公开(公告)号：US20150018936A1

公开(公告)日：2015-01-15

申请号：US14498543

申请日：2014-09-26

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Yung-Ming Chen ,  Eric Aldenbrook

IPC: A61F2/89

CPC classification number: A61F2/89 ,  A61F2/82 ,  A61F2/90 ,  A61F2250/0071 ,  B05B13/0235 ,  B05B14/00 ,  B05D1/002 ,  B05D3/0406 ,  B05D2258/02

Abstract: A stent with at least one severable supporting device and methods of coating using the same are disclosed. The severable supporting device can be an end tube or a tab attached to some portion of the stent by at least one “gate” or attachment. The end tube or tab may be part of the design of the stent when it is originally manufactured, or it may be attached to the stent in a secondary process by a biocompatible glue or solder. The end tube or tab can be used to support a stent during a coating process eliminating the need for a mandrel which would otherwise contact the stent during the coating process.

Abstract translation: 公开了具有至少一个可分割支撑装置的支架和使用其的涂覆方法。 可分开的支撑装置可以是通过至少一个“门”或附件附接到支架的一些部分的端管或突出部。 当最初制造时，端管或突片可以是支架的设计的一部分，或者可以通过生物相容的胶或焊料在二次过程中附接到支架。 终端管或接头可用于在涂覆过程中支撑支架，从而消除了在涂覆过程期间将接触支架的心轴的需要。

公开(公告)号：US20140338214A1

公开(公告)日：2014-11-20

申请号：US14302326

申请日：2014-06-11

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Charles R. Bobson ,  Kurt Scheinpflug ,  Yung-Ming Chen ,  Jeff H. Smith

IPC: B05D3/00 ,  A61F2/82 ,  F26B21/00

CPC classification number: B05D3/007 ,  A61F2/82 ,  A61F2240/002 ,  F26B21/004

Abstract: A coating device for coating a medical device with a drug-eluting material uses an in-process drying station between coats to improve a drug release profile. The drying station includes a heat nozzle configured for applying a uniform drying gas.

Abstract translation: 用药物洗脱物质涂覆医疗装置的涂覆装置使用涂层之间的过程中的干燥站来改善药物释放曲线。 干燥台包括配置成施加均匀干燥气体的热喷嘴。

公开(公告)号：US08852670B2

公开(公告)日：2014-10-07

申请号：US14014033

申请日：2013-08-29

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Arkady Kokish ,  Yung-Ming Chen ,  Jason Van Sciver ,  Roberto Listek

IPC: B05C13/00 ,  B05C5/00 ,  B05D3/00 ,  B05D5/00 ,  B05B13/02 ,  A61F2/82

CPC classification number: A61F2/82 ,  B05B13/0242

Abstract: A coating and drying apparatus for the application of a coating substance to a stent and drying the stent is provided.

Abstract translation: 提供了一种用于将涂层物质施用于支架并干燥支架的涂布和干燥装置。

公开(公告)号：US20180154051A1

公开(公告)日：2018-06-07

申请号：US15797218

申请日：2017-10-30

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed F.A. Hossainy ,  Fuh-Wei Tang ,  Lothar W. Kleiner ,  Thierry Glauser ,  Yiwen Tang ,  Wouter E. Roorda ,  Stephen D. Pacetti ,  Gina Zhang ,  Yung-Ming Chen ,  Andrew F. McNiven ,  Sean A. McNiven ,  Brandon J. Yoe

IPC: A61L31/10 ,  A61L27/54 ,  A61L31/16 ,  A61L27/40 ,  A61L27/44 ,  A61L27/50 ,  A61L31/12 ,  A61L31/14

CPC classification number: A61L31/10 ,  A61L27/40 ,  A61L27/44 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00

Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.

公开(公告)号：US20180142952A1

公开(公告)日：2018-05-24

申请号：US15874772

申请日：2018-01-18

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Yung-Ming Chen ,  Matthew J. Gillick ,  Michael T. Martins ,  John E. Papp

IPC: F26B25/06 ,  F26B9/00

CPC classification number: F26B25/066 ,  F26B9/003

Abstract: A coating device for coating a medical device with a drug-eluting material uses an in-process drying station between coats to improve a drug release profile. The drying station includes a dryer having a telescoping plenum which provides a drying chamber for the stent or scaffold to reside while a heated gas is passed over the stent/scaffold. The drying chamber improves efficiency in drying, predictability or drug release rate, uniformity of coating material properties lengthwise over the stent/scaffold and provides a platform that can effectively support stents that are over 40 mm in length.

公开(公告)号：US09821091B2

公开(公告)日：2017-11-21

申请号：US13953656

申请日：2013-07-29

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed F. A. Hossainy ,  Fuh-Wei Tang ,  Lothar W. Kleiner ,  Thierry Glauser ,  Yiwen Tang ,  Wouter E. Roorda ,  Stephen D. Pacetti ,  Gina Zhang ,  Yung-Ming Chen ,  Andrew F. McNiven ,  Sean A. McNiven ,  Brandon J. Yoe

IPC: A61L31/10 ,  A61L27/40 ,  A61L27/44 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61L27/40 ,  A61L27/44 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00

Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.

公开(公告)号：US09500409B2

公开(公告)日：2016-11-22

申请号：US14177485

申请日：2014-02-11

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Sidney Watterodt ,  Sang joon Park ,  David Rego ,  Anthony S. Andreacchi ,  Yung-Ming Chen ,  Arnoldo M. Currlin ,  Antonio Garcia ,  Jason Van Sciver ,  Bryan D. Glenn ,  Matthew J. Gillick ,  John E. Papp

IPC: F26B25/06 ,  F26B15/04 ,  F26B25/00 ,  B23K26/40 ,  A61F2/91

CPC classification number: F26B25/003 ,  A61F2/91 ,  B23K26/402 ,  B23K2103/42 ,  B23K2103/50 ,  F26B15/04 ,  F26B15/18 ,  F26B25/06 ,  F26B25/12

Abstract: Various embodiments of methods and devices for drying coated stents in an oven are described herein.

Abstract translation: 本文描述了用于在烘箱中干燥涂层支架的方法和装置的各种实施例。

公开(公告)号：US20160228912A1

公开(公告)日：2016-08-11

申请号：US15130621

申请日：2016-04-15

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Yung-Ming Chen ,  Henjen Ho

IPC: B05D1/02 ,  A61L31/16 ,  A61F2/82 ,  A61L31/08

CPC classification number: B05D1/02 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61F2250/0071 ,  A61L31/08 ,  A61L31/16 ,  A61L2420/02 ,  B05B12/18 ,  B05B13/0442

Abstract: A multiple stent structure including a plurality of stent bodies arranged end to end in which adjacent stent bodies of the structure are connected by a severable connecting portion disposed between the adjacent stent bodies is disclosed. A method of coating a plurality of stents including depositing a coating on the multiple stent structure and severing the severable connecting portions to disconnect the plurality of stent bodies is disclosed.

Abstract translation: 公开了一种多支架结构，其包括端对端设置的多个支架主体，其中通过设置在相邻的支架体之间的可分离连接部分将该结构的相邻支架体连接在一起。 公开了一种涂覆多个支架的方法，包括在多支架结构上沉积涂层并切断可分离的连接部分以断开多个支架主体。

公开(公告)号：US09375876B2

公开(公告)日：2016-06-28

申请号：US14928823

申请日：2015-10-30

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Yung-Ming Chen ,  Jason Van Sciver ,  Syed F. A. Hossainy ,  Stephen Pacetti

IPC: A61F2/06 ,  B05D3/02 ,  B29C65/76 ,  A61F2/91 ,  B05D3/04 ,  B05D1/38 ,  A61F2/82 ,  A61F2/86 ,  B29C65/10 ,  A61L31/14 ,  B29K67/00 ,  B29K105/00 ,  B29L31/00

CPC classification number: B29C65/76 ,  A61F2/82 ,  A61F2/86 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2310/00389 ,  A61L31/14 ,  A61L31/148 ,  A61L2420/02 ,  B05D1/38 ,  B05D3/0254 ,  B05D3/0473 ,  B29C65/10 ,  B29K2067/046 ,  B29K2105/258 ,  B29L2031/7534

Abstract: Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.

公开(公告)号：US09204981B2

公开(公告)日：2015-12-08

申请号：US14659276

申请日：2015-03-16

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Yung-Ming Chen ,  Jason Van Sciver ,  Syed F. A. Hossainy ,  Stephen Pacetti

IPC: A61F2/06 ,  B05D3/02 ,  A61F2/82 ,  A61L31/14

CPC classification number: B29C65/76 ,  A61F2/82 ,  A61F2/86 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2310/00389 ,  A61L31/14 ,  A61L31/148 ,  A61L2420/02 ,  B05D1/38 ,  B05D3/0254 ,  B05D3/0473 ,  B29C65/10 ,  B29K2067/046 ,  B29K2105/258 ,  B29L2031/7534

Abstract: Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.

Abstract translation: 本文描述了用于涂覆支架的方法的各种实施例。 公开了将包含聚合物组分和溶剂的组合物施用到支架基底，然后将聚合物组分暴露于等于或大于聚合物组分的Tg的温度。 重复施加和暴露一次或多次以形成涂层，结果是在最终曝光步骤之后涂层的溶剂含量处于适合成品支架的水平​​。