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公开(公告)号：US20220098160A1
公开(公告)日：2022-03-31
申请号：US17052078
申请日：2019-02-28
Applicant: BIOCAD
Inventor： Aleksei Leonidovich MINDICH , Svetlana Leonidovna GORBUNOVA , Aleksandra Vladimirovna POPKOVA , Artsiom Evgenievich SHEKHAUTSOU , Andrei Ivanovich ALAFINOV , Mariia Andreevna KASATKINA , Natalia Vladimirovna KOZHEMYAKINA , Anna Sergeevna KUSHAKOVA , Elena Aleksandrovna MAKSIMENKO , Leonid Evgen`evich MIKHAYLOV , Mariia Sergeevna MISHINA , Anna Jur'evna CHESTNOVA , Dmitry Valentinovich MOROZOV
IPC: C07D239/80 , A61P35/00 , C07D239/95 , C07D237/28 , C07D215/48 , C07D471/04
Abstract: The present invention relates to novel compounds of formula (1), which have the properties of a CDK8/19 inhibitor, and to a pharmaceutical composition containing said compounds, and to the use of said compounds and composition as pharmaceutical preparations for treating diseases or disorders.
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公开(公告)号：US20220064612A1
公开(公告)日：2022-03-03
申请号：US17276016
申请日：2019-09-13
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Dmitriy Aleksandrovich MADERA , Aleksandr Vladimirovich KARABELSKII , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV , Konstantin Viktorovich SEVERINOV , Sergey Anatolevich SHMAKOV , Dmitrii Aleksandrovich SUTORMIN , Georgii Evgenevich POBEGALOV , Aleksandra Andreevna VASILEVA , Polina Anatolevna SELKOVA , Anatolii Nikolaevich ARSENIEV , Tatyana Igorevna ZYUBKO , Iana Vitalevna FEDOROVA
Abstract: The present invention relates to the field of biotechnology, molecular biology and medicine, in particular to nuclease enzyme and use thereof. More specifically, the present invention relates to PaCas9 nuclease enzyme. The invention also relates to a nucleic acid encoding said nuclease, a genetic construct, an expression vector, a delivery vector, which comprise said nucleic acid, a liposome comprising said nuclease or nucleic acid encoding said nuclease, a method for producing a nuclease, methods for delivery, and a host cell comprising a nucleic acid encoding said nuclease.
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公开(公告)号：US20220056133A1
公开(公告)日：2022-02-24
申请号：US17417570
申请日：2019-12-24
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Olga Vladimirovna BRITANOVA , Dmitry Borisovich STAROVEROV , Anna Valentinovna EVSTRATEVA , Alexey Konstantinovich MISORIN , Timofey Aleksandrovich NEMANKIN , Mariia Aleksandrovna SHCHEMELEVA , Anna Konstantinovna VLADIMIROVA , Arina Vitalevna ANIKINA , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV , Pavel Andreevich IAKOVLEV , Sergey Anatolievich LUKYANOV
IPC: C07K16/28 , A61K45/06 , A61K39/395
Abstract: The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.
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公开(公告)号：US20210246138A1
公开(公告)日：2021-08-12
申请号：US17264670
申请日：2019-07-31
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Aleksei Leonidovich MINDICH , Anna Jur'evna CHESTNOVA , Mariia Andreevna KASATKINA , Andrei Ivanovich ALAFINOV , Aleksei Sergeevich GAVRILOV , Anton Aleksandrovich EVDOKIMOV , Liliana Vyacheslavovna LENSHMIDT , Elena Aleksandrovna MAKSIMENKO , Mariia Sergeevna MISHINA , Sergei Aleksandrovich SILONOV , Evgenii Jur'evich SMIRNOV , Pavel Andreevich IAKOVLEV , Dmitry Valentinovich MOROZOV
IPC: C07D471/04 , A61P35/00
Abstract: The present invention relates to novel compounds of formula I: which have the properties of CDK8/19 inhibitors, to a pharmaceutical composition comprising said compounds, and to use thereof as a medicine for treating diseases and disorders.
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公开(公告)号：US20200369771A1
公开(公告)日：2020-11-26
申请号：US16605865
申请日：2018-04-11
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Andrey Borisovich ULITIN , Victoria Mikhailovna EKIMOVA , Ekaterina Vladimirovna SOFRONOVA, , Yulia Sergeevna CHERNYKH , Sergei Andreevich AGEEV , Anna Konstantinovna VLADIMIROVA , Aleksei Aleksandrovich ALEKSANDROV , Pavel Alekseevich GREBNEV , Valery Vladimirovich SOLOVYEV , Iakov Iurevich USTIUGOV , Pavel Andreevich IAKOVLEV , Timofey Aleksandrovich NEMANKIN , Dmitry Valentinovich MOROZOV
IPC: C07K16/28 , A61K45/06 , A61K39/395
Abstract: The present invention relates to the field of biotechnology and provides antibodies that specifically binds to PD-L1. The invention also relates to DNA encoding said antibodies, to corresponding expression vectors and to methods of producing, and to methods of treatment using said antibodies.
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Patent Agency Ranking
公开(公告)号：US20200270345A1
公开(公告)日：2020-08-27
申请号：US16753587
申请日：2018-10-03
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Kirill Vladimirovich SOLOVYEV , Andrei Borisovich ULITIN , Timofey Aleksandrovich NEMANKIN , Valery Vladimirovich SOLOVYEV , Dmitry Valentinovich MOROZOV
IPC: C07K16/28
Abstract: The present invention relates to the field of bioengineering, specifically to antibodies or their antigen-binding fragments, and to the use thereof. More particularly, the present invention relates to antibodies that bind specifically to CD47 and PD-L1. The invention also relates to a nucleic acid that codes for the given antibody or for the antigen-binding fragment thereof, to an expression vector, to a method of producing the antibody, and to a use of the aforementioned antibodies and compositions in cancer treatment.
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公开(公告)号：US20240091383A1
公开(公告)日：2024-03-21
申请号：US18274496
申请日：2022-01-28
Applicant: JOINT STOCK COMPANY «BIOCAD»
Inventor： Dmitriy Aleksandrovich MADERA , Anna Sergeevna VESELOVA , Aleksei Sergeevich SIUTKIN , Pavel Mikhailovich GERSHOVICH , Dmitry Valentinovich MOROZOV
CPC classification number: A61K48/0058 , C12N15/86 , C12N2310/141 , C12N2310/31 , C12N2750/14143
Abstract: The present application relates to the fields of biotechnology, virology, genetics, and molecular biology. More specifically, the present invention relates to an isolated nucleic acid for producing a gene therapy viral product, said isolated nucleic acid comprising a nucleic acid that encodes the SMN1 protein having the amino acid sequence of SEQ ID NO: 1, and a nucleic acid that encodes the microRNA miR-23a, an expression cassette and a vector based thereon, as well as an AAV9-based recombinant virus for expressing the SMN1 gene in target cells, a pharmaceutical composition that includes said recombinant virus, and various uses of the above recombinant virus and the above composition.
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公开(公告)号：US20230203171A1
公开(公告)日：2023-06-29
申请号：US17998567
申请日：2021-06-07
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Dmitrii Aleksandrovich TOLSTYKH , Alina Aleksandrovna TSUKUR , Ekaterina Aleksandrovna LOMKOVA , Aleksandr Olegovich IAKOVLEV , Anton Aleksandrovich LUTCKII , Iuliia Nikolaevna LINKOVA , Arina Valerevna ZINKINA-ORIKHAN , Dmitry Valentinovich MOROZOV
CPC classification number: C07K16/2866 , A61K47/12 , A61K47/10 , A61K47/183 , A61K31/519 , A61K9/08 , A61P19/02 , A61P37/06 , C07K2317/21
Abstract: The disclosure relates to the field of pharmacy and medicine, specifically to aqueous compositions of anti-IL-6R antibody levilimab which may be used as a medicinal product for treating IL-6R-associated diseases.
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公开(公告)号：US20220213209A1
公开(公告)日：2022-07-07
申请号：US17605933
申请日：2020-04-23
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Andrei Borisovich ULITIN , Olesya Nikolaevna KOZLOVA , Aleksandr Andreevich GORDEEV , Ksenia Mihailovna BURNYSHEVA , Anastasia Nikolaevna ISHUTINOVA , Aleksandra Aleksandrovna SOZONOVA , Sergei Andreevich AGEEV , Aleksandr Nikolaevich DORONIN , Vladimir Sergeevich TSYMPILOV , Ivan Vladimirovich MITROSHIN , Valery Vladimirovich SOLOVYEV , Iakov Iurevich USTIUGOV , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV
Abstract: The present invention relates to biotechnology, in particular to antibodies or antigen-binding fragments thereof, and to use thereof. More particularly, the present invention relates to monoclonal antibodies that specifically bind to GITR. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with GITR.
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公开(公告)号：US20220089761A1
公开(公告)日：2022-03-24
申请号：US17288234
申请日：2019-10-30
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Pavel Andreevich IAKOVLEV , Natalia Eugenievna PESTOVA , Arina Vitalevna ANIKINA , Anna Alexandrovna TRUDOVISHNIKOVA , Mariia Aleksandrovna SHCHEMELEVA , Nina Grachyaevna KHARATIAN , Valery Vladimirovich SOLOVYEV , Alexey Konstantinovich MISORIN , Sergei Vasilyevich DIDUK , Anna Vladimirovna EROSHOVA , Veronika Sergeevna USATOVA , Elena Andreevna KRENDELEVA , Iakov Iurevich USTIUGOV , Aleksei Aleksandrovich ALEKSANDROV , Iana Andreevna SMIRNOVA , Svetlana Vladimirovna KOSKOVA , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV
Abstract: The present invention relates to biotechnology and provides a monoclonal antibody that specifically binds to CD20. The invention also relates to DNA encoding said antibody, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibody.
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