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    Coryneform Bacteria Which Produce Chemical Compounds I
    15.
    发明申请
    Coryneform Bacteria Which Produce Chemical Compounds I 审中-公开
    生产化学化合物的棒状细菌I

    公开(公告)号：US20070111291A1

    公开(公告)日：2007-05-17

    申请号：US11612208

    申请日：2006-12-18

    申请人： Brigitte Bathe ,  Caroline Kreutzer ,  Bettina Mockel ,  Georg Thierbach

    发明人： Brigitte Bathe ,  Caroline Kreutzer ,  Bettina Mockel ,  Georg Thierbach

    IPC分类号： C12P13/24 ,  C12P13/22 ,  C12P13/04 ,  C12P13/20 ,  C12P13/14 ,  C12P13/08 ,  C12N15/74 ,  C12N1/21

    CPC分类号： C12R1/15 ,  C12N15/52 ,  C12P13/08

    摘要： The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.

    摘要翻译： 本发明涉及除了至少一个拷贝存在于编码合成蛋白质或RNA的开放阅读框（ORF），基因或等位基因的天然位点（基因座）外的棒状细菌， 在每种情况下，该开放阅读框（ORF）的第二个，任选的第三或第四个拷贝，基因或等位基因在每种情况下都是整合到染色体中的形式的第二个，任选的第三或第四个位点，并且用于制备化合物 通过这些细菌的发酵。

    Coryneform bacteria which produce chemical compounds I
    16.
    发明授权
    Coryneform bacteria which produce chemical compounds I 有权
    产生化学化合物I的棒状细菌

    公开(公告)号：US07160711B2

    公开(公告)日：2007-01-09

    申请号：US10358405

    申请日：2003-02-05

    申请人： Brigitte Bathe ,  Caroline Kreutzer ,  Bettina Mockel ,  Georg Thierbach

    发明人： Brigitte Bathe ,  Caroline Kreutzer ,  Bettina Mockel ,  Georg Thierbach

    IPC分类号： C12N1/12 ,  C12N15/00

    CPC分类号： C12R1/15 ,  C12N15/52 ,  C12P13/08

    摘要： The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.

    摘要翻译： 本发明涉及除了至少一个拷贝存在于编码合成蛋白质或RNA的开放阅读框（ORF），基因或等位基因的天然位点（基因座）外的棒状细菌， 在每种情况下，该开放阅读框（ORF）的第二个，任选的第三或第四个拷贝，基因或等位基因在每种情况下都是整合到染色体中的形式的第二个，任选的第三或第四个位点，并且用于制备化合物 通过这些细菌的发酵。

    Nucleotide sequences which code for the pck gene
    18.
    发明授权
    Nucleotide sequences which code for the pck gene 有权
    编码pck基因的核苷酸序列

    公开(公告)号：US06420151B1

    公开(公告)日：2002-07-16

    申请号：US09455777

    申请日：1999-12-07

    申请人： Bernard Eikmanns ,  Christian Riedel ,  Hermann Sahm ,  Bettina Mockel

    发明人： Bernard Eikmanns ,  Christian Riedel ,  Hermann Sahm ,  Bettina Mockel

    IPC分类号： C12P2106

    CPC分类号： C12N9/88 ,  C12P13/08

    摘要： Isolated polynucleotide from coryneform bacteria, comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for the polypeptide which is expressed by the pck gene contained on vector pK19mobsacB&Dgr;pck in the deposited E.coli strain DSM 13047, c) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, d) polynucleotide which is complementary to the polynucleotides of a), b) or c) and e) polynucleotide comprising at least 15 successive bases of the polynucleotide sequence of a), b), c) or d).

    摘要翻译： 来自棒状细菌的分离的多核苷酸，包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸的程度相同的多核苷酸， b）与编码由沉积的大肠杆菌菌株DSM 13047中载体pK19mobsacBDELTApck上包含的pck基因表达的多肽的多核苷酸的程度至少70％相同的多核苷酸，c）编码 多肽，其包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列，d）与a），b）或c）和ee）的多核苷酸互补的多核苷酸， 包含a），b），c）或d）的多核苷酸序列的至少15个连续碱基的多核苷酸。

    Process for Preparing L-amino Acids
    20.
    发明申请
    Process for Preparing L-amino Acids 审中-公开
    L-氨基酸的制备方法

    公开(公告)号：US20070122832A1

    公开(公告)日：2007-05-31

    申请号：US11615860

    申请日：2006-12-22

    申请人： Bettina Mockel ,  Mike Farwick ,  Thomas Hermann ,  Achim Marx ,  Walter Pfefferle

    发明人： Bettina Mockel ,  Mike Farwick ,  Thomas Hermann ,  Achim Marx ,  Walter Pfefferle

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P13/08 ,  C12N9/10 ,  C12N15/74 ,  C12N1/21

    CPC分类号： C12N9/1205 ,  C07K14/34 ,  C12N9/10 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/20 ,  C12P13/222 ,  C12P13/225 ,  C12P13/227 ,  C12P13/24

    摘要： The invention relates to isolated polynucleotides comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the citA gene is present in attenuated form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

    摘要翻译： 本发明涉及分离的多核苷酸，其包含多核苷酸序列，所述多核苷酸序列选自a）多核苷酸，其与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸的程度相同至少70％ b）编码多肽的多核苷酸，其包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列，c）与a）的多核苷酸互补的多核苷酸， 或b），和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少有citA基因 以减毒形式存在，并且使用包含根据本发明的序列的多核苷酸作为杂交探针。