公开(公告)号：US10953345B2

公开(公告)日：2021-03-23

申请号：US14252711

申请日：2014-04-14

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Klaus Witt ,  Konstantin Shoykhet ,  Dwight Stoll

IPC: B01D15/14 ,  G01N30/20 ,  G01N30/46

Abstract: A sample dispatcher is disclosed and is configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a liquid separation system. The liquid separation system is configured for separating compounds of the sample fluids and comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises one or more sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof, and a bypass channel.

公开(公告)号：US20190064124A1

公开(公告)日：2019-02-28

申请号：US15691202

申请日：2017-08-30

Applicant: Agilent Technologies, Inc.

Inventor： Klaus Witt ,  Konstantin Shoykhet ,  Philip Herzog ,  Iwan Bouzid

IPC: G01N30/32 ,  G01N30/20 ,  G01N30/86

Abstract: To determine a corrected flow rate value of a mobile phase flowing in a liquid chromatography (LC) system, a flow rate of the mobile phase at a selected reference position in the LC system is measured to produce one or more flow rate values. A model of the LC system is applied to the flow rate value(s) to determine the corrected flow rate value(s). The model includes a distribution of capacitive elements and resistive elements arranged according to a topology of the LC system. The capacitive and resistive elements are representative of system and solvent properties affecting flow rate while operating the LC system. The system and solvent properties may be properties affecting the flow rate while operating the LC system under dynamic conditions.

公开(公告)号：US09823226B2

公开(公告)日：2017-11-21

申请号：US14898392

申请日：2013-06-14

Applicant: Agilent Technologies, Inc.

Inventor： Klaus Witt ,  Konstantin Shoykhet ,  Manfred Berndt

IPC: G01N1/00 ,  G01N30/00 ,  G01N30/20 ,  G01N30/46 ,  G01N30/02

CPC classification number: G01N30/20 ,  G01N30/465 ,  G01N2030/027 ,  G01N2030/202 ,  G01N2030/208

Abstract: Disclosed is a sample dispatcher configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a separation system configured for separating compounds of the sample fluids. The separation system comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises a plurality of sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof. The sample dispatcher is configured for selectively coupling one of the plurality of sample reservoirs between the mobile phase drive and the separation unit, and further for coupling at least two of the plurality of sample reservoirs in parallel between the mobile phase drive and the separation unit.

公开(公告)号：US20160334031A1

公开(公告)日：2016-11-17

申请号：US14975342

申请日：2015-12-18

Applicant: Agilent Technologies, Inc.

Inventor： Konstantin Shoykhet ,  Klaus Witt ,  Stephan Buckenmaier ,  Dwight Stoll

IPC: F16K99/00 ,  B01D15/10 ,  G01N27/447 ,  B01L3/00

CPC classification number: F16K99/0028 ,  B01D15/10 ,  B01D15/1878 ,  B01D15/40 ,  B01L3/50273 ,  B01L2400/0475 ,  F16K2099/0084 ,  G01N27/44791 ,  G01N30/32 ,  G01N30/465 ,  G01N2030/202 ,  G01N2030/328

Abstract: A fluid processing device (10) for processing fluid, wherein the fluid processing device (10) comprises a first fluid drive unit (20) configured for driving a first fluid along a first flow path (85), a second fluid drive unit (20′) configured for driving a second fluid along a second flow path (86), and a fluidic switch (90) fluidically coupled to the first flow path (85) and to the second flow path (86) and configured for being switchable for transferring first fluid from the first flow path (85) into the second flow path (86) without interruption of fluid flow along at least one of the first flow path (85) and the second flow path (86).

Abstract translation: 一种用于处理流体的流体处理装置（10），其中所述流体处理装置（10）包括构造成沿着第一流动路径（85）驱动第一流体的第一流体驱动单元（20），第二流体驱动单元 被配置为沿着第二流动路径（86）驱动第二流体的流体开关（90）以及流体连接到第一流动路径（85）和第二流动路径（86）的流体开关（90），并被配置为可转换 第一流体从第一流动路径（85）进入第二流动路径（86），而不中断沿着第一流动路径（85）和第二流动路径（86）中的至少一个的流体流动。

公开(公告)号：US20160327514A1

公开(公告)日：2016-11-10

申请号：US15148924

申请日：2016-05-06

Applicant: Agilent Technologies, Inc.

Inventor： Konstantin Shoykhet ,  Klaus Witt

IPC: G01N27/447

CPC classification number: G01N30/32 ,  G01N2030/324 ,  G01N2030/326

Abstract: A sample separation apparatus includes a metering device for metering a predefined amount of fluidic sample to be separated by a sample separation apparatus, a metering path for fluidically coupling the metering device and a sample source providing fluidic sample to be metered, and a control device. The control device is configured for controlling operation of the metering device for at least partially compensating for a deviation between a target value to be metered and an actual value of an amount of fluidic sample that is metered, the deviation resulting from a thermally induced volume change in the sample separation apparatus.

Abstract translation: 样品分离装置包括计量装置，用于计量由样品分离装置分离的预定量的流体样品，用于流体耦合计量装置的计量路径和提供要计量的流体样品的样品源以及控制装置。 控制装置被配置为控制计量装置的操作，用于至少部分地补偿要计量的目标值与计量的流体样品量的实际值之间的偏差，由热诱导的体积变化导致的偏差 在样品分离装置中。

公开(公告)号：US20160138577A1

公开(公告)日：2016-05-19

申请号：US14901580

申请日：2013-06-28

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Konstantin Shoykhet ,  Klaus Witt ,  Hans Georg Weissgerber

IPC: F04B19/22

CPC classification number: F04B19/22 ,  F04B13/02 ,  F04B15/02 ,  G01N30/32 ,  G01N30/34 ,  G01N2030/326

Abstract: Disclosed is a pumping apparatus (200) configured for delivering a fluid. The pumping apparatus (200) comprises a pumping chamber (220) configured for receiving one or more fluids (310, 320) in defined proportions and for further delivering the received fluids, an outlet (240), fluidically coupling to a first position (350) in the pumping chamber (220), for outleting the fluid to be delivered, and a channel (410). The channel (410) fluidically couples on one side to a second position (340) in the pumping chamber (220) and on the other side to the outlet (240), so that—in operation—a first portion of the delivered fluid as outlet at the outlet (240) is received from the first position (350) in the pumping chamber (220), and a second portion of the delivered fluid as outlet at the outlet (240) is received from the second position (340) in the pumping chamber (220). One of the first (350) and second (340) positions is a spatial position within the pumping chamber (220) where fluid components having a first property would tend to accumulate during operation of the pumping apparatus (200) if such position were not coupled to the outlet (240), with such accumulation resulting from variations in the first property.

Abstract translation: 公开了一种被配置为输送流体的泵送装置（200）。 泵送装置（200）包括泵送室（220），其构造成用于以一定比例接收一个或多个流体（310,320）并且用于进一步输送所接收的流体;流体耦合到第一位置（350）的出口（240） ）在泵送室（220）中，用于输送待输送的流体和通道（410）。 通道（410）在一侧流体耦合到泵送室（220）中的第二位置（340），而在另一侧与出口（240）流体耦合，使得在运行中 - 输送流体的第一部分作为 在出口（240）处的出口从泵送室（220）中的第一位置（350）接收，并且作为出口（240）处的出口的输送流体的第二部分从第二位置（340）被接收在 泵送室（220）。 第一（350）和第二（340）位置中的一个位置是泵送室（220）内的空间位置，其中具有第一特性的流体部件将在泵送装置（200）的操作期间倾向于积聚，如果该位置未耦合 到出口（240），由于第一性质的变化而产生这种累积。

公开(公告)号：US20150285239A1

公开(公告)日：2015-10-08

申请号：US14677558

申请日：2015-04-02

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Konstantin Shoykhet ,  Klaus Witt

IPC: F04B49/00 ,  F04B51/00

CPC classification number: F04B51/00 ,  F04B23/06 ,  F04B49/08 ,  F04B49/20 ,  G01N30/32 ,  G01N30/36 ,  G01N2030/326

Abstract: A device for determining a leakage of fluid in a piston pump, wherein the piston pump comprises a piston arranged in such a manner that it can reciprocate in a piston chamber for delivering fluid, wherein the device comprises a control unit for controlling the piston in such a manner that the piston executes two piston chamber evacuation processes with different evacuation times, in each case for at least partial evacuating of fluid located in the piston chamber, and a determination unit for determining the leakage based on a comparison of fluid quantities evacuated from the piston chamber in the two piston chamber evacuation processes.

Abstract translation: 一种用于确定活塞泵中的流体泄漏的装置，其中所述活塞泵包括以能够在用于输送流体的活塞室中往复运动的方式布置的活塞，其中所述装置包括用于控制活塞的控制单元 活塞执行具有不同排气时间的两个活塞室排空过程的方式，在每种情况下至少部分抽空位于活塞室中的流体;以及确定单元，用于基于从所述活塞室排出的流体量的比较来确定泄漏 活塞室在两个活塞室排空过程中。

公开(公告)号：US20150122655A1

公开(公告)日：2015-05-07

申请号：US14400312

申请日：2012-05-10

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Konstantin Choikhet ,  Klaus Witt

IPC: B01D15/18 ,  G01N30/72 ,  G01N27/447

CPC classification number: B01D15/18 ,  G01N27/44704 ,  G01N30/32 ,  G01N30/34 ,  G01N30/463 ,  G01N30/465 ,  G01N30/6095 ,  G01N30/72 ,  G01N2030/322 ,  G01N2030/328

Abstract: A sample separation apparatus (200) for separating a fluidic sample, the sample separation apparatus (200) comprising a first separation unit (204) for separating the fluidic sample, a first fluid drive (202) configured for conducting the fluidic sample to be separated through the first separation unit (204), a second separation unit (208), arranged downstream of the first separation unit (204), for further separating the fluidic sample after treatment by the first separation unit (204), a second fluid drive (206) configured for at least partially conducting the fluidic sample, after treatment by the first separation unit (204), through the second separation unit (208), and a fluidic valve (218) having fluidic interfaces (222, 224, 226, 228) fluidically coupled to the first fluid drive (202) and the second fluid drive (206) and being switchable for performing the separation of the fluidic sample, wherein the sample separation apparatus (200) is configured for adjusting a pressure at a predefined position to a predefined value, wherein the predefined position is in a fluidic path between an outlet (270) of the first separation unit (204) and an inlet (272) of the second separation unit (208) or in fluid communication with this fluidic path.

Abstract translation: 一种用于分离流体样品的样品分离装置（200），所述样品分离装置（200）包括用于分离流体样品的第一分离单元（204），被配置用于传导待分离的流体样品的第一流体驱动器（202） 通过第一分离单元（204），布置在第一分离单元（204）下游的第二分离单元（208），用于在第一分离单元（204）处理之后进一步分离流体样品，第二流体驱动器 206）构造成用于在通过第一分离单元（204）经过第二分离单元（208）处理之后至少部分地传导流体样品，以及具有流体界面（222,224,226,228）的流体阀 ）流体耦合到第一流体驱动器（202）和第二流体驱动器（206）并且可切换以执行流体样品的分离，其中样品分离装置（200）构造成用于调节流体样品 预定位置到预定值，其中预定位置处于第一分离单元（204）的出口（270）和第二分离单元（208）的入口（272）之间的流体路径中，或者与该流体连通 流体路径

公开(公告)号：US20140305228A1

公开(公告)日：2014-10-16

申请号：US14342714

申请日：2011-09-04

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Klaus Witt ,  Hans-Georg Haertl

IPC: G01N1/20 ,  B01D39/14

CPC classification number: G01N1/20 ,  B01D39/00 ,  B01D39/10 ,  B01D39/14 ,  B01D2239/065 ,  B01D2239/069 ,  B01D2239/1216

Abstract: A filter for filtering debris out of a fluid flowing along a fluid flow direction in a fluidic member of a sample separation device, the filter comprising a plurality of filter structures stacked along the fluid flow direction and each having pores with defined pore size, wherein the defined pore size of the stacked filter structures decreases along the fluid flow direction.

Abstract translation: 一种过滤器，用于从在样品分离装置的流体构件中沿着流体流动方向流动的流体中过滤碎屑，所述过滤器包括沿着流体流动方向堆叠的多个过滤器结构，并且每个具有限定的孔径的孔，其中 层叠的过滤器结构的限定孔径沿着流体流动方向减小。

公开(公告)号：US09945762B2

公开(公告)日：2018-04-17

申请号：US14586882

申请日：2014-12-30

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Edwin E. Wikfors ,  Brian A. Bidlingmeyer ,  Klaus Witt

IPC: G01N30/06 ,  G01N1/28 ,  G01N30/20 ,  G01N30/36 ,  G01N30/34

CPC classification number: G01N1/28 ,  G01N30/20 ,  G01N30/36 ,  G01N2030/202 ,  G01N2030/207 ,  G01N2030/342

Abstract: A method and a system for introducing a sample into a mobile phase of a chromatography system is provided. The method includes initially directing the mobile phase directly into a separation unit of the chromatography system, bypassing a sample loop, the mobile phase including a combined solvent, metered from a pressurized first solvent and a second solvent; loading the sample into the sample loop, while the mobile phase continues to be directed directly into the separation unit; pressurizing the sample in the sample loop with the pressurized first solvent, while the mobile phase continues to be directed directly into the separation unit; and switching the sample loop into the mobile phase, thereby introducing the pressurized sample to the separation unit.