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公开(公告)号：US20140066761A1
公开(公告)日：2014-03-06
申请号：US13774876
申请日：2013-02-22
CPC分类号： A61K49/223 , A61B5/0035 , A61B5/0095 , A61B8/481 , A61B8/5261
摘要： Provided herein are dual contrast agents or nanocomposite particles designed to enhance optoacoustic-ultrasonic imaging. The contrast agents or particles have a core designed to enhance response to incident transient ultrasonic pressure waves and at least two layers disposed around the core. The inner first layer is designed to effectively absorb incident transient optical waves, convert absorbed optical energy into heat and demonstrates significant thermal expansion and/or conversion of thermal energy into acoustic pressure. The outer second layer thermally insulates the inner layer from the surrounding aqueous environment and enhances the generation of transient ultrasonic pressure waves during optoacoustic-ultrasonic imaging and sensing. Also provided are methods of enhancing contrast in a tissue optoacoustic-ultrasonic imaging and producing enhanced optoacoustic images by contacting the tissue with the dual contrast agent or nanocomposite particles.
摘要翻译： 本文提供了设计用于增强光声超声成像的双重造影剂或纳米复合材料颗粒。 造影剂或颗粒具有被设计用于增强对入射的瞬时超声波压力波的响应和设置在芯周围的至少两层的核心。 内部第一层被设计成有效地吸收入射的瞬态光波，将吸收的光能转换成热，并且显示出热能的显着热膨胀和/或转换成声压。 外部第二层使内层与周围的水环境热绝缘，并在光声超声成像和感测期间增强了瞬态超声波压力波的产生。 还提供了增强组织光声超声成像中的对比度并通过使组织与双重造影剂或纳米复合颗粒接触而产生增强的光声图像的方法。
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公开(公告)号：US06498942B1
公开(公告)日：2002-12-24
申请号：US09633597
申请日：2000-08-07
IPC分类号： A61B500
CPC分类号： G01N21/1702 , A61B5/0095 , A61B5/14553 , A61B5/4076 , A61B8/0808
摘要： An optoacoustic apparatus is disclosed which includes a radiation source of pulsed radiation and a probe having a front face to be placed in close proximity to or in contact with a tissue site of an animal body. The probe further includes a plurality of optical fibers terminating at the surface of the front face of the probe and connected at their other end to a pulsed laser. The front face of the probe also has mounted therein or thereon a transducer for detecting an acoustic response from blood in the tissue site to the radiation pulses connected to a processing unit which converts the transducer signal into a measure of venous blood oxygenation.
摘要翻译： 公开了一种光声装置，其包括脉冲辐射的辐射源和具有被放置在紧邻动物身体的组织部位或与动物身体的组织部位接触的前面的探针。 该探针还包括多个光纤，其终止于探针正面的表面并在其另一端连接到脉冲激光。 探针的前表面还安装有用于检测从组织部位的血液到连接到处理单元的辐射脉冲的声响应的换能器，该处理单元将换能器信号转换为静脉血氧的测量。
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13.发明申请公开(公告)号：US20150150452A1
公开(公告)日：2015-06-04
申请号：US14556316
申请日：2014-12-01
IPC分类号： A61B5/00 , A61B8/08 , A61B8/00 , A61B5/145 , A61B5/1464 , A61B8/14 , A61B5/1455
CPC分类号： A61B5/0035 , A61B5/0095 , A61B5/14546 , A61B5/14552 , A61B5/1464 , A61B5/4362 , A61B5/4848 , A61B5/7425 , A61B8/0866 , A61B8/14 , A61B8/4416 , A61B8/4444 , A61B8/5261
摘要： Provided herein are dual modality imaging systems and methods within displayed anatomical structures of placenta in real time. The imaging system comprises a dual modality laser optoacoustic and ultrasonic platform with a plurality of subsystems for delivering near infrared light, optoacoustic and ultrasonic pulses to the placenta and/or associated tissue and deep anatomic structures, for detecting ultrasonic pulses generated or reflected within the tissue using a multi-channel optoacoustic-ultrasound probe and associated transducers. The dual modality imaging system displays the results obtained as quantitative functional images of the parameters coregistered with anatomic tissue images. A multichannel electronic system comprising a computer tangibly storing software enables processor-executable instructions to calculate quantitative functional parameters of the placental blood within specific anatomical tissue structures and display quantitative functional optoacoustic images of the functional parameters within specific anatomical structures in the tissue that are visualized by ultrasound.
摘要翻译： 本文提供了在胎盘显示的解剖结构中实时的双重模态成像系统和方法。 成像系统包括具有多个子系统的双模式激光光声和超声波平台，用于将近红外光，光声和超声脉冲传送到胎盘和/或相关联的组织和深部解剖结构，用于检测组织内产生或反射的超声波脉冲 使用多通道光声超声探头和相关传感器。 双模态成像系统显示获得的结果作为与解剖组织图像核心参数的定量功能图像。 包括有形存储软件的计算机的多通道电子系统使得处理器可执行指令能够计算特定解剖组织结构内的胎盘血液的定量功能参数，并且在组织中的特定解剖结构内显示功能参数的定量功能光声图像，所述功能参数可由 超声波。
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公开(公告)号：US20130190596A1
公开(公告)日：2013-07-25
申请号：US13748563
申请日：2013-01-23
IPC分类号： A61B5/00
CPC分类号： A61B5/0095 , A61B5/004 , A61B5/02007 , A61B5/026 , A61B5/4884 , A61B5/70 , A61B2562/14 , A61B2562/146
摘要： Provided herein are systems and methods for dynamic optoacoustic imaging of the peripheral vasculature. The system generally comprises a short pulse laser, a fiberoptic laser light delivery system, and imaging module, a scanning system, and electronics/computer system for system control and three-dimensional and two-dimensional optoacoustic image visualization. A method is provided for optoacoustic imaging of an appendage using the dynamic optoacoustic imaging system where an appendage of a subject is imaged under conditions of normal, maximum and minimum tolerable temperatures and displaying differential anatomical images of peripheral vasculature in the appendage and functional diagnostic parameters as a function of time and temperature. From this data medical conditions of the appendage may be diagnosed.
摘要翻译： 本文提供了用于外周脉管系统的动态光声成像的系统和方法。 该系统通常包括短脉冲激光器，光纤激光发射系统，成像模块，扫描系统和用于系统控制和三维和二维光声图像可视化的电子/计算机系统。 提供了一种使用动态光声成像系统对附属物进行光声成像的方法，其中对象的附属物在正常，最大和最小可容忍的温度条件下成像，并且在附肢和功能诊断参数中显示外周脉管系统的差异解剖图像， 时间和温度的功能。 从这些数据可以诊断附属物的医疗状况。
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15.发明申请Laser Optoacoustic Ultrasonic Imaging System (LOUIS) and Methods of Use 审中-公开激光光声超声成像系统（LOUIS）及使用方法公开(公告)号：US20130190595A1
公开(公告)日：2013-07-25
申请号：US13748498
申请日：2013-01-23
IPC分类号： A61B5/00
CPC分类号： A61B5/0095 , A61B5/0035 , A61B5/4312 , A61B5/708 , A61B8/0825 , A61B8/4416 , A61B8/483 , A61B2562/14 , A61B2562/146 , A61B2576/00
摘要： Provided herein are the systems, methods, components for a three-dimensional tomography system. The system is a dual-modality imaging system incorporates a laser ultrasonic system and a laser optoacoustic system. The dual-modality imaging system has means for generate tomographic images of a volume of interest in a subject body based on speed of sound, ultrasound attenuation and/or ultrasound backscattering and for generating optoacoustic tomographic images of distribution of the optical absorption coefficient in the subject body based on absorbed optical energy density or various quantitative parameters derivable therefrom. Also provided is a method for increasing contrast, resolution and accuracy of quantitative information obtained within a subject utilizing the dual-modality imaging system. The method comprises producing an image of an outline boundary of a volume of interest and generating spatially or temporally coregistered images based on speed of sound and/or ultrasonic attenuation and on absorbed optical energy within the outlined volume.
摘要翻译： 本文提供了用于三维断层摄影系统的系统，方法，组件。 该系统是采用激光超声波系统和激光光声系统的双模态成像系统。 双模态成像系统具有用于基于声速，超声衰减和/或超声后向散射来生成对象体内感兴趣体积的断层摄影图像的装置，并且用于产生在受试者中光吸收系数的分布的光声层析图像 基于吸收的光学能量密度或从其导出的各种定量参数。 还提供了一种用于增加使用双模态成像系统在受试者内获得的定量信息的对比度，分辨率和精度的方法。 该方法包括产生感兴趣体积的轮廓边界的图像，并且基于声速和/或超声波衰减以及轮廓体积内的吸收的光能产生空间或时间上的核心图像。
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公开(公告)号：US07500953B2
公开(公告)日：2009-03-10
申请号：US10764213
申请日：2004-01-23
IPC分类号： A61B8/14
CPC分类号： A61K49/225 , A61B5/0059 , A61B5/0095 , A61B5/415 , A61B5/418 , B82Y15/00 , G01N21/1702 , G01N21/4795 , G01N21/554 , G01N2021/1706
摘要： A method of enhancing detection for a specific object in a body. A nanoparticulate is administered to the body for location in an area to be explored for detection of the object, if present. The nanoparticulate is at least partially metallic, has a formed non-spherical shape having a minimal characteristic dimension in the range from about 1 to about 3000 nanometers, and has a formed composition capable of producing thermal pressure either in the nanoparticulate or in the object greater than the object could produce in the absence of the nanoparticulate. Electromagnetic radiation is directed into the body. The electromagnetic radiation has a specific wavelength or spectrum of wavelengths in the range from 300 nm to 300 mm selected so that the wavelength or wavelength spectrum is longer by a factor of at least 3 than the minimum characteristic dimension of the nanoparticulate. The nanoparticulate absorbs the electromagnetic radiation more than would one or more non-aggregated spherically shaped particles of the same total volume with a composition identical to the nanoparticulate. The nanoparticulate produces an enhanced optoacoustic signal resulting from the absorption that is received and converted into an electronic signal and presented for assessment of the at least one parameter by a human or a machine.
摘要翻译： 一种增强体内特定物体检测的方法。 将纳米颗粒施用于身体，用于在要被探查的区域中的位置，以检测物体（如果存在）。 纳米颗粒至少部分是金属的，具有形成的非球形形状，具有在约1至约3000纳米范围内的最小特征尺寸，并且具有能够在纳米颗粒或物体中产生热压力的成形组合物更大 比物体在不存在纳米颗粒时可以产生。 电磁辐射被引导到体内。 电磁辐射具有选定的300nm至300mm范围内的波长的特定波长或光谱，使得波长或波长光谱比纳米颗粒的最小特征尺寸至少3倍。 纳米颗粒比一种或多种相同总体积的非聚集球形颗粒吸收电磁辐射，其组成与纳米颗粒相同。 纳米颗粒产生由接收的吸收产生的增强的光声信号，并将其转换为电子信号，并呈现用于由人或机器评估至少一个参数。
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公开(公告)号：US5840023A
公开(公告)日：1998-11-24
申请号：US594758
申请日：1996-01-31
IPC分类号： G01N29/00 , A61B5/00 , A61B8/00 , A61B8/08 , A61B17/00 , A61F9/008 , A61K49/22 , G01N21/00 , G01N21/17
CPC分类号： G01N21/1702 , A61B5/0095 , A61B5/1459 , A61B8/08 , A61F9/008 , A61K49/225 , A61B2017/00128 , A61F2009/00851 , A61F2009/00897
摘要： The laser optoacoustic imaging system described herein utilizes time-resolved measurement of profiles of laser-induced transient pressure (acoustic) waves. The pressure waves are emitted by acoustic sources preferentially generated in absorbing tissues of diagnostic interest. This technique allows visualization of absorbed light distribution in turbid, layered and heterogeneous tissues irradiated by laser pulses in vivo. The laser optoacoustic tomography can be used for the characterization of structure and properties of normal tissue, and for the detection of tissue pathological changes. The optical heterogeneities that can be imaged with the laser optoacoustic imaging system include abnormal tissues such as tumors, injured tissues, blood vessels and other layered tissues. Further, three dimensional images of organs and portions of organs can be obtained.
摘要翻译： 本文描述的激光光声成像系统利用激光诱导瞬态压力（声波）的轮廓的时间分辨测量。 压力波由在诊断感兴趣的吸收组织中优先产生的声源发射。 这种技术允许在体内通过激光脉冲辐射的混浊，分层和异质组织中的吸收光分布的可视化。 激光光声层析成像可用于表征正常组织的结构和性质，并用于检测组织病理变化。 可以用激光光声成像系统成像的光学异质性包括异常组织如肿瘤，损伤组织，血管和其他层状组织。 此外，可以获得器官和器官部分的三维图像。
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