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公开(公告)号：US10690897B2
公开(公告)日：2020-06-23
申请号：US15132053
申请日：2016-04-18
Applicant: CANON KABUSHIKI KAISHA
Inventor： Koji Makara , Yoichi Otsuka , Masafumi Kyogaku , Hiroyuki Hashimoto
Abstract: A laser scanning microscope apparatus includes an irradiation unit including an objective lens, a photodetector unit, an XY-scanning unit, and a Z-scanning unit. The irradiation unit focuses a laser beam with the objective lens to a specimen. The photodetector unit detects light generated from a position irradiated with the laser beam focused. The XY-scanning unit scans the laser beam in an X-direction perpendicular to an optical axis of the objective lens and in a Y-direction perpendicular to the optical axis and the X-direction. The Z-scanning unit scans the laser beam in a Z-direction parallel to the optical axis. When acquiring XY-two-dimensional image data by detecting the light while scanning the irradiated position in the X-direction and the Y-direction, the apparatus detects the light while scanning the irradiated position also in the Z-direction.
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公开(公告)号：US20160306152A1
公开(公告)日：2016-10-20
申请号：US15132053
申请日：2016-04-18
Applicant: CANON KABUSHIKI KAISHA
Inventor： Koji Makara , Yoichi Otsuka , Masafumi Kyogaku , Hiroyuki Hashimoto
CPC classification number: G02B21/008 , G01N21/6428 , G01N21/6458 , G01N21/65 , G01N2021/655 , G01N2201/06113 , G01N2201/105 , G02B21/0032 , G02B21/0036 , G02B21/0064 , G02B21/0076
Abstract: A laser scanning microscope apparatus includes an irradiation unit including an objective lens, a photodetector unit, an XY-scanning unit, and a Z-scanning unit. The irradiation unit focuses a laser beam with the objective lens to a specimen. The photodetector unit detects light generated from a position irradiated with the laser beam focused. The XY-scanning unit scans the laser beam in an X-direction perpendicular to an optical axis of the objective lens and in a Y-direction perpendicular to the optical axis and the X-direction. The Z-scanning unit scans the laser beam in a Z-direction parallel to the optical axis. When acquiring XY-two-dimensional image data by detecting the light while scanning the irradiated position in the X-direction and the Y-direction, the apparatus detects the light while scanning the irradiated position also in the Z-direction.
Abstract translation: 激光扫描显微镜装置包括具有物镜，光电检测器单元，XY扫描单元和Z扫描单元的照射单元。 照射单元将具有物镜的激光束聚焦到样本。 光检测器单元检测从被聚焦的激光束照射的位置产生的光。 XY扫描单元在垂直于物镜的光轴的X方向和垂直于光轴和X方向的Y方向扫描激光束。 Z扫描单元沿平行于光轴的Z方向扫描激光束。 当通过在X方向和Y方向扫描照射位置时检测光来获取XY二维图像数据时，该装置也在沿Z方向扫描照射位置的同时检测光。
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3.发明授权Test apparatus and method of observing biopsy specimen sampled by using test apparatus 有权使用试验仪器对采样的活检标本进行观察的试验装置和方法公开(公告)号：US09107651B2
公开(公告)日：2015-08-18
申请号：US14289504
申请日：2014-05-28
Applicant: CANON KABUSHIKI KAISHA
Inventor： Shuya Satoh , Hiroyuki Hashimoto
CPC classification number: A61B10/0266 , A61B5/0075 , A61B5/0086 , A61B5/6848 , A61B10/0275
Abstract: A test apparatus includes a biopsy needle for sampling a biopsy specimen. The biopsy needle includes a specimen holder that holds the sampled biopsy specimen, and an optical window disposed in the specimen holder and configured to allow optical detection. A biopsy specimen held by the specimen holder of the test apparatus is measured by using a third-order nonlinear Raman microscope.
Abstract translation: 测试装置包括用于取样活检样本的活检针。 活检针包括保持采样的活检样本的样本保持器和设置在样本保持器中并被配置为允许光学检测的光学窗口。 通过使用三阶非线性拉曼显微镜测量由测试装置的样本保持器保持的活检样本。
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公开(公告)号：US08986943B2
公开(公告)日：2015-03-24
申请号：US13830802
申请日：2013-03-14
Applicant: Canon Kabushiki Kaisha
Inventor： Yohei Murayama , Hiroyuki Hashimoto , Manabu Komatsu , Kazuhiro Ban
CPC classification number: G01N1/30 , G01N1/31 , G01N2001/282 , G01N2001/317
Abstract: A pre-treatment method for analyzing a specified portion in a specimen composed of a biological tissue includes the steps of preparing a specimen to be analyzed, determining a specified portion in the specimen; and applying an analysis inhibitor to a portion except the specified portion of the specimen using a droplet spray method.
Abstract translation: 用于分析由生物组织构成的试样中的指定部位的预处理方法包括准备待分析试样的步骤，确定试样的规定部位; 并使用液滴喷雾法将分析抑制剂施加到除了特定部分的部分之外的部分。
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5.发明申请TEST APPARATUS AND METHOD OF OBSERVING BIOPSY SPECIMEN SAMPLED BY USING TEST APPARATUS 有权使用测试仪器测量生物样本的测试装置和方法公开(公告)号：US20140354987A1
公开(公告)日：2014-12-04
申请号：US14289504
申请日：2014-05-28
Applicant: CANON KABUSHIKI KAISHA
Inventor： Shuya Satoh , Hiroyuki Hashimoto
CPC classification number: A61B10/0266 , A61B5/0075 , A61B5/0086 , A61B5/6848 , A61B10/0275
Abstract: A test apparatus includes a biopsy needle for sampling a biopsy specimen. The biopsy needle includes a specimen holder that holds the sampled biopsy specimen, and an optical window disposed in the specimen holder and configured to allow optical detection. A biopsy specimen held by the specimen holder of the test apparatus is measured by using a third-order nonlinear Raman microscope.
Abstract translation: 测试装置包括用于取样活检样本的活检针。 活检针包括保持采样的活检样本的样本保持器和设置在样本保持器中并被配置为允许光学检测的光学窗口。 通过使用三阶非线性拉曼显微镜测量由测试装置的样本保持器保持的活检样本。
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Patent Agency Ranking
公开(公告)号：US20130203105A1
公开(公告)日：2013-08-08
申请号：US13830802
申请日：2013-03-14
Applicant: CANON KABUSHIKI KAISHA
Inventor： Yohei Murayama , Hiroyuki Hashimoto , Manabu Komatsu , Kazuhiro Ban
IPC: G01N1/30
CPC classification number: G01N1/30 , G01N1/31 , G01N2001/282 , G01N2001/317
Abstract: A pre-treatment method for analyzing a specified portion in a specimen composed of a biological tissue includes the steps of preparing a specimen to be analyzed, determining a specified portion in the specimen; and applying an analysis inhibitor to a portion except the specified portion of the specimen using a droplet spray method.
Abstract translation: 用于分析由生物组织构成的试样中的指定部位的预处理方法包括准备待分析试样的步骤，确定试样的规定部位; 并使用液滴喷雾法将分析抑制剂施加到除了特定部分的部分之外的部分。
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公开(公告)号：US20130158882A1
公开(公告)日：2013-06-20
申请号：US13772123
申请日：2013-02-20
Applicant: CANON KABUSHIKI KAISHA
Inventor： Manabu Komatsu , Hiroyuki Hashimoto
IPC: G06F19/26
CPC classification number: G06F19/26 , G01N33/6848 , H01J49/0004 , Y10T436/24
Abstract: An object of the present invention is to provide a method of comprehensively visualizing a constituent in tumor tissue or the like at a cellular level.The present invention provides a method of forming a two-dimensional distribution image of a target constituent based on information on the mass of constituents of the tissue section wherein, as the internal standard material, any one of actin, tubulin and GAPDH is used in the intracellular region, one of histone and nucleic acid is used in the nuclear region, and one of albumin and cytokine is used in the extracellular region.
Abstract translation: 本发明的目的是提供一种在细胞水平上全面显示肿瘤组织等中的成分的方法。 本发明提供一种基于组织部位成分质量的信息形成目标成分的二维分布图像的方法，其中作为内标物质，使用肌动蛋白，微管蛋白和GAPDH中的任一种 细胞内区域，组蛋白和核酸之一用于核区域，白蛋白和细胞因子之一用于细胞外区域。
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8.发明申请公开(公告)号：US20170062196A1
公开(公告)日：2017-03-02
申请号：US15253344
申请日：2016-08-31
Applicant: CANON KABUSHIKI KAISHA
Inventor： Kota Iwasaki , Hiroyuki Hashimoto
IPC: H01J49/00 , H01J49/16 , H01J49/28 , H01J37/244 , H01J37/12 , H01J37/141 , H01J49/10 , H01J49/06
CPC classification number: H01J49/0004 , H01J37/12 , H01J37/141 , H01J37/244 , H01J49/06 , H01J49/142 , H01J49/161 , H01J2237/226
Abstract: A charged particle image measuring device includes a sample stage, a charged particle lens opposite the sample stage, a two-dimensional detector, a first diaphragm disposed between the sample stage and a position of a crossover that is formed by the charged particle lens and that is closest to a sample, and a second diaphragm disposed between the first diaphragm and the two-dimensional detector.
Abstract translation: 带电粒子图像测量装置包括样品台，与样品台相对的带电粒子透镜，二维检测器，设置在样品台与由带电粒子透镜形成的交叉位置之间的第一隔膜， 最靠近样品，第二隔膜设置在第一隔膜和二维检测器之间。
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公开(公告)号：US09754772B2
公开(公告)日：2017-09-05
申请号：US15253344
申请日：2016-08-31
Applicant: CANON KABUSHIKI KAISHA
Inventor： Kota Iwasaki , Hiroyuki Hashimoto
IPC: H01J49/00 , H01J49/16 , H01J49/06 , H01J37/244 , H01J37/12 , H01J37/141 , H01J49/14
CPC classification number: H01J49/0004 , H01J37/12 , H01J37/141 , H01J37/244 , H01J49/06 , H01J49/142 , H01J49/161 , H01J2237/226
Abstract: A charged particle image measuring device includes a sample stage, a charged particle lens opposite the sample stage, a two-dimensional detector, a first diaphragm disposed between the sample stage and a position of a crossover that is formed by the charged particle lens and that is closest to a sample, and a second diaphragm disposed between the first diaphragm and the two-dimensional detector.
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公开(公告)号：US08569690B2
公开(公告)日：2013-10-29
申请号：US13772123
申请日：2013-02-20
Applicant: Canon Kabushiki Kaisha
Inventor： Manabu Komatsu , Hiroyuki Hashimoto
CPC classification number: G06F19/26 , G01N33/6848 , H01J49/0004 , Y10T436/24
Abstract: An object of the present invention is to provide a method of comprehensively visualizing a constituent in tumor tissue or the like at a cellular level.The present invention provides a method of forming a two-dimensional distribution image of a target constituent based on information on the mass of constituents of the tissue section wherein, as the internal standard material, any one of actin, tubulin and GAPDH is used in the intracellular region, one of histone and nucleic acid is used in the nuclear region, and one of albumin and cytokine is used in the extracellular region.
Abstract translation: 本发明的目的是提供一种在细胞水平上全面显示肿瘤组织等中的成分的方法。 本发明提供一种基于组织部位成分质量的信息形成目标成分的二维分布图像的方法，其中作为内标物质，使用肌动蛋白，微管蛋白和GAPDH中的任一种 细胞内区域，组蛋白和核酸之一用于核区域，白蛋白和细胞因子之一用于细胞外区域。
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