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公开(公告)号：US09464033B2
公开(公告)日：2016-10-11
申请号：US14807436
申请日：2015-07-23
Applicant: Acucela Inc.
Inventor： Ian Leslie Scott , Vladimir Aleksandrovich Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Jennifer Gage , Feng Hong
IPC: C07C321/00 , C07C215/68 , C07D309/06 , C07D333/16 , C07C211/27 , C07C211/30 , C07C215/30 , C07C215/42 , C07C217/14 , C07C217/48 , C07C217/62 , C07C217/72 , C07C235/34 , C07C237/20 , C07C251/40 , C07C255/58 , C07C323/29 , C07C323/36 , C07D209/32 , C07D213/14 , C07D309/10 , C07D333/06 , C07D335/02 , C07C217/64 , C07D213/38 , C07D309/12 , C07C215/28 , C07C317/28 , C07C323/25
CPC classification number: C07C215/68 , C07C211/27 , C07C211/30 , C07C215/28 , C07C215/30 , C07C215/42 , C07C217/14 , C07C217/48 , C07C217/62 , C07C217/64 , C07C217/72 , C07C235/34 , C07C237/20 , C07C251/40 , C07C255/58 , C07C317/28 , C07C323/25 , C07C323/29 , C07C323/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D209/32 , C07D213/14 , C07D213/38 , C07D309/06 , C07D309/10 , C07D309/12 , C07D333/06 , C07D333/16 , C07D335/02
Abstract: Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
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公开(公告)号：US09421210B2
公开(公告)日：2016-08-23
申请号：US14630897
申请日：2015-02-25
Applicant: Acucela Inc.
Inventor： Ian Leslie Scott , Vladimir Aleksandrovich Kuska , Anna Gall , Mark W. Orme , Jennifer Gage , Thomas L. Little, Jr. , Qin Jiang , Lana Michele Rossiter , Kevin F. McGee, Jr. , Ryo Kubota
IPC: C07C211/27 , C07C217/18 , A61K31/5375 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/16 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07D295/03 , C07C225/06 , C07C323/33 , C07D207/06 , C07D211/14 , A61K31/137 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495
CPC classification number: A61K31/5375 , A61K31/137 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495 , C07C211/27 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/10 , C07C217/16 , C07C217/18 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/06 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07C323/33 , C07C2602/14 , C07C2602/16 , C07D207/06 , C07D211/14 , C07D295/03
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号：US09314467B2
公开(公告)日：2016-04-19
申请号：US14630889
申请日：2015-02-25
Applicant: Acucela Inc.
Inventor： Ian Leslie Scott , Vladimir Aleksandrovich Kuska , Anna Gall , Mark W. Orme , Jennifer Gage , Thomas L. Little, Jr. , Qin Jiang , Lana Michele Rossiter , Kevin F. McGee, Jr. , Ryo Kubota
IPC: C07C211/27 , A61K31/137 , A61K31/5375 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/16 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07D295/03 , C07C217/10 , C07C225/06 , C07C323/33 , C07D207/06 , C07D211/14 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495
CPC classification number: A61K31/5375 , A61K31/137 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495 , C07C211/27 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/10 , C07C217/16 , C07C217/18 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/06 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07C323/33 , C07C2602/14 , C07C2602/16 , C07D207/06 , C07D211/14 , C07D295/03
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号：US20150239825A1
公开(公告)日：2015-08-27
申请号：US14631763
申请日：2015-02-25
Applicant: Acucela Inc.
Inventor： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, JR. , Anna Gall , Feng Hong
IPC: C07C217/20
CPC classification number: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供的是烷氧基衍生物化合物和包含这些化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。
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公开(公告)号：US11446261B2
公开(公告)日：2022-09-20
申请号：US16865195
申请日：2020-05-01
Applicant: Acucela Inc.
Inventor： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, Jr. , Anna Gall , Feng Hong
IPC: A61K31/137 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06 , C07C217/20 , C07C215/20 , C07C309/06 , C07C217/84 , C07C323/33 , A61K31/165 , A61K31/222
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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Patent Agency Ranking
公开(公告)号：US10201545B2
公开(公告)日：2019-02-12
申请号：US14631711
申请日：2015-02-25
Applicant: Acucela Inc.
Inventor： Ian Leslie Scott , Vladimir Aleksandrovich Kuksa , Anna Gall , Mark W. Orme , Jennifer Gage , Thomas L. Little, Jr. , Qin Jiang , Lana Michele Rossiter , Kevin F. McGee, Jr. , Ryo Kubota
IPC: A61K31/137 , A61K31/5375 , C07C217/18 , C07C211/27 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/16 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07D295/03 , C07C217/10 , C07C225/06 , C07C323/33 , C07D207/06 , C07D211/14 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号：US20170049722A1
公开(公告)日：2017-02-23
申请号：US15260127
申请日：2016-09-08
Applicant: Acucela Inc.
Inventor： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, JR. , Anna Gall , Feng Hong
IPC: A61K31/137 , A61K31/222 , A61K31/165
CPC classification number: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供的是烷氧基衍生物化合物和包含这些化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。
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公开(公告)号：US20160193160A1
公开(公告)日：2016-07-07
申请号：US15072250
申请日：2016-03-16
Applicant: Acucela Inc.
Inventor： Ian Leslie Scott , Vladimir Aleksandrovich Kuksa , Anna Gall , Mark W. Orme , Jennifer Gage , Thomas L. Little, JR. , Qin Jiang , Lana Michele Rossiter , Kevin F. McGee , Ryo Kubota
IPC: A61K31/137
CPC classification number: A61K31/5375 , A61K31/137 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495 , C07C211/27 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/10 , C07C217/16 , C07C217/18 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/06 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07C323/33 , C07C2602/14 , C07C2602/16 , C07D207/06 , C07D211/14 , C07D295/03
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号：US20150329473A1
公开(公告)日：2015-11-19
申请号：US14807436
申请日：2015-07-23
Applicant: Acucela Inc.
Inventor： Ian Leslie Scott , Vladimir Aleksandrovich Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Jennifer Gage , Feng Hong
IPC: C07C211/27 , C07D333/16 , C07D335/02 , C07D213/38 , C07C255/58 , C07D309/06
CPC classification number: C07C215/68 , C07C211/27 , C07C211/30 , C07C215/28 , C07C215/30 , C07C215/42 , C07C217/14 , C07C217/48 , C07C217/62 , C07C217/64 , C07C217/72 , C07C235/34 , C07C237/20 , C07C251/40 , C07C255/58 , C07C317/28 , C07C323/25 , C07C323/29 , C07C323/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D209/32 , C07D213/14 , C07D213/38 , C07D309/06 , C07D309/10 , C07D309/12 , C07D333/06 , C07D333/16 , C07D335/02
Abstract: Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
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公开(公告)号：US20150239836A1
公开(公告)日：2015-08-27
申请号：US14631779
申请日：2015-02-25
Applicant: Acucela Inc.
Inventor： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, JR. , Anna Gall , Feng Hong
IPC: C07C323/33 , C07C217/84 , C07C217/62
CPC classification number: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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