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公开(公告)号：US20200078002A1
公开(公告)日：2020-03-12
申请号：US16680739
申请日：2019-11-12
Applicant: CARDIOVALVE LTD.
Inventor： Gil Hacohen , Yossi Gross , Tal Reich
Abstract: A transluminal sheath is advanced into a femoral vein of a subject, through an inferior vena cava of the subject, into a right atrium of a heart of the subject, and transseptally into a left atrium of the heart. A surrounding-sheath is advanced out of a distal end of the transluminal sheath, into the left atrium, and toward a commissure of a mitral valve of the heart. A commissural helix is implanted at the commissure by advancing the commissural helix out of the surrounding-sheath and through the commissure into a left ventricle of the heart, such that the commissural helix wraps around at least some chordae tendineae at the commissure and facilitates sealing of the commissure. Subsequently to the implantation of the commissural helix, the surrounding-sheath is extracted from the heart. Other embodiments are also described.
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公开(公告)号：US10524910B2
公开(公告)日：2020-01-07
申请号：US15329920
申请日：2015-07-30
Applicant: CARDIOVALVE LTD.
Inventor： Tal Hammer , Meni Iamberger , Yaron Herman , Yuval Zipory , Eran Hoffer , Michael Albitov , Natalia Kruglova , Tal Reich , Ilia Hariton , Aviram Baum
Abstract: A rod (508) is transfemorally advanceable to the heart. An implant (460) comprises (i) a first frame (462), compressed around a first longitudinal site of a distal portion of the rod, (ii) a second frame (464), compressed around a third longitudinal site of the distal portion, (iii) a valve member (50), disposed within the second frame, and (iv) a flexible sheet (466), coupling the first frame to the second frame, and disposed around a second longitudinal site of the distal portion, the second longitudinal site being between the first longitudinal site and the third longitudinal site. An extracorporeal controller (569) is coupled to a proximal portion of the rod, and is operably coupled to the distal portion of the rod. Operating the controller bends the distal portion of the rod causing articulation between the frames. Other embodiments are also described.
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公开(公告)号：US10245143B2
公开(公告)日：2019-04-02
申请号：US15213791
申请日：2016-07-19
Applicant: CARDIOVALVE LTD.
Inventor： Yossi Gross , Gil Hacohen , Eran Miller , Yuval Zipory , Tal Reich , Meir Kutzik , Rotem Neeman
Abstract: Apparatus for use at a native heart valve of a subject is described. For some applications, the apparatus comprises a prosthetic valve support, configured (a) to be implanted at the native valve, (b) to facilitate, at a first period, implantation at the native valve of a first prosthetic valve, and (c) to facilitate, at a second period, implantation at the native valve of a second prosthetic valve. Other embodiments are also described.
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公开(公告)号：US10226341B2
公开(公告)日：2019-03-12
申请号：US15197069
申请日：2016-06-29
Applicant: CARDIOVALVE LTD.
Inventor： Yossi Gross , Gil Hacohen , Eran Miller , Yuval Zipory , Tal Reich , Meir Kutzik , Rotem Neeman
Abstract: For some applications, apparatus is provided for facilitating implantation of a prosthetic valve at a native heart valve of a subject, the apparatus comprising a prosthetic valve support, the prosthetic valve support (a) being configured to be transluminally-deliverable to the native valve and to be deployable at the native valve, and (b) comprising one or more tissue-engaging elements, configured to couple the prosthetic valve support to leaflets of the native valve without eliminating check valve functionality of the native valve. Other embodiments are also described.
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公开(公告)号：US11937795B2
公开(公告)日：2024-03-26
申请号：US17683875
申请日：2022-03-01
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Tal Reich , Paul Kaye
CPC classification number: A61B17/0057 , A61F2/2427 , A61M27/002 , A61B2017/00247 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61F2/2412 , A61F2/2436 , A61F2002/249 , A61F2210/0057 , A61M2210/125
Abstract: During a medical procedure, a transseptal fenestration is made at a septum of the heart and a shunt is implanted into the transseptal fenestration. During the same medical procedure, a transapical puncture is made into a left ventricle of the heart. A prosthetic valve is delivered via the transapical puncture and implanted at a mitral valve of the heart. Subsequently to delivering the prosthetic valve and making the transseptal fenestration, the transapical puncture is closed. Other embodiments are also described.
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Patent Agency Ranking
公开(公告)号：US11701225B2
公开(公告)日：2023-07-18
申请号：US16746489
申请日：2020-01-17
Applicant: CARDIOVALVE LTD.
Inventor： Tal Hammer , Meni Iamberger , Yuval Zipory , Michael Albitov , Tal Reich , Ilia Hariton
CPC classification number: A61F2/2436 , A61F2/2418 , A61F2/2439 , A61F2002/828 , A61F2220/0025 , A61F2230/001 , A61F2230/0067 , A61F2250/0039
Abstract: Apparatus includes a delivery tool and a prosthetic valve, the prosthetic valve includes a first frame, and a second frame coupled to the first frame. The delivery tool includes a first catheter, a second catheter, and a rod. A steerable portion of the second catheter extends out of the first catheter, and a steerable distal portion of the rod extends out of the second catheter. An extracorporeal rod-controller is operably coupled to the rod such that operating the extracorporeal rod-controller steers the steerable distal portion of the rod. In a delivery state of the apparatus, the prosthetic valve is compressed onto the rod, distal to the distal end of the second catheter, and the apparatus is transfemorally and transseptally advanceable into a left atrium of a heart of a subject. Other embodiments are also described.
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公开(公告)号：US10531866B2
公开(公告)日：2020-01-14
申请号：US15433547
申请日：2017-02-15
Applicant: CARDIOVALVE LTD.
Inventor： Ilia Hariton , Tal Reich , Paul Kaye
Abstract: A method is provided, comprising: (1) making a transapical puncture into a left ventricle of the heart; (2) making a transseptal fenestration in the heart; (3) delivering a prosthetic valve via the transapical puncture and implanting the prosthetic valve at a mitral valve of the heart; and (4) subsequently to delivering the prosthetic valve and making the transseptal fenestration, closing the transapical puncture. Other embodiments are also described.
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公开(公告)号：US10512456B2
公开(公告)日：2019-12-24
申请号：US15691032
申请日：2017-08-30
Applicant: CARDIOVALVE LTD.
Inventor： Gil Hacohen , Yossi Gross , Tal Reich
Abstract: A transluminal sheath is advanced transfemorally into a left atrium of a heart of the subject. A surrounding-sheath is advanced out of a distal end of the transluminal sheath, into the atrium, and toward a commissure of the mitral valve. A helix is implanted at the mitral valve by advancing the helix out of the surrounding-sheath and through the commissure into a left ventricle of the subject, such that the helix wraps around at least some chordae tendineae of the mitral valve. A prosthetic valve is collapsed into a collapsed state, and subsequently to implanting the helix and collapsing the prosthetic valve, the prosthetic valve is advanced, in its collapsed state, through the transluminal sheath to the mitral valve. The prosthetic valve is implanted in the mitral valve by expanding it such that the helix facilitates anchoring of the prosthetic valve and sealing of the commissure.
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公开(公告)号：US10695173B2
公开(公告)日：2020-06-30
申请号：US16460313
申请日：2019-07-02
Applicant: CARDIOVALVE LTD.
Inventor： Yossi Gross , Gil Hacohen , Eran Miller , Tal Reich
Abstract: An apparatus for use with a prosthetic heart valve at a native heart valve comprises an adjustable-lumen prosthetic valve support. In a delivery state, the prosthetic valve support is transluminally deliverable to the heart. The prosthetic valve support is transitionable, within the heart, into an implantation state for implantation at the native valve. In the implantation state, the prosthetic valve support has an inner edge that defines a lumen through the prosthetic valve support, the lumen having a first diameter. After the prosthetic valve support is implanted at the native valve, the prosthetic valve support is transitionable into an enlarged state in which the lumen has a second diameter that is greater than the first diameter. In the enlarged state, the prosthetic valve support is configured to support, at the native valve, the prosthetic heart valve within the lumen.
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公开(公告)号：US10531872B2
公开(公告)日：2020-01-14
申请号：US16040831
申请日：2018-07-20
Applicant: CARDIOVALVE LTD.
Inventor： Gil Hacohen , Yossi Gross , Tal Reich
Abstract: Embodiments of the present disclosure are directed to prosthetic heart valves and methods of use thereof. In one implementation, a prosthetic heart valve may include an annular spacer having a spacer opening therein and a disc-shaped wall configured to obstruct blood flow. The annular spacer may be configured for engaging with a native heart valve opening, such as the orifice of a mitral valve. The spacer opening may be sized to be smaller than the native heart valve opening. The prosthetic heart valve may also include a central valve section configured for disposal within the spacer opening. The central valve section may be separate from the annular spacer and may include one or more prosthetic valve leaflets.
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