring the efficacy of a curative or preventive treatment of an inflammatory disease in an individual and/or a method for monitoring the development of an inflammatory disease associated with inflammation-related platelet activation in an individual.
The present invention also relates to a kit for detecting inflammation-related platelet activation, as well as the use thereof.

公开(公告)号：US20230236542A1

公开(公告)日：2023-07-27

申请号：US18012045

申请日：2021-06-23

Applicant: Biomerieux ,  Universite Jean Monnet Saint Etienne ,  Centre National de la Recherche Scientifique (CNRS)

Inventor： Nicolas Faure ,  Frédéric Pinston ,  Corinne Fournier ,  Loïc Denis ,  Thomas Olivier

IPC: G03H1/04 ,  G03H1/02 ,  G03H1/08 ,  G03H1/00

CPC classification number: G03H1/0406 ,  G03H1/02 ,  G03H1/0808 ,  G03H1/0005 ,  G03H2001/0088 ,  G03H2001/0044 ,  G03H2001/0204 ,  G03H2210/50 ,  G03H2001/0212

Abstract: A focus adjustment method for acquiring an image of a surface of interest of a sample by a holographic imager includes the steps of:



placing the sample including at least one reference object having a known shape and described by characterising parameters having at least position parameters
acquiring an image and determining the position of the reference object with respect to the acquisition plane, by applying a light diffraction model involving the spatial parameters of the reference object estimated by approximating the appearance of the reference object in the holographic image acquired, and
determining the position of the surface of interest with respect to the acquisition plane from a position of the reference object and focus adjustment of the image acquisition.

公开(公告)号：US20220257418A1

公开(公告)日：2022-08-18

申请号：US17735417

申请日：2022-05-03

Applicant: UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Aurelien BERNARD ,  Philippe GAIN ,  Cyril MAUCLAIR ,  Gilles THURET

IPC: A61F9/008 ,  B23K26/067 ,  B23K26/38 ,  A61F9/009 ,  A61F9/013

Abstract: A device for cutting human or animal tissue including a femtosecond laser that can emit a L.A.S.E.R. beam in the form of impulses. The device directs and focuses the beam onto or into the tissue for the cutting thereof. The device further includes and element to shape the L.A.S.E.R. beam, positioned in the trajectory of the beam, and to modulate the energy distribution of the L.A.S.E.R. beam in the focal plane thereof, corresponding to the cutting plane.

公开(公告)号：US11176727B2

公开(公告)日：2021-11-16

申请号：US16303948

申请日：2017-05-26

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITÉ CLAUDE BERNARD LYON 1 ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Romeo Salemme ,  Alessandro Farne ,  Valérie Gaveau ,  Anaël Belle ,  Eric Koun ,  Francesco Pavani

IPC: G06T15/00 ,  G06T7/70 ,  A61B5/16 ,  A61B5/00 ,  A61B5/11 ,  A61B5/12 ,  G06F3/01 ,  G06T7/20 ,  H04S7/00

Abstract: This method for acquiring a spatial map of auditory perception of a subject comprises a plurality of successive test sequences, each test sequence comprising steps of: a) calibration (1002) of the subject's position, by displaying instructions to the subject, using a head-mounted visual display system worn by the subject, in order to acquire a reference position of the subject, the subject's position being measured using a video motion capture system by measuring the spatial coordinates of a first optical marker worn by the subject, b) choosing (1004) spatial coordinates of a target location of a sound source, said target cation being located around the subject, c) emitting (1006) a predefined sound, using a sound source placed at said target location, d) in response to acquisition instructions generated by the subject using an acquisition interface, acquiring (1008) an estimated location of said sound source, by using the video motion capture system to measure the spatial coordinates of a second optical marker held and pointed by the subject towards a perceived location of the sound source.

公开(公告)号：US10969678B2

公开(公告)日：2021-04-06

申请号：US16311287

申请日：2017-06-21

Applicant: H.E.F. ,  UNIVERSITE JEAN MONNET SAINT ETIENNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Inventor： Maxime Bichotte ,  Yves Jourlin ,  Laurent Dubost

IPC: G03F1/68

Abstract: The invention relates to a system (2) for producing an optical mask (35) for surface treatment, in particular surface microtexturing, said system (2) comprising: a layer of material (20) which has an outer surface (21) that is exposed to the outside environment; and a generating and depositing device for generating and depositing droplets (30) on the outer surface (21) of the layer of material (20) in which a specific arrangement (31), forming the optical mask (35) on the outer surface (21) of the layer of material (20). The invention also relates to a treatment plant comprising a system (2) of said type. The invention further relates to a method for producing a mask as well as to a method for surface treatment.

公开(公告)号：US20210071033A1

公开(公告)日：2021-03-11

申请号：US16971059

申请日：2019-02-27

Applicant: ELKEM SILICONES France SAS ,  Institut National des Sciences Appliquées LYON ,  Université Claude Bernard Lyon 1 ,  Centre national de la recherche scientifique ,  UNIVERSITE JEAN MONNET SAINT ETIENNE

Inventor： François GANACHAUD ,  Daniel PORTINHA DE ALMEIDA ,  Etienne FLEURY ,  Gabriel DUAUX ,  Aymeric GENEST ,  Emmanuel POUGET

IPC: C09D183/08 ,  C08L83/08

Abstract: Silicone material obtained by a reaction between:—at least one organopolysiloxane (A) that has a molar mass of less than 70,000 g/mol, preferably less than 50,000 g/mol, and contains siloxyl units I.1 and I.2; and—at least one organic compound (B) carrying at least two carboxylic acid groups and having no unsaturation. Y a  Z b 1  SiO 4 - ( a + b ) 2 ( I  .1 ) Z c 2  SiO 4 - c 2 ( I  .2 )

公开(公告)号：US20180046087A1

公开(公告)日：2018-02-15

申请号：US15552951

申请日：2016-02-22

Applicant: Wolfgang IFF ,  Universite Jean Monnet Saint Etienne ,  Centre National De la Recherche Scientifique

Inventor： Wolfgang IFF ,  Alexandre TISHCHENKO

IPC: G03F7/20 ,  G06F17/12

CPC classification number: G03F7/70158 ,  G03F7/70316 ,  G03F7/705 ,  G03F7/70958 ,  G06F17/12

Abstract: The invention concerns a numerical calculation procedure of the diffraction of a structure (1) whose numerical model defines the dielectric permittivity at each point comprizing the steps of: definition of a numerical modellization of the diffraction model of a structure including: the splitting of the numerical model of the dielectric permittivity into N numerical models of dielectric permittivity; the determination of the diffraction model of the said layers from the numerical model of this layer; numerical calculation of the diffraction of the structure including: an initial iteration during which one performs: one wave propagation in the direction of layers 1 to N, and one wave propagation in the direction of the layers N to 1, ulterior iterations, each ulterior iteration of index k including: one wave propagation in the direction of layers 2 to N: one wave propagation in the direction of layers N−1 to 1.