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11.发明申请公开(公告)号：US20200230198A1
公开(公告)日：2020-07-23
申请号：US16311108
申请日：2017-06-16
摘要： Antiviral protease inhibitors are disclosed, along with related antiviral dipeptidyl compounds, macrocyclic derivatives thereof and methods of using the same to treat or prevent viral infection and disease from coronaviruses, caliciviruses, and picornaviruses.
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公开(公告)号：US10668048B2
公开(公告)日：2020-06-02
申请号：US16048009
申请日：2018-07-27
IPC分类号： A61K31/407 , C07D487/22 , A01N43/90 , C07D273/08 , C07D321/00 , A01N43/72 , A01N43/22 , A61P31/04 , A61K31/357 , A61K31/395
摘要： Antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds comprise a three-dimensional complementary binding pocket for phosphatidylglycerol, disrupting membrane function in a bacteriostatic or bactericidal manner. Methods of inhibiting bacterial growth and/or treating Gram-positive or Gram-negative bacterial infection using such compounds are also disclosed.
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公开(公告)号：US20190213981A1
公开(公告)日：2019-07-11
申请号：US16244981
申请日：2019-01-10
发明人： John David Hunsicker
摘要： Structures and methods are provided for adjusting a size of a slide ring aperture for a musical instrument. Embodiments include a trumpet slide ring spacer adapted to be mounted on an instrument and retained within a valve slide ring.
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公开(公告)号：US20190145375A1
公开(公告)日：2019-05-16
申请号：US16186876
申请日：2018-11-12
IPC分类号： F03D1/06
摘要： A winglet is provided for retrofitting to a wind turbine. Aerodynamic and centrifugal forces for winglets having a range of configurations including winglet height, taper ratio, twist, and cant angle are modeled, wherein the winglet height, taper ratio, twist, and cant angle are used to define a grid in a Vector Lattice. An increase in a coefficient of power Cp of each winglet design when applied to a predetermined main blade of the wind turbine can be determined. A winglet configuration can then be selected wherein the coefficient of power Cp of the main blade and winglet is at least 2% greater than the coefficient of power Cp of the main blade alone, and wherein a ratio of normal aerodynamic force generated by the winglet to centrifugal force generated by the winglet during rotation at a nominal rated speed is in a range between 0.75 and 2.
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公开(公告)号：US20190072395A1
公开(公告)日：2019-03-07
申请号：US16123659
申请日：2018-09-06
摘要： An automated process designs an indoor wayfinding system using wireless beacons interacting with a mobile smartphone to guide a user to a destination. Image processing and computational geometric techniques extracting necessary information about an indoor space to determine beacon placement and support path computations for navigation. An architectural floor plan of the indoor space of interest is scanned to extract all the points of interest (doors, stairs, elevators, etc.), to identify walking paths within this space, and to create a connectivity graph representation of the space upon which path computations for navigation can be performed. Optimized locations where beacons should be placed on the indoor floor plan are identified very quickly and with minimal effort.
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公开(公告)号：US20190056353A1
公开(公告)日：2019-02-21
申请号：US16078847
申请日：2017-04-12
IPC分类号： G01N27/62 , H01J49/00 , G01R23/165 , G01R23/20
摘要： Method and apparatus for generating asymmetric high-voltage waveforms with near-rectangular profiles. The method comprises producing selected low-frequency components of the Fourier series for a rectangular waveform explicitly and adding them to the amplified residual of lower-amplitude near-rectangular waveform upon filtering out certain frequencies.
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公开(公告)号：US10188716B2
公开(公告)日：2019-01-29
申请号：US15886112
申请日：2018-02-01
发明人： James G. Bann , Masaru Miyagi
IPC分类号： A61K39/002 , A61K39/07 , A61K39/40 , A61K45/06 , A61K39/00
摘要： Immunogenic compositions against Bacillus anthracis comprising a stabilized protective antigen complex are disclosed. The stabilized complex comprises protective antigen protein and capillary morphogenesis protein-2, with the capillary morphogenesis protein-2 being bound to the protective antigen protein along a binding interface. The stabilized protective antigen complex has increased thermal and structural stability, along with resistance to premature proteolytic degradation. Methods of using the same to induce an immunogenic response in a subject against B. anthracis infection are also disclosed.
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18.发明授权Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses 有权针对微小核糖核酸病毒超级集群的3C或3C样蛋白酶的广谱抗病毒药物：小核糖核酸病毒，杯状病毒和冠状病毒公开(公告)号：US09474759B2
公开(公告)日：2016-10-25
申请号：US14347756
申请日：2012-09-27
申请人： Kansas State University Research Foundation , The Ohio State University , Wichita State University
发明人： Kyeong-Ok Chang , Yunjeong Kim , William C. Groutas , Duy Hua , Linda J. Saif
IPC分类号： A61K38/06 , A61K31/5377 , A61K31/4015 , A61K31/422 , A61K31/427 , A61K45/06 , C07D207/27
CPC分类号： A61K31/5377 , A61K31/4015 , A61K31/422 , A61K31/427 , A61K38/06 , A61K45/06 , C07D207/27 , C12N2770/16011 , C12N2770/20011 , C12N2770/32111 , C12N2770/32311 , C12N2770/32411 , C12N2770/32611 , Y02A50/463
摘要： Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl α-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.
摘要翻译： 公开了抗病毒蛋白酶抑制剂，包括肽基醛，肽基α-酮酰胺，硫酸氢酯盐和肽基杂环，以及相关的抗病毒化合物，以及使用它们来治疗或预防病毒感染和疾病的方法。 该化合物对属于小核糖核酸病毒超级群集的病毒具有广谱活性，其包括重要的人和动物病原体，包括诺维病毒，肠道病毒，脊髓灰质炎病毒，口蹄疫病毒，甲型肝炎病毒，人类鼻病毒（常见病因 感冒），人类冠状病毒（普通感冒的另一原因），传染性胃肠炎病毒，鼠肝炎病毒，猫感染性腹膜炎病毒和严重急性呼吸综合征冠状病毒。
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公开(公告)号：US20160270945A1
公开(公告)日：2016-09-22
申请号：US15027984
申请日：2014-10-06
发明人： John S. Tomblin , Thomas Aldag , William T. McCarvill , Kimberly M. Reuter , Joel D. White , Andrea C. Meyer
CPC分类号： A61F5/05825 , A61F5/01 , A61F5/05841 , A61F5/0585 , A61F13/04 , A61L15/08 , A61L15/12 , A61L15/125 , A61L15/14 , C08L35/04 , C08L33/10
摘要： A fiber-reinforced composite article useful in supporting or immobilizing an injured body part is disclosed. The composite is a multi-layer, flexible precursor including fiber reinforcement plies, which can be rapidly cured into a rigid body using a thermosetting resin. Methods of making and using the same are also disclosed, along with kits containing such composite articles.
摘要翻译： 公开了一种用于支撑或固定受伤身体部位的纤维增强复合制品。 该复合材料是包括纤维增强层的多层柔性前体，其可以使用热固性树脂快速固化成刚体。 还公开了制备和使用它们的方法，以及含有这种复合制品的试剂盒。
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公开(公告)号：US20160066835A1
公开(公告)日：2016-03-10
申请号：US14785261
申请日：2014-01-16
发明人： Jibo He , Jeremy Patterson
CPC分类号： A61B5/486 , A61B5/0077 , A61B5/0205 , A61B5/024 , A61B5/02438 , A61B5/1032 , A61B5/14542 , A61B5/14546 , A61B5/6895 , A61B5/6897 , A61B5/6898 , A61B5/7257 , A61B5/742 , A61B2503/10 , A63B24/0062 , A63B24/0075 , A63B24/0087 , A63B71/0619 , A63B2024/0065 , A63B2024/0068 , A63B2220/806 , A63B2230/06
摘要： A method, system, and computer program for non-invasively monitoring a physiological parameter and providing biofeedback. The method, system, and computer program provide for the non-invasive detection of a physiological parameter by detecting changes in color channel values of a user in a live video feed and presenting biofeedback to the user indicating the relative position of the physiological parameter to an optimal range.
摘要翻译： 一种用于非侵入性监测生理参数并提供生物反馈的方法，系统和计算机程序。 方法，系统和计算机程序通过检测实况视频馈送中的用户的颜色通道值的变化并向用户呈现生理参数来指示生理参数的相对位置来提供对生理参数的非侵入性检测 最佳范围。
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