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    CLINICAL ANALYSIS APPARATUS
    1.
    发明申请
    CLINICAL ANALYSIS APPARATUS 审中-公开
    临床分析仪器

    公开(公告)号：US20090321263A1

    公开(公告)日：2009-12-31

    申请号：US12377516

    申请日：2007-09-17

    申请人： Youichi Endo ,  Yoshihiro Seto ,  Shinji Satomura ,  Masayoshi Hayashi ,  Mitsuo Watanabe ,  Colin Kennedy ,  Michael Greenstein ,  Cheryl Cathey

    发明人： Youichi Endo ,  Yoshihiro Seto ,  Shinji Satomura ,  Masayoshi Hayashi ,  Mitsuo Watanabe ,  Colin Kennedy ,  Michael Greenstein ,  Cheryl Cathey

    IPC分类号： G01N27/26

    CPC分类号： G01N35/028 ,  B01L3/5027 ,  B01L13/02 ,  B01L2200/027 ,  B01L2400/0421 ,  B01L2400/0487 ,  G01N21/6456 ,  G01N35/025

    摘要： To enable reuse of expensive microchips in a clinical analysis apparatus, while constantly and efficiently obtaining accurate analysis results. A clinical apparatus employs microchips to analyze substances, which are contained in samples and are targets of measurement. The clinical analysis apparatus is equipped with: a stocking section; a dispensing mechanism, for dispensing reagents stocked in the stocking section and samples to the microchips; and a measuring section, for measuring the measurement target substance within the samples. The measuring section includes: a dispensing station, at which the microchips are provided; a detecting station, for detecting the measurement target substance; and a cleansing station, at which microchips are cleansed following detection of the measurement target substance. The dispensing station, the detecting station, and the cleansing station are provided at a predetermined pitch from upstream to downstream positions. The microchips are continuously rotated through the stations to perform measurement repeatedly.

    摘要翻译： 为了在临床分析仪器中重新使用昂贵的微芯片，同时不断有效地获得准确的分析结果。 临床装置采用微芯片分析样品中含有的物质，是测量对象。 临床分析仪器配有：放养部分; 分配机构，用于分配储存在放养部分中的试剂和样品到微芯片; 以及用于测量样品内的测量目标物质的测量部分。 测量部分包括：分配站，在其上提供微芯片; 用于检测测量目标物质的检测站; 以及在检测到测定对象物质之后清洁微芯片的清洁台。 从上游到下游位置以预定间距设置分配站，检测站和清洁站。 微型芯片连续旋转通过台站进行重复测量。

    Method for separating components in liquid specimen and apparatus used in said method
    3.
    发明授权
    Method for separating components in liquid specimen and apparatus used in said method 失效
    用于分离液体试样中的组分的方法和用于所述方法的装置

    公开(公告)号：US6149818A

    公开(公告)日：2000-11-21

    申请号：US386149

    申请日：1999-08-31

    申请人： Kenji Nakamura ,  Shinji Satomura ,  Masayoshi Hayashi ,  Hideyoshi Arashima ,  Tetsushi Okuyama ,  Nobuhiro Hanafusa ,  Koji Tanimizu

    发明人： Kenji Nakamura ,  Shinji Satomura ,  Masayoshi Hayashi ,  Hideyoshi Arashima ,  Tetsushi Okuyama ,  Nobuhiro Hanafusa ,  Koji Tanimizu

    IPC分类号： B01D15/08 ,  G01N30/16 ,  G01N30/24 ,  G01N30/40 ,  G01N30/88

    CPC分类号： G01N30/40 ,  B01D15/1807 ,  B01D15/14 ,  G01N2030/402 ,  G01N2030/407 ,  G01N30/16 ,  G01N30/24 ,  G01N30/88

    摘要： The object of the present invention is to provide a method for separating components in a liquid specimen and an apparatus used in said method, by which it is possible to avoid carryover even when the specimen injector is not washed using washing solution and also to avoid the increase of inner pressure in column of the separation device or ineffective separating operation even when many liquid specimens are separated by many times using the same separation device. In the present invention, the liquid specimen is introduced into the separation device from a direction opposite to eluting direction of the separation device which retains an adsorbent, and by separating and eluting the specimen from eluting outlet together with the eluant, trace quantity of insoluble substances and the specimen remained on the specimen introducing passage can be removed by elution procedure. As a result, it is possible to avoid carryover, to prevent the increase of inner pressure in the column of the separation device and to prevent ineffective separating operation caused by clogging of the column.

    摘要翻译： 本发明的目的是提供一种用于分离液体试样中的组分和所述方法中使用的装置的方法，即使当使用洗涤溶液不洗涤试样注射器时也可以避免携带，并且避免 即使使用相同的分离装置多次分离多个液体样品，分离装置的塔内部压力增加或分离操作无效。 在本发明中，将液体试样从与保留吸附剂的分离装置的洗脱方向相反的方向引入分离装置，通过从洗脱液与洗脱液一起分离和洗脱试样，追踪微量的不溶物 残留在样品导入通道上的样品可以通过洗脱程序除去。 结果，可以避免残留，以防止分离装置的塔中的内压增加，并且防止由于柱的堵塞而导致的无效的分离操作。

    Process for separating and measuring glycoprotein
    4.
    发明授权
    Process for separating and measuring glycoprotein 失效
    糖蛋白分离和测定方法

    公开(公告)号：US5591589A

    公开(公告)日：1997-01-07

    申请号：US340299

    申请日：1994-11-14

    申请人： Hideo Katoh ,  Kenji Nakamura ,  Shinji Satomura

    发明人： Hideo Katoh ,  Kenji Nakamura ,  Shinji Satomura

    IPC分类号： G01N33/574 ,  G01N33/68 ,  G01N33/53

    CPC分类号： G01N33/6803 ,  G01N33/57469 ,  G01N33/57476 ,  Y10S435/973 ,  Y10S436/827

    摘要： The degree of a structure change of the sugar chain of a glycoprotein caused by a disease can be measured with high precision rapidly by separating and measuring two or more forms of glycoproteins which are different in sugar chain structure but have substantially the same protein structure, by using a combination of a lectin capable of recognizing the specific sugar chain structure of at least one of these glycoprotein analytes to be measured, and a first antibody which has a property of binding to all the glycoprotein analytes but is kept from binding to glycoprotein analyte(s) having the lectin attached thereto; and separating and measuring glycoprotein analyte(s) having the first antibody attached thereto and glycoprotein analyte(s) having no first antibody attached thereto, by utilizing differences in properties between the former glycoprotein analyte(s) and the latter glycoprotein analyte(s).

    摘要翻译： 由疾病引起的糖蛋白的糖链的结构变化程度可以通过分离和测定两种或多种形式的糖链结构不同但具有基本相同的蛋白质结构的糖蛋白，通过快速测定，由 使用能够识别待测量的这些糖蛋白分析物中的至少一种的特定糖链结构的凝集素的组合和具有结合所有糖蛋白分析物但不与糖蛋白分析物结合的性质的第一抗体（ s）具有凝集素附着; 并且通过利用前一种糖蛋白分析物和后一种糖蛋白分析物之间的特性差异来分离和测量具有附着于其上的第一抗体的糖蛋白分析物和与其无关的第一抗体的糖蛋白分析物。

    Stabilization of oxidase
    5.
    发明授权
    Stabilization of oxidase 失效
    氧化酶稳定

    公开(公告)号：US4543326A

    公开(公告)日：1985-09-24

    申请号：US441156

    申请日：1982-11-12

    申请人： Yoshinobu Miyashita ,  Shinji Satomura

    发明人： Yoshinobu Miyashita ,  Shinji Satomura

    IPC分类号： C12N9/04 ,  C12N9/96 ,  C12Q1/26 ,  C12Q1/48 ,  C12Q1/44 ,  C12Q1/46 ,  C12Q1/54

    CPC分类号： C12N9/0006 ,  C12N9/96 ,  C12Q1/26 ,  Y10S435/81

    摘要： An oxidase selected from the group consisting of glycerol-3-phosphate oxidase, choline oxidase and glucose oxidase can be stabilized by adding thereto an acidic amino acid or a salt thereof. The resulting stabilized composition can be used for quantitatively determining the content of glycerol-3-phosphate, choline, triglyceride, glucose, etc., in a biological fluid.

    摘要翻译： 可以通过向其中加入酸性氨基酸或其盐来稳定选自甘油-3-磷酸氧化酶，胆碱氧化酶和葡萄糖氧化酶的氧化酶。 得到的稳定化组合物可用于定量测定生物流体中甘油-3-磷酸，胆碱，甘油三酯，葡萄糖等的含量。

    Process for separating and measuring trace components
    8.
    发明授权
    Process for separating and measuring trace components 失效
    分离和测量痕量组分的方法

    公开(公告)号：US5780247A

    公开(公告)日：1998-07-14

    申请号：US488009

    申请日：1995-06-07

    申请人： Shinji Satomura ,  Kenji Nakamura ,  Shuji Matuura

    发明人： Shinji Satomura ,  Kenji Nakamura ,  Shuji Matuura

    IPC分类号： C12Q1/40 ,  C12Q1/48 ,  G01N33/543 ,  G01N33/76 ,  G01N33/574

    CPC分类号： G01N33/54306 ,  C12Q1/40 ,  C12Q1/48 ,  G01N33/76 ,  Y10S435/971 ,  Y10S435/973 ,  Y10S436/824 ,  Y10S436/827

    摘要： Two or more analytes having the same action, or having different actions in spite of their similar structures, or two or more analytes having the same action and the same detectable chemical characteristics, in samples derived from living bodies, etc., can be measured rapidly and easily by forming one or more complexes with one or more affinity substances, separating the complexes by using high pressure liquid chromatography, followed by measurement of the amount of an affinity substance or one of the analytes.

    摘要翻译： 具有相同作用的两种或更多种分析物，或者具有相似结构的不同作用，或者来自活体等的样品中具有相同作用和相同可检测化学特性的两种或更多种分析物可以快速测量 并且通过与一种或多种亲和物质形成一种或多种配合物，通过使用高压液相色谱法分离复合物，然后测量亲和物质或分析物之一，容易地。

    Electrophoresis
    10.
    发明授权
    Electrophoresis 有权
    电泳

    公开(公告)号：US07842175B2

    公开(公告)日：2010-11-30

    申请号：US10472753

    申请日：2002-04-03

    申请人： Tomohisa Kawabata ,  Kenji Nakamura ,  Shinji Satomura

    发明人： Tomohisa Kawabata ,  Kenji Nakamura ,  Shinji Satomura

    IPC分类号： G01N27/447

    CPC分类号： G01N33/532 ,  C12Q1/68 ,  G01N27/44726 ,  C12Q2565/125 ,  C12Q2563/179

    摘要： The invention relates to a method for separating a target for measurement utilizing electrophoresis, particularly capillary electrophoresis efficiently in high sensitivity and in a short period of time. It also relates to a method for measuring said target separated by said method for separation. The invention provides a method for separating a target for measurement and a method for measuring said target separated by said method for separation, characterized by using a substance to which is bound a nucleic acid chain labeled by a marker and which has an affinity for said target for measurement.

    摘要翻译： 本发明涉及一种利用电泳，特别是高灵敏度和短时间内有效毛细管电泳分离测定靶的方法。 本发明还涉及一种用于分离由所述分离方法分离的所述靶的测量方法。 本发明提供了一种用于分离测量目标的方法和由所述分离方法分离的用于测量所述靶的方法，其特征在于使用结合由标记物标记的核酸链的物质，所述核酸链对所述靶标具有亲和力 用于测量。