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公开(公告)号：US20070010422A1
公开(公告)日：2007-01-11
申请号：US11531602
申请日：2006-09-13
申请人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Press , Nai Wang , Pingwah Tang
发明人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Press , Nai Wang , Pingwah Tang
IPC分类号： A61K38/16 , A61K38/22 , A61K31/715 , A61K31/56 , C07C237/10
CPC分类号： C07C233/83 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K38/00 , A61K47/18 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/60 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68
摘要： Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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12.发明授权Modified amino acids and compositions comprising the same for delivering active agents 失效修饰的氨基酸和包含其的组合物用于递送活性剂
公开(公告)号：US6071510A
公开(公告)日：2000-06-06
申请号：US839094
申请日：1997-04-23
IPC分类号： A61K9/00 , A61K9/16 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/20 , A61K47/22 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07D207/34 , C07D213/81 , C07D295/215 , C07D317/68 , C07D333/38 , A61K31/70 , A61K38/17 , A61K47/12 , C07C229/06
CPC分类号： C07D213/81 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/4803 , A61K9/1617 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07D207/34 , C07D295/215 , C07D317/68 , C07D333/38 , A61K9/0043 , A61K9/0056 , C07C2101/14 , C07C2101/18 , C07C2103/74
摘要： The present invention provides modified amino acids for delivering active agents, and particularly biologically or chemically active agents. The preferred modified amino acids of the present invention include N-acylated or sulfonated amino acids. These modified amino acids are used as carriers to facilitate the delivery of a cargo to a target. Such modified amino acids are well suited to form non-covalent mixtures with biologically-active agents for oral administration to animals. Methods for the preparation and administration of the modified amino acids and compositions including the same are also provided.
摘要翻译： 本发明提供用于递送活性剂，特别是生物或化学活性剂的改性氨基酸。 本发明优选的修饰氨基酸包括N-酰化或磺化的氨基酸。 这些修饰的氨基酸用作载体以便于将货物运送到目标物。 这种修饰的氨基酸非常适合于与动物口服给药的生物活性剂形成非共价混合物。 还提供了修饰氨基酸的制备和给药方法及其组合物。
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公开(公告)号：US5866536A
公开(公告)日：1999-02-02
申请号：US798033
申请日：1997-02-06
IPC分类号： C07D295/20 , A61K9/00 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/197 , A61K31/198 , A61K31/40 , A61K31/44 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/48 , C07C53/126 , C07C53/134 , C07C229/08 , C07C229/10 , C07C229/42 , C07C231/12 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/62 , C07C235/64 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C239/06 , C07C239/08 , C07C259/06 , C07C271/22 , C07C303/22 , C07C303/40 , C07C309/59 , C07C311/19 , C07D207/34 , C07D207/416 , C07D213/75 , C07D213/81 , C07D295/215 , C07D317/68 , C07D333/38 , A61K31/725 , C07C229/06
CPC分类号： C07D333/38 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/4803 , A61K9/0019 , A61K9/1617 , A61K9/4858 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07D207/34 , C07D213/81 , C07D295/215 , C07D317/68 , A61K9/0043 , A61K9/0056 , C07C2101/14 , C07C2101/18 , C07C2103/74
摘要： Carrier compounds, compositions, and dosage unit forms therefor which are useful in the delivery of active agents are provided. The present invention provides a compound having the formula: ##STR1## or a salt thereof, wherein the compound may be used in a composition or dosage unit form for delivery of at least one active agent, including a peptide, mucopolysaccharide, carbohydrate, or a lipid. Methods of administration and preparation of the compounds and compositions of the invention are provided as well, including oral administration. Further, the compositions of the invention may be prepared by mixing at least one active agent, at least one carrier compound, and, optionally, a dosing vehicle.
摘要翻译： 提供了可用于递送活性剂的载体化合物，组合物和剂量单位形式。 本发明提供具有下式的化合物或其盐，其中所述化合物可以组合物或剂量单位形式用于递送至少一种活性剂，包括肽，粘多糖，碳水化合物或 脂质。 还提供了本发明化合物和组合物的施用和制备方法，包括口服给药。 此外，本发明的组合物可以通过混合至少一种活性剂，至少一种载体化合物和任选的给药载体来制备。
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公开(公告)号：US5643957A
公开(公告)日：1997-07-01
申请号：US335148
申请日：1994-10-25
申请人： Andrea Leone-Bay , Duncan R. Paton , Koc-Kan Ho , Frenel DeMorin
发明人： Andrea Leone-Bay , Duncan R. Paton , Koc-Kan Ho , Frenel DeMorin
IPC分类号： A61K9/06 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/16 , A61K31/352 , A61K31/727 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/25 , A61K38/27 , A61K38/28 , A61K39/00 , A61K39/395 , A61K47/18 , A61K47/42 , C07C229/42 , C07C233/48 , C07C233/51 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/82 , C07C233/87 , C07C235/26 , C07C235/38 , C07C235/64 , C07C235/78 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/107 , C07K5/06 , A01N37/12 , A61K31/195
CPC分类号： A61K38/25 , A61K31/16 , A61K31/352 , A61K31/727 , A61K38/212 , A61K38/23 , A61K38/27 , A61K47/183 , A61K9/1617 , A61K9/1641 , C07C229/42 , C07C233/48 , C07C233/55 , C07C233/63 , C07C233/82 , C07C233/87 , C07C235/26 , C07C235/38 , C07C235/64 , C07C235/78 , C07C235/84 , C07C237/22 , C07C279/14 , C07K1/1077 , C07K5/06043 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要： Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译： 提供了可用于递送活性剂的改性氨基酸化合物。 也提供给药和制备方法。
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公开(公告)号：US07744910B2
公开(公告)日：2010-06-29
申请号：US11531602
申请日：2006-09-13
申请人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Bruce Press , Nai Fang Wang , Pingwah Tang
发明人： David Gschneidner , Andrea Leone-Bay , Eric Wang , Lynn Errigo , Koc-Kan Ho , Jeffrey Bruce Press , Nai Fang Wang , Pingwah Tang
CPC分类号： C07C233/83 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K38/00 , A61K47/18 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/60 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68
摘要： Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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公开(公告)号：US07067119B2
公开(公告)日：2006-06-27
申请号：US10617266
申请日：2003-07-09
IPC分类号： A61K31/192 , A61K47/12 , C07C229/34
CPC分类号： C07D333/38 , A61K9/0019 , A61K9/0043 , A61K9/0056 , A61K9/1617 , A61K9/4858 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/541 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/34 , C07D213/81 , C07D295/215 , C07D317/68
摘要： Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration and methods of preparation of the modified amino acid compounds are also provided.
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公开(公告)号：US06663887B2
公开(公告)日：2003-12-16
申请号：US10090012
申请日：2002-02-21
申请人： Andrea Leone-Bay , Duncan R. Paton , Koc-Kan Ho , Frenel DeMorin
发明人： Andrea Leone-Bay , Duncan R. Paton , Koc-Kan Ho , Frenel DeMorin
IPC分类号： A61K648
CPC分类号： A61K31/727 , A61K9/1617 , A61K9/1641 , A61K31/16 , A61K31/352 , A61K38/212 , A61K38/23 , A61K38/25 , A61K38/27 , A61K47/183 , C07C229/42 , C07C233/48 , C07C233/55 , C07C233/63 , C07C233/82 , C07C233/87 , C07C235/26 , C07C235/38 , C07C235/64 , C07C235/78 , C07C235/84 , C07C237/22 , C07C279/14 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07K1/1077 , C07K5/06043
摘要： Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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公开(公告)号：US06623731B2
公开(公告)日：2003-09-23
申请号：US10038426
申请日：2001-10-19
IPC分类号： A61K31195
CPC分类号： C07D333/38 , A61K9/0019 , A61K9/0043 , A61K9/0056 , A61K9/1617 , A61K9/4858 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/541 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/34 , C07D213/81 , C07D295/215 , C07D317/68
摘要： Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are provided, and methods of preparation of the modified amino acid compound are provided.
摘要翻译： 提供了可用于递送活性剂的改性氨基酸化合物。 活性剂可以是肽，例如rhGH。 提供口服，皮下，舌下和鼻内给药的给药方法，提供修饰的氨基酸化合物的制备方法。
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公开(公告)号：US6001347A
公开(公告)日：1999-12-14
申请号：US798031
申请日：1997-02-06
IPC分类号： C07D295/20 , A61K9/00 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/197 , A61K31/198 , A61K31/40 , A61K31/44 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/48 , C07C53/126 , C07C53/134 , C07C229/08 , C07C229/10 , C07C229/42 , C07C231/12 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/62 , C07C235/64 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C239/06 , C07C239/08 , C07C259/06 , C07C271/22 , C07C303/22 , C07C303/40 , C07C309/59 , C07C311/19 , C07D207/34 , C07D207/416 , C07D213/75 , C07D213/81 , C07D295/215 , C07D317/68 , C07D333/38 , A61K31/715 , C07C229/34
CPC分类号： C07D333/38 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/4803 , A61K9/0019 , A61K9/1617 , A61K9/4858 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07D207/34 , C07D213/81 , C07D295/215 , C07D317/68 , A61K9/0043 , A61K9/0056 , C07C2101/14 , C07C2101/18 , C07C2103/74
摘要： Carrier compounds, compositions, and dosage unit forms therefor which are useful in the delivery of active agents are provided. The present invention provides a compound having the formula: ##STR1## or a salt thereof, wherein the compound may be used in a composition or dosage unit form for delivery of at least one active agent, including a peptide, mucopolysaccharide, carbohydrate, or a lipid. Methods of administration and preparation of the compounds and compositions of the invention are provided as well, including oral administration. Further, the compositions of the invention may be prepared by mixing at least one active agent, at least one carrier compound, and, optionally, a dosing vehicle.
摘要翻译： 提供了可用于递送活性剂的载体化合物，组合物和剂量单位形式。 本发明提供具有下式的化合物或其盐，其中所述化合物可以组合物或剂量单位形式用于递送至少一种活性剂，包括肽，粘多糖，碳水化合物或脂质。 还提供了本发明化合物和组合物的施用和制备方法，包括口服给药。 此外，本发明的组合物可以通过混合至少一种活性剂，至少一种载体化合物和任选的给药载体来制备。
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公开(公告)号：US5965121A
公开(公告)日：1999-10-12
申请号：US798023
申请日：1997-02-06
IPC分类号： C07D295/20 , A61K9/00 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/197 , A61K31/198 , A61K31/40 , A61K31/44 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/48 , C07C53/126 , C07C53/134 , C07C229/08 , C07C229/10 , C07C229/42 , C07C231/12 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/62 , C07C235/64 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C239/06 , C07C239/08 , C07C259/06 , C07C271/22 , C07C303/22 , C07C303/40 , C07C309/59 , C07C311/19 , C07D207/34 , C07D207/416 , C07D213/75 , C07D213/81 , C07D295/215 , C07D317/68 , C07D333/38 , A61K31/725
CPC分类号： C07D333/38 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/4803 , A61K9/0019 , A61K9/1617 , A61K9/4858 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07D207/34 , C07D213/81 , C07D295/215 , C07D317/68 , A61K9/0043 , A61K9/0056 , C07C2101/14 , C07C2101/18 , C07C2103/74
摘要： Carrier compounds, compositions, and dosage unit forms therefor which are useful in the delivery of active agents are provided. The present invention provides a compound having the formula: ##STR1## or a salt thereof, wherein the compound may be used in a composition or dosage unit form for delivery of at least one active agent, including a peptide, mucopoly-saccharide, carbohydrate, of a lipid. Methods of administration and preparation of the compounds and compositions of the invention are provided as well, including oral administration. Further, the compositions of the invention may be prepared by mixing at least one active agent, at least one carrier compound, and, optionally, a dosing vehicle.
摘要翻译： 提供了可用于递送活性剂的载体化合物，组合物和剂量单位形式。 本发明提供具有下式的化合物或其盐，其中该化合物可以组合物或剂量单位形式用于递送至少一种活性剂，包括脂质的肽，粘多糖，碳水化合物 。 还提供了本发明化合物和组合物的施用和制备方法，包括口服给药。 此外，本发明的组合物可以通过混合至少一种活性剂，至少一种载体化合物和任选的给药载体来制备。
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