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    Implantable biosensor from stratified nanostructured membranes
    1.
    发明授权
    Implantable biosensor from stratified nanostructured membranes 失效
    来自分层纳米结构膜的可植入生物传感器

    公开(公告)号：US07863038B2

    公开(公告)日：2011-01-04

    申请号：US10403845

    申请日：2003-03-31

    申请人： Massoud Motamedi ,  Nicholas A. Kotov ,  James P. Wicksted ,  Rinat Esenaliev

    发明人： Massoud Motamedi ,  Nicholas A. Kotov ,  James P. Wicksted ,  Rinat Esenaliev

    IPC分类号： C12M1/36

    CPC分类号： A61B5/14532 ,  A61B5/1459 ,  C12Q1/006 ,  G01N33/54373

    摘要： A new class of biosensors and methods for making and using same are disclosed. The biosensors are multi-layered membrane composites, where at least one layer is prepared by the layer-by-layer process and at least one layer is responsive to changes is a property of a biological system such as changes in the concentration of an atom, ion, molecule or molecular assembly. Because the biosensors are multi-layered, a single biosensor is capable monitor a number of different properties of a biological system simultaneously. The biosensors are monitored by systems that impinge an excitation waveform on the biosensors and analyze a reflected and/or a transmitted resultant waveform. Additionally, the biosensors can be associated with field activated electronic components so that implantable, self-contained analytical devices can be constructed and monitored by field generators, where data is transmitted to an analyzer after field activation.

    摘要翻译： 公开了一类新的生物传感器及其制造和使用方法。 生物传感器是多层膜复合材料，其中至少一层通过逐层工艺制备，并且至少一层对变化有反应是生物系统的性质，例如原子浓度的变化， 离子，分子或分子组装。 由于生物传感器是多层次的，所以单个生物传感器能够同时监测生物系统的许多不同性质。 通过在生物传感器上引发激发波形的系统监测生物传感器，并分析反射和/或发射的合成波形。 此外，生物传感器可以与场激活的电子部件相关联，使得可以由现场发生器构建和监测可植入的，独立的分析装置，其中在场激活之后将数据传输到分析器。

    Method for delivering energy to tissue and apparatus
    2.
    发明授权
    Method for delivering energy to tissue and apparatus 有权
    将能量传递给组织和设备的方法

    公开(公告)号：US07074233B1

    公开(公告)日：2006-07-11

    申请号：US10877811

    申请日：2004-06-25

    申请人： Ashok Gowda ,  Roger J. McNichols ,  Massoud Motamedi ,  Pankaj J. Pasricha

    发明人： Ashok Gowda ,  Roger J. McNichols ,  Massoud Motamedi ,  Pankaj J. Pasricha

    IPC分类号： A61N5/067

    CPC分类号： A61B18/18 ,  A61B18/1815 ,  A61B2017/22051 ,  A61B2018/00023 ,  A61B2018/2261

    摘要： Disclosed is a method for delivering energy to a tissue. The method includes providing an apparatus which includes an energy delivery component and an inflatable member disposed around the energy delivery component. At a minimum, the inflatable member is constructed of a flexible inner wall and a flexible outer wall, which, taken together, enclose a cavity therebetween. The inflatable member is expanded such that the inflatable member's outer wall contacts the tissue's surface. Cooling fluid is disposed in the cavity, and energy is delivered to the energy delivery component so that at least a portion of the energy delivered to the energy delivery component passes through the inflatable member's inner wall, through the cooling fluid disposed in the cavity, through the inflatable member's outer wall, and into the tissue. Various apparatus suitable for use in delivering energy to tissues are also disclosed, as is a method for treating GERD or otherwise reducing reflux of a subject's stomach contents into the subject's esophagus.

    摘要翻译： 公开了一种向组织输送能量的方法。 该方法包括提供一种包括能量输送部件和围绕能量输送部件设置的可充气部件的装置。 至少，可膨胀构件由柔性内壁和柔性外壁构成，它们一起在其间包围空腔。 可膨胀构件被膨胀，使得可膨胀构件的外壁接触组织的表面。 冷却流体设置在空腔中，并且能量被输送到能量输送部件，使得输送到能量输送部件的能量的至少一部分通过可膨胀构件的内壁，穿过设置在空腔中的冷却流体，通过 充气构件的外壁，并进入组织。 还公开了适用于向组织递送能量的各种装置，以及用于治疗GERD或以其它方式减少受试者的胃内容物回流到受试者的食道中的方法。

    CONTINUOUS NONINVASIVE GLUCOSE MONITORING IN DIABETIC, NON-DIABETIC, AND CRITICALLY ILL PATIENTS WITH OCT
    3.
    发明申请
    CONTINUOUS NONINVASIVE GLUCOSE MONITORING IN DIABETIC, NON-DIABETIC, AND CRITICALLY ILL PATIENTS WITH OCT 审中-公开
    在糖尿病，非糖尿病和临床相关患者中连续使用无创性葡萄糖监测

    公开(公告)号：US20070232872A1

    公开(公告)日：2007-10-04

    申请号：US11685574

    申请日：2007-03-13

    申请人： Donald Prough ,  Rinat Esenaliev ,  Massoud Motamedi

    发明人： Donald Prough ,  Rinat Esenaliev ,  Massoud Motamedi

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0066 ,  A61B5/14532 ,  A61B5/412

    摘要： New optical coherence tomography (OCT) techniques are disclosed which are designed to improve OCT glucose concentration measure accuracy and are capable of being performed on a continuous basis. New multi-wavelength optical coherence tomography (OCT) techniques are also disclosed and designed to reduce artifacts do to water. New optical coherence tomography (OCT) techniques are also disclosed for determining local profusion rates, local analyte transport rates and tissue analyte transport rates as a measure of tissue health, disease progression and state and tissue transplantation effectiveness.

    摘要翻译： 公开了新的光学相干断层扫描（OCT）技术，其被设计用于提高OCT葡萄糖浓度测量精度并且能够连续地执行。 还公开并设计了新的多波长光学相干断层扫描（OCT）技术以减少对水的伪影。 还公开了新的光学相干断层扫描（OCT）技术，用于确定局部渗透率，局部分析物传输速率和组织分析物传输速率，作为组织健康，疾病进展和状态和组织移植有效性的量度。

    Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit
    4.
    发明授权
    Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit 有权
    连续光声监测血红蛋白浓度和血细胞比容

    公开(公告)号：US06751490B2

    公开(公告)日：2004-06-15

    申请号：US09796992

    申请日：2001-03-01

    申请人： Rinat Esenaliev ,  Massoud Motamedi ,  Donald Prough

    发明人： Rinat Esenaliev ,  Massoud Motamedi ,  Donald Prough

    IPC分类号： A61B500

    CPC分类号： A61B5/14535 ,  A61B5/0095 ,  A61B5/1455

    摘要： An optoacoustic apparatus is disclosed which includes a radiation source of pulsed optical radiation and a probe having a front face to be placed in contact with a tissue site of an animal body. The probe further includes an optical fiber terminating at the surface of the front face of the probe and connected to a pulsed laser. The front face of the probe also has mounted therein or thereon a piezoelectric transducer for detecting an acoustic response to the radiation pulses connected to a processing unit which converts the transducer signal into a measure of hemoglobin concentration and/or hematocrit of blood.

    摘要翻译： 公开了一种光声装置，其包括脉冲光辐射的辐射源和具有与动物体的组织部位接触的前表面的探针。 探头还包括终端于探头正面的表面并连接到脉冲激光的光纤。 探针的前表面也安装在其中或其上安装有用于检测连接到处理单元的辐射脉冲的声响应的压电换能器，其将换能器信号转换成血红蛋白浓度和/或血细胞比容的测量。

    Apparatus for emitting therapeutic energy within tissue
    7.
    发明授权
    Apparatus for emitting therapeutic energy within tissue 失效
    用于在组织内发射治疗能量的装置

    公开(公告)号：US06736808B1

    公开(公告)日：2004-05-18

    申请号：US09707102

    申请日：2000-11-06

    申请人： Massoud Motamedi ,  David L. Ware

    发明人： Massoud Motamedi ,  David L. Ware

    IPC分类号： A61B1736

    CPC分类号： A61B18/00 ,  A61B18/1492 ,  A61B18/24 ,  A61B2017/00053 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00292 ,  A61B2017/22051 ,  A61B2018/00214 ,  A61B2018/00392 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/126 ,  A61B2018/2261 ,  A61N5/0601

    摘要： A catheter capable of both sensing myocardial electrical activity and delivering ablating energy within myocardial tissue is disclosed. The catheter comprises electrodes on the outer sheath and contains a movable fiber optic cable that can be percutaneously advanced beyond the catheter body and into the myocardium for myocardial heating and coagulation, or modification of tissues responsible for cardiac arrhythmias. The fiber optic tip is designed to diffuse ablating energy radially to ablate a larger volume of tissue than is possible with a bare fiber optic tip. In addition, the tip is treated so that energy is not propagated in a forward direction, thus helping to prevent unwanted perforation of the heart tissue. Also disclosed is a method of cardioprotection from ischemia comprising inducing local hyperthermia in heart tissue.

    摘要翻译： 公开了能够检测心肌电活动并在心肌组织内传递消融能量的导管。 该导管包括在外护套上的电极，并且包含可经皮导管的可移动光纤电缆，其可以超过导管主体并进入用于心肌加热和凝结的心肌，或改变负责心律失常的组织。 光纤尖端被设计成径向扩散消融能量以消除比裸光纤尖端可能的更大体积的组织。 此外，尖端被处理使得能量不向前传播，从而有助于防止心脏组织的不期望的穿孔。 还公开了一种从缺血中心脏保护的方法，包括在心脏组织中诱导局部热疗。

    Methods for noninvasive analyte sensing
    8.
    发明授权
    Methods for noninvasive analyte sensing 有权
    非侵入性分析物检测方法

    公开(公告)号：US06725073B1

    公开(公告)日：2004-04-20

    申请号：US10197655

    申请日：2002-07-17

    申请人： Massoud Motamedi ,  Rinat O. Esenaliev

    发明人： Massoud Motamedi ,  Rinat O. Esenaliev

    IPC分类号： A61B500

    CPC分类号： A61B5/0066 ,  A61B5/14532 ,  A61B5/1455 ,  G01B9/02007 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/70

    摘要： Methods for measuring analyte concentration within a tissue using optical coherence tomography (OCT). Radiation is generated, and a first portion of the radiation is directed to the tissue to generate backscattered radiation. A second portion of the radiation is directed to a reflector to generate reference radiation. The backscattered radiation and the reference radiation is detected to produce an interference signal. The analyte concentration is calculated using the interference signal.

    摘要翻译： 使用光学相干断层扫描（OCT）测量组织内分析物浓度的方法。 产生辐射，并且辐射的第一部分被引导到组织以产生反向散射辐射。 辐射的第二部分被引导到反射器以产生参考辐射。 检测反向散射辐射和参考辐射以产生干扰信号。 使用干扰信号计算分析物浓度。