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公开(公告)号：US20250064728A1
公开(公告)日：2025-02-27
申请号：US18805710
申请日：2024-08-15
Applicant: Boston Scientific Scimed, Inc.
Inventor： Nicolas Ball-Jones , Joseph Thomas Delaney, JR. , Yen-Hao Hsu , Cristian Parisi
Abstract: In some aspects, the present disclosure provides a system for forming a hydrogel composition that comprises (a) a first reservoir containing a reactive polymer that comprises a plurality of first reactive groups; (b) a second reservoir containing a multifunctional compound that comprises a plurality of second reactive groups, the second reactive groups reacting with the first reactive groups to form covalent bonds at a pH greater than 7.4; and (c) a third reservoir containing a biologically innocuous buffer having a pH in a range of 8 to 12. Other aspects of the present disclosure pertain methods of treatment using such systems.
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公开(公告)号：US20250059237A1
公开(公告)日：2025-02-20
申请号：US18804679
申请日：2024-08-14
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph Thomas Delaney, JR. , Rick Dorn , Yen-Hao Hsu , Cristian Parisi
Abstract: In various aspects, the present disclosure pertains to methods of forming an iodinated peptide compound that comprises: (a) forming a multifunctional precursor compound comprising (i) a residue of an amine-protected peptide that comprises two or more amino acid residues with primary-amine-containing side groups and (ii) a multifunctional moiety linked to the amine-protected peptide residue through an amide group or an ester group; (b) reacting the multifunctional precursor compound in an amide coupling reaction or an esterification coupling reaction with an iodinated compound to form an iodinated, amine-protected peptide compound comprising n iodinated moieties that are covalently attached to the amine-protected peptide residue through a residue of the multifunctional moiety; and (c) deprotecting the iodinated, amine-protected peptide compound to form the iodinated peptide compound.
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13.发明公开公开(公告)号：US20240358896A1
公开(公告)日：2024-10-31
申请号：US18649602
申请日：2024-04-29
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Peijiang Wang , Cristian Parisi , Drew Carlton Wolos
CPC classification number: A61L27/54 , A61L27/26 , A61L27/52 , A61L27/58 , A61L2400/06
Abstract: In some embodiments, the present disclosure pertains to an injectable suspension that contains radiopaque crosslinked hydrogel particles in a carrier fluid that comprises one or more types of linear hydrophilic polymers. In some embodiments, the present disclosure pertains to kits that comprise a syringe preloaded with an injectable suspension that contains radiopaque crosslinked hydrogel particles in a carrier fluid that comprises one or more types of linear hydrophilic polymers. In some embodiments, the present disclosure pertains to methods of treatment comprising injecting into a subject an injectable suspension that contains radiopaque crosslinked hydrogel particles in a carrier fluid that comprises one or more types of linear hydrophilic polymers.
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14.发明公开公开(公告)号：US20240317944A1
公开(公告)日：2024-09-26
申请号：US18615619
申请日：2024-03-25
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu
CPC classification number: C08J3/075 , C08G18/10 , C08G18/30 , C08J3/24 , C08J2375/04
Abstract: In some aspects, a system for forming a hydrogel composition is described that comprises (a) a multifunctional cyclic carbonate compound and (b) a radiopaque, reactive polymer that comprises a plurality of amino groups that are reactive with the multifunctional cyclic carbonate groups of the multifunctional cyclic carbonate compound. In other aspects, a radiopaque crosslinked hydrogel composition is described that comprises a crosslinked reaction product of a multifunctional cyclic carbonate compound and a radiopaque, reactive polymer that comprises a plurality of amino groups. In further aspects, a method of treatment is described that comprises administering to a subject a mixture that comprises a multifunctional cyclic carbonate compound and a radiopaque, reactive polymer that comprises a plurality of amino groups, wherein the mixture is administered under conditions such that the multifunctional cyclic carbonate compound and the radiopaque, reactive multi-arm polymer crosslink after administration.
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公开(公告)号：US20240316220A1
公开(公告)日：2024-09-26
申请号：US18614277
申请日：2024-03-22
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Joseph Thomas Delaney, JR. , Cristian Parisi
CPC classification number: A61K49/0442 , A61K49/0073 , A61K49/0438 , A61M5/19
Abstract: In some aspects, the present disclosure pertains to systems for forming a crosslinked polymer composition, the systems comprising (a) an iodinated multifunctional compound comprising either a plurality of electron-rich dienophile-containing moieties or a plurality of electron-poor diene-containing moieties and (b) a multifunctional multi-arm polymer comprising either a plurality of electron-poor diene-containing moieties in the case where the iodinated multifunctional compound comprises a plurality of electron-rich dienophile-containing moieties or a plurality of electron-rich dienophile-containing moieties in the case where the iodinated multifunctional compound comprises a plurality of electron-poor diene-containing moieties, wherein the crosslinked polymer composition is formed by a cycloaddition reaction occurring between the iodinated multifunctional compound and the multifunctional multi-arm polymer. Other aspects of the present disclosure pertain to crosslinked networks formed by such systems and to methods of treatment using such systems.
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Patent Agency Ranking
公开(公告)号：US20240075190A1
公开(公告)日：2024-03-07
申请号：US18449907
申请日：2023-08-15
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Joseph Thomas Delaney, Jr. , Cristian Parisi
CPC classification number: A61L27/52 , C08L79/02 , C08L2203/02 , C08L2312/00
Abstract: In some aspects, the present disclosure pertains to systems for forming a hydrogel that comprise (a) an iodinated polyamino compound and (b) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having unsaturated end groups that are reactive with amino groups of the iodinated polyamino compound. Other aspects of the present disclosure pertain to medical hydrogels that are formed by crosslinking the iodinated polyamino compound and the reactive multi-arm polymer of such systems. Further aspects of the present disclosure pertain to medical procedures that can be performed using such systems.
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公开(公告)号：US20250043082A1
公开(公告)日：2025-02-06
申请号：US18781773
申请日：2024-07-23
Applicant: Boston Scientific Scimed, Inc.
Inventor： Nicolas Ball-Jones , Yen-Hao Hsu , Sasha Viola Rios , Joseph Thomas Delaney, JR. , Rick Dorn , Cristian Parisi
Abstract: In some aspects, the present disclosure pertains to methods that comprise (a) performing a ring-opening polymerization of one or more types of amino acid N-carboxyanhydride (NCA) monomers that comprise at least one type of protected amino acid NCA monomer having a protected pendant amine group in the presence of an initiator compound to produce intermediate peptide compounds that comprise an amino acid chain having protected pendant amine groups covalently attached to a residue of the initiator and (b) deprotecting the intermediate peptide compounds to form final peptide compounds that comprise an amino acid chain having pendant amine groups covalently attached to the residue of the initiator.
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公开(公告)号：US20240366503A1
公开(公告)日：2024-11-07
申请号：US18653739
申请日：2024-05-02
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu
Abstract: In some aspects, the present disclosure pertains to a radiopaque, reactive polymer comprising one or more hydrophilic polymer segments having a plurality of hydrophilic polymer segment ends, a plurality of iodinated cyclic anhydride residues covalently linked to the plurality of hydrophilic polymer segment ends, and a plurality of reactive moieties covalently linked to the iodinated cyclic anhydride residues. In some aspects, the present disclosure pertains to a system for forming a hydrogel composition that comprises (a) a nucleophilic compound and (b) such a radiopaque, reactive polymer. In some aspects, the present disclosure pertains to a method of treatment comprising administering to a subject a mixture that comprises (a) a nucleophilic compound and (b) such a radiopaque, reactive polymer under conditions such that the nucleophilic compound and the radiopaque, reactive polymer crosslink after administration.
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公开(公告)号：US20240335568A1
公开(公告)日：2024-10-10
申请号：US18627837
申请日：2024-04-05
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Joseph Thomas Delaney, JR. , Cristian Parisi , Heather Cirka , Alexis Compton
IPC: A61K49/04
CPC classification number: A61K49/0438 , A61K49/0457 , A61K49/0495
Abstract: In some aspects, the present disclosure pertains to radiopaque hydrogel compositions that comprise a radiopaque polysaccharide that comprises a plurality of radiopaque moieties that are covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide. In some aspects, the present disclosure pertains to radiopaque hydrogel compositions that comprise a carboxylate-anion-containing polysaccharide that is ionically crosslinked by multivalent cations. In other aspects, the present disclosure pertains to kits that contain such radiopaque hydrogel compositions, to methods of treatment that comprise administering such radiopaque hydrogel compositions to patients, and to methods of making such radiopaque hydrogel compositions.
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公开(公告)号：US12090509B2
公开(公告)日：2024-09-17
申请号：US18054188
申请日：2022-11-10
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph T. Delaney, Jr. , John Kummailil , Paul V. Grosso , Yen-Hao Hsu
CPC classification number: B05D1/18 , B05D1/02 , B05D2202/00
Abstract: Methods of treating a substrate, e.g., forming a coating on the substrate, are described. The method may include applying a solution comprising a multifunctional molecule or a multifunctional-polymer molecule to at least a portion of a surface of the substrate. The surface may comprise a metal or metal alloy and the multifunctional molecule or a multifunctional-polymer molecule may bond to the surface via at least one sulfur group of a plurality of sulfur groups of the multifunctional molecule. The method may include combining the multifunctional molecule with a polymer molecule to form the multifunctional polymer molecule before or after applying the solution. The polymer molecule may bond to an internal carbon group or a terminal sulfur group of the multifunctional molecule.
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