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公开(公告)号：US10450550B2
公开(公告)日：2019-10-22
申请号：US16152709
申请日：2018-10-05
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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公开(公告)号：US09404092B2
公开(公告)日：2016-08-02
申请号：US15046011
申请日：2016-02-17
申请人： CODEXIS, INC.
CPC分类号： C12N9/0006 , C12N9/0008 , C12P7/28 , C12P13/02 , C12P17/02 , C12Y101/01184
摘要： The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α-chloroalcohols from α-chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
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公开(公告)号：US20150031095A1
公开(公告)日：2015-01-29
申请号：US14504558
申请日：2014-10-02
申请人： Codexis, Inc.
CPC分类号： C12N9/001 , C07K2319/00 , C12N9/0036 , C12N15/00 , C12P7/24 , C12P7/26 , C12P7/52 , C12P7/62 , C12P13/002 , C12Y103/01031 , C12Y106/99001 , Y02P20/52
摘要： The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
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公开(公告)号：US20140322796A1
公开(公告)日：2014-10-30
申请号：US14274589
申请日：2014-05-09
申请人： Codexis, Inc.
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12N15/52 , C12N15/80 , C12N15/81 , C12P7/04 , C12P7/10 , C12P19/02 , C12P19/14 , C12P2203/00 , Y02E50/16
摘要： The invention relates to recombinant expression of variant forms of C1 CBH1a and homologs thereof, having improved thermostability, low-pH tolerance, specific activity and other desirable properties. Also provided are methods for producing ethanol and other valuable organic compounds by combining cellobiohydrolase variants with cellulosic materials.
摘要翻译： 本发明涉及C1 CBH1a及其同系物的变体形式的重组表达，具有改善的热稳定性，低pH耐受性，比活性和其它所需性质。 还提供了通过将纤维二糖水解酶变体与纤维素材料结合来生产乙醇和其它有价值的有机化合物的方法。
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公开(公告)号：US12084697B2
公开(公告)日：2024-09-10
申请号：US18158339
申请日：2023-01-23
申请人： Codexis, Inc.
发明人： Oscar Alvizo , David Elgart , Robert Kevin Orr , James Nicholas Riggins , Anna Fryszkowska , Katrina W. Lexa , Xiang Yi , Da Duan , Courtney Dianne Moffett , Nikki Dellas , Vesna Mitchell
CPC分类号： C12N9/84 , C07K14/62 , C12P21/02 , C12Y305/01011 , C07K2319/21
摘要： The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.
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公开(公告)号：US11965192B2
公开(公告)日：2024-04-23
申请号：US17537941
申请日：2021-11-30
申请人： Codexis, Inc.
发明人： Jovana Nazor , Vesna Mitchell , David Elgart , Katrina W. Lexa , Nikki Dellas , Robert Kevin Orr , Oscar Alvizo , Ravi David Garcia , Judy Victoria Antonio Viduya , Courtney Dianne Moffett
CPC分类号： C12N9/84 , C07K14/62 , C12P21/02 , C12Y305/01011
摘要： The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
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公开(公告)号：US20240026313A1
公开(公告)日：2024-01-25
申请号：US18476753
申请日：2023-09-28
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
CPC分类号： C12N9/0071 , C07K14/80 , C12Y114/14001 , C12P13/001 , C12N9/0042 , C12Y106/02004
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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公开(公告)号：US11591588B2
公开(公告)日：2023-02-28
申请号：US17091479
申请日：2020-11-06
申请人： Codexis, Inc.
发明人： Oscar Alvizo , David Elgart , Robert Kevin Orr , James Nicholas Riggins , Anna Fryszkowska , Katrina W. Lexa , Xiang Yi , Da Duan , Courtney Dianne Moffett , Nikki Dellas , Vesna Mitchell
摘要： The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.
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公开(公告)号：US20210254119A1
公开(公告)日：2021-08-19
申请号：US17239953
申请日：2021-04-26
申请人： Codexis, Inc.
发明人： Jeffrey C. Moore , Jack Liang , Jonathan Penfield , Jovana Nazor , Nikki Dellas , Vesna Mitchell , Da Duan , Iman Farasat , Agustina Rodriguez-Granillo , Grant Murphy , Nicholas Marshall
摘要： The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.
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公开(公告)号：US09617568B2
公开(公告)日：2017-04-11
申请号：US15176851
申请日：2016-06-08
申请人： Codexis, Inc.
CPC分类号： C12N9/001 , C07K2319/00 , C12N9/0036 , C12N15/00 , C12P7/24 , C12P7/26 , C12P7/52 , C12P7/62 , C12P13/002 , C12Y103/01031 , C12Y106/99001 , Y02P20/52
摘要： The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
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