公开(公告)号：US20240375104A1

公开(公告)日：2024-11-14

申请号：US18691779

申请日：2022-09-13

Applicant: Nathan SWAMI ,  James P. LANDERS ,  Vahid FARMEHINI ,  Sadie Marie KIENDZIOR ,  UNIVERSITY OF VIRGINIA ,  University Of Virginia Patent Foundation

Inventor： Nathan Swami ,  James P. Landers ,  Vahid Farmehini ,  Sadie Marie Kiendzior

IPC: B01L3/00 ,  B06B1/06

Abstract: A circuit implementation for on-chip real-time resonance frequency measurement and feedback control may be used to provide improved selective particle trapping. The circuit may be based on monitoring current drawn from the amplifier used to stimulate the piezo transducer, as the high impedance measurement sensitivity in this mode does not lower the power available for stimulation of the piezo transducer. The enhanced level of control of acoustic trapping using this current mode may be used for various localized channel perturbations, including drift, wash steps and buffer swaps, as well as for selective sperm cell trapping from a heterogeneous sample that includes lysed epithelial cells.

公开(公告)号：US20240361226A1

公开(公告)日：2024-10-31

申请号：US18765836

申请日：2024-07-08

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Nathan SWAMI ,  Walter VARHUE ,  Vahid FARMEHINI

IPC: G01N15/1031 ,  B01L3/00 ,  G01N15/01 ,  G01N33/483 ,  G01R27/16

CPC classification number: G01N15/1031 ,  B01L3/502715 ,  B01L3/502761 ,  G01N33/4833 ,  G01R27/16 ,  B01L2200/0647 ,  B01L2300/0627 ,  G01N15/01

Abstract: An exemplary method and system is disclosed that facilitate the integration of on-chip impedance sensors and measurement circuitries, e.g., in characterizing internal microfluidic structures and/or in cell or particle cytometry, for quantifying the impedance/frequency response of microfluidic device under the same, or similar, conditions used for particle manipulation. In some embodiments, the exemplary method and system employs a circuit configured for automated determination and quantification of parasitic voltage drops during AC electrokinetic particle manipulation, without the need to use valuable biological samples or model particles. The determined impedance response can be used to assess efficacy of the microfluidic device geometry as well as to provide control signals to inform downstream cell separation decisions.

公开(公告)号：US20240342310A1

公开(公告)日：2024-10-17

申请号：US18625283

申请日：2024-04-03

Applicant: University of Virginia Patent Foundation ,  Sun Yat Sen Memorial Hospital, Sun Yat Sen University

Inventor： Hui Li ,  Qiong Wang ,  Hai Huang

IPC: A61K48/00 ,  A61K38/00 ,  A61P35/00 ,  C07K14/47

CPC classification number: A61K48/005 ,  A61P35/00 ,  C07K14/47 ,  A61K38/00 ,  C07K2319/02

Abstract: Disclosed herein are peptides and peptidomimetics that inhibit the progression of prostate cancer by up-regulating FLRT3. Also disclosed are methods for treating an FLRT3-attenuated cancer in a subject that involve administering to the subject the disclosed polypeptide or peptidomimetic or a polynucleotide encoding the disclosed peptide.

公开(公告)号：US12115182B2

公开(公告)日：2024-10-15

申请号：US17831191

申请日：2022-06-02

Applicant: University of Maryland, Baltimore ,  University of Virginia Patent Foundation

Inventor： Christine Lau ,  Yunge Zhao ,  Joel M. Linden ,  Barbara J. Mann ,  Preeti Chhabra ,  Kenneth Lewis Brayman ,  Sanford Feldman

IPC: A61K31/7076 ,  A61K31/404 ,  A61K31/519 ,  A61K31/53 ,  A61K45/06 ,  A61P31/14 ,  A61P37/06

CPC classification number: A61K31/7076 ,  A61K31/404 ,  A61K31/519 ,  A61K31/53 ,  A61K45/06 ,  A61P31/14 ,  A61P37/06

Abstract: The present invention relates methods of treating cytokine storm syndrome comprising administering to a patient in need thereof a therapeutically effective amount of an adenosine A2A receptor agonist.

公开(公告)号：US20240293047A1

公开(公告)日：2024-09-05

申请号：US18278549

申请日：2022-02-23

Applicant: University of Virginia Patent Foundation

Inventor： BORIS P. KOVATCHEV ,  MARC D. BRETON ,  CHIARA FABRIS ,  DAYU LV

IPC: A61B5/145 ,  A61B5/00 ,  G16H10/20 ,  G16H20/17 ,  G16H50/20 ,  G16H50/50

CPC classification number: A61B5/14532 ,  A61B5/7264 ,  G16H10/20 ,  G16H20/17 ,  G16H50/20 ,  G16H50/50

Abstract: Provided are a method, system and computer-readable storage medium for quantitative physiological assessment and prediction of clinical subtypes of glucose metabolism disorders, including but not limited to, Type 1 diabetes, obesity, pre-diabetes, gestational diabetes, or variants of Type 2 diabetes. The method allows a virtual population of in silico entities to be created, reproducing faithfully the clinical subtype distributions observed in vivo. Potential applications of this method may include, but are not limited to: (a) enabling in silico experiments assessing and/or predicting, for a real patient, treatment or intervention outcomes for a given population/clinical-subtype level; (b) pre-clinical testing of properties of new medications; (c) augmenting limited clinical trial data with in silico experiments to an extent that the domain of their validity and test corner cases may not be observed in vivo.

公开(公告)号：US20240245849A1

公开(公告)日：2024-07-25

申请号：US18599531

申请日：2024-03-08

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Marc D. BRETON ,  Stephen D. PATEK ,  Boris P. KOVATCHEV

IPC: A61M5/142 ,  A61B5/00 ,  A61B5/145 ,  A61M5/168 ,  A61M5/172 ,  G16H10/65 ,  G16H20/17 ,  G16H40/60 ,  G16H40/63 ,  G16H50/20

CPC classification number: A61M5/142 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/486 ,  A61B5/4866 ,  A61B5/7275 ,  A61B5/746 ,  A61M5/168 ,  A61M5/172 ,  A61M5/1723 ,  G16H10/65 ,  G16H20/17 ,  G16H40/60 ,  G16H40/63 ,  G16H50/20 ,  A61M2005/14208 ,  A61M2205/18 ,  A61M2205/3576 ,  A61M2205/502 ,  A61M2205/507

Abstract: An insulin monitoring system includes one or more processors, one or more computer-readable storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include: first program instructions to track, in real time, the amount of insulin active in a patient; second program instructions to calculate the amount of insulin need of the patient by tracking the patient's metabolic states; third program instructions to compare the insulin active in the patient with the insulin need of the patient; and fourth program instructions to determine an insulin fault level based on the comparison.

公开(公告)号：US12042530B2

公开(公告)日：2024-07-23

申请号：US17170044

申请日：2021-02-08

Applicant: University of Virginia Patent Foundation ,  The University of Birmingham

Inventor： Donald F. Hunt ,  Jeffrey Shabanowitz ,  Stacy Alyse Malaker ,  Victor H. Engelhard ,  Angela L. Ambakhutwala ,  Kara L. Cummings ,  Rebecca C. Obeng ,  Mark Cobbold

IPC: A61K38/00 ,  A61K35/15 ,  A61K35/17 ,  A61K39/00 ,  A61K45/06 ,  C07K16/28 ,  G01N33/574 ,  G01N33/68

CPC classification number: A61K39/0011 ,  A61K35/15 ,  A61K35/17 ,  A61K39/001106 ,  A61K39/00111 ,  A61K39/001113 ,  A61K39/001132 ,  A61K39/001151 ,  A61K39/001156 ,  A61K39/001157 ,  A61K39/001162 ,  A61K39/001164 ,  A61K39/001166 ,  A61K39/001181 ,  A61K39/001182 ,  A61K39/001184 ,  A61K39/001186 ,  A61K39/001188 ,  A61K39/001189 ,  A61K39/00119 ,  A61K39/001192 ,  A61K39/001193 ,  A61K39/001194 ,  A61K39/001195 ,  A61K39/001197 ,  A61K45/06 ,  C07K16/2809 ,  C07K16/2833 ,  G01N33/57496 ,  G01N33/6863 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55516 ,  A61K2039/57 ,  C07K2317/31

Abstract: A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of disease cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., cancer, (b) to function as immunotherapeutics in adoptive T cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex.

公开(公告)号：US20240219501A1

公开(公告)日：2024-07-04

申请号：US18402720

申请日：2024-01-02

Applicant: University of Virginia Patent Foundation

Inventor： Zhixing Wang ,  John P. Mugler, III ,  Craig H. Meyer ,  Adrienne E. Campbell

IPC: G01R33/563 ,  G01R33/56 ,  G01R33/561 ,  G01R33/565

CPC classification number: G01R33/56341 ,  G01R33/5608 ,  G01R33/5617 ,  G01R33/56509

Abstract: Acquiring magnetic resonance imaging (MRI) data includes steps of using a computer to implement software program steps in a diffusion preparation software component and a spiral ring echo readout software component. The method implements the diffusion preparation software component by (i) applying at least a first diffusion gradient and a last diffusion gradient along a selected direction; and (ii) applying a magnitude stabilizer gradient, along said selected direction, after the last diffusion gradient. The method implements the spiral ring echo readout software component by (i) applying a rephasing gradient along said selected direction after a refocusing RF pulse; (ii) applying a dephasing gradient along said selected direction prior to a subsequent refocusing RF pulse; and (iii) acquiring spiral ring echo readout data between the refocusing RF pulse and the subsequent refocusing RF pulse.

公开(公告)号：US20240209007A1

公开(公告)日：2024-06-27

申请号：US18284962

申请日：2022-03-29

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Robert Jerard GILLIARD, Jr. ,  Kelsie E. KRANTZ

IPC: C07F5/02

CPC classification number: C07F5/027

Abstract: Disclosed herein are anionic boron compounds. The anionic boron compounds include anionic boronic heterocycles. optionally ligated with carbenes. The anionic boron compounds are useful synthetic intermediates for boron heterocycles, as well as for sensing applications.

公开(公告)号：US12016588B2

公开(公告)日：2024-06-25

申请号：US17046428

申请日：2019-04-10

Applicant: University of Virginia Patent Foundation

Inventor： John A. Hossack ,  Nishaki Mehta

IPC: A61B17/3211 ,  A61B17/00 ,  A61B17/32

CPC classification number: A61B17/3211 ,  A61B2017/00876 ,  A61B2017/320052 ,  A61B2017/32113

Abstract: A surgical incision apparatus and method for puncturing a cutaneous layer of a subject for providing guided access to a subcutaneous organ or subcutaneous cavity (or specified target region) of the subject. The apparatus may include a retention body configured for securing a cutting tool therein and a housing configured for receiving the retention body. The apparatus includes a guidewire holder member configured for receiving a guidewire therein and aligning with the guidewire to allow the cutting tool to travel along the guidewire. The retention body is configured to be movably attached relative to the housing to allow the retention body and cutting tool to advance toward the subject to a deployed position, and subsequently withdraw to a retracted position.