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公开(公告)号：US07036667B2
公开(公告)日：2006-05-02
申请号：US10837707
申请日：2004-05-04
Applicant: Michael Greenstein , Colin Kennedy , Huan Phan , Stephan Bianchi , Jonathan Reed Harris , Daren Walter Hebold , Robert Andrew Howard , Andrew Leonard Zee
Inventor： Michael Greenstein , Colin Kennedy , Huan Phan , Stephan Bianchi , Jonathan Reed Harris , Daren Walter Hebold , Robert Andrew Howard , Andrew Leonard Zee
IPC: B65D85/00
CPC classification number: B01L9/527 , B01L2200/025 , B01L2200/0689 , B01L2200/185 , B01L2300/041 , B65D85/70
Abstract: A container is provided for shipping and storing a pre-wetted and pre-conditioned microfluidic “sipper” chip. The container contains both dry compartments and wet compartments. A base contains a fluid-filled reservoir configured to house the capillaries. The opening of the reservoir is sealed with an O-ring. The plastic mount of the chip rests on the base in a dry compartment. The upper surface of the chip contains several wells containing fluid. A gasket is provided with plugs configured to be disposed within and seal the wells. Alternatively, the wells are first sealed with a foil film adhered to the well openings with an adhesive and a gasket is disposed between the foil and a cover, which is removably attached to the base. When the cover is closed, the gasket and O-ring seal the wet compartments to prevent leakage and to slow evaporation.
Abstract translation: 提供了用于运输和存储预润湿和预调节微流控“吸嘴”芯片的容器。 容器包含干燥隔室和湿隔间。 基座包含配置成容纳毛细管的流体填充的储存器。 储罐的开口用O形圈密封。 芯片的塑料安装座位于干燥隔间的底座上。 芯片的上表面包含几个含有流体的孔。 垫圈设置有被配置为设置在井中并密封井的塞子。 或者，孔首先用粘合剂粘附到井口上的箔膜密封，并且垫片设置在箔和盖之间，盖可拆卸地附接到基座。 当盖子关闭时，垫圈和O形圈密封湿隔间，以防止泄漏并减缓蒸发。
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公开(公告)号：US20060054300A1
公开(公告)日：2006-03-16
申请号：US11228749
申请日：2005-09-16
Applicant: Colin Kennedy
Inventor： Colin Kennedy
IPC: B22D11/045
CPC classification number: B22D11/045
Abstract: A horizontal continuous casting apparatus comprising an inert gas-purged resistance-heated type furnace 1, a crucible 6 for containing molten metal and having an outlet 8 for molten metal, coupled to a casting die 14, and a first clamping device 28-30, 32 for securing the die 14 in sealing communication with the crucible 6. A carrier adaptor 44 of an oxidation resistant refractory material comprises: a feed nozzle 50 between the crucible outlet 8 and a casting die inlet 39, a female mounting portion 52 for receiving, in sealing inter-engagement, a male mounting portion 54 of the die 14, and sealing means 58 for inter-engagement with the furnace wall 34 around the aperture 36. A second clamping device 68, 70, 72 is provided for releasably securing the carrier adaptor 44, in sealing inter-engagement, to the crucible 6 and furnace wall 34. The first clamping device 28-30, 32 releasably secures the casting die 14 to the carrier adapter 44.
Abstract translation: 一种水平连续铸造装置，包括惰性气体净化电阻加热型炉1，用于容纳熔融金属的坩埚6，并具有连接到铸造模具14的熔融金属出口8和第一夹紧装置28-30， 32用于固定模具14与坩埚6密封连通。 耐氧化耐火材料的载体适配器44包括：在坩埚出口8和铸模入口39之间的进料喷嘴50，用于在密封相互接合中接收模具的阳安装部分54的阴安装部分52 14以及用于与围绕孔36的炉壁34相互接合的密封装置58。 提供了第二夹紧装置68,70,72，用于可释放地将承载适配器44密封在坩埚6和炉壁34中。 第一夹紧装置28-30,30可释放地将铸模14固定到载体适配器44上。
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公开(公告)号：US20050011764A1
公开(公告)日：2005-01-20
申请号：US10915744
申请日：2004-08-11
Applicant: Manfred Berndt , Patrick Kaltenbach , Colin Kennedy
Inventor： Manfred Berndt , Patrick Kaltenbach , Colin Kennedy
CPC classification number: B01L3/502715 , B01L2200/027 , B01L2200/10 , B01L2300/0819 , B01L2400/0421
Abstract: In a system for operation or handling of a laboratory microchip (41) for chemical processing or analysis, the microchip (41) is mounted in a first physical unit (42). The microchip (41) is arranged on a mounting plate, such that it is readily accessible from the top and thus the fitting and removal of the microchip is considerably simplified. Furthermore, the first physical unit (42) comprises an optical device (43) for contactless detection of the results of the chemical processes conducted on the microchip. The supply systems necessary for the operation of the microchip are arranged in a module unit that has a separable connection with a second physical unit. The proposed modular layout enables ease of interchangeability of the required supply systems and thus, overall, ease of adaptability of the proposed system for various types of microchips.
Abstract translation: 在用于操作或处理用于化学处理或分析的实验室微芯片（41）的系统中，微芯片（41）安装在第一物理单元（42）中。 微芯片（41）设置在安装板上，使得其从顶部容易接近，因此微芯片的装配和移除被大大简化。 此外，第一物理单元（42）包括用于非接触式检测在微芯片上进行的化学处理结果的光学装置（43）。 微芯片操作所需的供电系统被布置在与第二物理单元具有可分离连接的模块单元中。 所提出的模块化布局使得所需供应系统的可互换性变得容易，并且因此总体而言，所提出的系统适用于各种类型的微芯片。
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公开(公告)号：US6074725A
公开(公告)日：2000-06-13
申请号：US987803
申请日：1997-12-10
Applicant: Colin Kennedy
Inventor： Colin Kennedy
CPC classification number: B32B38/14 , B01L3/502707 , B32B3/30 , B41M3/006 , B81C1/00119 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2400/0415 , B81B2201/058 , B81C2201/0184 , B81C2201/0185 , B81C2201/019 , Y10T428/24744 , Y10T428/24826 , Y10T428/24876 , Y10T428/24893 , Y10T428/24926 , Y10T436/2575
Abstract: Laminates having microfluidic structures disposed between sheets of the laminate are provided. The microfluidic structures are raised on a sheet of laminate, typically by printing the structure on the sheet. Printing methods include Serigraph, ink-jet, intaligo, offset printing and thermal laser printing.
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公开(公告)号：US20120255346A1
公开(公告)日：2012-10-11
申请号：US13437414
申请日：2012-04-02
Applicant: Colin Kennedy , Syed Husain , Dale von Behren , Rick Bernal
Inventor： Colin Kennedy , Syed Husain , Dale von Behren , Rick Bernal
IPC: G01N1/10
CPC classification number: G01N1/38 , G01N13/00 , G01N33/15 , G01N35/025 , G01N2013/003 , G01N2013/006 , G01N2035/00198
Abstract: The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 μl to 1 ml from the dissolution vessels to wells of an external receptacle.
Abstract translation: 本发明提供了用于溶出度测试的系统和方法。 该系统包括多个溶解容器和位于溶解容器上方的剂量载体。 剂量载体保持多个可移除的转盘，其接收单独的剂量以进行溶解测试。 接收片剂或沉降片的转盘通常具有第一配置，而接收篮子的转盘通常具有第二配置。 转盘的两种不同配置可在相同的剂量环上互换。 所述系统还包括位于所述剂量载体上方的驱动头，所述驱动头具有篮状心轴和可移除地且可互换地连接的混合桨。 与系统整合的移液器将从溶出容器到外部容器的孔的体积范围为50μl至1ml的样品等分试样。
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Patent Agency Ranking
公开(公告)号：US08158059B2
公开(公告)日：2012-04-17
申请号：US11648050
申请日：2006-12-28
Applicant: Colin Kennedy , Syed Husain , Dale von Behren , Rick Bernal
Inventor： Colin Kennedy , Syed Husain , Dale von Behren , Rick Bernal
IPC: G01N21/00
CPC classification number: G01N1/38 , G01N13/00 , G01N33/15 , G01N35/025 , G01N2013/003 , G01N2013/006 , G01N2035/00198
Abstract: The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 μl to 1 ml from the dissolution vessels to wells of an external receptacle.
Abstract translation: 本发明提供了用于溶出度测试的系统和方法。 该系统包括多个溶解容器和位于溶解容器上方的剂量载体。 剂量载体保持多个可移除的转盘，其接收单独的剂量以进行溶解测试。 接收片剂或沉降片的转盘通常具有第一配置，而接收篮子的转盘通常具有第二配置。 转盘的两种不同配置可在相同的剂量环上互换。 所述系统还包括位于所述剂量载体上方的驱动头，所述驱动头具有篮状心轴和可移除地且可互换地连接的混合桨。 与系统整合的移液器将从溶出容器到外部容器的孔的体积范围为50μl至1ml的样品等分试样。
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公开(公告)号：US20090321263A1
公开(公告)日：2009-12-31
申请号：US12377516
申请日：2007-09-17
Applicant: Youichi Endo , Yoshihiro Seto , Shinji Satomura , Masayoshi Hayashi , Mitsuo Watanabe , Colin Kennedy , Michael Greenstein , Cheryl Cathey
Inventor： Youichi Endo , Yoshihiro Seto , Shinji Satomura , Masayoshi Hayashi , Mitsuo Watanabe , Colin Kennedy , Michael Greenstein , Cheryl Cathey
IPC: G01N27/26
CPC classification number: G01N35/028 , B01L3/5027 , B01L13/02 , B01L2200/027 , B01L2400/0421 , B01L2400/0487 , G01N21/6456 , G01N35/025
Abstract: To enable reuse of expensive microchips in a clinical analysis apparatus, while constantly and efficiently obtaining accurate analysis results. A clinical apparatus employs microchips to analyze substances, which are contained in samples and are targets of measurement. The clinical analysis apparatus is equipped with: a stocking section; a dispensing mechanism, for dispensing reagents stocked in the stocking section and samples to the microchips; and a measuring section, for measuring the measurement target substance within the samples. The measuring section includes: a dispensing station, at which the microchips are provided; a detecting station, for detecting the measurement target substance; and a cleansing station, at which microchips are cleansed following detection of the measurement target substance. The dispensing station, the detecting station, and the cleansing station are provided at a predetermined pitch from upstream to downstream positions. The microchips are continuously rotated through the stations to perform measurement repeatedly.
Abstract translation: 为了在临床分析仪器中重新使用昂贵的微芯片，同时不断有效地获得准确的分析结果。 临床装置采用微芯片分析样品中含有的物质，是测量对象。 临床分析仪器配有：放养部分; 分配机构，用于分配储存在放养部分中的试剂和样品到微芯片; 以及用于测量样品内的测量目标物质的测量部分。 测量部分包括：分配站，在其上提供微芯片; 用于检测测量目标物质的检测站; 以及在检测到测定对象物质之后清洁微芯片的清洁台。 从上游到下游位置以预定间距设置分配站，检测站和清洁站。 微型芯片连续旋转通过台站进行重复测量。
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公开(公告)号：US20070080063A1
公开(公告)日：2007-04-12
申请号：US11245878
申请日：2005-10-07
Applicant: Colin Kennedy , Evelio Perez
Inventor： Colin Kennedy , Evelio Perez
CPC classification number: B01L9/527 , B01L3/5027 , B01L2200/025 , B01L2300/043 , B01L2300/0645 , B01L2400/0415
Abstract: An electrode alignment apparatus may be used with a microfluidic device for accurate and repeatable alignment of electrode pins with reservoirs on the microfluidic device. The apparatus includes a base unit and an electrode block assembly that are moveable with respect to each other from an open position to a closed position. The electrode block assembly includes an interface array that is coupled to an interface array platform such that the interface array is moveable with respect to the interface array platform in three dimensions.
Abstract translation: 电极对准装置可以与微流体装置一起使用，用于精确和可重复地将电极针与微流体装置上的储存器对准。 该装置包括可从打开位置到关闭位置相对于彼此移动的基座单元和电极块组件。 电极块组件包括耦合到接口阵列平台的接口阵列，使得接口阵列在三维方面可相对于接口阵列平台移动。
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公开(公告)号：US20050161321A1
公开(公告)日：2005-07-28
申请号：US10500406
申请日：2002-12-20
Applicant: Colin Kennedy , Takako Kimura , Minoru Ino , Jun Sonobe
Inventor： Colin Kennedy , Takako Kimura , Minoru Ino , Jun Sonobe
CPC classification number: C25B15/00 , C23C16/4405 , C25B1/245
Abstract: To provide an apparatus for fluorine gas generation and supply that is disposed in the gas supply system of a semiconductor processing system and that in the event of abnormalities in the apparatus enables back up by a safe and inexpensive structure. An apparatus 30 for the generation and supply of gas is disposed in the gas supply system of a semiconductor processing system. This apparatus 30 contains an electrolytic cell 34 that generates fluorine gas and a cylinder 62 that holds a substitute gas selected from the group consisting of nitrogen fluoride, sulfur fluoride, and chlorine fluoride. The electrolytic cell 34 and cylinder 62 are connected to a gas switching section 56 that selectively supplies a gas utilization section with fluorine gas from the electrolytic cell 34 or with substitute gas from the cylinder 62. A controller 40 controls the gas switching section 56 in such a manner that, upon detection of an abnormal state at the electrolytic cell 34 by an electrolytic cell detector 36, substitute gas is supplied from the cylinder 62 to the gas utilization section.
Abstract translation: 为了提供一种设置在半导体处理系统的气体供给系统中的氟气生成和供给装置，并且在设备的异常情况下可以通过安全且廉价的结构进行备份。 在半导体处理系统的气体供给系统中设置有用于产生和供应气体的装置30。 该装置30包含产生氟气的电解槽34和保持选自氮氟化物，氟化硫和氯氟化物的替代气体的气缸62。 电解槽34和气缸62连接到气体切换部分56，气体切换部分56选择性地向气体利用部分供应来自电解槽34的氟气或来自气缸62的替代气体。 控制器40以这样一种方式控制气体切换部分56，当电解槽检测器36检测到电解槽34处的异常状态时，替代气体从气缸62供应到气体利用部分。
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公开(公告)号：US06509085B1
公开(公告)日：2003-01-21
申请号：US09546293
申请日：2000-04-10
Applicant: Colin Kennedy
Inventor： Colin Kennedy
IPC: B32B322
CPC classification number: B32B38/14 , B01L3/502707 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2400/0415 , B32B3/30 , B41M3/006 , B81B2201/058 , B81C1/00119 , B81C2201/0184 , B81C2201/0185 , B81C2201/019 , Y10T428/24744 , Y10T428/24826 , Y10T428/24876 , Y10T428/24893 , Y10T428/24926 , Y10T436/2575
Abstract: Laminates having microfluidic structures disposed between sheets of the laminate are provided. The microfluidic structures are raised on a sheet of laminate, typically by printing the structure on the sheet. Printing methods include Serigraph, ink-jet, intaligo, offset printing and thermal laser printing.
Abstract translation: 提供具有布置在层压板之间的微流体结构的层压板。 微流体结构在一层层压板上升高，通常通过将该结构印刷在片材上。 印刷方法包括丝印，喷墨，印花，胶版印刷和热激光打印。
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