公开(公告)号：US09269557B2

公开(公告)日：2016-02-23

申请号：US14016739

申请日：2013-09-03

Applicant: CANON KABUSHIKI KAISHA

Inventor： Yoichi Otsuka

IPC: H01J49/16 ,  H01J49/26 ,  H01J49/04 ,  H01J49/00

CPC classification number: H01J49/16 ,  H01J49/0004 ,  H01J49/0463 ,  H01J49/165 ,  H01J49/26

Abstract: An ionization device includes an irradiation unit to irradiate at least a region of a surface of a sample with laser light to scatter particles contained on the surface of the sample, a liquid holding unit having a distal end to hold a liquid on an outer periphery of the distal end, an extract electrode to extract ionized ions, and a voltage application unit to apply a voltage between the liquid holding unit and the extract electrode to generate the ions from the liquid held on the outer periphery of the distal end. The region and the distal end are disposed so as not to make contact with each other but to be in close proximity to each other so that the liquid held on the outer periphery of the distal end attracts particles desorbed from the sample as a result of irradiation with the laser light.

Abstract translation: 电离装置包括：照射单元，用激光照射样品表面的至少一部分区域，以散射包含在样品表面上的颗粒;液体保持单元，其具有用于将液体保持在外周的液体; 远端，提取离子化离子的提取电极，以及在液体保持单元和提取电极之间施加电压以从保持在远端外周的液体产生离子的电压施加单元。 该区域和远端被设置为不彼此接触而彼此靠近，使得保持在远端的外周上的液体由于照射而吸引从样品解吸的颗粒 与激光。

公开(公告)号：US09230787B2

公开(公告)日：2016-01-05

申请号：US14582536

申请日：2014-12-24

Applicant: CANON KABUSHIKI KAISHA

Inventor： Masafumi Kyogaku ,  Yoichi Otsuka

IPC: H01J49/10 ,  H01J49/04 ,  H01J49/40 ,  H01J49/00

CPC classification number: H01J49/0409 ,  H01J49/0004 ,  H01J49/0454 ,  H01J49/0459 ,  H01J49/10 ,  H01J49/40

Abstract: Provided is an ionization apparatus including: a holder configured to hold a sample; a probe configured to determine a part to be ionized of the sample held by the holder; an extract electrode configured to extract ionized ions of the sample; a liquid supply unit configured to supply liquid to a part of a region of the sample; and a unit configured to apply a first voltage between the probe and the extract electrode, in which the first voltage is pulse-modulated.

公开(公告)号：US20150318157A9

公开(公告)日：2015-11-05

申请号：US14446771

申请日：2014-07-30

Applicant: CANON KABUSHIKI KAISHA

Inventor： Yoichi Otsuka ,  Masafumi Kyogaku

IPC: H01J49/10 ,  H01J49/24 ,  H01J49/26 ,  H01J49/00

CPC classification number: H01J49/10 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0459 ,  H01J49/165 ,  H01J49/24 ,  H01J49/26

Abstract: A mass spectrometry apparatus includes a holding table that holds a specimen to be ionized, a probe that identifies a portion of the specimen to be ionized, an ion extraction electrode that extracts ions obtained by ionizing the specimen, a liquid supplying unit that supplies liquid to between the specimen and the probe to form a liquid bridge between the specimen and the probe, a vibrating unit that vibrates one of the probe and the holding table, an electric field generating unit that generates an electric field between the probe and the ion extraction electrode, a mass spectrometry unit that mass analyzes ions extracted by the ion extraction electrode, and a synchronization unit configured to synchronize a time at which ions are generated from the portion with a time at which the mass spectrometry unit measures the ions.

Abstract translation: 质谱装置包括：保持要离子化的样品的保持台，识别要离子化的样本的一部分的探针;提取通过使样本离子获得的离子的离子提取电极;将液体供给到 在试样和探针之间形成试样和探针之间的液桥，振动单元，其振动探针和保持台之一;电场产生单元，其在探针和离子提取电极之间产生电场 质量分析由离子提取电极提取的离子的质谱分析单元，以及同步单元，其被配置为使从该部分产生离子的时间与质谱分析单元测量离子的时间同步。

公开(公告)号：US09134246B2

公开(公告)日：2015-09-15

申请号：US14290833

申请日：2014-05-29

Applicant: CANON KABUSHIKI KAISHA

Inventor： Jumpei Naito ,  Kota Iwasaki ,  Masafumi Kyogaku ,  Yoichi Otsuka

IPC: G01J5/02 ,  G01N21/65 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/10 ,  G01J3/44 ,  G02B21/16 ,  G02B21/365 ,  H01S3/10

Abstract: An optical measurement device includes a light source unit including a first laser light source configured to emit a laser beam having a first wavelength and a second laser light source configured to emit a laser beam having a second wavelength, a measurement wave number setting unit, and a light source adjustment unit configured to adjust at least one of the first wavelength and the second wavelength such that a difference between or a sum of a first wave number corresponding to the first wavelength and a second wave number corresponding to the second wavelength matches a measurement wave number set through the measurement wave number setting unit.

Abstract translation: 光学测量装置包括：光源单元，包括被配置为发射具有第一波长的激光的第一激光光源和被配置为发射具有第二波长的激光束的第二激光源，测量波数设定单元，以及 光源调节单元，被配置为调节所述第一波长和所述第二波长中的至少一个，使得对应于所述第一波长的第一波数与对应于所述第二波长的第二波数之和或之和与测量值相匹配 通过测量波数设定单位设定波数。

公开(公告)号：US09058966B2

公开(公告)日：2015-06-16

申请号：US14018119

申请日：2013-09-04

Applicant: CANON KABUSHIKI KAISHA

Inventor： Yoichi Otsuka

IPC: H01J49/16 ,  H01J49/26 ,  H01J49/00

CPC classification number: H01J49/16 ,  H01J49/0004 ,  H01J49/26

Abstract: An ionization device includes: a holding portion configured to hold a sample; a probe configured to arrange a liquid on a surface of the sample to form a liquid bridge between the probe and the sample; an electrode configured to form, at the probe, a Taylor cone for ionizing a substance contained in the sample, and to release the ionized substance from the Taylor cone; a voltage applying unit configured to apply a voltage to the electrode; and a light source configured to emit laser light that irradiates the Taylor cone. A mass spectrometer including the ionization device, and an image display system including the mass spectrometer are also disclosed.

Abstract translation: 电离装置包括：保持部，被配置为保持样品; 探针，被配置为在样品的表面上布置液体，以在探针和样品之间形成液体桥; 电极，被配置为在所述探针处形成用于离子化所述样品中所含物质的泰勒锥并从所述泰勒锥体释放所述离子化物质; 电压施加单元，被配置为向所述电极施加电压; 以及被配置为发射照射泰勒锥的激光的光源。 还公开了包括电离装置的质谱仪和包括质谱仪的图像显示系统。

公开(公告)号：US08710436B2

公开(公告)日：2014-04-29

申请号：US14016944

申请日：2013-09-03

Applicant: Canon Kabushiki Kaisha

Inventor： Yoichi Otsuka

IPC: G01N1/22

CPC classification number: G01N1/22 ,  H01J49/0004 ,  H01J49/0031 ,  H01J49/0459 ,  H01J49/10

Abstract: An ionization device includes a support configured to support a sample, a probe configured to determine a portion of the sample to be ionized, an irradiation unit configured to emit laser light and is disposed to irradiate with the laser light a liquid bridge portion between the sample and the probe, an extract electrode configured to extract ions obtained by ionizing the sample, a liquid supply unit configured to supply a liquid to a region of the sample, and voltage application units configured to generate an electric field between a portion of the probe that is in contact with the liquid bridge portion and the extract electrode.

Abstract translation: 电离装置包括被配置为支撑样品的支架，被配置为确定待离子化样品的一部分的探针;被配置为发射激光的照射单元，并被设置成与激光照射在样品之间的液桥部分 探针，提取电极，被配置为提取通过电离样品获得的离子;液体供应单元，被配置为将液体供应到样品的区域;以及电压施加单元，被配置为在探针的一部分之间产生电场， 与液桥部分和提取电极接触。

公开(公告)号：US20150311055A1

公开(公告)日：2015-10-29

申请号：US14791062

申请日：2015-07-02

Applicant: CANON KABUSHIKI KAISHA

Inventor： Yoichi Otsuka ,  Masafumi Kyogaku

IPC: H01J49/16 ,  H01J49/04 ,  H01J49/00

CPC classification number: H01J49/10 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0459 ,  H01J49/165 ,  H01J49/24 ,  H01J49/26

Abstract: A mass spectrometry apparatus includes a holding table that holds a specimen to be ionized, a probe that identifies a portion of the specimen to be ionized, an ion extraction electrode that extracts ions obtained by ionizing the specimen, a liquid supplying unit that supplies liquid to between the specimen and the probe to form a liquid bridge between the specimen and the probe, a vibrating unit that vibrates one of the probe and the holding table, an electric field generating unit that generates an electric field between the probe and the ion extraction electrode, a mass spectrometry unit that mass analyzes ions extracted by the ion extraction electrode, and a synchronization unit configured to synchronize a time at which ions are generated from the portion with a time at which the mass spectrometry unit measures the ions.

公开(公告)号：US20150034821A1

公开(公告)日：2015-02-05

申请号：US14340668

申请日：2014-07-25

Applicant: CANON KABUSHIKI KAISHA

Inventor： Masafumi Kyogaku ,  Yoichi Otsuka

IPC: H01J49/04 ,  H01J49/10 ,  G01Q10/06 ,  H01J49/40 ,  H01J49/00

CPC classification number: G01Q10/065 ,  H01J49/0004 ,  H01J49/0459

Abstract: Provided is an ionization apparatus including: a holder configured to hold a sample; a probe configured to determine a part to be ionized of the sample held by the holder; an extract electrode configured to extract ionized ions of the sample; a liquid supply unit configured to supply liquid to a part of a region of the sample; and a unit configured to apply a first voltage between the probe and the extract electrode, in which the first voltage is pulse-modulated.

Abstract translation: 提供一种电离装置，包括：保持器，其构造成保持样品; 探针，被配置为确定由所述保持器保持的样品被离子化的部分; 提取电极，被配置为提取所述样品的离子化离子; 液体供应单元，被配置为向样品的一部分区域供应液体; 以及被配置为在所述探针和所述提取电极之间施加第一电压的单元，其中所述第一电压被脉冲调制。

公开(公告)号：US20130334030A1

公开(公告)日：2013-12-19

申请号：US13972063

申请日：2013-08-21

Applicant: CANON KABUSHIKI KAISHA ,  A SCHOOL CORPORATION KANSAI UNIVERSITY

Inventor： Yoichi Otsuka ,  Ryuichi Arakawa

IPC: B01J19/08

CPC classification number: H01J49/165 ,  H01J49/0454

Abstract: The present invention has an object to achieve soft ionization more easily when a slight amount of substance is ionized under an atmosphere pressure. The present invention provides an ionization method for a substance contained in a liquid, including: supplying the liquid to a substrate from a probe and forming a liquid bridge made of the liquid containing the substance dissolved therein, between the probe and the substrate; oscillating the substrate; and generating an electric field between an electrically conductive portion of the probe in contact with the liquid and an ion extraction electrode.

Abstract translation: 本发明的目的是在大气压下将少量物质电离时，更容易实现软电离。 本发明提供一种液体中所含物质的离子化方法，包括：从探针供应液体至基底，并形成由溶解于其中的物质形成的液体桥;探针与基底之间; 振荡基板; 以及在与液体接触的探针的导电部分和离子提取电极之间产生电场。

公开(公告)号：US10690897B2

公开(公告)日：2020-06-23

申请号：US15132053

申请日：2016-04-18

Applicant: CANON KABUSHIKI KAISHA

Inventor： Koji Makara ,  Yoichi Otsuka ,  Masafumi Kyogaku ,  Hiroyuki Hashimoto

IPC: G02B21/00 ,  G01N21/65 ,  G01N21/64

Abstract: A laser scanning microscope apparatus includes an irradiation unit including an objective lens, a photodetector unit, an XY-scanning unit, and a Z-scanning unit. The irradiation unit focuses a laser beam with the objective lens to a specimen. The photodetector unit detects light generated from a position irradiated with the laser beam focused. The XY-scanning unit scans the laser beam in an X-direction perpendicular to an optical axis of the objective lens and in a Y-direction perpendicular to the optical axis and the X-direction. The Z-scanning unit scans the laser beam in a Z-direction parallel to the optical axis. When acquiring XY-two-dimensional image data by detecting the light while scanning the irradiated position in the X-direction and the Y-direction, the apparatus detects the light while scanning the irradiated position also in the Z-direction.