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公开(公告)号：US20190119710A1
公开(公告)日：2019-04-25
申请号：US16235511
申请日：2018-12-28
申请人： BASF SE
发明人： Hartwig Schröder , Holger Hartmann , Qingzhao Wang , Shakir Siraj Ratani , Zheyuan Guo , Markus Pompejus
IPC分类号： C12P13/06 , C12P13/20 , C12P13/08 , C12P7/56 , C12P7/46 , C12N9/06 , C12N1/20 , C07K14/245 , C12P7/04
摘要： The present invention relates to a recombinant nucleic acid molecule, a recombinant micro-organism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
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公开(公告)号：US10208324B2
公开(公告)日：2019-02-19
申请号：US15103045
申请日：2014-12-08
申请人： BASF SE
发明人： Hartwig Schröder , Holger Hartmann , Qingzhao Wang , Shakir Ratani , Zheyuan Guo , Markus Pompejus
IPC分类号： C12N15/31 , C12P13/06 , C07K14/245 , C12N1/20 , C12N9/06 , C12P7/04 , C12P7/46 , C12P7/56 , C12P13/08 , C12P13/20
摘要： The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
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公开(公告)号：US09631212B2
公开(公告)日：2017-04-25
申请号：US14441215
申请日：2013-11-13
申请人： BASF SE
发明人： Oskar Zelder , Birgit Hoff , Hartwig Schroeder , Andrea Molt , Holger Hartmann , Klaus Ditrich , Michael Breuer , Rüdiger Reingrubber , Jakob Weber
IPC分类号： C12N15/80 , C12P17/04 , C12N15/67 , C07D307/93 , C12N15/52 , C07K14/37 , A01N37/46 , A01N63/04 , A01N37/42
CPC分类号： C12P17/04 , A01N37/42 , A01N37/46 , A01N63/04 , C07D307/93 , C07K14/37 , C12N15/52 , C12N15/67 , C12N15/80
摘要： The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
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公开(公告)号：US11788094B2
公开(公告)日：2023-10-17
申请号：US16062291
申请日：2016-12-08
申请人： BASF SE
CPC分类号： C12N15/75 , C12N9/0065 , C12N15/63 , C12P1/04 , C12Y111/01006
摘要： The present invention generally relates to the field of fermentation technology and microorganisms useful for such fermentations. The invention also relates to materials including nucleic acids and proteins useful for altering fermentation characteristics of microorganisms, and to microorganisms comprising such nucleic acids and/or proteins.
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公开(公告)号：US20200308235A1
公开(公告)日：2020-10-01
申请号：US15779595
申请日：2016-12-02
申请人： BASF SE
摘要： The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.
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公开(公告)号：US10208323B2
公开(公告)日：2019-02-19
申请号：US14731037
申请日：2015-06-04
申请人： BASF SE
发明人： Hartwig Schroeder , Holger Hartmann , Qingzhao Wang , Shakir Siraj Ratani , Zheyuan Guo , Markus Pompejus
IPC分类号： C12N15/00 , C12N1/20 , C12P13/06 , C07K14/245 , C12N9/06 , C12P7/04 , C12P7/46 , C12P7/56 , C12P13/08 , C12P13/20 , A61K38/00
摘要： The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
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公开(公告)号：US20180354999A1
公开(公告)日：2018-12-13
申请号：US15779646
申请日：2016-12-02
申请人： BASF SE
CPC分类号： C07K14/37 , C12N1/14 , C12N9/2437 , C12N15/01 , C12N15/80 , C12P19/14 , C12P21/00 , C12P21/02 , C12Q1/34
摘要： The present invention relates to a method of producing a recombinant polypeptide in a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 1 (CLR1) and to express the recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR1 and to the use of this filamentous fungus in the production of a recombinant polypeptide.
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公开(公告)号：US10047364B2
公开(公告)日：2018-08-14
申请号：US15024464
申请日：2014-09-11
申请人： BASF SE
发明人： Hartwig Schröder , Holger Hartmann , Qingzhao Wang , Shakir Ratani , Zheyuan Guo , Markus Pompejus
IPC分类号： C12N1/20 , C12N15/70 , C07K14/245 , C12P13/06 , C12P7/46 , C12N9/02 , C12N9/16 , C12P7/40 , C12P7/56 , C12P13/08 , C12P13/20
摘要： The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
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公开(公告)号：US09796992B2
公开(公告)日：2017-10-24
申请号：US14084030
申请日：2013-11-19
申请人： BASF SE
发明人： Oskar Zelder , Birgit Hoff , Hartwig Schröder , Andrea Molt , Holger Hartmann , Klaus Ditrich , Michael Breuer , Rüdiger Reingruber , Jakob Weber
摘要： The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polypeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
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20.发明申请公开(公告)号：US20150376663A1
公开(公告)日：2015-12-31
申请号：US14731037
申请日：2015-06-04
申请人： BASF SE
发明人： Hartwig Schroeder , Holger Hartmann , Qingzhao Wang , Shakir Ratani , Zheyuan Guo , Markus Pompejus
IPC分类号： C12P13/06 , C07K14/245 , C12N9/06
CPC分类号： C12P13/06 , C07K14/245 , C12N1/20 , C12N9/0016 , C12P7/04 , C12P7/46 , C12P7/56 , C12P13/08 , C12P13/20 , C12Y104/01001
摘要： The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
摘要翻译： 本发明涉及重组微生物，其用于制备丙氨酸的方法，以及重组核酸分子或重组微生物用于发酵生产丙氨酸的用途。
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