公开(公告)号：US20080124344A1

公开(公告)日：2008-05-29

申请号：US11814549

申请日：2006-07-18

申请人： Katherin E. Combs ,  Ling Ling Culbertson ,  Juan Delmas-Mata ,  Frederic de Sauvage ,  Liangfen Fan ,  Gretchen Frantz ,  Leslie Jane Green ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Franklin Peale ,  Heidi Phillips ,  Michelle Rohrer ,  Tracy E.W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Ching-Yun Wang ,  Wen Xiong ,  Peter Vogel

发明人： Katherin E. Combs ,  Ling Ling Culbertson ,  Juan Delmas-Mata ,  Frederic de Sauvage ,  Liangfen Fan ,  Gretchen Frantz ,  Leslie Jane Green ,  Erin Marie Massey ,  Dina Rebecca McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Franklin Peale ,  Heidi Phillips ,  Michelle Rohrer ,  Tracy E.W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Tracy Tzu-Ling Tang ,  Ching-Yun Wang ,  Wen Xiong ,  Peter Vogel

IPC分类号： A61K39/395 ,  A01K67/00 ,  A61P43/00

CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0375

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO226，​​PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断 ，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20090313707A1

公开(公告)日：2009-12-17

申请号：US11814361

申请日：2006-05-18

申请人： Katherin E. Combs ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Rosemary Girgis ,  Allison A. B. Horner ,  Harald Junge ,  Jagath Reddy Junutula ,  Erin Marie Massey ,  Dina R. McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Heidi Phillips ,  Ni Nancy Qian ,  Carolina Rangel ,  Tracy E. W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Peter Vogel ,  Weilan Ye

发明人： Katherin E. Combs ,  Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Rosemary Girgis ,  Allison A. B. Horner ,  Harald Junge ,  Jagath Reddy Junutula ,  Erin Marie Massey ,  Dina R. McLain ,  Charles Montgomery ,  Bobby Joe Payne ,  Heidi Phillips ,  Ni Nancy Qian ,  Carolina Rangel ,  Tracy E. W. Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Peter Vogel ,  Weilan Ye

IPC分类号： G01N33/00 ,  C12N5/06 ,  C12Q1/02

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括PRO69122，PRO204，PRO214，PRO222，PRO234，PRO265，PRO309，PRO332，PRO342，PRO356，PRO540，PRO618，PRO944，PRO994，PRO1079，PRO1110，PRO1122，PRO1138，PRO1190，PRO1272中的中断 ，PRO1286，PRO1295，PRO1309，PRO1316，PRO1383，PRO1384，PRO1431，PRO1434，PRO1475，PRO1481，PRO1568，PRO1573，PRO1599，PRO1604，PRO1605，PRO1693，PRO1753，PRO1755，PRO1777，PRO1788，PRO1864，PRO1925，PRO1926，PRO3566，PRO4330。 ，PRO4423，PRO36935，PRO4977，PRO4979，PRO4980，PRO4981，PRO5801，PRO5995，PRO6001，PRO6095，PRO6182，PRO7170，PRO7171，PRO7436，PRO9912，PRO9917，PRO37337，PRO37496，PRO19646，PRO21718，PRO19820，PRO21201，PRO20026，PRO20110，PRO23203 或PRO35250基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20080189799A1

公开(公告)日：2008-08-07

申请号：US11978234

申请日：2007-10-26

申请人： Liangfen Fan ,  Glenn Friedrich ,  Laurie Jeanette Minze ,  Charles Montgomery ,  Bobby Joe Payne ,  Carolina Rangel ,  Arthur T. Sands ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Brian Zambrowicz

发明人： Liangfen Fan ,  Glenn Friedrich ,  Laurie Jeanette Minze ,  Charles Montgomery ,  Bobby Joe Payne ,  Carolina Rangel ,  Arthur T. Sands ,  Tracy Ellen Willis Sevaux ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Brian Zambrowicz

IPC分类号： C12N15/11 ,  A01K67/027

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2267/03 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/7151 ,  C07K14/775 ,  C07K14/8114 ,  C07K14/8121 ,  C12N9/1051 ,  C12N9/12 ,  C12N9/1205 ,  C12N2799/027 ,  C12N2800/60

摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.

摘要翻译： 本发明涉及基因工程小鼠，衍生自这些小鼠的细胞，以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠，细胞，多核苷酸，多肽和抗体的方法。

公开(公告)号：US20090077680A1

公开(公告)日：2009-03-19

申请号：US12099465

申请日：2008-04-08

申请人： Alejandro Abuin ,  Joel Edwards ,  Charles Montgomery ,  Bobby Joe Payne ,  Carolina Rangel ,  Arthur T. Sands ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Teresa Gail Townsend ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Peter Vogel ,  Brian Zambrowicz

发明人： Alejandro Abuin ,  Joel Edwards ,  Charles Montgomery ,  Bobby Joe Payne ,  Carolina Rangel ,  Arthur T. Sands ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Teresa Gail Townsend ,  Rosemary Girgis ,  Allison Anne Byers Horner ,  Peter Vogel ,  Brian Zambrowicz

IPC分类号： A01K67/027 ,  C12N5/06 ,  C07K16/18

CPC分类号： A01K67/0276 ,  A01K2217/054 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356 ,  C12N15/8509 ,  C12N2840/44

摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.

摘要翻译： 本发明涉及基因工程小鼠，衍生自这些小鼠的细胞，以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠，细胞，多核苷酸，多肽和抗体的方法。

公开(公告)号：US20110097330A1

公开(公告)日：2011-04-28

申请号：US11722967

申请日：2006-02-27

申请人： Allison Anne Byers Horner ,  Catherine Batac Clarke ,  Katherin E. Combs ,  Frederic J. de Sauvage ,  Joel Edwards ,  Paul Godowski ,  Deanna Grant Wilson ,  Wenhu Huang ,  Lorelei Diane Ketcherside ,  Erin Marie Massey ,  Charles Montgomery ,  Bobby Joe Payne ,  Andrew Peterson ,  Ni Nancy Qian ,  Jeffrey J. Schrick ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Colleen M. Viator ,  Peter Vogel ,  Weilan Ye ,  Jung-Hua Yeh ,  Zhiyong Ding

发明人： Allison Anne Byers Horner ,  Catherine Batac Clarke ,  Katherin E. Combs ,  Frederic J. de Sauvage ,  Joel Edwards ,  Paul Godowski ,  Deanna Grant Wilson ,  Wenhu Huang ,  Lorelei Diane Ketcherside ,  Erin Marie Massey ,  Charles Montgomery ,  Bobby Joe Payne ,  Andrew Peterson ,  Ni Nancy Qian ,  Jeffrey J. Schrick ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Colleen M. Viator ,  Peter Vogel ,  Weilan Ye ,  Jung-Hua Yeh ,  Zhiyong Ding

IPC分类号： A61K49/00 ,  C07K16/18 ,  A61K39/00 ,  A61P25/00 ,  A61P9/00 ,  A61P37/00 ,  A61P27/02 ,  A61P25/24 ,  A61P25/22 ,  A61P25/18 ,  A61P27/06 ,  A61P27/12 ,  A61P9/10 ,  A61P19/02 ,  A61P19/10 ,  C12Q1/68 ,  C12N5/071 ,  C12N5/0735 ,  C12Q1/02

CPC分类号： C07K14/47 ,  A01K2217/075 ,  A61K2039/505 ,  G01N2500/00

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供转基因小鼠，其包括PRO179，PRO181，PRO244，PRO247，PRO269，PRO293，PRO298，PRO339，PRO341，PRO347，PRO531，PRO537，PRO718，PRO773，PRO860，PRO871，PRO872，PRO813，PRO828，PRO1100中的中断 ，PRO1114，PRO115，PRO1126，PRO1133，PRO1154，PRO1185，PRO1194，PRO1287，PRO1291，PRO1293，PRO1310，PRO1312，PRO1335，PRO1339，PRO2155，PRO1356，PRO1385，PRO1412，PRO1487，PRO1758，PRO1779，PRO1785，PRO1889，PRO90318，PRO3434 ，PRO3579，PRO4322，PRO4343，PRO4347，PRO4403，PRO4976，PRO260，PRO6014，PRO6027，PRO6181，PRO6714，PRO9922，PRO7179，PRO7476，PRO9824，PRO19814，PRO19836，PRO20088，PRO70789，PRO50298，PRO51592，PRO1757，PRO4421，PRO9903，PRO1106 ，PRO1411，PRO1486，PRO1565，PRO4399或PRO4404基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20090193532A1

公开(公告)日：2009-07-30

申请号：US12099459

申请日：2008-04-08

申请人： Alejandro Abuin ,  Joel A. Edwards ,  Charles Montgomery ,  Carolina Rangel ,  Arthur T. Sands ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Brian Zambrowicz

发明人： Alejandro Abuin ,  Joel A. Edwards ,  Charles Montgomery ,  Carolina Rangel ,  Arthur T. Sands ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Brian Zambrowicz

IPC分类号： A01K67/027

CPC分类号： A01K67/0276 ,  A01K2217/075

摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.

公开(公告)号：US20080160034A1

公开(公告)日：2008-07-03

申请号：US11572702

申请日：2005-08-23

申请人： Jane Brennan ,  Frederic J. de Sauvage ,  Weilan Ye ,  Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Bobby Joe Payne ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel

发明人： Jane Brennan ,  Frederic J. de Sauvage ,  Weilan Ye ,  Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Bobby Joe Payne ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel

IPC分类号： A61K39/395 ,  A01K67/00 ,  C12N5/06 ,  A61P27/02 ,  C07K16/18 ,  G01N33/567

CPC分类号： A01K67/0276 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/02 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245, PRO246, PRO258, PRO287, PRO328, PRO344, PRO357, PRO526, PRO724, PRO731, PRO732, PRO1003, PRO1104, PRO1151, PRO1244, PRO1298, PRO1313, PRO1570, PRO1886, PRO1891, PRO4409, PRO5725, PRO5994, PRO6097, PRO7425, PRO10102, PRO10282, PRO61709 or PRO779 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供转基因小鼠，其包括PRO196，PRO217，PRO231，PRO236，PRO245，PRO246，PRO258，PRO287，PRO328，PRO344，PRO357，PRO526，PRO724，PRO731，PRO732，PRO1003，PRO1104，PRO1151，PRO1244，PRO1298中的中断 ，PRO1313，PRO1570，PRO1886，PRO1891，PRO4409，PRO5725，PRO5994，PRO6097，PRO7425，PRO10102，PRO10282，PRO61709或PRO779基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US07858843B2

公开(公告)日：2010-12-28

申请号：US11814361

申请日：2006-05-18

申请人： Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Charles Montgomery ,  Zheng-Zheng Shi ,  Mary Jean Sparks

发明人： Ling Ling Culbertson ,  Frederic J. de Sauvage ,  Charles Montgomery ,  Zheng-Zheng Shi ,  Mary Jean Sparks

IPC分类号： G01N33/00 ,  C12N5/06 ,  C12Q1/02

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括PRO69122，PRO204，PRO214，PRO222，PRO234，PRO265，PRO309，PRO332，PRO342，PRO356，PRO540，PRO618，PRO944，PRO994，PRO1079，PRO1110，PRO1122，PRO1138，PRO1190，PRO1272中的中断 ，PRO1286，PRO1295，PRO1309，PRO1316，PRO1383，PRO1384，PRO1431，PRO1434，PRO1475，PRO1481，PRO1568，PRO1573，PRO1599，PRO1604，PRO1605，PRO1693，PRO1753，PRO1755，PRO1777，PRO1788，PRO1864，PRO1925，PRO1926，PRO3566，PRO4330 ，PRO4423，PRO36935，PRO4977，PRO4979，PRO4980，PRO4981，PRO5801，PRO5995，PRO6001，PRO6095，PRO6182，PRO7170，PRO7171，PRO7436，PRO9912，PRO9917，PRO37337，PRO37496，PRO19646，PRO21718，PRO19820，PRO21201，PRO20026，PRO20110，PRO23203 或PRO35250基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US08227661B2

公开(公告)日：2012-07-24

申请号：US12907655

申请日：2010-10-19

申请人： Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Ni Nancy Qian ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Mindy Oox

发明人： Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Ni Nancy Qian ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Mindy Oox

IPC分类号： G01N33/00 ,  A01K67/00 ,  A01K67/027

CPC分类号： A01K67/0276 ,  A01K2217/054 ,  A01K2227/105 ,  A01K2267/03 ,  A61K47/6843 ,  A61K47/6913 ,  A61K49/0008 ,  A61K51/1018 ,  C12N15/8509 ,  Y10T436/146666

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供包含PRO227，PRO233，PRO238，PRO1328，PRO4342，PRO7423，PRO10096，PRO21384，PRO353或PRO1885基因中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20110093960A1

公开(公告)日：2011-04-21

申请号：US12907655

申请日：2010-10-19

申请人： Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Ni Nancy Qian ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Mindy Oox

发明人： Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Ni Nancy Qian ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Mindy Oox

IPC分类号： G01N33/00 ,  G01N33/48 ,  C12Q1/02 ,  C12Q1/68

CPC分类号： A01K67/0276 ,  A01K2217/054 ,  A01K2227/105 ,  A01K2267/03 ,  A61K47/6843 ,  A61K47/6913 ,  A61K49/0008 ,  A61K51/1018 ,  C12N15/8509 ,  Y10T436/146666

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供包含PRO227，PRO233，PRO238，PRO1328，PRO4342，PRO7423，PRO10096，PRO21384，PRO353或PRO1885基因中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。