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11.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 125P5C8 USEFUL IN TREATMENT AND DETECTION OF CANCER 失效核酸和相关蛋白125P5C8有效治疗和检测癌症公开(公告)号：US20100266498A1
公开(公告)日：2010-10-21
申请号：US12820083
申请日：2010-06-21
申请人： Mary FARIS , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
发明人： Mary FARIS , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
IPC分类号： A61K51/10 , C07K14/435 , A61K39/395 , A61P35/00 , G01N33/53 , C12Q1/68 , C12N5/09
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , Y02A50/466
摘要： A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 125P5C8 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为125P5C8）及其编码的蛋白及其变体，其中125P5C8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，125P5C8提供诊断，预后， 癌症的预防和/或治疗靶标。 125P5C8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与125P5C8反应的抗体或T细胞可用于主动或被动免疫。
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12.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 151P3D4 USEFUL IN TREATMENT AND DETECTION OF CANCER 失效核酸和相关蛋白151P3D4用于治疗和检测癌症公开(公告)号：US20100168214A1
公开(公告)日：2010-07-01
申请号：US12687768
申请日：2010-01-14
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： A61K31/7088 , C07H21/04 , C12N15/83 , C12N5/00 , C12P21/06
CPC分类号： C07K14/47 , A61K38/00 , C12N9/78 , Y10T436/25
摘要： A novel gene (designated 151P3D4) and its encoded protein, and variants thereof, are described wherein 151P3D4 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 151P3D4 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 151P3D4 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 151P3D4 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为151P3D4）及其编码的蛋白及其变体，其中151P3D4在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，151P3D4提供诊断，预后， 癌症的预防和/或治疗靶标。 151P3D4基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与151P3D4反应的抗体或T细胞可用于主动或被动免疫。
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13.发明授权Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers 有权核酸和相应的蛋白质可用于检测和治疗各种癌症公开(公告)号：US07736654B2
公开(公告)日：2010-06-15
申请号：US10121024
申请日：2002-04-10
申请人： Aya Jakobovits , Pia M. Challita-Eid , Mary Faris , Wangmao Ge , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Arthur B. Raitano , Daniel E. H. Afar
发明人： Aya Jakobovits , Pia M. Challita-Eid , Mary Faris , Wangmao Ge , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Arthur B. Raitano , Daniel E. H. Afar
IPC分类号： A61K39/00
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.
摘要翻译： 图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此， 基因 2提供癌症的诊断，预后，预防和/或治疗靶点。 图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。
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14.发明申请公开(公告)号：US20100055120A1
公开(公告)日：2010-03-04
申请号：US12561832
申请日：2009-09-17
CPC分类号： C07K14/4748 , A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/53 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/73 , G01N33/566 , G01N33/57415 , Y02A50/466
摘要： PSCA and its encoded protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, propylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译： PSCA及其编码的蛋白质及其变体，其中PSCA在正常成人组织中显示组织特异性表达，并且在表I中列出的癌症中异常表达。因此，PSCA提供诊断，预后，丙糖和/或治疗靶标 为癌症。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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15.发明授权Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer 有权核酸和相应的标题为161P2F10B的蛋白质可用于治疗和检测癌症公开(公告)号：US07667018B2
公开(公告)日：2010-02-23
申请号：US11655822
申请日：2007-01-19
申请人： Aya Jakobovits , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Wangmao Ge , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Pia M. Challita-Eid
发明人： Aya Jakobovits , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Wangmao Ge , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Pia M. Challita-Eid
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K16/40 , C07K2317/20 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/30 , C12N9/16 , C12Q1/6886 , C12Q2600/158 , G01N33/57492 , Y02A50/466
摘要： A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 描述了新颖的基因0161P2F10B（也称为161P2F10B）及其编码的蛋白质及其变体，其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，161P2F10B提供了诊断， 癌症的预后，预防和/或治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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16.发明申请NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 254P1D6B USEFUL IN TREATMENT AND DETECTION OF CANCER 失效核酸和相关蛋白质被授予254P1D6B有用的治疗和检测癌症公开(公告)号：US20090263318A1
公开(公告)日：2009-10-22
申请号：US12405166
申请日：2009-03-16
申请人： ARTHUR B. RAITANO , AYA JAKOBOVITS , PIA M. CHALLITA-EID , WANGMAO GE , JUAN J. PEREZ-VILLAR , STEVEN B. KANNER
发明人： ARTHUR B. RAITANO , AYA JAKOBOVITS , PIA M. CHALLITA-EID , WANGMAO GE , JUAN J. PEREZ-VILLAR , STEVEN B. KANNER
IPC分类号： A61K51/10 , C07K16/18 , A01K67/027 , C12N5/16 , C12N5/00 , A61K39/395 , G01N33/566 , A61P35/00
CPC分类号： C07K14/47
摘要： A novel gene 254P1D6B and its encoded protein, and variants thereof, are described wherein 254P1D6B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 254P1D6B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 254P1D6B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 254P1D6B can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因254P1D6B及其编码的蛋白及其变体，其中254P1D6B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，254P1D6B提供诊断，预后，预防和/ 或癌症的治疗靶标。 254P1D6B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与254P1D6B反应的抗体或T细胞可用于主动或被动免疫。
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17.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 184P1E2 USEFUL IN TREATMENT AND DETECTION OF CANCER 失效核酸和相关蛋白质184P1E2有用的治疗和检测癌症公开(公告)号：US20090148854A1
公开(公告)日：2009-06-11
申请号：US12357154
申请日：2009-01-21
申请人： Pia M. CHALLITA-EID , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. CHALLITA-EID , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： C12Q1/68 , G01N33/566 , G01N33/53 , C12Q1/02
CPC分类号： C07K14/47 , A61K38/00 , C12N9/78 , Y10T436/25
摘要： A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 184P1E2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 184P1E2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 184P1E2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为184P1E2）及其编码的蛋白及其变体，其中184P1E2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，184P1E2提供诊断，预后， 癌症的预防和/或治疗靶标。 184P1E2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与184P1E2反应的抗体或T细胞可用于主动或被动免疫。
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18.发明授权Nucleic acid and corresponding protein entitled 85P1B3 useful in treatment and detection of cancer 失效核酸和相应的标题为85P1B3的蛋白质可用于治疗和检测癌症公开(公告)号：US07501502B2
公开(公告)日：2009-03-10
申请号：US11489907
申请日：2006-07-19
申请人： Arthur B. Raitano , Mary Faris , Rene S. Hubert , Daniel Afar , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Mary Faris , Rene S. Hubert , Daniel Afar , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
CPC分类号： C07K14/47
摘要： A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 85P1B3 provides a diagnostic and/or therapeutic target for cancers. The 85P1B3 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
摘要翻译： 描述了一种新型基因（命名为85P1B3）及其编码的蛋白质。 虽然85P1B3在正常成人组织中表现出组织特异性表达，但是在多种癌症中异常表达，如表1所示。因此，85P1B3为癌症提供了诊断和/或治疗靶点。 85P1B3基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。
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19.发明申请Nucleic acids and corresponding proteins entitled 273P4B7 useful in treatment and detection of cancer 审中-公开核酸和相应的蛋白质，名称为273P4B7，可用于治疗和检测癌症公开(公告)号：US20070298424A1
公开(公告)日：2007-12-27
申请号：US11708975
申请日：2007-02-20
申请人： Pia Challita-Eid , Mary Faris , Arthur Raitano , Aya Jakobovits , Wangmao Ge
发明人： Pia Challita-Eid , Mary Faris , Arthur Raitano , Aya Jakobovits , Wangmao Ge
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/567
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 273P4B7 and its encoded protein, and variants thereof, are described wherein 273P4B7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table 1. Consequently, 273P4B7 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 273P4B7 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 273P4B7 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因273P4B7及其编码的蛋白质及其变体，其中273P4B7在正常成人组织中表现出组织特异性表达，并且在表1中列出的癌症中异常表达。因此，273P4B7提供诊断，预后，预防和/ 或癌症的治疗靶标。 273P4B7基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与273P4B7反应的抗体或T细胞可用于主动或被动免疫。
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20.发明授权Antibodies that recognize the 85P1B3 protein useful in treatment and detection of cancer 有权识别85P1B3蛋白的抗体可用于治疗和检测癌症公开(公告)号：US07217799B2
公开(公告)日：2007-05-15
申请号：US09942052
申请日：2001-08-28
申请人： Arthur B. Raitano , Mary Faris , Rene S. Hubert , Daniel E. Afar , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Mary Faris , Rene S. Hubert , Daniel E. Afar , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
CPC分类号： C07K14/47
摘要： A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 85P1B3 provides a diagnostic and/or therapeutic target for cancers. The 85P1B3 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
摘要翻译： 描述了一种新型基因（命名为85P1B3）及其编码的蛋白质。 虽然85P1B3在正常成人组织中表现出组织特异性表达，但是在多种癌症中异常表达，如表1所示。因此，85P1B3为癌症提供了诊断和/或治疗靶点。 85P1B3基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。
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