公开(公告)号：US10343996B2

公开(公告)日：2019-07-09

申请号：US16049434

申请日：2018-07-30

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC: C07D211/78 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/60 ,  C07D211/76 ,  C07D211/88 ,  C07D211/90 ,  C07D211/94 ,  C07D211/96 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/16 ,  C07D207/26 ,  C07D207/263 ,  C07D207/267 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277 ,  C07D207/46 ,  C07D223/04 ,  C07D223/10 ,  C07D241/04 ,  C07D241/08 ,  C07D265/30 ,  C07D265/32 ,  C07D309/04 ,  C07D309/30 ,  C07D241/52

Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

公开(公告)号：US20130267699A1

公开(公告)日：2013-10-10

申请号：US13797736

申请日：2013-03-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC: C07D265/32 ,  C07D207/16 ,  C07D223/10 ,  C07D211/60

CPC classification number: C07D211/78 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/16 ,  C07D207/26 ,  C07D207/263 ,  C07D207/267 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277 ,  C07D207/46 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/60 ,  C07D211/76 ,  C07D211/88 ,  C07D211/90 ,  C07D211/94 ,  C07D211/96 ,  C07D223/04 ,  C07D223/10 ,  C07D241/04 ,  C07D241/08 ,  C07D241/52 ,  C07D265/30 ,  C07D265/32 ,  C07D309/04 ,  C07D309/30

Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

Abstract translation: 本发明提供具有季中心的杂环化合物和制备化合物的方法。 方法包括制备式（II）化合物的方法：包括用过渡金属催化剂处理式（I）化合物，并且在化合价和稳定性允许的烷基化条件下进行。

公开(公告)号：US20230098847A1

公开(公告)日：2023-03-30

申请号：US17867233

申请日：2022-07-18

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC: C07D211/78 ,  C07D265/32 ,  C07D211/60 ,  C07D207/16 ,  C07D223/10 ,  C07D309/04 ,  C07D223/04 ,  C07D241/04 ,  C07D241/08 ,  C07D241/52 ,  C07D207/06 ,  C07D265/30 ,  C07D207/08 ,  C07D207/10 ,  C07D207/26 ,  C07D207/263 ,  C07D207/27 ,  C07D207/46 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/76 ,  C07D211/88 ,  C07D211/94 ,  C07D211/96 ,  C07D309/30 ,  C07D207/267 ,  C07D207/273 ,  C07D207/277 ,  C07D211/90

Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

公开(公告)号：US10781213B2

公开(公告)日：2020-09-22

申请号：US16692518

申请日：2019-11-22

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Eric R. Welin ,  Scott C. Virgil ,  Pamela Tadross ,  Gerit M. Pototschnig ,  Aurapat (Fa) Ngamnithiporn ,  Kenji Negoro ,  Guillaume Lapointe ,  Max Klatte ,  Christopher Haley ,  Christian Gruenanger ,  Emil Glibstrup ,  Christopher Gilmore ,  Kevin McCormack Allan

IPC: C07D471/18 ,  A61P35/00 ,  C07D401/04

Abstract: (−)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of treating proliferative diseases with the same are provided.

公开(公告)号：US20200157049A1

公开(公告)日：2020-05-21

申请号：US16427629

申请日：2019-05-31

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC: C07D211/78 ,  C07D265/32 ,  C07D211/60 ,  C07D207/16 ,  C07D223/10 ,  C07D309/04 ,  C07D223/04 ,  C07D241/04 ,  C07D241/08 ,  C07D241/52 ,  C07D207/06 ,  C07D265/30 ,  C07D207/08 ,  C07D207/10 ,  C07D207/26 ,  C07D207/263 ,  C07D207/27 ,  C07D207/46 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/76 ,  C07D211/88 ,  C07D211/94 ,  C07D211/96 ,  C07D309/30 ,  C07D207/267 ,  C07D207/273 ,  C07D207/277 ,  C07D211/90

Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

公开(公告)号：US20200048201A1

公开(公告)日：2020-02-13

申请号：US16511138

申请日：2019-07-15

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Aurapat Ngamnithiporn ,  Carina I. Jette ,  Shoshana Bachman ,  Scott C. Virgil ,  Sebastian Lackner

IPC: C07D211/86 ,  B01J31/24 ,  C07D309/32 ,  C07D407/06 ,  C07D409/06 ,  C07D309/30 ,  C07D211/76

Abstract: The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic α-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.

公开(公告)号：US20190048009A1

公开(公告)日：2019-02-14

申请号：US16038968

申请日：2018-07-18

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Eric R. Welin ,  Scott C. Virgil ,  Pamela Tadross ,  Gerit Maria Pototschnig ,  Aurapat (Fa) Ngamnithiporn ,  Kenji Negoro ,  Guillaume Lapointe ,  Max Klatte ,  Christopher Haley ,  Christian Gruenanger ,  Emil Glibstrup ,  Christopher Gilmore ,  Kevin McCormack Allan

IPC: C07D471/18 ,  C07D401/04 ,  A61P35/00

CPC classification number: C07D471/18 ,  A61P35/00 ,  C07D401/04

Abstract: (−)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of treating proliferative diseases with the same are provided.

公开(公告)号：US20180339968A1

公开(公告)日：2018-11-29

申请号：US16049434

申请日：2018-07-30

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC: C07D211/78 ,  C07D223/10 ,  C07D309/04 ,  C07D207/16 ,  C07D211/60 ,  C07D211/90 ,  C07D207/277 ,  C07D207/273 ,  C07D207/267 ,  C07D309/30 ,  C07D211/96 ,  C07D211/94 ,  C07D211/88 ,  C07D211/76 ,  C07D211/38 ,  C07D211/34 ,  C07D211/22 ,  C07D211/18 ,  C07D211/16 ,  C07D207/46 ,  C07D207/27 ,  C07D207/263 ,  C07D207/26 ,  C07D207/10 ,  C07D207/08 ,  C07D265/30 ,  C07D207/06 ,  C07D241/52 ,  C07D241/08 ,  C07D241/04 ,  C07D223/04 ,  C07D265/32

CPC classification number: C07D211/78 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/16 ,  C07D207/26 ,  C07D207/263 ,  C07D207/267 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277 ,  C07D207/46 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/60 ,  C07D211/76 ,  C07D211/88 ,  C07D211/90 ,  C07D211/94 ,  C07D211/96 ,  C07D223/04 ,  C07D223/10 ,  C07D241/04 ,  C07D241/08 ,  C07D241/52 ,  C07D265/30 ,  C07D265/32 ,  C07D309/04 ,  C07D309/30

Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

公开(公告)号：US09422259B2

公开(公告)日：2016-08-23

申请号：US14529911

申请日：2014-10-31

Applicant: California Institute of Technology

Inventor： Hosea Nelson ,  Kei Murakami ,  Scott C. Virgil ,  Brian M. Stoltz ,  Jonathan R. Gordon

IPC: C07D313/06 ,  C07D311/00 ,  C07D493/08 ,  C07D493/18 ,  C07D493/16

CPC classification number: C07D311/00 ,  C07D493/08 ,  C07D493/16 ,  C07D493/18

Abstract: Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided.

Abstract translation: 提供由式I表示的化合物，其包括合成的经斯曲肽内酯和巴利内酯产物。 还提供了这些化合物的衍生物和合成方法。